DK3725786T3 - CRYSTALLINE FORM AND SALT FORM OF TGF-ßRI INHIBITOR AND METHOD OF PREPARATION THEREOF - Google Patents
CRYSTALLINE FORM AND SALT FORM OF TGF-ßRI INHIBITOR AND METHOD OF PREPARATION THEREOF Download PDFInfo
- Publication number
- DK3725786T3 DK3725786T3 DK18888487.8T DK18888487T DK3725786T3 DK 3725786 T3 DK3725786 T3 DK 3725786T3 DK 18888487 T DK18888487 T DK 18888487T DK 3725786 T3 DK3725786 T3 DK 3725786T3
- Authority
- DK
- Denmark
- Prior art keywords
- ßri
- tgf
- inhibitor
- preparation
- crystalline form
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711331447 | 2017-12-13 | ||
PCT/CN2018/120905 WO2019114792A1 (en) | 2017-12-13 | 2018-12-13 | Crystal form and salt form of tgf-βri inhibitor and preparation method therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3725786T3 true DK3725786T3 (en) | 2023-11-27 |
Family
ID=66818947
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK18888487.8T DK3725786T3 (en) | 2017-12-13 | 2018-12-13 | CRYSTALLINE FORM AND SALT FORM OF TGF-ßRI INHIBITOR AND METHOD OF PREPARATION THEREOF |
Country Status (13)
Country | Link |
---|---|
US (1) | US11236112B2 (en) |
EP (1) | EP3725786B1 (en) |
JP (1) | JP7028977B2 (en) |
KR (1) | KR102507328B1 (en) |
CN (1) | CN111479809B (en) |
AU (1) | AU2018383853B2 (en) |
BR (1) | BR112020011602A2 (en) |
CA (1) | CA3085498C (en) |
DK (1) | DK3725786T3 (en) |
ES (1) | ES2960412T3 (en) |
PT (1) | PT3725786T (en) |
RU (1) | RU2750702C1 (en) |
WO (1) | WO2019114792A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112851695A (en) * | 2021-01-27 | 2021-05-28 | 复旦大学附属华山医院 | Application of formamide compound in preparation of spinal cord tumor resisting medicine and kit |
CN112759592A (en) * | 2021-02-01 | 2021-05-07 | 无锡鸣鹭医药科技有限公司 | Synthetic method of 6-iodo [1,2,3] triazolo [1,5-a ] pyridine |
CN115969801B (en) * | 2023-03-21 | 2023-08-25 | 劲方医药科技(上海)有限公司 | Pharmaceutical composition for cancer and preparation method thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3038004A (en) * | 1958-04-18 | 1962-06-05 | Burroughs Wellcome Co | Quaternary ammonium compounds |
GB0020721D0 (en) * | 2000-08-22 | 2000-10-11 | Merck Sharp & Dohme | Therapeutic agents |
PT1397364E (en) * | 2001-05-24 | 2007-10-22 | Lilly Co Eli | Novel pyrrole derivatives as pharmaceutical agents |
OA12929A (en) * | 2002-09-18 | 2006-10-13 | Pfizer Prod Inc | Pyrazole derivatives as transforming growth (TGF) inhibitors. |
WO2004050659A1 (en) | 2002-11-27 | 2004-06-17 | Eli Lilly And Company | Novel compounds as pharmaceutical agents |
MY151835A (en) | 2006-01-31 | 2014-07-14 | Array Biopharma Inc | Kinase inhibitors and methods of use thereof |
AU2010299483B2 (en) * | 2009-09-24 | 2014-08-28 | Sun Pharmaceutical Industries Limited | Process for the preparation of sorafenib tosylate |
US8080568B1 (en) * | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
US10822337B2 (en) | 2015-04-01 | 2020-11-03 | Rigel Pharmaceuticals, Inc. | TGF-β inhibitorC |
AU2017284124B2 (en) | 2016-06-13 | 2021-06-03 | Genfleet Therapeutics (Shanghai) Inc. | Benzotriazole-derived α and β unsaturated amide compound used as TGF-βR1 inhibitor |
-
2018
- 2018-12-13 DK DK18888487.8T patent/DK3725786T3/en active
- 2018-12-13 ES ES18888487T patent/ES2960412T3/en active Active
- 2018-12-13 JP JP2020532602A patent/JP7028977B2/en active Active
- 2018-12-13 CN CN201880080169.9A patent/CN111479809B/en active Active
- 2018-12-13 CA CA3085498A patent/CA3085498C/en active Active
- 2018-12-13 EP EP18888487.8A patent/EP3725786B1/en active Active
- 2018-12-13 KR KR1020207020214A patent/KR102507328B1/en active Active
- 2018-12-13 AU AU2018383853A patent/AU2018383853B2/en active Active
- 2018-12-13 US US16/771,977 patent/US11236112B2/en active Active
- 2018-12-13 RU RU2020121754A patent/RU2750702C1/en active
- 2018-12-13 WO PCT/CN2018/120905 patent/WO2019114792A1/en unknown
- 2018-12-13 PT PT188884878T patent/PT3725786T/en unknown
- 2018-12-13 BR BR112020011602-5A patent/BR112020011602A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2019114792A1 (en) | 2019-06-20 |
KR102507328B1 (en) | 2023-03-07 |
US11236112B2 (en) | 2022-02-01 |
ES2960412T3 (en) | 2024-03-04 |
US20210079021A1 (en) | 2021-03-18 |
JP2021506791A (en) | 2021-02-22 |
EP3725786A1 (en) | 2020-10-21 |
AU2018383853A1 (en) | 2020-07-30 |
EP3725786A4 (en) | 2021-04-28 |
EP3725786B1 (en) | 2023-08-23 |
CN111479809A (en) | 2020-07-31 |
CN111479809B (en) | 2021-10-29 |
CA3085498A1 (en) | 2019-06-20 |
JP7028977B2 (en) | 2022-03-02 |
RU2750702C1 (en) | 2021-07-01 |
PT3725786T (en) | 2023-10-17 |
AU2018383853B2 (en) | 2021-06-03 |
BR112020011602A2 (en) | 2020-12-08 |
KR20200106163A (en) | 2020-09-11 |
CA3085498C (en) | 2023-04-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP3634380C0 (en) | INHIBITION OF CRYSTAL GROWTH OF ROFLUMILAST | |
DK3661921T3 (en) | SELECTIVE INHIBITORS OF THE NLRP3 INFLAMMATOME | |
DK3259253T3 (en) | SULPHONYLURAES AND RELATED COMPOUNDS AND USE OF SAME | |
DK3548033T3 (en) | COMPOUNDS AND THEIR METHOD OF USE | |
DK3356529T3 (en) | COMPOSITIONS AND METHODS FOR INHIBITING LENA EXPRESSION OF LPA | |
DK3292134T3 (en) | METHOD OF GROWING AKKERMANSIA | |
DK3484469T3 (en) | COMPOSITIONS AND METHODS FOR POTENTIATION OF ANTIMICROBIES | |
HUE064559T2 (en) | Crystalline form of MAGL inhibitor | |
DK3248967T3 (en) | Crystalline form of a benzimidazole derivative and a process for its preparation | |
DK3262046T3 (en) | SALTS OF PI3K INHIBITOR AND MANUFACTURING METHODS | |
DK3447051T3 (en) | METHOD OF PREPARING TYROSINKINASE INHIBITOR AND DERIVATIVES THEREOF | |
DK3144001T3 (en) | Compositions of selenoorganic compounds and methods of their use | |
DK3429998T3 (en) | Process for the preparation of quinolin-2-yl-phenylamine derivatives and their salts | |
DK3067355T3 (en) | CRYSTALS OF DIAZABICYCLOOCTAN DERIVATIVES AND METHOD OF MANUFACTURE OF CRYSTALS OF DIAZABICYCLOOCTAN DERIVATIVES | |
DK3551625T3 (en) | HETEROCYCLIC INHIBITORS OF MCT4 | |
DK3215493T3 (en) | SYNTHESIS OF COPANLISIB AND DIHYDROCHLORIDE SALT | |
IL282552A (en) | Crystalline forms of mnk inhibitors | |
DK3412674T3 (en) | Trifluoroacetate salt of a TLR7 agonist and its crystalline crystal B, methods of preparation and uses | |
DK3572062T3 (en) | AQUEOUS CAPSULE AND METHOD FOR MANUFACTURE OF AQUEOUS CAPSULE | |
DK3205653T3 (en) | CRYSTAL FORM OF BACK SULPHATE OF JAK INHIBITORS AND METHOD OF MANUFACTURE THEREOF | |
DK3347342T3 (en) | PROCEDURE FOR MANUFACTURE OF BIGUANIDIN SALTS AND S-TRIAZINES | |
DK3398598T3 (en) | SULFONAMIDE DERIVATIVE AND METHOD OF PREPARATION AND USE THEREOF | |
DK3636640T3 (en) | CRYSTAL OF HETEROCYCLIDENAACETA MID DERIVATIVE | |
ZA201904460B (en) | Inhibitors of nhe-mediated antiport | |
ZA202007037B (en) | Crystal form of c-met inhibitor and salt form thereof and preparation method therefor |