DK411686A - PEPTIDES - Google Patents
PEPTIDES Download PDFInfo
- Publication number
- DK411686A DK411686A DK411686A DK411686A DK411686A DK 411686 A DK411686 A DK 411686A DK 411686 A DK411686 A DK 411686A DK 411686 A DK411686 A DK 411686A DK 411686 A DK411686 A DK 411686A
- Authority
- DK
- Denmark
- Prior art keywords
- amino acid
- insulin
- replacements
- previously unknown
- human insulin
- Prior art date
Links
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Previously unknown, rapidly acting human insulin analogues having a lower tendency for self-association into dimers, tetramers, hexamers or polymers. The previously unknown insulin analogues are formed by replacing one or more of the amino acid residues in human insulin with naturally occurring amino acid residues. The amino acid residue replacements are preferably more hydrophilic than the natural amino acid residue at the position in question in the molecule. Furthermore, the insulin analogue has the same charge as or a greater negative at neutral pH than human insulin. Preferred amino acid replacements are Asp, Glu, Ser, Thr, His and Ile, and more preferred replacements are Asp and Glu. The previously unknown insulin analogues can be used for preparing rapidly acting insulin solutions.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK411686A DK159274C (en) | 1985-08-30 | 1986-08-29 | QUICK EFFECT HUMAN INSULIN ANALOGS AND INJECTABLE SOLUTIONS WITH QUICK-EFFECTIVE EFFECTS CONTAINING SUCH INSULIN ANALOGS |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK395685 | 1985-08-30 | ||
| DK395685A DK395685D0 (en) | 1985-08-30 | 1985-08-30 | PEPTIDES |
| DK467785 | 1985-10-14 | ||
| DK467785A DK467785D0 (en) | 1985-10-14 | 1985-10-14 | PEPTIDES |
| DK411686 | 1986-08-29 | ||
| DK411686A DK159274C (en) | 1985-08-30 | 1986-08-29 | QUICK EFFECT HUMAN INSULIN ANALOGS AND INJECTABLE SOLUTIONS WITH QUICK-EFFECTIVE EFFECTS CONTAINING SUCH INSULIN ANALOGS |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK411686D0 DK411686D0 (en) | 1986-08-29 |
| DK411686A true DK411686A (en) | 1987-03-03 |
| DK159274B DK159274B (en) | 1990-09-24 |
| DK159274C DK159274C (en) | 1991-03-11 |
Family
ID=27221914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK411686A DK159274C (en) | 1985-08-30 | 1986-08-29 | QUICK EFFECT HUMAN INSULIN ANALOGS AND INJECTABLE SOLUTIONS WITH QUICK-EFFECTIVE EFFECTS CONTAINING SUCH INSULIN ANALOGS |
Country Status (1)
| Country | Link |
|---|---|
| DK (1) | DK159274C (en) |
-
1986
- 1986-08-29 DK DK411686A patent/DK159274C/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK159274C (en) | 1991-03-11 |
| DK411686D0 (en) | 1986-08-29 |
| DK159274B (en) | 1990-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CTFF | Application for supplementary protection certificate (spc) filed |
Free format text: CA 1999 00030, 19991207, EXPIRES: 20110829 |
|
| CTFG | Supplementary protection certificate (spc) issued |
Free format text: PRODUCT NAME: INSULIN ASPART Spc suppl protection certif: CA 1999 00030 Filing date: 19991207 |
|
| PUP | Patent expired |