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DK3728288T3 - Fremgangsmåder til forbedret fjernelse af urenheder under protein a-kromatografi - Google Patents

Fremgangsmåder til forbedret fjernelse af urenheder under protein a-kromatografi Download PDF

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Publication number
DK3728288T3
DK3728288T3 DK18842505.2T DK18842505T DK3728288T3 DK 3728288 T3 DK3728288 T3 DK 3728288T3 DK 18842505 T DK18842505 T DK 18842505T DK 3728288 T3 DK3728288 T3 DK 3728288T3
Authority
DK
Denmark
Prior art keywords
chromatography
procedures
proteins under
improved removal
under protein
Prior art date
Application number
DK18842505.2T
Other languages
English (en)
Inventor
Carl A Beigie
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Application granted granted Critical
Publication of DK3728288T3 publication Critical patent/DK3728288T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804Affinity chromatography
    • B01D15/3809Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/42Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424Elution mode
    • B01D15/426Specific type of solvent
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/22Affinity chromatography or related techniques based upon selective absorption processes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/34Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/36Extraction; Separation; Purification by a combination of two or more processes of different types
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK18842505.2T 2017-12-21 2018-12-20 Fremgangsmåder til forbedret fjernelse af urenheder under protein a-kromatografi DK3728288T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762609214P 2017-12-21 2017-12-21
US201862694387P 2018-07-05 2018-07-05
PCT/US2018/066890 WO2019126554A1 (en) 2017-12-21 2018-12-20 Methods for enhanced removal of impurities during protein a chromatography

Publications (1)

Publication Number Publication Date
DK3728288T3 true DK3728288T3 (da) 2022-03-28

Family

ID=65241305

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18842505.2T DK3728288T3 (da) 2017-12-21 2018-12-20 Fremgangsmåder til forbedret fjernelse af urenheder under protein a-kromatografi

Country Status (18)

Country Link
US (2) US11236126B2 (da)
EP (2) EP3728288B1 (da)
JP (3) JP2021506925A (da)
KR (2) KR102753090B1 (da)
CN (2) CN118496346A (da)
AU (1) AU2018392697A1 (da)
BR (1) BR112020012165A2 (da)
CA (1) CA3086186A1 (da)
CY (1) CY1125448T1 (da)
DK (1) DK3728288T3 (da)
ES (1) ES2907744T3 (da)
HU (1) HUE057850T2 (da)
IL (2) IL311002A (da)
MX (2) MX2020006586A (da)
SG (1) SG11202005809TA (da)
TW (1) TWI815838B (da)
WO (1) WO2019126554A1 (da)
ZA (1) ZA202003440B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220314142A1 (en) * 2019-07-01 2022-10-06 Pfizer Inc. Improvements to wash solutions for protein a chromatography in an antibody purification process
CN112827217A (zh) * 2020-12-29 2021-05-25 苏州良辰生物医药科技有限公司 一种层析柱清洗液及其应用
WO2024017826A2 (en) * 2022-07-19 2024-01-25 Glaxosmithkline Intellectual Property Development Limited Methods for purifying recombinant polypeptides
CN115894604B (zh) * 2022-12-16 2024-01-23 康日百奥生物科技(苏州)有限公司 重组蛋白澄清纯化方法
EP4438614A1 (en) * 2023-03-31 2024-10-02 Sanofi Methods for purifying heteromultimeric antibodies
CN116474744B (zh) * 2023-05-19 2024-11-05 荆楚理工学院 一种多孔吸附剂及其制备方法及应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4871667A (en) * 1984-11-26 1989-10-03 Agency Of Industrial Science & Technology Process for preparing muconic acid
US5750402A (en) * 1995-06-02 1998-05-12 Plant Cell Technology, Inc. Compositions and methods to prevent microbial contamination of plant tissue culture media
NZ562949A (en) * 2005-04-11 2009-05-31 Medarex Inc Protein purification using HCIC and ion exchange chromatography
JP2006343214A (ja) * 2005-06-09 2006-12-21 Matsushita Electric Ind Co Ltd 免疫反応測定方法及びそれに用いる免疫反応測定用試薬
EP1994054A4 (en) * 2006-01-06 2012-11-07 Amgen Inc METHODS AND SYSTEMS FOR ISOLATING TARGET MOLECULES OF COMPLEX COLUMN CHROMATOGRAPHY SOLUTIONS USING ELEMENTS CONTAINING ORGANIC SOLVENTS
TW201024318A (en) * 2008-10-20 2010-07-01 Abbott Lab Isolation and purification of antibodies using protein A affinity chromatography
CA2770235C (en) * 2009-08-06 2021-06-29 Genentech, Inc. Method to improve virus removal in protein purification
LT2513134T (lt) * 2009-12-18 2017-11-27 Novartis Ag Praplovimo tirpalas ir afininės chromatografijos metodas
MX344268B (es) * 2010-10-11 2016-12-09 Abbvie Inc * Proceso para purificacion de proteinas.
US20120301429A1 (en) * 2011-05-27 2012-11-29 Hartman Taymar E Dac hyp compositions and methods
DK3041857T3 (da) * 2013-09-04 2019-07-22 Emd Millipore Corp Protein a-kromatografi
US20170066839A1 (en) * 2015-09-08 2017-03-09 Merck Patent Gmbh Novel affinity chromatography media for removal of anti-a and/or anti-b antibodies

Also Published As

Publication number Publication date
ZA202003440B (en) 2021-10-27
WO2019126554A1 (en) 2019-06-27
BR112020012165A2 (pt) 2020-11-24
KR102753090B1 (ko) 2025-01-14
JP2023145727A (ja) 2023-10-11
SG11202005809TA (en) 2020-07-29
TW202400623A (zh) 2024-01-01
EP3728288B1 (en) 2022-01-19
IL311002A (en) 2024-04-01
MX2024010249A (es) 2024-09-05
EP4050016A1 (en) 2022-08-31
IL275418B1 (en) 2024-03-01
IL275418B2 (en) 2024-07-01
TW201936629A (zh) 2019-09-16
US20220242902A1 (en) 2022-08-04
KR20200103740A (ko) 2020-09-02
AU2018392697A1 (en) 2020-08-06
ES2907744T3 (es) 2022-04-26
MX2020006586A (es) 2020-10-08
RU2020123917A3 (da) 2022-01-26
RU2020123917A (ru) 2022-01-26
CN111712510A (zh) 2020-09-25
EP3728288A1 (en) 2020-10-28
US20190233468A1 (en) 2019-08-01
TWI815838B (zh) 2023-09-21
HUE057850T2 (hu) 2022-06-28
CN111712510B (zh) 2024-06-14
US11236126B2 (en) 2022-02-01
IL275418A (en) 2020-08-31
JP2025028973A (ja) 2025-03-05
CY1125448T1 (el) 2024-02-16
CN118496346A (zh) 2024-08-16
CA3086186A1 (en) 2019-06-27
KR20250011233A (ko) 2025-01-21
JP2021506925A (ja) 2021-02-22

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