DK641687D0 - Phosphinsyrederivater - Google Patents

Phosphinsyrederivater

Info

Publication number: DK641687D0
Authority: DK; Denmark
Prior art keywords: phosphinic
Prior art date: 1986-12-15

Application number

DK641687A

Other languages

English (en)

Other versions

DK641687A (da

Inventor

Michael John Broadhurst

Balraj Krishan Handa

William Henry Johnson

Geoffrey Lawton

Peter James Machin

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-15

Filing date

1987-12-07

Publication date

1987-12-07

1986-12-15 Priority claimed from GB868629876A external-priority patent/GB8629876D0/en

1987-12-07 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1987-12-07 Publication of DK641687D0 publication Critical patent/DK641687D0/da

1988-06-16 Publication of DK641687A publication Critical patent/DK641687A/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK641687A 1986-12-15 1987-12-07 Phosphinsyrederivater DK641687A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB868629876A GB8629876D0 (en)	1986-12-15	1986-12-15	Phosphinic acid derivatives
GB878722245A GB8722245D0 (en)	1986-12-15	1987-09-22	Phosphinic acid derivatives

Publications (2)

Publication Number	Publication Date
DK641687D0 true DK641687D0 (da)	1987-12-07
DK641687A DK641687A (da)	1988-06-16

Family

ID=26291694

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK641687A DK641687A (da)	1986-12-15	1987-12-07	Phosphinsyrederivater

Country Status (19)

Country	Link
US (2)	US4885283A (da)
EP (1)	EP0276436B1 (da)
CN (1)	CN1017337B (da)
AU (1)	AU606901B2 (da)
CA (1)	CA1326737C (da)
CS (1)	CS272231B2 (da)
DE (1)	DE3786250T2 (da)
DK (1)	DK641687A (da)
ES (1)	ES2056810T3 (da)
FI (1)	FI89059C (da)
HU (1)	HU203109B (da)
IE (1)	IE62334B1 (da)
IL (1)	IL84766A (da)
MC (1)	MC1881A1 (da)
NO (1)	NO171788C (da)
NZ (1)	NZ222824A (da)
PH (1)	PH25030A (da)
PT (1)	PT86366B (da)
ZW (1)	ZW23187A1 (da)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE68925240T2 (de) *	1988-06-23	1996-06-13	Banyu Pharma Co Ltd	Phosphinsäure-Derivate
US5239078A (en) *	1990-11-21	1993-08-24	Glycomed Incorporated	Matrix metalloprotease inhibitors
US5183900A (en) *	1990-11-21	1993-02-02	Galardy Richard E	Matrix metalloprotease inhibitors
US5268384A (en) *	1990-11-21	1993-12-07	Galardy Richard E	Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors
US5114953A (en) *	1990-11-21	1992-05-19	University Of Florida	Treatment for tissue ulceration
US5189178A (en) *	1990-11-21	1993-02-23	Galardy Richard E	Matrix metalloprotease inhibitors
CA2058797A1 (en) *	1991-02-01	1992-08-02	Michael John Broadhurst	Amino acid derivatives
FR2676059B1 (fr) *	1991-05-02	1993-07-23	Commissariat Energie Atomique	Nouveaux derives de peptides utilisables comme inhibiteurs de collagenases bacteriennes.
EP0520573A1 (en) *	1991-06-27	1992-12-30	Glaxo Inc.	Cyclic imide derivatives
JPH07503016A (ja) *	1992-01-15	1995-03-30	メルク　エンド　カンパニー　インコーポレーテッド	変形防止剤としての置換されたホスフィン酸含有ペプチジル誘導体
US5326760A (en) *	1992-06-29	1994-07-05	Glaxo, Inc.	Aminobutanoic acid compounds having metalloprotease inhibiting properties
US6037472A (en) *	1993-11-04	2000-03-14	Syntex (U.S.A.) Inc.	Matrix metalloprotease inhibitors
AU5825094A (en) *	1993-11-19	1995-06-06	Astra Aktiebolag	Novel dipeptide derivatives
GB9405076D0 (en)	1994-03-16	1994-04-27	Inst Of Ophtalmology	A medical use of matrix metalloproteinase inhibitors
US5476847A (en) *	1994-06-29	1995-12-19	Schering Corporation	Derivatives of phosphinic acid useful as endothelin converting enzyme inhibitors
US5831004A (en)	1994-10-27	1998-11-03	Affymax Technologies N.V.	Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5840698A (en) *	1994-10-27	1998-11-24	Affymax Technologies N.V.	Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US6011021A (en) *	1996-06-17	2000-01-04	Guilford Pharmaceuticals Inc.	Methods of cancer treatment using naaladase inhibitors
FR2730235A1 (fr) *	1995-02-06	1996-08-09	Commissariat Energie Atomique	Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15
IL134816A (en) *	1995-12-08	2003-02-12	Agouron Pharma	Substituted diarylether sulfonic acids and their preparation
US6500948B1 (en)	1995-12-08	2002-12-31	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
DK0780386T3 (da) *	1995-12-20	2003-02-03	Hoffmann La Roche	Matrixmetalloproteaseinhibitorer
US5795877A (en) *	1996-12-31	1998-08-18	Guilford Pharmaceuticals Inc.	Inhibitors of NAALADase enzyme activity
TR199802638T2 (xx)	1996-06-17	1999-03-22	Guilford Pharmaceuticals, Inc.	Kanser tedavisinde naaladase inhibit�rleri kullan�m�.
US6046180A (en) *	1996-06-17	2000-04-04	Guilford Pharmaceuticals Inc.	NAALADase inhibitors
US6054444A (en) *	1997-04-24	2000-04-25	Guilford Pharmaceuticals Inc.	Phosphonic acid derivatives
US5902817A (en) *	1997-04-09	1999-05-11	Guilford Pharmaceuticals Inc.	Certain sulfoxide and sulfone derivatives
US6384022B1 (en)	1996-06-17	2002-05-07	Guilford Pharmaceuticals Inc.	Prodrugs of NAALAdase inhibitors
US6071965A (en) *	1996-06-17	2000-06-06	Guilford Pharmaceuticals Inc.	Phosphinic alkanoic acid derivatives
US6025345A (en) *	1996-06-17	2000-02-15	Guilford Pharmaceuticals Inc.	Inhibitors of NAALADase enzyme activity
US6025344A (en) *	1996-06-17	2000-02-15	Guilford Pharmaceuticals Inc.	Certain dioic acid derivatives useful as NAALADase inhibitors
US5863536A (en) *	1996-12-31	1999-01-26	Guilford Pharmaceuticals Inc.	Phosphoramidate derivatives
US5672592A (en) *	1996-06-17	1997-09-30	Guilford Pharmaceuticals Inc.	Certain phosphonomethyl-pentanedioic acid derivatives thereof
US5977090A (en) *	1996-09-27	1999-11-02	Guilford Pharmaceuticals Inc.	Pharmaceutical compositions and methods of treating compulsive disorders using NAALADase inhibitors
WO1998003516A1 (en) *	1996-07-18	1998-01-29	Pfizer Inc.	Phosphinate based inhibitors of matrix metalloproteases
US6953788B1 (en)	1996-09-19	2005-10-11	Aventis Pharmaceuticals Inc.	3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
US5962521A (en) *	1997-04-04	1999-10-05	Guilford Pharmaceuticals Inc.	Hydroxamic acid derivatives
US6174915B1 (en)	1997-03-25	2001-01-16	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6008243A (en) *	1996-10-24	1999-12-28	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US5985900A (en) *	1997-04-01	1999-11-16	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US5981209A (en) *	1997-12-04	1999-11-09	Guilford Pharmaceuticals Inc.	Use of NAALADase activity to identify prostate cancer and benign prostatic hyperplasia
US6028216A (en) *	1997-12-31	2000-02-22	Guilford Pharmaceuticals Inc.	Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives
US6121252A (en) *	1998-03-30	2000-09-19	Guilford Pharmaceuticals Inc.	Phosphinic acid derivatives
US6329418B1 (en)	1998-04-14	2001-12-11	The Procter & Gamble Company	Substituted pyrrolidine hydroxamate metalloprotease inhibitors
US6265609B1 (en)	1998-07-06	2001-07-24	Guilford Pharmaceuticals Inc.	Thio-substituted pentanedioic acid derivatives
HUP0103382A3 (en)	1998-07-06	2002-12-28	Guilford Pharmaceuticals Inc B	Naaladase inhibitors useful as pharmaceutical compounds and compositions
US6395718B1 (en)	1998-07-06	2002-05-28	Guilford Pharmaceuticals Inc.	Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors
NZ525513A (en)	1998-08-07	2004-09-24	Pont Pharmaceuticals Du	Succinoylamino lactams as inhibitors of Abeta protein production
HRP990246A2 (en)	1998-08-07	2000-06-30	Du Pont Pharm Co	Succinoylamino benzodiazepines as inhibitors of a beta protein production
EP1129355B1 (en) *	1998-11-12	2005-07-20	Bristol-Myers Squibb Pharma Company	Use of radioligands to screen inhibitors of amyloid-beta peptide production
US6737038B1 (en)	1998-11-12	2004-05-18	Bristol-Myers Squibb Company	Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
US6313159B1 (en)	1999-08-20	2001-11-06	Guilford Pharmaceuticals Inc.	Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors
GB9922577D0 (en) *	1999-09-23	1999-11-24	Center For Clinical & Basic Re	Substituted phosphinate based peptide derivatives
US6696456B1 (en) *	1999-10-14	2004-02-24	The Procter & Gamble Company	Beta disubstituted metalloprotease inhibitors
EP1265865A2 (en) *	2000-03-21	2002-12-18	The Procter & Gamble Company	Difluorobutyric acid derivatives and their use as metalloprotease inhibitors
SK13362002A3 (sk) *	2000-03-21	2003-04-01	The Procter & Gamble Company	Metalloproteázové inhibítory zahŕňajúce vedľajší karbocyklický reťazec
HUP0300235A2 (hu)	2000-03-21	2003-08-28	The Procter & Gamble Co.	Heterociklikus oldalláncot tartalmazó, N-szubsztituált metalloproteáz inhibitorok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
AU783857B2 (en)	2000-06-01	2005-12-15	Bristol-Myers Squibb Pharma Company	Lactams substituted by cyclic succinates as inhibitors of a beta protein production
US8283135B2 (en)	2000-06-30	2012-10-09	The Procter & Gamble Company	Oral care compositions containing combinations of anti-bacterial and host-response modulating agents
AU2003233154A1 (en)	2002-06-10	2003-12-22	Pfizer Inc.	Metabolites of prinomastat and their sythesis
FI3122757T3 (fi) *	2014-02-28	2023-10-10	Hangzhou Dac Biotech Co Ltd	Varautuneita linkkereitä ja niiden konjugointikäyttötapoja

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4226610A (en) *	1978-04-15	1980-10-07	Meiji Selka Kaisha, Ltd.	Herbicidal compounds, preparation thereof and herbicides containing the same
JPS60163899A (ja) *	1984-02-03	1985-08-26	Sankyo Co Ltd	レニン阻害ペプチド類
US4661473A (en) *	1984-03-27	1987-04-28	Merck & Co., Inc.	Renin inhibitors containing peptide isosteres
EP0210545A3 (en) *	1985-07-24	1988-07-20	Merck & Co. Inc.	Phosphorous containing enzyme inhibitors
EP0209848A3 (en) *	1985-07-24	1988-07-27	Merck & Co. Inc.	Enzyme inhibitors

1987
- 1987-11-30 ZW ZW231/87A patent/ZW23187A1/xx unknown
- 1987-12-01 US US07/126,643 patent/US4885283A/en not_active Expired - Fee Related
- 1987-12-03 AU AU82176/87A patent/AU606901B2/en not_active Ceased
- 1987-12-07 CA CA000553634A patent/CA1326737C/en not_active Expired - Fee Related
- 1987-12-07 DK DK641687A patent/DK641687A/da not_active Application Discontinuation
- 1987-12-07 NZ NZ222824A patent/NZ222824A/xx unknown
- 1987-12-09 IL IL8476687A patent/IL84766A/en not_active IP Right Cessation
- 1987-12-09 CS CS879002A patent/CS272231B2/cs unknown
- 1987-12-10 MC MC871933A patent/MC1881A1/xx unknown
- 1987-12-10 DE DE87118328T patent/DE3786250T2/de not_active Expired - Fee Related
- 1987-12-10 ES ES87118328T patent/ES2056810T3/es not_active Expired - Lifetime
- 1987-12-10 EP EP87118328A patent/EP0276436B1/en not_active Expired - Lifetime
- 1987-12-11 HU HU875593A patent/HU203109B/hu not_active IP Right Cessation
- 1987-12-14 CN CN87101164.6A patent/CN1017337B/zh not_active Expired
- 1987-12-14 PH PH36216A patent/PH25030A/en unknown
- 1987-12-14 NO NO875214A patent/NO171788C/no unknown
- 1987-12-14 IE IE338387A patent/IE62334B1/en not_active IP Right Cessation
- 1987-12-14 FI FI875484A patent/FI89059C/fi not_active IP Right Cessation
- 1987-12-15 PT PT86366A patent/PT86366B/pt not_active IP Right Cessation
1989
- 1989-09-22 US US07/410,779 patent/US5006651A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK641687A (da)	1988-06-16
IE62334B1 (en)	1995-01-25
NZ222824A (en)	1990-08-28
FI89059B (fi)	1993-04-30
AU8217687A (en)	1988-06-16
IL84766A (en)	1994-02-27
NO875214D0 (no)	1987-12-14
PT86366B (pt)	1990-11-20
ZW23187A1 (en)	1988-06-29
DE3786250D1 (en)	1993-07-22
CS900287A2 (en)	1990-03-14
ES2056810T3 (es)	1994-10-16
PT86366A (en)	1988-01-01
IE873383L (en)	1988-06-15
HU203109B (en)	1991-05-28
EP0276436B1 (en)	1993-06-16
FI89059C (fi)	1993-08-10
NO875214L (no)	1988-06-16
CA1326737C (en)	1994-02-01
EP0276436A1 (en)	1988-08-03
US5006651A (en)	1991-04-09
CN87101164A (zh)	1988-06-29
MC1881A1 (fr)	1989-01-24
NO171788C (no)	1993-05-05
PH25030A (en)	1991-01-28
HUT46699A (en)	1988-11-28
US4885283A (en)	1989-12-05
NO171788B (no)	1993-01-25
FI875484A0 (fi)	1987-12-14
CS272231B2 (en)	1991-01-15
IL84766A0 (en)	1988-05-31
DE3786250T2 (de)	1993-10-07
FI875484A (fi)	1988-06-16
CN1017337B (zh)	1992-07-08
AU606901B2 (en)	1991-02-21

Publication	Publication Date	Title
DK641687A (da)	1988-06-16	Phosphinsyrederivater
AT399804B (de)	1995-07-25	Sportschuh
DK126388A (da)	1988-05-10	Referenceelektrode
ATA246886A (de)	1988-01-15	Schachtsystem
ATA48386A (de)	1988-08-15	Kranbahn
BR8603659A (pt)	1988-02-09	Mini-infiltrometro
ATA179487A (de)	1990-12-15	Maishaecksler
BR8603768A (pt)	1988-05-17	Perspectivografo
IT8634302V0 (it)	1986-06-05	X
ES1000391Y (es)	1989-12-01	Formulario unibanda
ES295560Y (es)	1987-09-16	Estuche
ES1000383Y (es)	1988-07-01	Estuche
BR6602294U (pt)	1987-03-24	Estojo
BR6600844U (pt)	1988-02-09	Conjunto bolsa-almofada
BR6600999U (pt)	1988-02-23	Conjunto otorrino laringologico
BR6600838U (pt)	1987-05-19	Saleiro
BR6601345U (pt)	1988-04-12	Lousa magica
BR6600378U (pt)	1987-11-03	Agenda-calendario
BR6600467U (pt)	1987-11-10	Antiassalt
BR6600495U (pt)	1987-11-10	Micro-fragmentadora
BR6600559U (pt)	1987-12-01	Mini-tripe
BR6600239U (pt)	1987-10-13	Condutivimetro
BR6600849U (pt)	1987-06-23	Jaqueta-mochila
BR6600893U (pt)	1987-09-29	Aiveca
BR6601109U (pt)	1988-03-29	Elipsografo

Legal Events

Date	Code	Title	Description
1996-06-10	AHS	Application shelved for other reasons than non-payment