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DK550079A - PROCEDURE FOR PREPARING KETAL AND THIOKETAL DERIVATIVES OF MERCAPTOACYL PROLINES - Google Patents

PROCEDURE FOR PREPARING KETAL AND THIOKETAL DERIVATIVES OF MERCAPTOACYL PROLINES

Info

Publication number
DK550079A
DK550079A DK550079A DK550079A DK550079A DK 550079 A DK550079 A DK 550079A DK 550079 A DK550079 A DK 550079A DK 550079 A DK550079 A DK 550079A DK 550079 A DK550079 A DK 550079A
Authority
DK
Denmark
Prior art keywords
procedure
ketal
preparing
thioketal
derivatives
Prior art date
Application number
DK550079A
Other languages
Danish (da)
Other versions
DK159115C (en
DK159115B (en
Inventor
J Krapcho
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of DK550079A publication Critical patent/DK550079A/en
Publication of DK159115B publication Critical patent/DK159115B/en
Application granted granted Critical
Publication of DK159115C publication Critical patent/DK159115C/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D497/00Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10Spiro-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DK550079A 1978-12-22 1979-12-21 A LOGIC PROCEDURE FOR PREPARING A KETAL OR THIOKETAL DERIVATIVE OF A MERCAPTOACYL PROLINE DK159115C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97231478A 1978-12-22 1978-12-22
US97231478 1978-12-22

Publications (3)

Publication Number Publication Date
DK550079A true DK550079A (en) 1980-06-23
DK159115B DK159115B (en) 1990-09-03
DK159115C DK159115C (en) 1991-02-11

Family

ID=25519507

Family Applications (1)

Application Number Title Priority Date Filing Date
DK550079A DK159115C (en) 1978-12-22 1979-12-21 A LOGIC PROCEDURE FOR PREPARING A KETAL OR THIOKETAL DERIVATIVE OF A MERCAPTOACYL PROLINE

Country Status (31)

Country Link
JP (1) JPS5594357A (en)
AT (1) AT374174B (en)
AU (1) AU533149B2 (en)
BE (1) BE880815A (en)
CA (1) CA1132985A (en)
CH (1) CH642065A5 (en)
CS (1) CS215036B2 (en)
DD (1) DD148338A5 (en)
DE (1) DE2951200A1 (en)
DK (1) DK159115C (en)
ES (2) ES487180A0 (en)
FI (1) FI70886C (en)
FR (1) FR2444669A1 (en)
GB (1) GB2039478B (en)
GR (1) GR78384B (en)
HK (1) HK15684A (en)
HU (1) HU179644B (en)
IE (1) IE49321B1 (en)
IL (1) IL58930A (en)
IT (1) IT1126841B (en)
LU (1) LU82023A1 (en)
NL (1) NL7909246A (en)
NO (1) NO153569C (en)
NZ (1) NZ192449A (en)
PH (1) PH19213A (en)
PL (1) PL133414B1 (en)
PT (1) PT70620A (en)
SE (1) SE451839B (en)
SU (1) SU1115668A3 (en)
YU (1) YU314879A (en)
ZA (1) ZA796720B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2455585A1 (en) * 1979-05-04 1980-11-28 Ono Pharmaceutical Co OXOAMINOACID DERIVATIVES, MANUFACTURING METHOD AND PHARMACEUTICAL COMPOSITION
US4288368A (en) * 1979-07-30 1981-09-08 E. R. Squibb & Sons, Inc. Dithioacylproline derivatives
US4291040A (en) * 1979-10-22 1981-09-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
US4356182A (en) * 1979-10-22 1982-10-26 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines
HU184082B (en) * 1979-12-29 1984-06-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid
US4284624A (en) 1980-05-02 1981-08-18 E. R. Squibb & Sons, Inc. Mixed disulfides
US4316905A (en) * 1980-07-01 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of various 4-substituted prolines
US4311705A (en) * 1980-10-06 1982-01-19 E. R. Squibb & Sons, Inc. Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
US4416831A (en) 1981-04-27 1983-11-22 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds
US4374131A (en) 1981-04-27 1983-02-15 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinyl-alkanoyl compounds
US4416833A (en) 1981-05-04 1983-11-22 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4381297A (en) 1981-05-04 1983-04-26 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4555506A (en) * 1981-12-24 1985-11-26 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and use as hypotensives
US4560680A (en) * 1982-03-15 1985-12-24 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
ZA832762B (en) * 1982-04-30 1983-12-28 Squibb & Sons Inc Substituted 4-phenoxy prolines
US4452790A (en) * 1982-06-23 1984-06-05 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4703043A (en) * 1982-06-23 1987-10-27 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive
US4616005A (en) * 1982-06-23 1986-10-07 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4567166A (en) * 1982-07-14 1986-01-28 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension
US4709046A (en) * 1983-05-09 1987-11-24 E. R. Squibb & Sons, Inc. Acylmercaptoalkanoyl and mercaptoalkanoyl spiro compounds
CA2021409A1 (en) * 1989-08-21 1991-02-22 Donald S. Karanewsky Phosphonate substituted amino or imino acids useful as antihypertensives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
US4091024A (en) * 1976-12-03 1978-05-23 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
IT7851510A0 (en) * 1977-10-28 1978-10-16 Sandoz Ag AMIDES OF CYCLIC AMINO ACIDS THEIR PREPARATION AND THEIR APPLICATION AS MEDICINES
PH15381A (en) * 1978-02-21 1982-12-17 Squibb & Sons Inc Halogen substituted mercaptoacylamino acids
CA1144930A (en) * 1978-08-11 1983-04-19 Miguel A. Ondetti Mercaptoacyl derivatives of substituted prolines

Also Published As

Publication number Publication date
CA1132985A (en) 1982-10-05
NO153569B (en) 1986-01-06
GB2039478B (en) 1983-02-16
ZA796720B (en) 1980-11-26
PL220609A1 (en) 1980-12-01
DK159115C (en) 1991-02-11
ES8103039A1 (en) 1981-02-16
ES488752A0 (en) 1981-02-16
SE451839B (en) 1987-11-02
SU1115668A3 (en) 1984-09-23
ES8102094A1 (en) 1980-12-16
NL7909246A (en) 1980-06-24
NO794181L (en) 1980-06-24
FR2444669A1 (en) 1980-07-18
IT7951167A0 (en) 1979-12-21
CH642065A5 (en) 1984-03-30
GR78384B (en) 1984-09-26
SE7910550L (en) 1980-06-23
FI70886B (en) 1986-07-18
DD148338A5 (en) 1981-05-20
HK15684A (en) 1984-03-02
HU179644B (en) 1982-11-29
AT374174B (en) 1984-03-26
IE792468L (en) 1980-06-22
IE49321B1 (en) 1985-09-18
NZ192449A (en) 1984-05-31
AU533149B2 (en) 1983-11-03
IL58930A0 (en) 1980-03-31
BE880815A (en) 1980-06-23
NO153569C (en) 1986-05-21
FR2444669B1 (en) 1983-06-03
AU5371479A (en) 1980-06-26
ATA805479A (en) 1983-08-15
DK159115B (en) 1990-09-03
FI70886C (en) 1986-10-27
FI794027A (en) 1980-06-23
IL58930A (en) 1983-07-31
PL133414B1 (en) 1985-05-31
JPS5594357A (en) 1980-07-17
DE2951200A1 (en) 1980-07-10
ES487180A0 (en) 1980-12-16
IT1126841B (en) 1986-05-21
CS215036B2 (en) 1982-06-25
LU82023A1 (en) 1980-04-23
YU314879A (en) 1983-04-30
PH19213A (en) 1986-02-04
GB2039478A (en) 1980-08-13
PT70620A (en) 1980-01-01

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