DK3649152T3 - ROR1-antistoffer - Google Patents
ROR1-antistofferInfo
- Publication number
- DK3649152T3 DK3649152T3 DK18742575.6T DK18742575T DK3649152T3 DK 3649152 T3 DK3649152 T3 DK 3649152T3 DK 18742575 T DK18742575 T DK 18742575T DK 3649152 T3 DK3649152 T3 DK 3649152T3
- Authority
- DK
- Denmark
- Prior art keywords
- ror1 antibodies
- ror1
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1710835.8A GB201710835D0 (en) | 2017-07-05 | 2017-07-05 | ROR1 Antibodies |
| PCT/GB2018/051914 WO2019008377A1 (en) | 2017-07-05 | 2018-07-05 | ANTIBODY ROR1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3649152T3 true DK3649152T3 (da) | 2025-11-10 |
Family
ID=59592560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18742575.6T DK3649152T3 (da) | 2017-07-05 | 2018-07-05 | ROR1-antistoffer |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11466083B2 (da) |
| EP (1) | EP3649152B1 (da) |
| JP (1) | JP7242573B2 (da) |
| CN (1) | CN110891973B (da) |
| AU (1) | AU2018297630B2 (da) |
| CA (1) | CA3068196A1 (da) |
| DK (1) | DK3649152T3 (da) |
| ES (1) | ES3048696T3 (da) |
| GB (1) | GB201710835D0 (da) |
| MX (1) | MX2019015348A (da) |
| WO (1) | WO2019008377A1 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201710836D0 (en) * | 2017-07-05 | 2017-08-16 | Ucl Business Plc | ROR1 Car T-Cells |
| GB201710835D0 (en) * | 2017-07-05 | 2017-08-16 | Ucl Business Plc | ROR1 Antibodies |
| WO2020018964A1 (en) | 2018-07-20 | 2020-01-23 | Fred Hutchinson Cancer Research Center | Compositions and methods for controlled expression of antigen-specific receptors |
| US20230416942A1 (en) * | 2020-08-21 | 2023-12-28 | Yale University | Nanobody Compositions and Methods of Use of the Same |
| CN113480656B (zh) * | 2020-08-24 | 2022-06-03 | 岸迈生物科技(苏州)有限公司 | 抗ror1抗体 |
| WO2022048581A1 (zh) * | 2020-09-03 | 2022-03-10 | 和铂医药(上海)有限责任公司 | 靶向ror1的抗体或其抗原结合片段及制备方法和应用 |
| JP2023550628A (ja) * | 2020-11-23 | 2023-12-04 | スカウト バイオ， インコーポレイテッド | 抗原結合分子およびその使用 |
| WO2022182562A1 (en) * | 2021-02-23 | 2022-09-01 | BioLegend, Inc. | ANTI-SARS-CoV-2 SPIKE GLYCOPROTEIN S1 AGENTS AND COMPOSITIONS |
| WO2022182891A1 (en) | 2021-02-25 | 2022-09-01 | Lyell Immunopharma, Inc. | Ror1 targeting chimeric antigen receptor |
| CN115151572B (zh) * | 2021-07-23 | 2023-09-15 | 浙江时迈药业有限公司 | 针对ror1的抗体及其用途 |
| CN113956359B (zh) * | 2021-10-29 | 2022-09-16 | 叶鑫淼 | 一种抗体及其在抗肿瘤中的应用 |
| EP4458850A4 (en) * | 2021-12-28 | 2025-05-21 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | ANTI-ROR1 ANTIBODY, ANTI-ROR1 ANTIBODY-DRUG CONJUGATE AND THEIR MEDICAL USES |
| CN119604529A (zh) * | 2022-07-11 | 2025-03-11 | 翰森生物有限责任公司 | 抗体、其抗原结合片段及其药物用途 |
| CN115724973B (zh) * | 2022-09-26 | 2023-07-11 | 普健生物（武汉）科技有限公司 | 抗人ror1高亲和力兔单克隆抗体及其应用 |
| CN116903740B (zh) * | 2023-04-21 | 2024-04-30 | 星奕昂(上海)生物科技有限公司 | 靶向ror1的抗体及其应用 |
| WO2025044937A1 (zh) * | 2023-08-31 | 2025-03-06 | 正大天晴药业集团股份有限公司 | 靶向受体酪氨酸激酶样孤儿受体1的抗体及其应用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1673398T3 (pl) | 2003-10-16 | 2011-05-31 | Amgen Res Munich Gmbh | Multispecyficzne deimmunizowane cząsteczki wiążące CD3 |
| WO2007146957A2 (en) | 2006-06-13 | 2007-12-21 | Irm Llc | Ror1 as a therapeutic target for lung cancer |
| US9316646B2 (en) * | 2009-04-23 | 2016-04-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-human ROR1 antibodies |
| EP2496605A1 (en) * | 2009-11-02 | 2012-09-12 | Oxford Biotherapeutics Ltd. | Ror1 as therapeutic and diagnostic target |
| WO2011079902A2 (en) | 2009-12-18 | 2011-07-07 | Biolnvent International Ab | Biological materials and uses thereof |
| EP3219731A1 (en) | 2010-10-01 | 2017-09-20 | Oxford BioTherapeutics Ltd | Anti-ror1 antibodies |
| US9758586B2 (en) | 2010-12-01 | 2017-09-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric rabbit/human ROR1 antibodies |
| GB201020995D0 (en) | 2010-12-10 | 2011-01-26 | Bioinvent Int Ab | Biological materials and uses thereof |
| DK3604339T3 (da) | 2011-01-14 | 2021-04-12 | Univ California | Terapeutiske antistoffer mod ror-1-protein og fremgangsmåder til anvendelse af samme |
| SI2884999T2 (sl) | 2012-08-20 | 2026-01-30 | Fred Hutchinson Cancer Center | Metoda in sestavki za celično imunoterapijo |
| AU2013306390B2 (en) * | 2012-08-24 | 2018-07-05 | The Regents Of The University Of California | Antibodies and vaccines for use in treating ROR1 cancers and inhibiting metastasis |
| EP2789630A1 (en) | 2013-04-09 | 2014-10-15 | EngMab AG | Bispecific antibodies against CD3e and ROR1 |
| AP2016009586A0 (en) | 2014-05-29 | 2016-11-30 | Macrogenics Inc | Tri-specific binding molecules and methods of use thereof |
| DK3174557T3 (da) * | 2014-07-29 | 2019-02-04 | Cellectis | ROR1(NTRKR1)-specifikke kimære antigenreceptorer til cancerimmunterapi |
| EP3194432B1 (en) | 2014-07-31 | 2019-04-10 | Cellectis | Ror1 specific multi-chain chimeric antigen receptor |
| CN106999576B (zh) | 2014-09-08 | 2021-09-03 | 国立癌症研究中心 | 癌细胞特异性抗体、抗癌剂、及癌症的检查方法 |
| AU2015329966A1 (en) | 2014-10-09 | 2017-04-27 | Engmab Sàrl | Bispecific antibodies against CD3epsilon and ROR1 for use in the treatment of ovarian cancer |
| US11952421B2 (en) | 2014-10-09 | 2024-04-09 | Bristol-Myers Squibb Company | Bispecific antibodies against CD3EPSILON and ROR1 |
| WO2016094873A2 (en) | 2014-12-12 | 2016-06-16 | Emergent Product Development Seattle, Llc | Receptor tyrosine kinase-like orphan receptor 1 binding proteins and related compositions and methods |
| CA2973964A1 (en) * | 2015-01-16 | 2016-07-21 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for ror1 |
| CA2973773C (en) | 2015-02-02 | 2023-10-17 | Kancera Ab | 2-phenyl-3h-imidazo[4,5-b]pyridine derivatives useful as inhibitors of mammalian tyrosine kinase ror1 activity |
| US20180147271A1 (en) | 2015-05-18 | 2018-05-31 | Bluebird Bio, Inc. | Anti-ror1 chimeric antigen receptors |
| US11155615B2 (en) * | 2015-05-18 | 2021-10-26 | Eureka Therapeutics, Inc. | Anti-ROR1 antibodies |
| EA201891066A1 (ru) | 2015-10-30 | 2018-10-31 | ЭнБиИ-ТЕРАПЬЮТИКС АГ | Антитела к ror1 |
| UA125718C2 (uk) | 2016-01-20 | 2022-05-25 | Зе Скріппс Ресеарч Інстітьют | Композиції антитіл до ror1 і пов'язані з ними способи |
| JP2019506158A (ja) | 2016-01-22 | 2019-03-07 | ヤンセン バイオテツク，インコーポレーテツド | 抗ｒｏｒ１抗体、ｒｏｒ１×ｃｄ３二重特異性抗体、及びそれらの使用法 |
| US20170233472A1 (en) | 2016-02-17 | 2017-08-17 | Macrogenics, Inc. | ROR1-Binding Molecules, and Methods of Use Thereof |
| WO2017156479A1 (en) | 2016-03-11 | 2017-09-14 | Bluebird Bio, Inc. | Ror1 chimeric antigen receptors |
| KR102466810B1 (ko) | 2016-07-11 | 2022-11-11 | 칸세라 아베 | 포유류 티로신 키나제 ror1 활성의 저해제로서 유용한 2-페닐이미다조[4,5-b]피리딘-7-아민 유도체 |
| US20200338210A1 (en) | 2016-12-22 | 2020-10-29 | Ardeagen Corporation | Anti-ror1 antibody and conjugates thereof |
| BR112019024654A2 (pt) | 2017-05-23 | 2020-06-09 | Dragonfly Therapeutics Inc | proteína de ligação nkg2d, cd16 e ror1 ou ror2 |
| CN111587124B (zh) | 2017-06-23 | 2024-01-12 | 维洛斯生物股份有限公司 | Ror1抗体免疫缀合物 |
| CN110869389B (zh) | 2017-06-25 | 2023-07-28 | 西雅图免疫公司 | 抗ror1抗体及其制备和使用方法 |
| GB201710835D0 (en) * | 2017-07-05 | 2017-08-16 | Ucl Business Plc | ROR1 Antibodies |
| GB201710836D0 (en) * | 2017-07-05 | 2017-08-16 | Ucl Business Plc | ROR1 Car T-Cells |
| GB201710838D0 (en) * | 2017-07-05 | 2017-08-16 | Ucl Business Plc | Bispecific antibodies |
| WO2019016381A1 (en) | 2017-07-20 | 2019-01-24 | Nbe-Therapeutics Ag | MULTISPECIFIC ANTIBODY PRODUCT BINDING TO DIFFERENT ROR1 EPITOPES |
| KR102486090B1 (ko) | 2017-08-07 | 2023-01-10 | 엔비이-테라퓨틱스 아게 | 생체 내 내성이 높은 항체 약물 결합체 |
| AU2018360031B2 (en) | 2017-11-03 | 2025-08-21 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-ROR1 immunotherapy |
| GB201721802D0 (en) | 2017-12-22 | 2018-02-07 | Almac Discovery Ltd | Ror1-specific antigen binding molecules |
| WO2019225777A1 (ko) | 2018-05-23 | 2019-11-28 | 에이비엘바이오 주식회사 | 항-ror1 항체 및 그 용도 |
-
2017
- 2017-07-05 GB GBGB1710835.8A patent/GB201710835D0/en not_active Ceased
-
2018
- 2018-07-05 ES ES18742575T patent/ES3048696T3/es active Active
- 2018-07-05 CN CN201880045361.4A patent/CN110891973B/zh active Active
- 2018-07-05 MX MX2019015348A patent/MX2019015348A/es unknown
- 2018-07-05 US US16/628,512 patent/US11466083B2/en active Active
- 2018-07-05 EP EP18742575.6A patent/EP3649152B1/en active Active
- 2018-07-05 AU AU2018297630A patent/AU2018297630B2/en active Active
- 2018-07-05 WO PCT/GB2018/051914 patent/WO2019008377A1/en not_active Ceased
- 2018-07-05 JP JP2019572456A patent/JP7242573B2/ja active Active
- 2018-07-05 CA CA3068196A patent/CA3068196A1/en active Pending
- 2018-07-05 DK DK18742575.6T patent/DK3649152T3/da active
-
2022
- 2022-07-21 US US17/869,872 patent/US20230220073A1/en not_active Abandoned
-
2024
- 2024-08-26 US US18/815,603 patent/US20250066472A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2019015348A (es) | 2020-07-20 |
| EP3649152B1 (en) | 2025-10-08 |
| CN110891973B (zh) | 2023-06-27 |
| CN110891973A (zh) | 2020-03-17 |
| AU2018297630A1 (en) | 2020-01-16 |
| US20250066472A1 (en) | 2025-02-27 |
| US20200354448A1 (en) | 2020-11-12 |
| CA3068196A1 (en) | 2019-01-10 |
| ES3048696T3 (en) | 2025-12-11 |
| US20230220073A1 (en) | 2023-07-13 |
| JP7242573B2 (ja) | 2023-03-20 |
| EP3649152A1 (en) | 2020-05-13 |
| JP2020530272A (ja) | 2020-10-22 |
| US11466083B2 (en) | 2022-10-11 |
| AU2018297630B2 (en) | 2025-03-06 |
| WO2019008377A1 (en) | 2019-01-10 |
| GB201710835D0 (en) | 2017-08-16 |
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