DK367279A - 7-amino-3-cephem-4-carboxylsyrederivater og deres fremstilling - Google Patents

7-amino-3-cephem-4-carboxylsyrederivater og deres fremstilling

Info

Publication number: DK367279A
Authority: DK; Denmark
Prior art keywords: cephem; amino; preparation; carboxylic acid; acid derivatives
Prior art date: 1974-09-03

Application number

DK367279A

Other languages

English (en)

Other versions

DK147483C (da

DK147483B (da

Inventor

W J Gottstein

M A Kaplan

A P Granatek

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-09-03

Filing date

1979-08-31

Publication date

1979-08-31

1979-08-31 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1979-08-31 Publication of DK367279A publication Critical patent/DK367279A/da

1984-08-27 Publication of DK147483B publication Critical patent/DK147483B/da

1985-03-25 Application granted granted Critical

1985-03-25 Publication of DK147483C publication Critical patent/DK147483C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C265/00—Derivatives of isocyanic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK367279A 1974-09-03 1979-08-31 Analogifremgangsmaade til fremstilling af cephalosporansyrederivater eller estere og salte deraf DK147483C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US50299174A	1974-09-03	1974-09-03
US50299174		1974-09-03
US05/590,971 US4297489A (en)	1974-09-03	1975-06-27	7-α-Amino-substituted acylamino-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids
US59097175		1975-06-27

Publications (3)

Publication Number	Publication Date
DK367279A true DK367279A (da)	1979-08-31
DK147483B DK147483B (da)	1984-08-27
DK147483C DK147483C (da)	1985-03-25

Family

ID=27054342

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
DK391075A DK145262C (da)	1974-09-03	1975-08-29	Analogifremgangsmaade til fremstilling af cephalosporansyrederivater og estere og salte deraf
DK367279A DK147483C (da)	1974-09-03	1979-08-31	Analogifremgangsmaade til fremstilling af cephalosporansyrederivater eller estere og salte deraf
DK240582A DK148796C (da)	1974-09-03	1982-05-27	Cephalosporansyrederivater til anvendelse som mellemprodukter ved fremstilling af andre cephalosporansyrederivater
DK423383A DK162388C (da)	1974-09-03	1983-09-16	Thioler til anvendelse som mellemprodukter ved fremstilling af cephalosporansyrederivater

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK391075A DK145262C (da)	1974-09-03	1975-08-29	Analogifremgangsmaade til fremstilling af cephalosporansyrederivater og estere og salte deraf

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DK240582A DK148796C (da)	1974-09-03	1982-05-27	Cephalosporansyrederivater til anvendelse som mellemprodukter ved fremstilling af andre cephalosporansyrederivater
DK423383A DK162388C (da)	1974-09-03	1983-09-16	Thioler til anvendelse som mellemprodukter ved fremstilling af cephalosporansyrederivater

Country Status (21)

Country	Link
US (1)	US4297489A (da)
JP (1)	JPS6150956B2 (da)
AR (1)	AR222771A1 (da)
BG (1)	BG27091A3 (da)
CA (4)	CA1135255A (da)
CH (1)	CH636882A5 (da)
DD (2)	DD130787A5 (da)
DE (2)	DE2538804C2 (da)
DK (4)	DK145262C (da)
ES (2)	ES440707A1 (da)
FI (1)	FI62841C (da)
FR (1)	FR2283686A1 (da)
HU (1)	HU169490B (da)
IE (1)	IE43123B1 (da)
IL (1)	IL48020A (da)
LU (1)	LU73306A1 (da)
NL (1)	NL161758C (da)
NO (1)	NO152509C (da)
OA (1)	OA05096A (da)
SE (3)	SE431548B (da)
YU (5)	YU213275A (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4286089A (en) *	1974-12-27	1981-08-25	Smithkline Corporation	7-Acyl-3-(substituted tetrazolyl thiomethyl)cephalosporins
US4278670A (en) *	1976-07-12	1981-07-14	Smithkline Corporation	7-Alpha-oxyiminoacylcephalosporins
US4101656A (en) *	1976-07-12	1978-07-18	Smithkline Corporation	7β-Acylamino-3-(alkanesulfonamidoalkyl substituted tetrazolylthiomethyl) cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them
DE2724092A1 (de) *	1977-05-27	1978-12-07	Smithkline Corp	Cephalosporine, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
FR2387235A1 (fr) *	1978-01-23	1978-11-10	Fujisawa Pharmaceutical Co	Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne
US4374994A (en) *	1979-07-05	1983-02-22	Bristol-Myers Company	Process for preparation of 5-mercaptotetrazolyl-1-acetic acid
US4243803A (en) *	1979-07-05	1981-01-06	Bristol-Myers Company	Production of 7-(2-aminomethylphenylacetamido)-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
EP0095029B1 (en) *	1979-11-30	1986-11-05	Fujisawa Pharmaceutical Co., Ltd.	5-thio-tetrazol compounds and their preparation
JPS56158791A (en) *	1980-05-10	1981-12-07	Taisho Pharmaceut Co Ltd	Cephalosporin compound
GR75083B (da) *	1980-09-17	1984-07-13	Lilly Co Eli
JPS57188594A (en) *	1981-05-15	1982-11-19	Eisai Co Ltd	Preparation of 7-(2-amino-2-phenylacetamido)cephem derivative
US4448958A (en) *	1982-10-20	1984-05-15	Bristol-Myers Company	Purification of ceforanide
US4749522A (en) *	1985-10-31	1988-06-07	Angio-Medical Corporation	Supercritical fluid extraction of animal derived materials
DE3641822A1 (de) *	1986-12-06	1988-06-16	Goedecke Ag	Verwendung von dihydrophenylaminosaeurederivaten und diese enthaltende arzneimittel zur immunmodulation und cytostase

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3819623A (en) *	1968-04-12	1974-06-25	Fujisawa Pharmaceutical Co	3,7-disubstituted cephalosporin compounds
DE1953861C2 (de) *	1969-10-25	1982-12-23	Fujisawa Pharmaceutical Co., Ltd., Osaka	7-Tetrazolylacetamido-3-thiomethyl-3-cephem-4- carbonsäuren
US3814755A (en) *	1972-08-30	1974-06-04	Bristol Myers Co	7-(omikron-aminomethylphenylacetamido)-3-(tetrazolo(4,5-b)pyridazin-6-ylthiomethyl)-3-cephem-4-carboxylic acid
GB1478055A (en)	1973-07-27	1977-06-29	Erba Carlo Spa	Cephalosporin compounds
US4074929A (en)	1973-08-29	1978-02-21	Amp Incorporated	Cable card edge connector
US4110338A (en) *	1973-10-31	1978-08-29	Fujisawa Pharmaceutical Co., Ltd.	Product and preparation of 1H-tetrazole-5-thiol derivatives
US4205166A (en) *	1974-02-20	1980-05-27	Fujisawa Pharmaceutical Co., Ltd.	7-Substituted-3-aminoalkyl-, acylaminoalkyl-, or hydroxyalkyl-substituted heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives and preparation thereof
US4092476A (en) *	1974-02-21	1978-05-30	Beecham Group Limited	Phthalidyl esters of 7-[(α amino, 2 substituted acetamido)-3-(heterocyclic-thio methyl)]cephalosporins
US4068074A (en) *	1974-04-05	1978-01-10	Yamanouchi Pharmaceutical Co., Ltd.	Cephalosporin derivatives having at the 3-position of the cephem ring a heterocyclic thiomethyl group with a carboxy or sulfo group and at the 7-position of the cephem ring an α-heterocylic acylaminophenyl-acetamide group
US4160086A (en) *	1974-04-27	1979-07-03	Beecham Group Limited	3-Heterocyclicthio-7-α-carboxy 2-aryl acetamido cephalosporanic acid
JPS612674B2 (da) *	1974-06-20	1986-01-27	Meiji Seika Co
US4182863A (en) *	1974-09-03	1980-01-08	Bristol-Myers Company	7-Amino-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
US4172196A (en) *	1974-09-03	1979-10-23	Bristol-Myers Company	Certain 7-α-substituted-α-hydroxyacetamido-3-(1-carboxymethyltetrazol-5-yl-thiomethyl)-3-cephem-4-carboxylic acids
DK154939C (da) *	1974-12-19	1989-06-12	Takeda Chemical Industries Ltd	Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4286089A (en) *	1974-12-27	1981-08-25	Smithkline Corporation	7-Acyl-3-(substituted tetrazolyl thiomethyl)cephalosporins
US4183925A (en) *	1975-03-27	1980-01-15	Pfizer Inc.	7-Aminophenylacetamido-Δ3 -cephem antibacterial agents and method of use
JPS525787A (en) *	1975-06-27	1977-01-17	Bristol Myers Co	Antiibacterial agent
US4013648A (en) *	1975-07-23	1977-03-22	Bristol-Myers Company	Δ2,3 -0-2-Isocephem-4-carboxylic acid and derivatives as antibacterial agents
US4220644A (en) *	1976-05-03	1980-09-02	Smithkline Corporation	7-Acylamino-3-(substituted tetrazolyl thiomethyl) cephalosporins
US4118563A (en) *	1977-11-25	1978-10-03	Bristol-Myers Company	Production of 7-(2-aminomethylphenylacetamido-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid

1975
- 1975-06-27 US US05/590,971 patent/US4297489A/en not_active Expired - Lifetime
- 1975-08-21 YU YU02132/75A patent/YU213275A/xx unknown
- 1975-08-27 CA CA000234276A patent/CA1135255A/en not_active Expired
- 1975-08-29 FI FI752434A patent/FI62841C/fi not_active IP Right Cessation
- 1975-08-29 DK DK391075A patent/DK145262C/da not_active IP Right Cessation
- 1975-09-01 NO NO752983A patent/NO152509C/no unknown
- 1975-09-01 SE SE7509702A patent/SE431548B/xx not_active IP Right Cessation
- 1975-09-01 IL IL48020A patent/IL48020A/xx unknown
- 1975-09-01 DE DE2538804A patent/DE2538804C2/de not_active Expired
- 1975-09-01 DE DE2560655A patent/DE2560655C2/de not_active Expired
- 1975-09-01 BG BG030902A patent/BG27091A3/xx unknown
- 1975-09-02 LU LU73306A patent/LU73306A1/xx unknown
- 1975-09-02 FR FR7526936A patent/FR2283686A1/fr active Granted
- 1975-09-02 HU HUBI521A patent/HU169490B/hu unknown
- 1975-09-02 OA OA55597A patent/OA05096A/xx unknown
- 1975-09-03 JP JP50106106A patent/JPS6150956B2/ja not_active Expired
- 1975-09-03 NL NL7510391.A patent/NL161758C/xx active
- 1975-09-03 ES ES440707A patent/ES440707A1/es not_active Expired
- 1975-09-03 DD DD7500196946A patent/DD130787A5/xx unknown
- 1975-09-03 AR AR260237A patent/AR222771A1/es active
- 1975-09-03 IE IE1916/75A patent/IE43123B1/en unknown
- 1975-09-03 DD DD188166A patent/DD123471A5/xx unknown
1977
- 1977-04-20 ES ES457998A patent/ES457998A1/es not_active Expired
1979
- 1979-08-31 DK DK367279A patent/DK147483C/da active
- 1979-09-14 SE SE7907672A patent/SE435279B/sv not_active IP Right Cessation
1980
- 1980-12-02 CH CH890980A patent/CH636882A5/de not_active IP Right Cessation
1981
- 1981-03-12 CA CA000372811A patent/CA1135254A/en not_active Expired
- 1981-03-12 CA CA372,810A patent/CA1123840A/en not_active Expired
- 1981-08-24 CA CA000384513A patent/CA1135256A/en not_active Expired
- 1981-09-16 YU YU2233/81A patent/YU44833B/xx unknown
- 1981-09-16 YU YU2231/81A patent/YU44964B/xx unknown
- 1981-09-16 YU YU02230/81A patent/YU223081A/xx unknown
- 1981-09-16 YU YU2232/81A patent/YU44669B/xx unknown
1982
- 1982-05-27 DK DK240582A patent/DK148796C/da not_active IP Right Cessation
1983
- 1983-09-16 DK DK423383A patent/DK162388C/da active
- 1983-10-07 SE SE8305539A patent/SE453507B/sv not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK145262B (da)	1982-10-18
NO152509B (no)	1985-07-01
JPS6150956B2 (da)	1986-11-06
FR2283686A1 (fr)	1976-04-02
IE43123L (en)	1976-03-03
CA1135256A (en)	1982-11-09
DK391075A (da)	1976-03-04
DK423383A (da)	1983-09-16
NO152509C (no)	1985-10-09
DK240582A (da)	1982-05-27
LU73306A1 (da)	1976-08-13
FI62841B (fi)	1982-11-30
BG27091A3 (bg)	1979-08-15
AR222771A1 (es)	1981-06-30
YU223181A (en)	1983-12-31
YU44833B (en)	1991-04-30
DK148796B (da)	1985-09-30
JPS5154580A (da)	1976-05-13
YU213275A (en)	1982-02-28
DK423383D0 (da)	1983-09-16
DE2538804C2 (de)	1986-10-16
DK147483C (da)	1985-03-25
DE2560655C2 (da)	1988-07-14
CA1135255A (en)	1982-11-09
FR2283686B1 (da)	1983-07-08
IL48020A0 (en)	1975-11-25
DD123471A5 (da)	1976-12-20
YU44964B (en)	1991-06-30
NO752983L (da)	1976-03-04
FI62841C (fi)	1983-03-10
DK162388B (da)	1991-10-21
YU223081A (en)	1983-12-31
SE435279B (sv)	1984-09-17
SE8305539D0 (sv)	1983-10-07
SE431548B (sv)	1984-02-13
CA1123840A (en)	1982-05-18
CH636882A5 (de)	1983-06-30
YU44669B (en)	1990-12-31
DK147483B (da)	1984-08-27
SE453507B (sv)	1988-02-08
SE7907672L (sv)	1979-09-14
DD130787A5 (de)	1978-05-03
US4297489A (en)	1981-10-27
DK145262C (da)	1983-03-14
OA05096A (fr)	1981-01-31
IE43123B1 (en)	1980-12-31
YU223281A (en)	1983-12-31
SE8305539L (sv)	1983-10-07
HU169490B (da)	1976-12-28
IL48020A (en)	1982-02-28
FI752434A (da)	1976-03-04
DK148796C (da)	1986-03-17
NL161758C (nl)	1980-03-17
CA1135254A (en)	1982-11-09
ES457998A1 (es)	1978-03-01
SE7509702L (sv)	1976-03-04
DE2538804A1 (de)	1976-07-15
DK162388C (da)	1992-03-16
ES440707A1 (es)	1977-07-01
YU223381A (en)	1983-06-30
NL7510391A (nl)	1976-03-05

Publication	Publication Date	Title
DK310575A (da)	1976-01-11	4-trifluormethyl-phenoxy-phenoxypropionsyreforbindelser samt deres fremstilling og anvendelse
DK567275A (da)	1976-06-14	3-amino-indazolcarboxylsyrederivater samt deres fremstilling og anvendelse
DK297076A (da)	1977-01-20	Phenyleddikesyrederivater og fremgangsmade til deres fremstilling
DK240475A (da)	1975-12-01	Thiopolymere deres derivater og fremgangsmader til deres fremstilling og brug
SE7606951L (sv)	1976-12-19	Imidyl-bensendi- och trikarbonsyra-derivat
NO793035L (no)	1976-02-11	Nye jodbenzenderivater og fremgangsmaate for deres fremstilling
DK384576A (da)	1977-02-27	Heteroarylbenzoxepin-eddikesyrederivater, deres fremstilling og anvendelser
DK588775A (da)	1976-06-24	D-homo-20-ketopregnaner og fremgangsmade til deres fremstilling
DK148576A (da)	1976-10-19	Fenylalkankarbonsyrederivater og fremgangsmade til deres fremstilling
DK211775A (da)	1975-11-16	Substituerede phenylguanidiner samt deres fremstilling og anvendelse
DK367279A (da)	1979-08-31	7-amino-3-cephem-4-carboxylsyrederivater og deres fremstilling
DK353575A (da)	1976-02-06	1-thiadiazolylimidazolidinoner samt deres fremstilling og anvendelse
SE7514687L (sv)	1976-07-01	Fenylettiksyraderivat
BE828925A (nl)	1975-11-10	13-thiaprostaanzuurderivaten
DK288375A (da)	1976-01-13	Prostansyrederivater og fremgangsmade til fremstilling deraf
DK526976A (da)	1977-05-29	Picolinsyrerivater og fremgangsmade til fremstilling heraf
DK191375A (da)	1975-11-04	Isoflavonderivater, deres fremstilling og anvendelse
NL7504171A (nl)	1975-10-15	Tetracyclinederivaten en hun bereiding.
DK548175A (da)	1976-06-06	Cyclopropancarboxylsyreestere samt deres fremstilling og anvendelse
DK224175A (da)	1975-11-22	Tiofenderivater og fremgangsmade til deres fremstilling
DK399275A (da)	1976-03-07	Basisk substituerede 3-sulfamoylbenzoesyrederivater og fremgangsmade til deres fremstilling
DK344375A (da)	1976-01-30	Oxyphenylbutazonderivater og deres fremstilling
DK354575A (da)	1976-02-06	Prostansyrederivater
DK590075A (da)	1976-06-25	Thiourinstofderivater samt deres fremstilling og anvendelse som fugicider
DK487375A (da)	1976-05-21	5,7-dihydroxytetrahydroisoquinolinderivater og fremgangsmade til fremstilling deraf