DK3728288T3 - Fremgangsmåder til forbedret fjernelse af urenheder under protein a-kromatografi - Google Patents
Fremgangsmåder til forbedret fjernelse af urenheder under protein a-kromatografi Download PDFInfo
- Publication number
- DK3728288T3 DK3728288T3 DK18842505.2T DK18842505T DK3728288T3 DK 3728288 T3 DK3728288 T3 DK 3728288T3 DK 18842505 T DK18842505 T DK 18842505T DK 3728288 T3 DK3728288 T3 DK 3728288T3
- Authority
- DK
- Denmark
- Prior art keywords
- chromatography
- procedures
- proteins under
- improved removal
- under protein
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title 2
- 108090000623 proteins and genes Proteins 0.000 title 2
- 238000004587 chromatography analysis Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
- B01D15/426—Specific type of solvent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762609214P | 2017-12-21 | 2017-12-21 | |
US201862694387P | 2018-07-05 | 2018-07-05 | |
PCT/US2018/066890 WO2019126554A1 (en) | 2017-12-21 | 2018-12-20 | Methods for enhanced removal of impurities during protein a chromatography |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3728288T3 true DK3728288T3 (da) | 2022-03-28 |
Family
ID=65241305
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK18842505.2T DK3728288T3 (da) | 2017-12-21 | 2018-12-20 | Fremgangsmåder til forbedret fjernelse af urenheder under protein a-kromatografi |
Country Status (18)
Country | Link |
---|---|
US (2) | US11236126B2 (da) |
EP (2) | EP3728288B1 (da) |
JP (3) | JP2021506925A (da) |
KR (2) | KR102753090B1 (da) |
CN (2) | CN118496346A (da) |
AU (1) | AU2018392697A1 (da) |
BR (1) | BR112020012165A2 (da) |
CA (1) | CA3086186A1 (da) |
CY (1) | CY1125448T1 (da) |
DK (1) | DK3728288T3 (da) |
ES (1) | ES2907744T3 (da) |
HU (1) | HUE057850T2 (da) |
IL (2) | IL311002A (da) |
MX (2) | MX2020006586A (da) |
SG (1) | SG11202005809TA (da) |
TW (1) | TWI815838B (da) |
WO (1) | WO2019126554A1 (da) |
ZA (1) | ZA202003440B (da) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20220314142A1 (en) * | 2019-07-01 | 2022-10-06 | Pfizer Inc. | Improvements to wash solutions for protein a chromatography in an antibody purification process |
CN112827217A (zh) * | 2020-12-29 | 2021-05-25 | 苏州良辰生物医药科技有限公司 | 一种层析柱清洗液及其应用 |
WO2024017826A2 (en) * | 2022-07-19 | 2024-01-25 | Glaxosmithkline Intellectual Property Development Limited | Methods for purifying recombinant polypeptides |
CN115894604B (zh) * | 2022-12-16 | 2024-01-23 | 康日百奥生物科技(苏州)有限公司 | 重组蛋白澄清纯化方法 |
EP4438614A1 (en) * | 2023-03-31 | 2024-10-02 | Sanofi | Methods for purifying heteromultimeric antibodies |
CN116474744B (zh) * | 2023-05-19 | 2024-11-05 | 荆楚理工学院 | 一种多孔吸附剂及其制备方法及应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4871667A (en) * | 1984-11-26 | 1989-10-03 | Agency Of Industrial Science & Technology | Process for preparing muconic acid |
US5750402A (en) * | 1995-06-02 | 1998-05-12 | Plant Cell Technology, Inc. | Compositions and methods to prevent microbial contamination of plant tissue culture media |
NZ562949A (en) * | 2005-04-11 | 2009-05-31 | Medarex Inc | Protein purification using HCIC and ion exchange chromatography |
JP2006343214A (ja) * | 2005-06-09 | 2006-12-21 | Matsushita Electric Ind Co Ltd | 免疫反応測定方法及びそれに用いる免疫反応測定用試薬 |
EP1994054A4 (en) * | 2006-01-06 | 2012-11-07 | Amgen Inc | METHODS AND SYSTEMS FOR ISOLATING TARGET MOLECULES OF COMPLEX COLUMN CHROMATOGRAPHY SOLUTIONS USING ELEMENTS CONTAINING ORGANIC SOLVENTS |
TW201024318A (en) * | 2008-10-20 | 2010-07-01 | Abbott Lab | Isolation and purification of antibodies using protein A affinity chromatography |
CA2770235C (en) * | 2009-08-06 | 2021-06-29 | Genentech, Inc. | Method to improve virus removal in protein purification |
LT2513134T (lt) * | 2009-12-18 | 2017-11-27 | Novartis Ag | Praplovimo tirpalas ir afininės chromatografijos metodas |
MX344268B (es) * | 2010-10-11 | 2016-12-09 | Abbvie Inc * | Proceso para purificacion de proteinas. |
US20120301429A1 (en) * | 2011-05-27 | 2012-11-29 | Hartman Taymar E | Dac hyp compositions and methods |
DK3041857T3 (da) * | 2013-09-04 | 2019-07-22 | Emd Millipore Corp | Protein a-kromatografi |
US20170066839A1 (en) * | 2015-09-08 | 2017-03-09 | Merck Patent Gmbh | Novel affinity chromatography media for removal of anti-a and/or anti-b antibodies |
-
2018
- 2018-12-20 MX MX2020006586A patent/MX2020006586A/es unknown
- 2018-12-20 AU AU2018392697A patent/AU2018392697A1/en active Pending
- 2018-12-20 ES ES18842505T patent/ES2907744T3/es active Active
- 2018-12-20 KR KR1020207020808A patent/KR102753090B1/ko active Active
- 2018-12-20 US US16/228,291 patent/US11236126B2/en active Active
- 2018-12-20 DK DK18842505.2T patent/DK3728288T3/da active
- 2018-12-20 CA CA3086186A patent/CA3086186A1/en active Pending
- 2018-12-20 HU HUE18842505A patent/HUE057850T2/hu unknown
- 2018-12-20 IL IL311002A patent/IL311002A/en unknown
- 2018-12-20 BR BR112020012165-7A patent/BR112020012165A2/pt unknown
- 2018-12-20 JP JP2020534539A patent/JP2021506925A/ja active Pending
- 2018-12-20 CN CN202410679387.1A patent/CN118496346A/zh active Pending
- 2018-12-20 SG SG11202005809TA patent/SG11202005809TA/en unknown
- 2018-12-20 EP EP18842505.2A patent/EP3728288B1/en active Active
- 2018-12-20 CN CN201880089518.3A patent/CN111712510B/zh active Active
- 2018-12-20 KR KR1020257000451A patent/KR20250011233A/ko active Pending
- 2018-12-20 IL IL275418A patent/IL275418B2/en unknown
- 2018-12-20 EP EP21217361.1A patent/EP4050016A1/en active Pending
- 2018-12-20 WO PCT/US2018/066890 patent/WO2019126554A1/en unknown
- 2018-12-21 TW TW107146337A patent/TWI815838B/zh active
-
2020
- 2020-06-09 ZA ZA2020/03440A patent/ZA202003440B/en unknown
- 2020-07-13 MX MX2024010249A patent/MX2024010249A/es unknown
-
2021
- 2021-12-17 US US17/554,758 patent/US20220242902A1/en active Pending
-
2022
- 2022-03-29 CY CY20221100241T patent/CY1125448T1/el unknown
-
2023
- 2023-08-04 JP JP2023127480A patent/JP2023145727A/ja active Pending
-
2024
- 2024-11-27 JP JP2024205879A patent/JP2025028973A/ja active Pending
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