DK3739061T3 - Methyleringsmønsteranalyse af haplotyper i væv i DNA-blanding - Google Patents
Methyleringsmønsteranalyse af haplotyper i væv i DNA-blanding Download PDFInfo
- Publication number
- DK3739061T3 DK3739061T3 DK20183986.7T DK20183986T DK3739061T3 DK 3739061 T3 DK3739061 T3 DK 3739061T3 DK 20183986 T DK20183986 T DK 20183986T DK 3739061 T3 DK3739061 T3 DK 3739061T3
- Authority
- DK
- Denmark
- Prior art keywords
- haplotypes
- tissues
- pattern analysis
- dna mixture
- methylation pattern
- Prior art date
Links
- 102000054766 genetic haplotypes Human genes 0.000 title 1
- 230000011987 methylation Effects 0.000 title 1
- 238000007069 methylation reaction Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562194702P | 2015-07-20 | 2015-07-20 | |
| EP16827235.9A EP3325663B1 (en) | 2015-07-20 | 2016-07-20 | Methylation pattern analysis of haplotypes in tissues in dna mixture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3739061T3 true DK3739061T3 (da) | 2022-04-19 |
Family
ID=57833669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK20183986.7T DK3739061T3 (da) | 2015-07-20 | 2016-07-20 | Methyleringsmønsteranalyse af haplotyper i væv i DNA-blanding |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10689706B2 (da) |
| EP (3) | EP4063517A1 (da) |
| CN (2) | CN115287348A (da) |
| AU (2) | AU2016295712B2 (da) |
| CA (1) | CA2993588A1 (da) |
| DK (1) | DK3739061T3 (da) |
| ES (1) | ES2911613T3 (da) |
| HU (1) | HUE059407T2 (da) |
| PT (1) | PT3739061T (da) |
| TW (2) | TWI798718B (da) |
| WO (1) | WO2017012544A1 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3169813B1 (en) | 2014-07-18 | 2019-06-12 | The Chinese University Of Hong Kong | Methylation pattern analysis of tissues in dna mixture |
| IL315032A (en) | 2016-11-30 | 2024-10-01 | Univ Hong Kong Chinese | Analysis of cell-free dna in urine and other samples |
| DK3574108T3 (da) | 2017-01-25 | 2024-09-16 | Univ Hong Kong Chinese | Diagnostisk anvendelse ved brug af nukleinsyrefragment |
| CN110770840B (zh) * | 2017-06-20 | 2025-01-28 | 伊鲁米那股份有限公司 | 用于对来自已知或未知基因型的多个贡献者的dna混合物分解和定量的方法和系统 |
| AU2018305609B2 (en) * | 2017-07-26 | 2023-01-19 | The Chinese University Of Hong Kong | Enhancement of cancer screening using cell-free viral nucleic acids |
| US20210087630A1 (en) * | 2018-02-18 | 2021-03-25 | Yissum Research Development Company Of The Hebrew University Of Jerusalmem Ltd. | Cell free dna deconvolusion and use thereof |
| DE202019005627U1 (de) | 2018-04-02 | 2021-05-31 | Grail, Inc. | Methylierungsmarker und gezielte Methylierungssondenpanels |
| US20190341127A1 (en) * | 2018-05-03 | 2019-11-07 | The Chinese University Of Hong Kong | Size-tagged preferred ends and orientation-aware analysis for measuring properties of cell-free mixtures |
| JP7497879B2 (ja) * | 2018-05-16 | 2024-06-11 | ツインストランド・バイオサイエンシズ・インコーポレイテッド | 核酸混合物および混合細胞集団を解析するための方法および試薬ならびに関連用途 |
| CA3111887A1 (en) | 2018-09-27 | 2020-04-02 | Grail, Inc. | Methylation markers and targeted methylation probe panel |
| US20200385813A1 (en) * | 2018-12-18 | 2020-12-10 | Grail, Inc. | Systems and methods for estimating cell source fractions using methylation information |
| CA3125647A1 (en) * | 2019-03-13 | 2020-09-17 | Grail, Inc. | Systems and methods for enriching for cancer-derived fragments using fragment size |
| MX389993B (es) * | 2019-08-16 | 2025-03-20 | Univ Hong Kong Chinese | Determinación de modificaciones de bases de ácidos nucleicos |
| WO2021077063A1 (en) * | 2019-10-18 | 2021-04-22 | Washington University | Methods and systems for measuring cell states |
| CN115066504A (zh) * | 2020-02-05 | 2022-09-16 | 香港中文大学 | 使用孕妇体内的长游离片段进行的分子分析 |
| CN114566220B (zh) * | 2020-11-27 | 2025-01-21 | 深圳华大生命科学研究院 | 基于dna甲基化水平确定样本类型的系统、可读介质及其应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| EP2557518B1 (en) | 2007-07-23 | 2017-03-15 | The Chinese University of Hong Kong | Determining a nucleic acid sequence imbalance |
| US8563242B2 (en) * | 2009-08-11 | 2013-10-22 | The Chinese University Of Hong Kong | Method for detecting chromosomal aneuploidy |
| AU2010315037B9 (en) | 2009-11-05 | 2015-04-23 | Sequenom, Inc. | Fetal genomic analysis from a maternal biological sample |
| ES3026544T3 (en) | 2009-11-06 | 2025-06-11 | Univ Hong Kong Chinese | Size-based genomic analysis for prenatal diagnosis |
| KR102333664B1 (ko) | 2010-11-30 | 2021-12-01 | 더 차이니즈 유니버시티 오브 홍콩 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
| WO2012078792A2 (en) * | 2010-12-07 | 2012-06-14 | Stanford University | Non-invasive determination of fetal inheritance of parental haplotypes at the genome-wide scale |
| JP6105485B2 (ja) * | 2011-01-05 | 2017-04-05 | ザ・チャイニーズ・ユニバーシティー・オブ・ホンコンＴｈｅ Ｃｈｉｎｅｓｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｈｏｎｇ Ｋｏｎｇ | 胎児の性染色体遺伝子型の非侵襲的出生前同定 |
| EP2860265B1 (en) * | 2011-02-24 | 2016-10-26 | The Chinese University of Hong Kong | Determining fetal DNA percentage for twins |
| US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| US9732390B2 (en) * | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| PL2898100T5 (pl) * | 2012-09-20 | 2023-11-06 | The Chinese University Of Hong Kong | Nieinwazyjny sposób określania metylomu płodu lub guza z wykorzystaniem osocza |
| EP2971126B1 (en) | 2013-03-15 | 2018-11-07 | The Chinese University Of Hong Kong | Determining fetal genomes for multiple fetus pregnancies |
| US20150004601A1 (en) * | 2013-06-28 | 2015-01-01 | Ariosa Diagnostics, Inc. | Massively parallel sequencing of random dna fragments for determination of fetal fraction |
| EP3099822A4 (en) | 2014-01-30 | 2017-08-30 | The Regents of the University of California | Methylation haplotyping for non-invasive diagnosis (monod) |
| DK4026917T5 (da) | 2014-04-14 | 2024-07-15 | Yissum Research And Development Company Of The Hebrew Univ Of Jerusalem Ltd | Fremgangsmåde og kit til bestemmelse af cellers eller vævs død eller dna's vævs- eller celleoprindelse ved dna-methyleringsanalyse |
| EP3169813B1 (en) | 2014-07-18 | 2019-06-12 | The Chinese University Of Hong Kong | Methylation pattern analysis of tissues in dna mixture |
-
2016
- 2016-07-20 EP EP22162789.6A patent/EP4063517A1/en active Pending
- 2016-07-20 AU AU2016295712A patent/AU2016295712B2/en active Active
- 2016-07-20 CN CN202210931079.4A patent/CN115287348A/zh active Pending
- 2016-07-20 PT PT201839867T patent/PT3739061T/pt unknown
- 2016-07-20 CA CA2993588A patent/CA2993588A1/en active Pending
- 2016-07-20 TW TW110121521A patent/TWI798718B/zh active
- 2016-07-20 EP EP20183986.7A patent/EP3739061B1/en active Active
- 2016-07-20 CN CN201680054736.4A patent/CN108138233B/zh active Active
- 2016-07-20 ES ES20183986T patent/ES2911613T3/es active Active
- 2016-07-20 TW TW105122965A patent/TWI732771B/zh active
- 2016-07-20 US US15/214,998 patent/US10689706B2/en active Active - Reinstated
- 2016-07-20 EP EP16827235.9A patent/EP3325663B1/en active Active
- 2016-07-20 HU HUE20183986A patent/HUE059407T2/hu unknown
- 2016-07-20 DK DK20183986.7T patent/DK3739061T3/da active
- 2016-07-20 WO PCT/CN2016/090642 patent/WO2017012544A1/en active Application Filing
-
2020
- 2020-05-14 US US16/874,215 patent/US20200270707A1/en active Pending
-
2022
- 2022-08-18 AU AU2022218555A patent/AU2022218555B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP4063517A1 (en) | 2022-09-28 |
| HK1252222A1 (zh) | 2019-05-24 |
| CA2993588A1 (en) | 2017-01-26 |
| TW201718871A (zh) | 2017-06-01 |
| EP3325663A4 (en) | 2018-07-25 |
| HK1248283A1 (en) | 2018-10-12 |
| US10689706B2 (en) | 2020-06-23 |
| EP3739061B1 (en) | 2022-03-23 |
| ES2911613T3 (es) | 2022-05-20 |
| AU2016295712B2 (en) | 2022-06-02 |
| AU2022218555A1 (en) | 2022-09-15 |
| HUE059407T2 (hu) | 2022-11-28 |
| CN108138233B (zh) | 2022-08-26 |
| EP3739061A1 (en) | 2020-11-18 |
| US20170029900A1 (en) | 2017-02-02 |
| CN108138233A (zh) | 2018-06-08 |
| TW202205300A (zh) | 2022-02-01 |
| WO2017012544A1 (en) | 2017-01-26 |
| TWI798718B (zh) | 2023-04-11 |
| TWI732771B (zh) | 2021-07-11 |
| US20200270707A1 (en) | 2020-08-27 |
| PT3739061T (pt) | 2022-04-05 |
| AU2016295712A1 (en) | 2018-02-08 |
| EP3325663B1 (en) | 2020-08-19 |
| AU2022218555B2 (en) | 2025-04-24 |
| EP3325663A1 (en) | 2018-05-30 |
| CN115287348A (zh) | 2022-11-04 |
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