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DK502389A - Pyridazinonderivater og fremgangsmaade til fremstilling deraf - Google Patents

Pyridazinonderivater og fremgangsmaade til fremstilling deraf

Info

Publication number
DK502389A
DK502389A DK502389A DK502389A DK502389A DK 502389 A DK502389 A DK 502389A DK 502389 A DK502389 A DK 502389A DK 502389 A DK502389 A DK 502389A DK 502389 A DK502389 A DK 502389A
Authority
DK
Denmark
Prior art keywords
alkyl
alkoxy
denotes
hydrogen
substituted
Prior art date
Application number
DK502389A
Other languages
English (en)
Other versions
DK502389D0 (da
DK170096B1 (da
Inventor
You Kusase
Masatoshi Murakata
Nobou Mochizuki
Michinori Takebayashi
Original Assignee
Nippon Soda Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Soda Co filed Critical Nippon Soda Co
Publication of DK502389D0 publication Critical patent/DK502389D0/da
Publication of DK502389A publication Critical patent/DK502389A/da
Application granted granted Critical
Publication of DK170096B1 publication Critical patent/DK170096B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/36—Benzo-cinnolines

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK502389A 1988-02-13 1989-10-10 4,5-dihydro-6-cykloalkenylaminophenyl-3(24)-pyridazinoner og fremgangsmåder til fremstilling deraf DK170096B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP3161888 1988-02-13
JP3161888 1988-02-13
JP7591088 1988-03-31
JP7591088 1988-03-31
PCT/JP1989/000127 WO1989007594A1 (en) 1988-02-13 1989-02-09 Pyridazinone derivatives
JP8900127 1989-02-09

Publications (3)

Publication Number Publication Date
DK502389D0 DK502389D0 (da) 1989-10-10
DK502389A true DK502389A (da) 1989-11-20
DK170096B1 DK170096B1 (da) 1995-05-22

Family

ID=26370117

Family Applications (1)

Application Number Title Priority Date Filing Date
DK502389A DK170096B1 (da) 1988-02-13 1989-10-10 4,5-dihydro-6-cykloalkenylaminophenyl-3(24)-pyridazinoner og fremgangsmåder til fremstilling deraf

Country Status (11)

Country Link
US (1) US5110925A (da)
EP (1) EP0357788B1 (da)
JP (1) JP2717687B2 (da)
KR (1) KR910005233B1 (da)
CA (1) CA1320957C (da)
DE (1) DE68910447T2 (da)
DK (1) DK170096B1 (da)
ES (1) ES2012646A6 (da)
FI (1) FI95570C (da)
NO (1) NO176275C (da)
WO (1) WO1989007594A1 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
JP2806192B2 (ja) * 1992-11-02 1998-09-30 日本曹達株式会社 血小板凝集抑制剤
US5678114A (en) * 1994-06-14 1997-10-14 Noritsu Koki Co., Ltd. Automatic photographic developing apparatus for photosensitive materials
WO1996015117A1 (fr) * 1994-11-11 1996-05-23 Nippon Soda Co., Ltd. Compose optiquement actif
US6110471A (en) * 1996-09-13 2000-08-29 The Board Of Trustees Of The Leland Stanford Junior University Non-hormonal method of contraception
AU6005999A (en) * 1998-10-09 2000-05-01 Nihon Nohyaku Co., Ltd. Pyridazinone derivatives
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
KR20080065704A (ko) 2005-11-09 2008-07-14 콤비네이토릭스, 인코포레이티드 의학적 이상의 치료 방법들, 조성물들, 및 키트들
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
MX357121B (es) 2011-03-01 2018-06-27 Synergy Pharmaceuticals Inc Star Proceso de preparacion de agonistas c de guanilato ciclasa.
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
EP3004138B1 (en) 2013-06-05 2024-03-13 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
JP6694385B2 (ja) 2013-08-09 2020-05-13 アーデリクス，インコーポレーテッド リン酸塩輸送阻害のための化合物及び方法
EP3038612B1 (en) * 2013-08-30 2020-07-29 Icahn School of Medicine at Mount Sinai Cyclic vinylogous amides as bromodomain inhibitors
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4019575A (en) * 1975-12-22 1977-04-26 Chevron Research Company System for recovering viscous petroleum from thick tar sand
JPS5746966A (en) * 1980-09-03 1982-03-17 Mitsui Toatsu Chem Inc Pyridazinone derivative and its production
US4665174A (en) * 1981-05-12 1987-05-12 Sumitomo Chemical Company, Limited Production of cyclopentenone derivatives
JPS58113180A (ja) * 1981-12-28 1983-07-05 Mitsui Toatsu Chem Inc ピリダジノン誘導体
DE3302442A1 (de) * 1983-01-26 1984-07-26 Basf Ag, 6700 Ludwigshafen Neue pyridazinone, verfahren zu ihrer herstellung, diese verbindungen enthaltende therapeutische mittel und deren verwendung
US4602019A (en) * 1983-04-22 1986-07-22 Warner-Lambert Company Indeno[1,2-c]pyridazin-3-one derivatives useful as cardiotonic and antihypertensive agents
US4666902A (en) * 1983-06-20 1987-05-19 Cassella Aktiengesellschaft Tetrahydropyridazinone derivatives, processes for their preparation and their use
GB2164643B (en) * 1984-07-27 1988-11-02 Boehringer Biochemia Srl Tricyclic dihydropyridazinones and pharmaceutical compositions containing them
JPH06763B2 (ja) * 1984-08-28 1994-01-05 吉富製薬株式会社 ベンゾ〔ｈ〕シンノリン誘導体
US4816454A (en) * 1984-09-21 1989-03-28 Cassella Aktiengesellschaft 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
US4681621A (en) * 1984-12-20 1987-07-21 Stauffer Chemical Company Herbicidal 2-(2-substituted benzoyl)-1,3-cyclopentanediones
DE3505609A1 (de) * 1985-02-19 1986-08-21 Merck Patent Gmbh, 6100 Darmstadt Benzimidazolyl-pyridazinone
GB2177689B (en) * 1985-07-09 1989-07-19 Boehringer Biochemia Srl Tricyclic dihydropyridazinones and pharmaceutical compositions containing them
JPH0633277B2 (ja) * 1986-01-10 1994-05-02 吉富製薬株式会社 ベンゾチオピラノ〔４，３−ｃ〕ピリダジン化合物
US4775411A (en) * 1986-06-09 1988-10-04 Stauffer Chemica Company Certain substituted 3-amino-2-benzoylcyclohex-2-enones
DE3867086D1 (de) * 1987-03-02 1992-02-06 Yoshitomi Pharmaceutical Benzothiepino(5,4-c)pyridazin-verbindungen und ihre pharmazeutischen wirkungen.
DE3804490A1 (de) * 1988-02-12 1989-08-24 Heumann Pharma Gmbh & Co Substituierte 6-phenyldihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPH0216991A (ja) * 1988-07-04 1990-01-19 Mitsui Toatsu Chem Inc Ｌ−トリプトファンの製法

Also Published As

Publication number Publication date
KR910005233B1 (ko) 1991-07-24
DE68910447T2 (de) 1994-03-17
EP0357788B1 (en) 1993-11-03
WO1989007594A1 (en) 1989-08-24
EP0357788A1 (en) 1990-03-14
US5110925A (en) 1992-05-05
JP2717687B2 (ja) 1998-02-18
NO176275C (no) 1995-03-08
NO894088L (no) 1989-10-12
CA1320957C (en) 1993-08-03
FI95570B (fi) 1995-11-15
JPH0256468A (ja) 1990-02-26
ES2012646A6 (es) 1990-04-01
DE68910447D1 (de) 1993-12-09
NO894088D0 (no) 1989-10-12
NO176275B (no) 1994-11-28
KR900700462A (ko) 1990-08-13
DK502389D0 (da) 1989-10-10
FI95570C (fi) 1996-02-26
FI894844A0 (fi) 1989-10-12
DK170096B1 (da) 1995-05-22

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed