DK457475A - - Google Patents

Info

Publication number: DK457475A
Authority: DK; Denmark

Application number

DK457475A

Other languages

Danish (da)

Other versions

DK140834B (da

DK140834C (es

Inventor

U Fischer

E Lorch

Original Assignee

Hoffmann La Roche & Co F

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-10-11

Filing date

1975-10-10

Publication date

1976-04-12

1975-10-10 Application filed by Hoffmann La Roche & Co F filed Critical Hoffmann La Roche & Co F

1976-04-12 Publication of DK457475A publication Critical patent/DK457475A/da

1979-11-26 Publication of DK140834B publication Critical patent/DK140834B/da

1980-04-28 Application granted granted Critical

1980-04-28 Publication of DK140834C publication Critical patent/DK140834C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK457475AA 1974-10-11 1975-10-10 Analogifremgangsmåde til fremstilling af biguanidsalte. DK140834B (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH1369774A CH602612A5 (es)	1974-10-11	1974-10-11

Publications (3)

Publication Number	Publication Date
DK457475A true DK457475A (es)	1976-04-12
DK140834B DK140834B (da)	1979-11-26
DK140834C DK140834C (es)	1980-04-28

Family

ID=4394567

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK457475AA DK140834B (da)	1974-10-11	1975-10-10	Analogifremgangsmåde til fremstilling af biguanidsalte.

Country Status (26)

Country	Link
US (1)	US4028402A (es)
JP (1)	JPS51125718A (es)
AR (1)	AR209457A1 (es)
AT (1)	AT343676B (es)
BE (1)	BE834369A (es)
BR (1)	BR7506595A (es)
CA (1)	CA1053258A (es)
CH (1)	CH602612A5 (es)
CU (1)	CU34371A (es)
DD (1)	DD123322A5 (es)
DE (1)	DE2542598A1 (es)
DK (1)	DK140834B (es)
ES (1)	ES441673A1 (es)
FI (1)	FI752626A (es)
FR (1)	FR2287221A1 (es)
GB (1)	GB1473256A (es)
IE (1)	IE41807B1 (es)
IL (1)	IL48116A (es)
LU (1)	LU73557A1 (es)
NL (1)	NL7511890A (es)
NO (1)	NO753447L (es)
PH (1)	PH12279A (es)
PL (1)	PL95259B1 (es)
SE (1)	SE7511357L (es)
SU (1)	SU572200A3 (es)
ZA (1)	ZA755861B (es)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2401898A1 (fr) *	1977-09-05	1979-03-30	Aec Chim Organ Biolog	Nouveau sel de l'acide patoique
DE19616486C5 (de)	1996-04-25	2016-06-30	Royalty Pharma Collection Trust	Verfahren zur Senkung des Blutglukosespiegels in Säugern
US20020006899A1 (en) *	1998-10-06	2002-01-17	Pospisilik Andrew J.	Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals
WO1998027982A1 (fr)	1996-12-24	1998-07-02	Sumitomo Pharmaceuticals Co., Ltd.	Composition contenant de l'acide ascorbique
DE19823831A1 (de)	1998-05-28	1999-12-02	Probiodrug Ges Fuer Arzneim	Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
DE19828113A1 (de)	1998-06-24	2000-01-05	Probiodrug Ges Fuer Arzneim	Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
DE19828114A1 (de)	1998-06-24	2000-01-27	Probiodrug Ges Fuer Arzneim	Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV
DE19834591A1 (de)	1998-07-31	2000-02-03	Probiodrug Ges Fuer Arzneim	Verfahren zur Steigerung des Blutglukosespiegels in Säugern
US20030176357A1 (en) *	1998-10-06	2003-09-18	Pospisilik Andrew J.	Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
DE19926233C1 (de)	1999-06-10	2000-10-19	Probiodrug Ges Fuer Arzneim	Verfahren zur Herstellung von Thiazolidin
DE19940130A1 (de) *	1999-08-24	2001-03-01	Probiodrug Ges Fuer Arzneim	Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung
CA2386379C (en)	1999-10-06	2009-12-15	Toshio Miyata	Carbonyl stress-decreasing agent
US20080076811A1 (en) *	2000-01-21	2008-03-27	Bork Balkan	Combinations comprising depeptidypeptidase-iv inhibitors and antidiabetic agents
DK2055302T3 (da) *	2000-03-31	2014-10-27	Royalty Pharma Collection Trust	Fremgangsmåde til forbedring af signalering af øceller ved diabetes mellitus og til forebyggelse deraf
FR2809310B1 (fr)	2000-05-26	2004-02-13	Centre Nat Rech Scient	Utilisation de derives de biguanide pour fabriquer un medicament ayant un effet cicatrisant
JP2005097117A (ja) *	2000-06-30	2005-04-14	Chugai Pharmaceut Co Ltd	糖尿病治療剤
US7132104B1 (en)	2000-10-27	2006-11-07	Probiodrug Ag	Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders
CA2422889C (en) *	2000-10-27	2010-01-26	Probiodrug Ag	Method for the treatment of neurological and neuropsychological disorders
US6890905B2 (en)	2001-04-02	2005-05-10	Prosidion Limited	Methods for improving islet signaling in diabetes mellitus and for its prevention
US7368421B2 (en)	2001-06-27	2008-05-06	Probiodrug Ag	Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
US20030130199A1 (en)	2001-06-27	2003-07-10	Von Hoersten Stephan	Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
DE10150203A1 (de)	2001-10-12	2003-04-17	Probiodrug Ag	Peptidylketone als Inhibitoren der DPIV
JP2005504766A (ja) *	2001-08-16	2005-02-17	プロバイオドラッグアーゲー	プロリンエンドペプチダーゼ阻害剤の、細胞内シグナルカスケード依存性イノシトール（１，４，５）トリホスフェート濃度調節への使用。
US6844316B2 (en)	2001-09-06	2005-01-18	Probiodrug Ag	Inhibitors of dipeptidyl peptidase I
PL372316A1 (en)	2002-02-28	2005-07-11	Prosidion Limited	Glutaminyl based dpiv inhibitors
US20030232761A1 (en) *	2002-03-28	2003-12-18	Hinke Simon A.	Novel analogues of glucose-dependent insulinotropic polypeptide
US20040033051A1 (en) *	2002-08-16	2004-02-19	Ip Kiril Kun Wan	Method and system for producing and displaying visual presentations which inhibit off-screen duplication
US20040058876A1 (en) *	2002-09-18	2004-03-25	Torsten Hoffmann	Secondary binding site of dipeptidyl peptidase IV (DP IV)
AU2003293311A1 (en) *	2002-09-18	2004-04-23	Prosidion Ltd.	Secondary binding site of dipeptidyl peptidase iv (dp iv)
EP1961416B1 (en)	2003-05-05	2013-01-23	Probiodrug AG	Use of inhibitors of glutaminyl cyclase for treating psoriasis, rheumatoid arthritis or atherosclerosis.
ATE462432T1 (de)	2003-05-05	2010-04-15	Probiodrug Ag	Glutaminylcyclase-hemmer
WO2005039548A2 (en) *	2003-10-15	2005-05-06	Probiodrug Ag	Use of effectors of glutaminyl and glutamate cyclases
US20100099721A1 (en) *	2003-11-03	2010-04-22	Probiodrug Ag	Novel compounds for the treatment of neurological disorders
US20050171112A1 (en) *	2003-11-03	2005-08-04	Probiodrug Ag	Combinations useful for the treatment of neuronal disorders
CA2554809C (en)	2004-02-05	2014-04-29	Probiodrug Ag	Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase
US8058312B2 (en) *	2007-01-29	2011-11-15	Hanall Biopharma Co., Ltd.	N, N-dimethyl imidodicarbonimidic diamide acetate, method for producing the same and pharmaceutical compositions comprising the same
WO2008097861A2 (en) *	2007-02-02	2008-08-14	Braincells, Inc.	MODULATION OF NEUROGENESIS WITH BIGUANIDES AND GSK3-ß AGENTS
JP5292404B2 (ja) *	2007-09-21	2013-09-18	ハンオルバイオファーマカンパニー，リミテッド	Ｎ，ｎ−ジメチルイミドジカルボンイミド酸ジアミドのジカルボン酸塩、その製造方法、及びその薬剤学的組成物
WO2009088220A2 (ko) *	2008-01-08	2009-07-16	Hanall Pharmaceutical Company. Ltd	Ｎ,ｎ-디메틸 이미도디카르본이미딕 디아미드의 니코틴산염, 그의 제조방법 및 그를 포함하는 약제학적 조성물
CN102159539B (zh) *	2008-06-26	2014-04-16	矽烷实验室股份公司	用于血糖控制的新型二甲双胍甘氨酸盐
US20110021634A1 (en)	2009-06-18	2011-01-27	Patel Pranav Dushyant	Processes for preparing metformin hydrochloride
WO2011049400A2 (ko) *	2009-10-23	2011-04-28	한올바이오파마주식회사	N,n-디메틸 이미도디카르본이미딕 디아미드의 산 부가염을 포함하는 항암용 약제학적 조성물
KR101324283B1 (ko)	2010-04-27	2013-11-01	한올바이오파마주식회사	바이구아나이드 화합물의 신규 염, 그의 제조방법, 그를 포함하는 약제학적 조성물
US11510886B2 (en)	2016-09-30	2022-11-29	Laboratorios Silanes, S.A. De C.V.	Metformin amino acid compounds and methods of using the same
BR112019006401A2 (pt)	2016-09-30	2019-06-25	Laboratorios Silanes S A De C V	glicinato de metformina, composições farmacêuticas que compreendem o mesmo e métodos de uso do mesmo
CN107118130A (zh) *	2017-05-11	2017-09-01	杜剑平	一类治疗肿瘤的药物化合物及其应用
CN106986791A (zh) *	2017-05-11	2017-07-28	杜剑平	一种治疗肿瘤的药物化合物及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3179562A (en) *	1961-08-23	1965-04-20	Du Pont	Treatment of diabetes with alpha, alpha substituted acetic acid derivatives

1974
- 1974-10-11 CH CH1369774A patent/CH602612A5/xx not_active IP Right Cessation
1975
- 1975-09-15 ZA ZA00755861A patent/ZA755861B/xx unknown
- 1975-09-17 IL IL48116A patent/IL48116A/xx unknown
- 1975-09-19 FI FI752626A patent/FI752626A/fi not_active Application Discontinuation
- 1975-09-24 DE DE19752542598 patent/DE2542598A1/de not_active Withdrawn
- 1975-10-06 IE IE2184/75A patent/IE41807B1/en unknown
- 1975-10-08 US US05/620,525 patent/US4028402A/en not_active Expired - Lifetime
- 1975-10-08 PH PH17640A patent/PH12279A/en unknown
- 1975-10-08 CU CU7534371A patent/CU34371A/es unknown
- 1975-10-09 CA CA237,343A patent/CA1053258A/en not_active Expired
- 1975-10-09 SE SE7511357A patent/SE7511357L/xx unknown
- 1975-10-09 JP JP50121432A patent/JPS51125718A/ja active Pending
- 1975-10-09 LU LU73557A patent/LU73557A1/xx unknown
- 1975-10-09 NL NL7511890A patent/NL7511890A/xx not_active Application Discontinuation
- 1975-10-09 BR BR7506595*A patent/BR7506595A/pt unknown
- 1975-10-09 FR FR7530907A patent/FR2287221A1/fr not_active Withdrawn
- 1975-10-09 SU SU7502178502A patent/SU572200A3/ru active
- 1975-10-10 ES ES441673A patent/ES441673A1/es not_active Expired
- 1975-10-10 BE BE160823A patent/BE834369A/xx unknown
- 1975-10-10 NO NO753447A patent/NO753447L/no unknown
- 1975-10-10 PL PL1975183923A patent/PL95259B1/pl unknown
- 1975-10-10 DD DD188797A patent/DD123322A5/xx unknown
- 1975-10-10 DK DK457475AA patent/DK140834B/da unknown
- 1975-10-10 AT AT776375A patent/AT343676B/de active
- 1975-10-10 GB GB4161175A patent/GB1473256A/en not_active Expired
- 1975-10-11 AR AR260639A patent/AR209457A1/es active

Also Published As

Publication number	Publication date
IL48116A (en)	1979-07-25
PL95259B1 (pl)	1977-10-31
CA1053258A (en)	1979-04-24
ES441673A1 (es)	1977-04-01
BE834369A (fr)	1976-04-12
DK140834B (da)	1979-11-26
DD123322A5 (es)	1976-12-12
SU572200A3 (ru)	1977-09-05
LU73557A1 (es)	1977-05-24
IL48116A0 (en)	1975-11-25
SE7511357L (sv)	1976-04-12
CU34371A (es)	1979-06-01
FI752626A (es)	1976-04-12
CH602612A5 (es)	1978-07-31
BR7506595A (pt)	1976-08-17
DK140834C (es)	1980-04-28
AR209457A1 (es)	1977-04-29
AU8497775A (en)	1977-03-24
JPS51125718A (en)	1976-11-02
PH12279A (en)	1978-12-12
IE41807B1 (en)	1980-03-26
AT343676B (de)	1978-06-12
NL7511890A (nl)	1976-04-13
GB1473256A (en)	1977-05-11
FR2287221A1 (fr)	1976-05-07
NO753447L (es)	1976-04-13
IE41807L (en)	1976-04-11
ZA755861B (en)	1976-08-25
DE2542598A1 (de)	1976-04-22
ATA776375A (de)	1977-10-15
US4028402A (en)	1977-06-07

Publication	Publication Date	Title
DK140834C (es)	1980-04-28
AU7459074A (es)	1976-04-29
AU485556B2 (es)	1976-08-26
BG20140A1 (es)	1975-11-05
BE826215A (es)	1975-06-30
AU480463A (es)	1976-01-08
AU480977A (es)	1975-10-30
AU481119A (es)	1976-02-05
AU481219A (es)	1975-11-06
AU481265A (es)	1976-05-13
AU481423A (es)	1975-12-04
AU481545A (es)	1976-01-22
AU481639A (es)	1975-09-18
AU480247A (es)	1975-09-25
AU480148A (es)	1976-07-01
BG20224A1 (es)	1975-11-05
BE833391A (es)	1975-12-31
BG19643A1 (es)	1975-10-10
BG19656A1 (es)	1975-10-10
BG19692A1 (es)	1975-10-10
BG19728A1 (es)	1975-10-10
BG19746A1 (es)	1975-10-10
BG19931A1 (es)	1975-10-30
BG19966A1 (es)	1975-10-30
BG20941A1 (es)	1976-01-20