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DK388384A - MONOCLONE ANTIBODIES WITH SPECIFICITY FOR MEMBRANE-ASSOCIATED ANTIGENS, THEIR PREPARATION AND USE - Google Patents

MONOCLONE ANTIBODIES WITH SPECIFICITY FOR MEMBRANE-ASSOCIATED ANTIGENS, THEIR PREPARATION AND USE Download PDF

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Publication number
DK388384A
DK388384A DK388384A DK388384A DK388384A DK 388384 A DK388384 A DK 388384A DK 388384 A DK388384 A DK 388384A DK 388384 A DK388384 A DK 388384A DK 388384 A DK388384 A DK 388384A
Authority
DK
Denmark
Prior art keywords
membrane
specificity
associated antigens
preparation
monoclone antibodies
Prior art date
Application number
DK388384A
Other languages
Danish (da)
Other versions
DK388384D0 (en
DK167936B1 (en
Inventor
Klaus Bosslet
Roland Kurrle
Hans-Harald Sedlacek
Ernst-Juergen Kanzy
Takako Katoh
Original Assignee
Behringwerke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke Ag filed Critical Behringwerke Ag
Publication of DK388384D0 publication Critical patent/DK388384D0/en
Publication of DK388384A publication Critical patent/DK388384A/en
Application granted granted Critical
Publication of DK167936B1 publication Critical patent/DK167936B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Monoclonal antibodies with defined specificity for membrane-associated antigens are prepared as described and can be used as diagnostic aids or carriers for pharmaceutical agents.
DK388384A 1983-08-12 1984-08-10 MONOCLONAL ANTIBODIES AGAINST ANTIGENS OF HUMAN CARCINOMA CELLS, THEIR PREPARATION AND USE, AND ANTIGENS OF CARCINOMA CELLS FROM HUMAN EPITHEL DK167936B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833329184 DE3329184A1 (en) 1983-08-12 1983-08-12 MONOCLONAL ANTIBODIES WITH SPECIFICITY FOR MEMBRANE-ASSOCIATED ANTIGENS
DE3329184 1983-08-12

Publications (3)

Publication Number Publication Date
DK388384D0 DK388384D0 (en) 1984-08-10
DK388384A true DK388384A (en) 1985-02-13
DK167936B1 DK167936B1 (en) 1994-01-03

Family

ID=6206422

Family Applications (1)

Application Number Title Priority Date Filing Date
DK388384A DK167936B1 (en) 1983-08-12 1984-08-10 MONOCLONAL ANTIBODIES AGAINST ANTIGENS OF HUMAN CARCINOMA CELLS, THEIR PREPARATION AND USE, AND ANTIGENS OF CARCINOMA CELLS FROM HUMAN EPITHEL

Country Status (7)

Country Link
EP (1) EP0141079B1 (en)
JP (1) JPS6089500A (en)
AT (1) ATE71411T1 (en)
CA (1) CA1277612C (en)
DE (2) DE3329184A1 (en)
DK (1) DK167936B1 (en)
ZA (1) ZA846214B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531301A1 (en) * 1985-09-02 1987-03-05 Behringwerke Ag MONOCLONAL ANTIBODIES AGAINST TUMOR ASSOCIATED GLYCOPROTEINS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
US6294172B1 (en) * 1983-08-12 2001-09-25 Dade Behring Marburg Gmbh Monoclonal antibodies with specificity for membrane-associated antigens
DE3416774A1 (en) * 1984-05-07 1985-11-14 Behringwerke Ag, 3550 Marburg MONOCLONAL ANTIBODIES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
DE3629640A1 (en) * 1986-08-30 1988-03-03 Behringwerke Ag USE OF MONOCLONAL ANTIBODIES FOR THE TREATMENT OF TUMORS
DE3432714A1 (en) * 1984-09-06 1986-04-24 Behringwerke Ag, 3550 Marburg TUMOR THERAPEUTICS AND METHOD FOR THE PRODUCTION THEREOF
US4701408A (en) * 1984-01-30 1987-10-20 Smithkline Beckman Corporation Monoclonal antibody to activated macrophages
JPS61104783A (en) * 1985-09-10 1986-05-23 Wakunaga Seiyaku Kk Hybridoma producing anti-human carcinoma monoclonal antibody
JPS61103837A (en) * 1984-10-26 1986-05-22 Wakunaga Seiyaku Kk Human anticancer monoclonal antibody
US4851332A (en) * 1985-04-01 1989-07-25 Sloan-Kettering Institute For Cancer Research Choriocarcinoma monoclonal antibodies and antibody panels
DE3786695T2 (en) * 1986-04-17 1993-12-16 Hybritech Inc Tumor Associated Antigen.
FR2606034B1 (en) * 1986-10-31 1989-06-02 Cird NOVEL SURFACE PROTEIN OF BASAL CELLS OF THE EPIDERMIS, ANTIBODIES CAPABLE OF RECOGNIZING THIS PROTEIN, AND THEIR USE, AND HYBRID CELL LINES CAPABLE OF SECRETING SUCH ANTIBODIES
FR2606033B1 (en) * 1986-10-31 1988-12-16 Cird CYTOPLASMIC PROTEIN OF THE SUBBASAL SKIN CELLS, ANTIBODIES CAPABLE OF RECOGNIZING THIS PROTEIN, AND HYBRID CELL LINES CAPABLE OF SECRETING SUCH ANTIBODIES
US5344919A (en) * 1987-02-19 1994-09-06 The Scripps Research Institute Integrin from human epithelial cells
US5320942A (en) * 1987-02-19 1994-06-14 Vito Quaranta Method of diagnosing the presence of abnormal epithelial tissue using monoclonal antibodies to the A6 B4 cell surface protein
DE3854821T2 (en) * 1987-02-19 1996-05-23 Scripps Clinic Res Cell surface marker for human pancreatic cancer cells
DE3825615A1 (en) * 1988-07-28 1990-02-01 Behringwerke Ag ANTIGENT CONSTRUCTS OF "MAJOR HISTOCOMPATIBILITY COMPLEX" CLASS I ANTIGENS WITH SPECIFIC CARRIER MOLECULES, THEIR PRODUCTION AND USE
DE3909799A1 (en) * 1989-03-24 1990-09-27 Behringwerke Ag MONOCLONAL ANTIBODIES (MAK) AGAINST TUMOR ASSOCIATED ANTIGENS, THEIR PRODUCTION AND USE
CA2015862A1 (en) * 1989-05-04 1990-11-04 Gajanan Nilaver Cell surface antigen that binds with l6 monoclonal antibody
DE3920358A1 (en) * 1989-06-22 1991-01-17 Behringwerke Ag BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
DE3935016A1 (en) * 1989-10-20 1991-04-25 Behringwerke Ag GLYCOSYL ETOPOSIDE PRODRUGS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN COMBINATION WITH FUNCTIONALIZED TUMOR-SPECIFIC ENZYME CONJUGATES
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
DE4133791A1 (en) * 1991-10-11 1993-04-15 Behringwerke Ag MONOCLONAL ANTIBODIES AGAINST TUMOR ASSOCIATED ANTIGENS, METHOD FOR THEIR PRODUCTION AND THEIR USE
US6030797A (en) * 1992-10-08 2000-02-29 Dade Behring Marburg Gmbh Monoclonal antibodies against tumor-associated antigens, processes for the preparation thereof and the use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4349528A (en) * 1979-11-21 1982-09-14 The Wistar Institute Monocolonal hybridoma antibody specific for high molecular weight carcinoembryonic antigen
US4579827A (en) * 1983-03-11 1986-04-01 Sloan-Kettering Institute For Cancer Research Monoclonal antibodies to human gastrointestinal cancers and hybridoma method of production of the monoclonal antibodies
US4569788A (en) * 1983-05-18 1986-02-11 The United States Of America As Represented By The Department Of Health And Human Services Monoclonal antibodies against non small cell lung cancer

Also Published As

Publication number Publication date
ZA846214B (en) 1985-03-27
EP0141079A2 (en) 1985-05-15
DK388384D0 (en) 1984-08-10
EP0141079B1 (en) 1992-01-08
JPH0542267B2 (en) 1993-06-28
JPS6089500A (en) 1985-05-20
DK167936B1 (en) 1994-01-03
CA1277612C (en) 1990-12-11
DE3329184A1 (en) 1985-02-21
DE3485432D1 (en) 1992-02-20
ATE71411T1 (en) 1992-01-15
EP0141079A3 (en) 1987-09-23

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired