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DK46081A - Fremgansmaade til fremstilling af pyranoner og de tilsvarende hydroxysyrer - Google Patents

Fremgansmaade til fremstilling af pyranoner og de tilsvarende hydroxysyrer

Info

Publication number
DK46081A
DK46081A DK46081A DK46081A DK46081A DK 46081 A DK46081 A DK 46081A DK 46081 A DK46081 A DK 46081A DK 46081 A DK46081 A DK 46081A DK 46081 A DK46081 A DK 46081A
Authority
DK
Denmark
Prior art keywords
pyranones
procedure
preparation
hydroxy acids
similar hydroxy
Prior art date
Application number
DK46081A
Other languages
English (en)
Inventor
T Y Lee
R L Smith
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK46081A publication Critical patent/DK46081A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/62—Unsaturated compounds containing ether groups, groups, groups, or groups containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Steroid Compounds (AREA)
DK46081A 1980-02-04 1981-02-03 Fremgansmaade til fremstilling af pyranoner og de tilsvarende hydroxysyrer DK46081A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11804880A 1980-02-04 1980-02-04
US06/175,459 US4282155A (en) 1980-02-04 1980-08-05 Antihypercholesterolemic compounds

Publications (1)

Publication Number Publication Date
DK46081A true DK46081A (da) 1981-08-05

Family

ID=26815915

Family Applications (1)

Application Number Title Priority Date Filing Date
DK46081A DK46081A (da) 1980-02-04 1981-02-03 Fremgansmaade til fremstilling af pyranoner og de tilsvarende hydroxysyrer

Country Status (8)

Country Link
US (1) US4282155A (da)
EP (1) EP0033536B1 (da)
DE (1) DE3165894D1 (da)
DK (1) DK46081A (da)
ES (1) ES8202549A1 (da)
GR (1) GR73078B (da)
IE (1) IE51476B1 (da)
PT (1) PT72393B (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351844A (en) * 1980-02-04 1982-09-28 Merck & Co., Inc. Hypocholesterolemic hydrogenation products and process of preparation
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
JPS56150037A (en) * 1980-04-22 1981-11-20 Sankyo Co Ltd Hydronaphthalene compound
US4343814A (en) * 1980-11-17 1982-08-10 Merck & Co., Inc. Hypocholesterolemic fermentation products
US4440927A (en) * 1981-06-19 1984-04-03 Merck & Co., Inc. Process for preparing inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase via a chiral synthon
US4490546A (en) * 1982-03-25 1984-12-25 Merck & Co., Inc. Process for 4a'(R),5'-dihydromevinolin
US4499289A (en) * 1982-12-03 1985-02-12 G. D. Searle & Co. Octahydronapthalenes
US4503072A (en) * 1982-12-22 1985-03-05 Merck & Co., Inc. Antihypercholesterolemic compounds
US4950775A (en) * 1985-10-11 1990-08-21 University Of California Antihypercholesterolemic compounds and synthesis thereof
US5208258A (en) * 1985-10-11 1993-05-04 The Regents Of The University Of California Antihypercholesterolemic compounds and synthesis thereof
US4841074A (en) * 1987-12-11 1989-06-20 Merck & Co., Inc. Intermediates and processes for 6-carboxy HMG-CoA reductase inhibitors
US4863957A (en) * 1987-12-21 1989-09-05 Rorer Pharmaceutical Corporation Novel HMG-CoA reductase inhibitors
US4904692A (en) * 1987-12-21 1990-02-27 Rorer Pharmaceutical Corporation Novel HMG-CoA reductase inhibitors
US5001144A (en) * 1987-12-21 1991-03-19 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors
US4994494A (en) * 1987-12-21 1991-02-19 Rhone-Poulenc Rorer Pharmaceuticals Inc. HMG-COA reductase inhibitors
US4900754A (en) * 1987-12-21 1990-02-13 Rorer Pharmaceutical Corp. HMG-COA reductase inhibitors
US5001128A (en) * 1987-12-21 1991-03-19 Rhone-Poulenc Rorer Pharmaceuticals Inc. HMG-COA reductase inhibitors
US4904691A (en) * 1987-12-21 1990-02-27 Rorer Pharmaceutical Corporation Novel HMG-CoA reductase inhibitors
US4939143A (en) * 1987-12-21 1990-07-03 Rorer Pharmaceutical Corporation Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors
US5132312A (en) * 1989-03-27 1992-07-21 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US4992429A (en) * 1989-08-24 1991-02-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Novel HMG-COA reductase inhibitors
US4946860A (en) * 1989-11-03 1990-08-07 Rorer Pharmaceutical Corporation Benzothiopyranyl derivatives as HMG-CoA reductase inhibitors
WO1991013616A1 (en) * 1990-03-08 1991-09-19 Rorer International (Overseas) Inc. NOVEL HMG-CoA REDUCTASE INHIBITORS
US5443771A (en) * 1992-09-15 1995-08-22 Gupta; Sankar D. Ceramic fibre and process therefor
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US6391583B1 (en) 1998-12-18 2002-05-21 Wisconsin Alumni Research Foundation Method of producing antihypercholesterolemic agents
SK282679B6 (sk) * 1999-04-16 2002-11-06 Biotika, A. S. Spôsob izolácie lovastatínu z vyfermentovanej pôdy
IN192861B (da) 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
GB2401606B (en) * 2002-02-25 2005-08-31 Kudos Pharm Ltd Pyranones useful as ATM inhibitors
CN103012344B (zh) * 2011-09-28 2014-11-12 北大方正集团有限公司 从洛伐他汀结晶母液中回收洛伐他汀的方法
CN102875505B (zh) * 2012-08-02 2015-08-05 丽珠集团新北江制药股份有限公司 一种美伐他汀的提取精制工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (da) * 1974-06-07 1981-03-18
US4049495A (en) * 1974-06-07 1977-09-20 Sankyo Company Limited Physiologically active substances and fermentative process for producing the same
DE2748825C2 (de) * 1976-11-02 1986-11-27 Sankyo Co., Ltd., Tokio/Tokyo Substituierte 3,5-Dihydroxyheptansäurederivate und diese enthaltende Arzneimittel gegen Hyperlipämie
IL60219A (en) * 1979-06-15 1985-05-31 Merck & Co Inc Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation

Also Published As

Publication number Publication date
EP0033536B1 (en) 1984-09-12
ES499077A0 (es) 1982-02-01
PT72393B (en) 1982-09-06
GR73078B (da) 1984-01-31
IE51476B1 (en) 1987-01-07
DE3165894D1 (en) 1984-10-18
EP0033536A2 (en) 1981-08-12
ES8202549A1 (es) 1982-02-01
PT72393A (en) 1981-02-01
US4282155A (en) 1981-08-04
IE810167L (en) 1981-08-04
EP0033536A3 (en) 1982-02-24

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