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DK54081A - PROCEDURE FOR THE PREPARATION OF INSULIN DERIVATIVES - Google Patents

PROCEDURE FOR THE PREPARATION OF INSULIN DERIVATIVES

Info

Publication number
DK54081A
DK54081A DK54081A DK54081A DK54081A DK 54081 A DK54081 A DK 54081A DK 54081 A DK54081 A DK 54081A DK 54081 A DK54081 A DK 54081A DK 54081 A DK54081 A DK 54081A
Authority
DK
Denmark
Prior art keywords
insulin
salt
preparation
water
threonine
Prior art date
Application number
DK54081A
Other languages
Danish (da)
Other versions
DK147437B (en
DK147437C (en
Inventor
J Markussen
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8095095&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK54081(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Industri As filed Critical Novo Industri As
Priority to DK54081A priority Critical patent/DK147437C/en
Publication of DK54081A publication Critical patent/DK54081A/en
Publication of DK147437B publication Critical patent/DK147437B/en
Application granted granted Critical
Publication of DK147437C publication Critical patent/DK147437C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Forklifts And Lifting Vehicles (AREA)

Abstract

Preparation of human insulin or threonine<B30> esters of human insulin, or a salt or complex thereof, by means of transpeptidating an insulin compound containing the human des(Thr<B30>) insulin moiety, or a salt or complex thereof which can be converted into it, with a L- threonine ester, or a salt thereof, in a mixture of water, a water-miscible, organic solvent and trypsin or an active trypsin derivative, with the content of water in the reaction mixture being less than 50% (volume/volume), and the reaction temperature being less than 50degreeC and, where appropriate, in the presence of an acid, after which the resulting threonine<B30> ester of human insulin is cleaved, if required.
DK54081A 1980-02-11 1981-02-09 METHOD FOR PREPARING HUMAN INSULIN OR THREON INBESTERS OF HUMAN INSULIN OR A SALT OR COMPLEX THEREOF DK147437C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK54081A DK147437C (en) 1980-02-11 1981-02-09 METHOD FOR PREPARING HUMAN INSULIN OR THREON INBESTERS OF HUMAN INSULIN OR A SALT OR COMPLEX THEREOF

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK57480 1980-02-11
DK57480A DK147109C (en) 1980-02-11 1980-02-11 METHOD FOR PREPARING HUMAN INSULIN OR HUMAN INSULINESTERS OR A SALT OR COMPLEX THEREOF
DK54081A DK147437C (en) 1980-02-11 1981-02-09 METHOD FOR PREPARING HUMAN INSULIN OR THREON INBESTERS OF HUMAN INSULIN OR A SALT OR COMPLEX THEREOF
DK54081 1981-02-09

Publications (3)

Publication Number Publication Date
DK54081A true DK54081A (en) 1981-08-12
DK147437B DK147437B (en) 1984-08-06
DK147437C DK147437C (en) 1986-12-08

Family

ID=8095095

Family Applications (3)

Application Number Title Priority Date Filing Date
DK147437D DK147437A (en) 1980-02-11 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DK57480A DK147109C (en) 1980-02-11 1980-02-11 METHOD FOR PREPARING HUMAN INSULIN OR HUMAN INSULINESTERS OR A SALT OR COMPLEX THEREOF
DK54081A DK147437C (en) 1980-02-11 1981-02-09 METHOD FOR PREPARING HUMAN INSULIN OR THREON INBESTERS OF HUMAN INSULIN OR A SALT OR COMPLEX THEREOF

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK147437D DK147437A (en) 1980-02-11 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DK57480A DK147109C (en) 1980-02-11 1980-02-11 METHOD FOR PREPARING HUMAN INSULIN OR HUMAN INSULINESTERS OR A SALT OR COMPLEX THEREOF

Country Status (19)

Country Link
JP (1) JPS56135452A (en)
AR (1) AR231277A1 (en)
AU (1) AU541528B2 (en)
BE (1) BE887480A (en)
CA (1) CA1162868A (en)
CH (1) CH655949A5 (en)
DE (1) DE3104949C2 (en)
DK (3) DK147109C (en)
ES (1) ES499238A0 (en)
FI (1) FI77876C (en)
GB (1) GB2069502B (en)
GR (1) GR73844B (en)
IT (1) IT1195038B (en)
NL (1) NL178797C (en)
NO (1) NO156247C (en)
NZ (1) NZ196224A (en)
PT (1) PT72485B (en)
SE (2) SE427025B (en)
ZA (1) ZA81898B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4601852A (en) * 1981-01-17 1986-07-22 Hoechst Aktiengesellschaft Process for the preparation of human or the derivatives thereof from pig insulin or the derivatives thereof

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK147437A (en) 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
WO1983001074A1 (en) * 1981-09-15 1983-03-31 Andresen, Finn, Hede Enzymatic preparation of human insulin or b-30 esters thereof
DK149824C (en) * 1982-01-22 1987-03-16 Carlsberg Biotechnology Ltd PROCEDURE FOR ENZYMATIC REPLACEMENT OF B-30 AMINO ACIDS IN INSULINES
EP0087238A1 (en) * 1982-02-08 1983-08-31 Biogen N.V. Am improved method for preparing human insulin from non-human insulin
DE3209184A1 (en) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt METHOD FOR CONVERTING PRAEPROINSULIN ANALOGS TO INSULINES
NL8201650A (en) * 1982-04-21 1983-11-16 Akzo Nv SEMISYNTHETIC PREPARATION OF HUMANE INSULIN.
DE3381980D1 (en) * 1982-04-23 1990-12-13 Wako Pure Chem Ind Ltd METHOD FOR THE SEMI-SYNTHESIS OF HUMAN INSULIN AND ALKALINE PROTEASE TO BE USED FOR THIS.
DK55183D0 (en) * 1983-02-09 1983-02-09 Nordisk Insulinlab METHOD OF MANUFACTURING HUMAN INSULIN
DE3334407A1 (en) * 1983-09-23 1985-04-04 Hoechst Ag, 6230 Frankfurt INSULINE DERIVATIVES MODIFIED IN POSITION B 30, METHOD FOR THE PRODUCTION AND USE THEREOF AND PHARMACEUTICAL AGENTS FOR THE TREATMENT OF THE DIABETES MELLITUS
US5157021A (en) * 1985-03-15 1992-10-20 Novo Nordisk A/S Insulin derivatives and pharmaceutical preparations containing these derivatives
DK119785D0 (en) * 1985-03-15 1985-03-15 Nordisk Gentofte INSULIN PREPARATION
SE449472B (en) * 1985-10-15 1987-05-04 Mth Gruppen Ab EQUIPMENT AT FLOOR STORES
CA1339416C (en) * 1987-02-25 1997-09-02 Liselotte Langkjaer Insulin derivatives
DK134189D0 (en) * 1989-03-20 1989-03-20 Nordisk Gentofte INSULIN COMPOUNDS
FI96503C (en) * 1994-08-26 1996-07-10 Hymatic Ltd Oy Method and apparatus for controlling a mast
CA2553392A1 (en) 2004-01-16 2005-08-11 Biodel Inc Sublingual drug delivery device
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
US8084420B2 (en) 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
US7713929B2 (en) 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
AU2007238114B2 (en) 2006-04-12 2010-10-14 Biodel, Inc. Rapid acting and long acting insulin combination formulations
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK146482C (en) * 1979-04-13 1986-10-06 Shionogi & Co METHOD FOR PREPARING A B30-THREONINE INSULIN
DK147437A (en) 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DE3101382A1 (en) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "METHOD FOR PRODUCING HUMANISULIN OR ITS DERIVATIVES FROM PIG INSULIN OR ITS DERIVATIVES"

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4601852A (en) * 1981-01-17 1986-07-22 Hoechst Aktiengesellschaft Process for the preparation of human or the derivatives thereof from pig insulin or the derivatives thereof

Also Published As

Publication number Publication date
DK147109C (en) 1986-12-08
DK147109B (en) 1984-04-09
ES8205858A1 (en) 1982-08-01
BE887480A (en) 1981-08-11
IT8119620A0 (en) 1981-02-10
AR231277A1 (en) 1984-10-31
FI77876B (en) 1989-01-31
JPS56135452A (en) 1981-10-22
GB2069502B (en) 1984-08-08
PT72485A (en) 1981-03-01
DK147437A (en) 1900-01-01
IT1195038B (en) 1988-09-28
DK147437B (en) 1984-08-06
SE451143B (en) 1987-09-07
NL178797B (en) 1985-12-16
SE8100926L (en) 1982-08-11
SE8100928L (en) 1981-08-12
DE3104949C2 (en) 1984-04-26
FI810385L (en) 1981-08-12
PT72485B (en) 1982-10-14
NL178797C (en) 1986-05-16
DK147437C (en) 1986-12-08
DE3104949A1 (en) 1981-11-26
CA1162868A (en) 1984-02-28
CH655949A5 (en) 1986-05-30
IT8119620A1 (en) 1982-08-10
AU6718081A (en) 1981-08-20
NL8100624A (en) 1981-09-01
SE427025B (en) 1983-02-28
FI77876C (en) 1989-05-10
ZA81898B (en) 1982-03-31
NO156247C (en) 1987-08-19
DK57480A (en) 1981-08-12
JPH0211240B2 (en) 1990-03-13
NO156247B (en) 1987-05-11
AU541528B2 (en) 1985-01-10
GR73844B (en) 1984-05-07
ES499238A0 (en) 1982-08-01
NZ196224A (en) 1984-08-24
GB2069502A (en) 1981-08-26
NO810443L (en) 1981-08-12

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