DK509988A - Cephemforbindelser - Google Patents

Cephemforbindelser

Info

Publication number: DK509988A
Authority: DK; Denmark
Prior art keywords: cephems
Prior art date: 1987-09-14

Application number

DK509988A

Other languages

Danish (da)

English (en)

Other versions

DK509988D0 (da

Inventor

Kazuo Sakane

Kohji Kawabata

Kenzi Miyai

Yoshiko Inamoto

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-14

Filing date

1988-09-13

Publication date

1989-03-15

1987-09-14 Priority claimed from GB878721568A external-priority patent/GB8721568D0/en

1988-06-28 Priority claimed from GB888815361A external-priority patent/GB8815361D0/en

1988-09-13 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1988-09-13 Publication of DK509988D0 publication Critical patent/DK509988D0/da

1989-03-15 Publication of DK509988A publication Critical patent/DK509988A/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK509988A 1987-09-14 1988-09-13 Cephemforbindelser DK509988A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB878721568A GB8721568D0 (en)	1987-09-14	1987-09-14	Cephem compounds
GB888815361A GB8815361D0 (en)	1988-06-28	1988-06-28	New cephem compound & process for preparation thereof

Publications (2)

Publication Number	Publication Date
DK509988D0 DK509988D0 (da)	1988-09-13
DK509988A true DK509988A (da)	1989-03-15

Family

ID=26292732

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK509988A DK509988A (da)	1987-09-14	1988-09-13	Cephemforbindelser

Country Status (22)

Country	Link
US (1)	US4952578A (zh)
EP (1)	EP0307804B1 (zh)
JP (1)	JPH01151589A (zh)
KR (1)	KR0133560B1 (zh)
CN (1)	CN1024669C (zh)
AU (1)	AU617358B2 (zh)
CA (1)	CA1338842C (zh)
DE (1)	DE3885688T2 (zh)
DK (1)	DK509988A (zh)
ES (1)	ES2061581T3 (zh)
FI (1)	FI92322C (zh)
HK (1)	HK18396A (zh)
HU (1)	HU211830A9 (zh)
IE (1)	IE63094B1 (zh)
IL (1)	IL87731A (zh)
NO (1)	NO171853C (zh)
NZ (1)	NZ226143A (zh)
OA (1)	OA09014A (zh)
PH (1)	PH24719A (zh)
PT (1)	PT88481B (zh)
RU (1)	RU1787158C (zh)
UA (1)	UA41865C2 (zh)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5194432A (en) *	1985-11-22	1993-03-16	Fujisawa Pharmaceutical Co., Ltd.	Cephem compounds
CA1293719C (en) *	1986-09-22	1991-12-31	Takao Takaya	Cephem compounds and processes for preparation thereof
US5162520A (en) *	1986-09-22	1992-11-10	Fujisawa Pharmaceutical Co., Ltd.	Intermediates for cephem compounds
US5663163A (en) *	1987-09-07	1997-09-02	Fujisawa Pharmaceutical Co., Ltd.	Cephem compounds and processes for preparation thereof
GB8905301D0 (en) *	1989-03-08	1989-04-19	Fujisawa Pharmaceutical Co	New cephem compound and a process for preparation thereof
EP0517041A1 (en) *	1991-06-07	1992-12-09	Fujisawa Pharmaceutical Co., Ltd.	New Cephem Compounds
JP4251873B2 (ja) *	2001-05-01	2009-04-08	アステラス製薬株式会社	セフェム化合物
KR100463920B1 (ko) *	2002-10-18	2004-12-30	제일약품주식회사	신규 세프디토렌 피복실 메지틸렌 설폰산염 및 그 제조방법
EP1556389B9 (en) *	2002-10-30	2015-09-09	Astellas Pharma Inc.	Cephem compounds
AU2003902380A0 (en) *	2003-05-16	2003-06-05	Fujisawa Pharmaceutical Co., Ltd.	Cephem compounds
EP1663245B1 (en) *	2003-09-18	2010-04-07	Astellas Pharma Inc.	Cephem compounds
CN1321109C (zh) *	2003-11-07	2007-06-13	天津药物研究院	一种头孢烯类鎓盐化合物及其制备方法和以该化合物合成硫酸头孢吡唑的方法
CN101747348B (zh) *	2008-12-11	2013-02-06	石药集团中奇制药技术（石家庄）有限公司	一种硫酸头孢噻利晶型及其制备方法
CN101781318B (zh) *	2010-02-26	2013-07-31	烟台宝华生物技术有限公司	头孢母核衍生化合物、由其制备的头孢烯类鎓盐化合物及采用其制备硫酸头孢吡唑的方法
CN101830913B (zh) *	2010-04-09	2012-10-31	烟台宝华生物技术有限公司	头孢母核衍生化合物、由其制备的头孢烯类鎓盐化合物及采用其制备硫酸头孢吡唑的方法
CN101993450B (zh) *	2010-11-03	2011-11-30	湖南欧亚生物有限公司	一种硫酸头孢噻利的制备方法
CN102336771A (zh) *	2011-07-11	2012-02-01	珠海联邦制药股份有限公司	一种硫酸头孢噻利中间体的制备方法
RS66326B1 (sr)	2011-09-09	2025-01-31	Merck Sharp & Dohme Llc	Ceftolozan/tazobaktam za lečenje intrapulmonalnih infekcija
US8809314B1 (en)	2012-09-07	2014-08-19	Cubist Pharmacueticals, Inc.	Cephalosporin compound
US8476425B1 (en)	2012-09-27	2013-07-02	Cubist Pharmaceuticals, Inc.	Tazobactam arginine compositions
CN102875572B (zh) *	2012-10-26	2014-07-30	四川科伦药物研究有限公司	一种硫酸头孢噻利中间体的精制方法
US9872906B2 (en)	2013-03-15	2018-01-23	Merck Sharp & Dohme Corp.	Ceftolozane antibiotic compositions
NZ700372A (en)	2013-03-15	2016-01-29	Merck Sharp & Dohme	Ceftolozane antibiotic compositions
US20140274990A1 (en)	2013-03-15	2014-09-18	Cubist Pharmaceuticals, Inc.	Ceftolozane pharmaceutical compositions
US10376496B2 (en)	2013-09-09	2019-08-13	Merck, Sharp & Dohme Corp.	Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en)	2013-09-27	2015-04-02	Calixa Therapeutics, Inc.	Solid forms of ceftolozane

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR63088B (en) *	1976-04-14	1979-08-09	Takeda Chemical Industries Ltd	Preparation process of novel cephalosporins
GB2037281B (en) *	1978-11-15	1983-01-19	Glaxo Group Ltd	7( -(2-amino-4-thiozolyl)-2-hydroximino-acetanuds)-cephalosporins
JPS584789A (ja) *	1981-04-03	1983-01-11	Fujisawa Pharmaceut Co Ltd	新規セフエム化合物およびその製造法
DE3279470D1 (en) *	1981-04-03	1989-04-06	Fujisawa Pharmaceutical Co	New cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds
US4401668A (en) *	1981-10-02	1983-08-30	Eli Lilly And Company	Pyrazinium substituted cephalosporins
EP0214600B1 (en) *	1985-09-03	1992-12-02	Otsuka Kagaku Kabushiki Kaisha	Cephalosporin derivatives
DE3539901A1 (de) *	1985-11-11	1987-05-14	Hoechst Ag	Cephalosporinderivate und verfahren zu ihrer herstellung
CN86107947A (zh) *	1985-11-22	1987-05-27	藤沢药品工业株式会社	新的头孢烯化合物及其制备方法

1988
- 1988-09-06 IE IE269288A patent/IE63094B1/en not_active IP Right Cessation
- 1988-09-07 US US07/241,419 patent/US4952578A/en not_active Expired - Lifetime
- 1988-09-09 ES ES88114722T patent/ES2061581T3/es not_active Expired - Lifetime
- 1988-09-09 EP EP88114722A patent/EP0307804B1/en not_active Expired - Lifetime
- 1988-09-09 PH PH37528A patent/PH24719A/en unknown
- 1988-09-09 IL IL87731A patent/IL87731A/xx not_active IP Right Cessation
- 1988-09-09 DE DE88114722T patent/DE3885688T2/de not_active Expired - Fee Related
- 1988-09-12 KR KR1019880011743A patent/KR0133560B1/ko not_active IP Right Cessation
- 1988-09-12 NZ NZ226143A patent/NZ226143A/en unknown
- 1988-09-13 FI FI884193A patent/FI92322C/fi not_active IP Right Cessation
- 1988-09-13 NO NO884058A patent/NO171853C/no not_active IP Right Cessation
- 1988-09-13 CA CA000577194A patent/CA1338842C/en not_active Expired - Fee Related
- 1988-09-13 PT PT88481A patent/PT88481B/pt not_active IP Right Cessation
- 1988-09-13 DK DK509988A patent/DK509988A/da not_active Application Discontinuation
- 1988-09-13 RU SU4356636A patent/RU1787158C/ru active
- 1988-09-13 CN CN88106644A patent/CN1024669C/zh not_active Expired - Fee Related
- 1988-09-14 JP JP63233183A patent/JPH01151589A/ja active Granted
- 1988-09-14 OA OA59431A patent/OA09014A/xx unknown
- 1988-09-14 AU AU22271/88A patent/AU617358B2/en not_active Ceased
1992
- 1992-02-24 UA UA5010902A patent/UA41865C2/uk unknown
1995
- 1995-06-22 HU HU95P/P00350P patent/HU211830A9/hu unknown
1996
- 1996-02-01 HK HK18396A patent/HK18396A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0307804A2 (en)	1989-03-22
AU617358B2 (en)	1991-11-28
FI92322C (fi)	1994-10-25
PT88481B (pt)	1992-11-30
NO884058D0 (no)	1988-09-13
ES2061581T3 (es)	1994-12-16
PT88481A (pt)	1988-10-01
KR0133560B1 (ko)	1998-04-23
EP0307804B1 (en)	1993-11-18
OA09014A (fr)	1991-03-31
HK18396A (en)	1996-02-09
FI884193A0 (fi)	1988-09-13
UA41865C2 (uk)	2001-10-15
NZ226143A (en)	1990-11-27
EP0307804A3 (en)	1989-11-08
KR890005124A (ko)	1989-05-11
IE882692L (en)	1989-03-14
DE3885688D1 (de)	1993-12-23
CN1032540A (zh)	1989-04-26
DE3885688T2 (de)	1994-04-07
NO884058L (no)	1989-03-15
JPH0576950B2 (zh)	1993-10-25
IL87731A0 (en)	1989-02-28
IL87731A (en)	1993-05-13
FI92322B (fi)	1994-07-15
RU1787158C (ru)	1993-01-07
US4952578A (en)	1990-08-28
PH24719A (en)	1990-10-01
AU2227188A (en)	1989-03-16
CN1024669C (zh)	1994-05-25
HU211830A9 (en)	1995-12-28
NO171853C (no)	1993-05-12
CA1338842C (en)	1997-01-14
FI884193A (fi)	1989-03-15
JPH01151589A (ja)	1989-06-14
DK509988D0 (da)	1988-09-13
NO171853B (no)	1993-02-01
IE63094B1 (en)	1995-03-22

Publication	Publication Date	Title
ATA30988A (de)	1992-02-15	Alpinski
DK509988D0 (da)	1988-09-13	Cephemforbindelser
DK179388A (da)	1988-10-11	Cephalosporinderivater
DK460087A (da)	1988-03-23	Cephemforbindelser
ATA174488A (de)	1996-01-15	Alpinski
ATA174288A (de)	1996-12-15	Alpinski
ATA224788A (de)	1993-01-15	Calcitoninsuppositorien
BR8705012A (pt)	1988-11-01	Mini-persiana
ATA48687A (de)	1989-07-15	Guellefass
AT389045B (de)	1989-10-10	Paraocclusaler loeffel
ATA294988A (de)	1990-12-15	Haecksler
KR890004375U (ko)	1989-04-17	도마
AT388649B (de)	1989-08-10	Sportschuh
ATA162787A (de)	1988-11-15	Hoergeraet
KR890000300U (ko)	1989-03-02	도마
SE8702494D0 (sv)	1987-06-16	Starkstromslina
BR6702017U (pt)	1989-04-11	Prendedor
BR6701063U (pt)	1988-12-27	Cesta-cofre
BR8700432A (pt)	1987-06-16	Tiro-laser
BR6700994U (pt)	1988-12-20	Isqueiro-cinzeiro
BR6700226U (pt)	1988-08-30	Mosquetao
BR6701228U (pt)	1989-01-17	Poltrona-cama
BR6701551U (pt)	1989-02-14	Metro-esquadro-profissional
BR6701645U (pt)	1989-02-28	Prendedor-cabide
BR6701671U (pt)	1987-12-08	Dessensibilizador

Legal Events

Date	Code	Title	Description
2003-04-28	AHB	Application shelved due to non-payment