DK3697418T3 - Forbedrede formuleringer af bromocriptin - Google Patents
Forbedrede formuleringer af bromocriptin Download PDFInfo
- Publication number
- DK3697418T3 DK3697418T3 DK18868516.8T DK18868516T DK3697418T3 DK 3697418 T3 DK3697418 T3 DK 3697418T3 DK 18868516 T DK18868516 T DK 18868516T DK 3697418 T3 DK3697418 T3 DK 3697418T3
- Authority
- DK
- Denmark
- Prior art keywords
- bromocriptin
- improved formulations
- formulations
- improved
- Prior art date
Links
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 title 1
- 229960002802 bromocriptine Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762573839P | 2017-10-18 | 2017-10-18 | |
| PCT/US2018/056554 WO2019079623A1 (en) | 2017-10-18 | 2018-10-18 | ENHANCED BROMOCRIPTINE FORMULATIONS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3697418T3 true DK3697418T3 (da) | 2024-10-07 |
Family
ID=66174253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18868516.8T DK3697418T3 (da) | 2017-10-18 | 2018-10-18 | Forbedrede formuleringer af bromocriptin |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US11510921B2 (da) |
| EP (2) | EP3697418B1 (da) |
| JP (3) | JP7231255B2 (da) |
| CN (1) | CN111818921A (da) |
| AU (2) | AU2018351131B2 (da) |
| CA (1) | CA3079522A1 (da) |
| DK (1) | DK3697418T3 (da) |
| ES (1) | ES2991048T3 (da) |
| HR (1) | HRP20241365T1 (da) |
| PL (1) | PL3697418T3 (da) |
| WO (1) | WO2019079623A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8431155B1 (en) | 2012-04-30 | 2013-04-30 | Veroscience Llc | Bromocriptine formulations |
| PL3445362T3 (pl) | 2016-04-20 | 2022-05-30 | Veroscience Llc | Kompozycja i sposób leczenia zaburzeń metabolicznych |
| ES2991048T3 (es) | 2017-10-18 | 2024-12-02 | Veroscience Llc | Formulaciones mejoradas de bromocriptina |
| US11607455B2 (en) | 2019-09-23 | 2023-03-21 | Veroscience Llc | Method for inducing tumor regression |
| US20230312885A1 (en) * | 2022-03-11 | 2023-10-05 | Celanese International Corporation | Cellulose Ester Polymer Product With Increased Melt Flow Rate |
| WO2025066935A1 (en) * | 2023-09-28 | 2025-04-03 | Hepaitech (Beijing) Biopharma Technology Co., Ltd. | Compounds, compositions and methods thereof |
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| US941005A (en) | 1906-03-24 | 1909-11-23 | Brandt Company | Designating, recording, and registering mechanism. |
| CH507249A (de) | 1968-05-31 | 1971-05-15 | Sandoz Ag | Verfahren zur Herstellung von 2-Brom-a-ergokryptin |
| GB8426922D0 (en) | 1984-10-24 | 1984-11-28 | Sandoz Ltd | Galenic formulation |
| US4749709A (en) | 1986-03-07 | 1988-06-07 | Louisiana State University And Agricultural And Mechanical College | Method of inhibiting body fat stores |
| US4659715A (en) | 1986-03-07 | 1987-04-21 | Louisiana State University And Agricultural And Mechanical College | Method of inhibiting body fat stores |
| US4783469A (en) | 1986-03-07 | 1988-11-08 | Meier Albert H | Method of inhibiting body fat stores |
| DE3722383A1 (de) | 1986-07-14 | 1988-01-28 | Sandoz Ag | Neue verwendung von bromocriptin |
| US4962197A (en) | 1988-02-12 | 1990-10-09 | Rowland Institute For Science | Photo-inactivation of cancer cells |
| US5830895A (en) | 1988-05-10 | 1998-11-03 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Methods for the determination and adjustment of prolactin daily rhythms |
| US5700800A (en) | 1988-05-10 | 1997-12-23 | Ergo Science Incorporated | Methods for the long term reduction of body fat stores, insulin resistance, hyperinsulinemia and hyperglycemia in vertebrates with a prolactin stimulatory compound |
| US6004972A (en) | 1988-05-10 | 1999-12-21 | The Board Of Supervisiors Of Louisiana State University And Agricultural And Mechanical College | Therapeutic process for the treatment of the pathologies of type II diabetes |
| US5585347A (en) | 1988-05-10 | 1996-12-17 | Ergo Science Incorporated | Methods for the determination and adjustment of prolactin daily rhythms |
| US5468755A (en) | 1988-05-10 | 1995-11-21 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Therapeutic process for the treatment of the pathologies of Type II diabetes |
| US5344832A (en) | 1990-01-10 | 1994-09-06 | The Board Of Supervisors Of Louisiana University And Agricultural And Mechanical College | Method for the long term reduction of body fat stores, insulin resistance, hyperinsulinemia and hyperglycemia in vertebrates |
| US5744477A (en) | 1988-05-10 | 1998-04-28 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Method for treatment of obesity using prolactin modulators and diet |
| US5668155A (en) | 1988-05-10 | 1997-09-16 | The General Hospital Corporation | Administration of pirenzepine, methyl scopolamine and other muscarinic receptor antagonists for treatment of lipid metabolism disorders |
| US5716933A (en) | 1988-05-10 | 1998-02-10 | Louisiana State University And Agricultural And Mechanical College | Process for the long term reduction of body fat stores, insulin resistance, and hyperinsulinemia in vertebrates |
| US5006526A (en) | 1988-10-17 | 1991-04-09 | Louisiana State University | Method of treating a vertebrate animal to reduce plasma triglycerides and cholesterol levels and to alleviate and prevent atherosclerosis |
| JPH02121919A (ja) | 1988-10-28 | 1990-05-09 | Grelan Pharmaceut Co Ltd | 柔軟性を有する錠剤 |
| IT1235053B (it) | 1989-04-07 | 1992-06-17 | Poli Ind Chimica Spa | Metodi per la preparazione di composizioni farmaceutiche a base di bromocriptina dotate di elevata stabilita' e prodotti derivanti. |
| CA2030174C (en) | 1990-01-10 | 1996-12-24 | Anthony H. Cincotta | Process for the long term reduction of body fat stores, insulin resistance, hyperinsulinemia and hypoglycemia in vertebrates |
| FR2680106B1 (fr) | 1991-08-09 | 1994-03-11 | Corbiere Gerome | Procede de realisation de formes pharmaceutiques stables d'un derive d'ergoline et les compositions pharmaceutiques ainsi obtenues. |
| US5186420A (en) | 1991-11-08 | 1993-02-16 | The United States Of America As Represented By The Secretary Of The Navy | Articulated fin/wing control system |
| US5696128A (en) | 1994-07-07 | 1997-12-09 | The Board Of Supervisors Of Louisiana University And Agricultural And Mechanical College | Method of regulating immune function |
| DE4322826A1 (de) * | 1993-07-08 | 1995-01-12 | Galenik Labor Freiburg Gmbh | Pharmazeutisches Präparat |
| IL112106A0 (en) | 1993-12-22 | 1995-03-15 | Ergo Science Inc | Accelerated release composition containing bromocriptine |
| US5565454A (en) | 1995-05-31 | 1996-10-15 | Ergo Science, Incorporated | Method for preventing intervention-associated stenosis and other symptoms associated with stenosis of blood vessels following non-bypass, invasive interventions |
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| EP0834308A1 (en) | 1996-09-30 | 1998-04-08 | LG Chemical Limited | Ophthalmic formulation for treating myopia comprising dopamine agonist and cyclodextrin |
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| US20040220190A1 (en) | 2002-07-29 | 2004-11-04 | Cincotta Anthony H. | Methods of treating metabolic syndrome using dopamine receptor agonists |
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| US20100035886A1 (en) | 2007-06-21 | 2010-02-11 | Veroscience, Llc | Parenteral formulations of dopamine agonists |
| US20210401824A1 (en) | 2007-06-21 | 2021-12-30 | Veroscience Llc | Parenteral Formulations of Dopamine Agonists |
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| US8741918B2 (en) | 2007-06-21 | 2014-06-03 | Veroscience Llc | Parenteral formulations of dopamine agonists |
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| CN102283844B (zh) | 2010-06-21 | 2014-06-25 | 山东新时代药业有限公司 | 含有克拉维酸的药物组合物及其用途 |
| WO2012068153A1 (en) | 2010-11-15 | 2012-05-24 | Sun Chemical Corporation | Compositions and methods to improve the setting properties and rub resistance of printing inks |
| RU2013122841A (ru) | 2010-11-23 | 2014-12-27 | ВЕРОСАЙЕНС ЭлЭлСи | Лечение метаболического синдрома, диабета ii типа, ожирения или преддиабета |
| CN102727894B (zh) | 2011-04-01 | 2015-10-07 | 鲁南制药集团股份有限公司 | 一种治疗糖尿病及其并发症的药物组合物及其应用 |
| TWI442945B (zh) | 2011-05-18 | 2014-07-01 | Univ Nat Taiwan | 雙效微脂體用於治療的方法 |
| US8431155B1 (en) | 2012-04-30 | 2013-04-30 | Veroscience Llc | Bromocriptine formulations |
| US9056139B2 (en) | 2012-06-28 | 2015-06-16 | Kean University | Fatty acid-salicylate conjugates with enhanced therapeutic properties |
| EP3008167A4 (en) | 2013-06-13 | 2017-06-07 | VeroScience LLC | Compositions and methods for treating metabolic disorders |
| JP6370630B2 (ja) | 2014-07-31 | 2018-08-08 | 株式会社ニューフレアテクノロジー | 気相成長装置および気相成長方法 |
| PL3445362T3 (pl) | 2016-04-20 | 2022-05-30 | Veroscience Llc | Kompozycja i sposób leczenia zaburzeń metabolicznych |
| US20170340271A1 (en) | 2016-05-26 | 2017-11-30 | Veroscience Llc | Methods for identifying responders to dopaminergic neuronal enhancing therapies for the treatment of elevated heart rate and metabolic or cardiovascular conditions |
| ES2991048T3 (es) * | 2017-10-18 | 2024-12-02 | Veroscience Llc | Formulaciones mejoradas de bromocriptina |
| US11607455B2 (en) | 2019-09-23 | 2023-03-21 | Veroscience Llc | Method for inducing tumor regression |
-
2018
- 2018-10-18 ES ES18868516T patent/ES2991048T3/es active Active
- 2018-10-18 AU AU2018351131A patent/AU2018351131B2/en active Active
- 2018-10-18 WO PCT/US2018/056554 patent/WO2019079623A1/en not_active Ceased
- 2018-10-18 US US16/623,183 patent/US11510921B2/en active Active
- 2018-10-18 DK DK18868516.8T patent/DK3697418T3/da active
- 2018-10-18 EP EP18868516.8A patent/EP3697418B1/en active Active
- 2018-10-18 EP EP23176381.4A patent/EP4233913A3/en active Pending
- 2018-10-18 CA CA3079522A patent/CA3079522A1/en active Pending
- 2018-10-18 CN CN201880081067.9A patent/CN111818921A/zh active Pending
- 2018-10-18 HR HRP20241365TT patent/HRP20241365T1/hr unknown
- 2018-10-18 JP JP2020522290A patent/JP7231255B2/ja active Active
- 2018-10-18 PL PL18868516.8T patent/PL3697418T3/pl unknown
-
2022
- 2022-05-03 US US17/735,217 patent/US11883399B2/en active Active
-
2023
- 2023-02-09 JP JP2023018110A patent/JP7586523B2/ja active Active
- 2023-06-14 US US18/209,699 patent/US12274698B2/en active Active
-
2024
- 2024-08-28 AU AU2024216408A patent/AU2024216408A1/en active Pending
- 2024-10-30 JP JP2024190314A patent/JP2025011338A/ja active Pending
-
2025
- 2025-03-17 US US19/081,823 patent/US20250275961A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US12274698B2 (en) | 2025-04-15 |
| AU2018351131A1 (en) | 2020-05-07 |
| PL3697418T3 (pl) | 2025-02-03 |
| EP3697418A4 (en) | 2021-07-14 |
| AU2024216408A1 (en) | 2024-09-19 |
| JP7586523B2 (ja) | 2024-11-19 |
| HRP20241365T1 (hr) | 2024-12-20 |
| JP2021500357A (ja) | 2021-01-07 |
| US20250275961A1 (en) | 2025-09-04 |
| US11510921B2 (en) | 2022-11-29 |
| EP4233913A2 (en) | 2023-08-30 |
| US11883399B2 (en) | 2024-01-30 |
| US20220265648A1 (en) | 2022-08-25 |
| EP3697418A1 (en) | 2020-08-26 |
| WO2019079623A1 (en) | 2019-04-25 |
| JP7231255B2 (ja) | 2023-03-01 |
| ES2991048T3 (es) | 2024-12-02 |
| US20230321090A1 (en) | 2023-10-12 |
| US20210177839A1 (en) | 2021-06-17 |
| CA3079522A1 (en) | 2019-04-25 |
| CN111818921A (zh) | 2020-10-23 |
| EP4233913A3 (en) | 2023-10-18 |
| JP2023055940A (ja) | 2023-04-18 |
| EP3697418B1 (en) | 2024-07-24 |
| JP2025011338A (ja) | 2025-01-23 |
| AU2018351131B2 (en) | 2024-05-30 |
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