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DK3604333T3 - Proteiner omfattende amino-terminale proksimale Shiga toksin A-underenhed-effektorregioner og cellemålrettede bindingsregioner af immunglobulin-typen, der er i stand til specifikt at binde CD38 - Google Patents

Proteiner omfattende amino-terminale proksimale Shiga toksin A-underenhed-effektorregioner og cellemålrettede bindingsregioner af immunglobulin-typen, der er i stand til specifikt at binde CD38 Download PDF

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Publication number
DK3604333T3
DK3604333T3 DK19195720.8T DK19195720T DK3604333T3 DK 3604333 T3 DK3604333 T3 DK 3604333T3 DK 19195720 T DK19195720 T DK 19195720T DK 3604333 T3 DK3604333 T3 DK 3604333T3
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regions
proteins
amino
cell
shiga toxin
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DK19195720.8T
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Eric Poma
Erin Willert
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Molecular Templates Inc
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DK19195720.8T 2014-03-11 2015-03-10 Proteiner omfattende amino-terminale proksimale Shiga toksin A-underenhed-effektorregioner og cellemålrettede bindingsregioner af immunglobulin-typen, der er i stand til specifikt at binde CD38 DK3604333T3 (da)

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Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2808726T3 (es) 2013-03-12 2021-03-01 Molecular Templates Inc Inmunotoxinas de unión a CD20 para inducir la internalización celular y procedimientos que usan las mismas
KR20160111951A (ko) 2014-01-27 2016-09-27 몰레큘러 템플레이츠, 인코퍼레이션. 포유류에 적용하기 위한 탈면역된 시가 독소 a 서브유닛 작동체 폴리펩티드
US11142584B2 (en) 2014-03-11 2021-10-12 Molecular Templates, Inc. CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same
AU2016215205B2 (en) 2015-02-05 2021-10-21 Molecular Templates, Inc. Multivalent CD20-binding molecules comprising shiga toxin a subunit effector regions and enriched compositions thereof
HRP20200640T1 (hr) 2015-05-30 2020-07-10 Molecular Templates, Inc. De-imunizirane, okosnice podjedinice shiga toksina a i molekule koje ciljaju stanice koje ih sadrže
MX2018001208A (es) 2015-07-26 2018-03-26 Molecular Templates Inc Moleculas con direccion a las celulas que comprenden efectores de la subunidad a de la toxina shiga y epitopos de celulas-t cd8+.
IL293710B2 (en) 2016-12-07 2024-10-01 Molecular Templates Inc Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation
CA3049456A1 (en) 2017-01-25 2018-08-02 Molecular Templates, Inc. Cell-targeting molecules comprising de-immunized, shiga toxin a subunit effectors and cd8+ t-cell epitopes
WO2019023247A1 (en) 2017-07-25 2019-01-31 Immutics, Inc. TREATMENT OF CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND ITS LIGAND
PE20201263A1 (es) * 2017-09-05 2020-11-19 Gladiator Biosciences Inc Suministro de cargas utiles a las celulas madre
CN109971725B (zh) * 2017-12-28 2024-02-02 上海细胞治疗研究院 抗体修饰的嵌合抗原受体修饰t细胞及其用途
IL268443B2 (en) 2018-04-17 2024-07-01 Molecular Templates Inc HER2-targeted molecules containing Shiga toxin subunit A scaffolds, without vaccination
EP3844192A1 (en) * 2018-08-30 2021-07-07 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
WO2020081493A1 (en) 2018-10-16 2020-04-23 Molecular Templates, Inc. Pd-l1 binding proteins
CN109829489A (zh) * 2019-01-18 2019-05-31 刘凯欣 一种基于多层特征的文物碎片重组方法及装置
WO2020154475A1 (en) 2019-01-23 2020-07-30 Molecular Templates, Inc. Proteins comprising modified immunoglobulin variable light chains
JP7418756B2 (ja) * 2019-01-23 2024-01-22 ミレニアム ファーマシューティカルズ, インコーポレイテッド 脱免疫化志賀毒素aサブユニットエフェクターを含むcd38結合性タンパク質
JP2022518282A (ja) * 2019-01-23 2022-03-14 ミレニアム ファーマシューティカルズ, インコーポレイテッド 抗cd38結合ドメイン
CN110142068B (zh) * 2019-06-12 2024-02-02 杭州华得森生物技术有限公司 一种上皮间质混合型循环肿瘤细胞检测试剂盒及方法
WO2021055816A1 (en) 2019-09-18 2021-03-25 Molecular Templates, Inc. Pd-l1 binding molecules comprising shiga toxin a subunit scaffolds
AU2020348861B2 (en) 2019-09-18 2024-10-24 Molecular Templates, Inc. PD-L1 binding molecules comprising Shiga toxin A Subunit scaffolds
US20210155671A1 (en) 2019-11-24 2021-05-27 Molecular Templates, Inc. Uses of cd20-binding molecules and additional therapeutic agents
JP2023528797A (ja) 2020-05-26 2023-07-06 トゥルーバインディング,インコーポレイテッド ガレクチン-3を遮断することにより炎症性疾患を処置する方法
EP4262858A1 (en) 2020-12-16 2023-10-25 Molecular Templates, Inc. Clinical methods for use of a pd-l1-binding molecule comprising a shiga toxin effector
EP4308242A1 (en) 2021-03-17 2024-01-24 Molecular Templates, Inc. Pd-l1 binding proteins comprising shiga toxin a subunit scaffolds and cd8+ t cell antigens
CN114410588B (zh) * 2022-01-29 2022-11-04 西安电子科技大学 一种α1β1整合素依赖增强型CAR巨噬细胞及其制备方法和应用
CN119096300A (zh) * 2022-02-09 2024-12-06 艾伯赛公司 利用生成式人工智能解锁从头抗体设计

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894443A (en) 1984-02-08 1990-01-16 Cetus Corporation Toxin conjugates
US5091178A (en) 1986-02-21 1992-02-25 Oncogen Tumor therapy with biologically active anti-tumor antibodies
US7838216B1 (en) 1986-03-05 2010-11-23 The United States Of America, As Represented By The Department Of Health And Human Services Human gene related to but distinct from EGF receptor gene
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
DE69031120T2 (de) 1989-05-19 1998-01-15 Genentech, Inc., South San Francisco, Calif. Her2 extrazellulare domäne
US5578482A (en) 1990-05-25 1996-11-26 Georgetown University Ligand growth factors that bind to the erbB-2 receptor protein and induce cellular responses
US5834229A (en) 1991-05-24 1998-11-10 Genentech, Inc. Nucleic acids vectors and host cells encoding and expressing heregulin 2-α
US5869445A (en) 1993-03-17 1999-02-09 University Of Washington Methods for eliciting or enhancing reactivity to HER-2/neu protein
US5612474A (en) 1994-06-30 1997-03-18 Eli Lilly And Company Acid labile immunoconjugate intermediates
AU3374795A (en) 1994-08-29 1996-03-22 Prizm Pharmaceuticals, Inc. Conjugates of vascular endothelial growth factor with targeted agents
CZ295838B6 (cs) 1996-09-09 2005-11-16 Zealand Pharma A/S Způsob výroby peptidů
JP2001500730A (ja) * 1996-09-10 2001-01-23 ヘンリー エム ジャクソン ファンデーション フォージ アドバンスメント オブ ミリタリー メディシン ヒスチジン―タグ付き志賀毒素およびトキソイド、該毒素およびトキソイドとの融合タンパク質ならびにそれらの精製及び調製方法
WO2000006194A2 (en) * 1997-02-05 2000-02-10 Biotransplant, Inc. Depletion of cells responsible for antibody-mediated graft rejection
IL147271A0 (en) 1999-07-02 2002-08-14 Genentech Inc Compounds that bind her2
US7306801B2 (en) 2000-05-15 2007-12-11 Health Research, Inc. Methods of therapy for cancers characterized by overexpression of the HER2 receptor protein
US7446185B2 (en) 2001-07-18 2008-11-04 The Regents Of The University Of California Her2/neu target antigen and use of same to stimulate an immune response
ATE471371T1 (de) * 2002-02-04 2010-07-15 Yoshida Hideo Antikrebsmittel mit verotoxinvarianten
DE60333732D1 (de) * 2002-03-01 2010-09-23 Immunomedics Inc Internalisierung von anti cd74 monoklonalen antikörpern und deren verwendungen
US20040248151A1 (en) 2002-04-05 2004-12-09 Ventana Medical Systems, Inc. Method for predicting the response to HER2-directed therapy
WO2003087131A2 (en) 2002-04-10 2003-10-23 Genentech, Inc Anti-her2 antibody variants
US7449480B2 (en) 2002-05-14 2008-11-11 Baylor College Of Medicine Small molecule inhibitors of HER2 expression
CA2485589A1 (en) 2002-05-14 2003-11-27 Baylor College Of Medicine Small molecule inhibitors of her2 expression
EP1583833A1 (en) 2003-01-03 2005-10-12 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Rhesus her2/neu, nucleotides encoding same, and uses thereof
DK1641818T3 (da) 2003-07-04 2009-03-16 Affibody Ab Polypeptider der har bindingsaffinitet for HER2
JP2007517763A (ja) 2003-08-01 2007-07-05 エイアンドジー ファーマスーティカル インコーポレイテッド Her2アンタゴニストを用いた治療への感受性を回復させる組成物および方法
KR20160096228A (ko) 2004-07-22 2016-08-12 제넨테크, 인크. Her2 항체 조성물
NZ586780A (en) * 2005-03-23 2012-02-24 Genmab As Antibodies against CD38 for treatment of multiple myeloma
FI20055417A0 (fi) 2005-07-20 2005-07-20 Glykos Finland Oy Syöpäpesifiset glykaanit ja niiden käyttö
EP2402367A1 (en) 2005-09-26 2012-01-04 Molecular Templates, Inc. Library from toxin mutants, and methods of using same
GB0524788D0 (en) 2005-12-05 2006-01-11 Affibody Ab Polypeptides
BRPI0720647A2 (pt) * 2006-12-29 2014-01-14 Osprey Pharmaceuticals Usa Inc Processos de seleção e produção de toxinas modificadas, conjugados contendo toxinas modificadas e usos dos mesmos
EP2173373B1 (en) 2007-06-06 2020-04-15 Sarepta Therapeutics, Inc. Soluble her2 and her3 splice variant proteins, splice-switching oligonucleotides, and their use in the treatment of disease
KR20100097716A (ko) 2007-11-27 2010-09-03 아블린쓰 엔.브이. 이종이량체 사이토킨 및/또는 이의 수용체에 대한 아미노산 서열과 이를 포함하는 폴리펩티드
EP2072525A1 (en) 2007-12-21 2009-06-24 Affibody AB New polypeptides having affinity for HER2
TWI472339B (zh) 2008-01-30 2015-02-11 Genentech Inc 包含結合至her2結構域ii之抗體及其酸性變異體的組合物
ES2342646B1 (es) 2008-06-02 2011-04-26 Institut De Recerca Hospital Universitari Vall Hebron Metodo de diagnostico de canceres que expresan el receptor her-2 o sus variantes truncadas.
KR20130108069A (ko) 2010-04-15 2013-10-02 알퍼 바이오테크, 엘엘씨 Her2 항원에 대한 모노클로날 항체 및 그를 위한 용도
EP3539988A3 (en) * 2010-05-27 2019-12-04 Genmab A/S Monoclonal antibodies against her2
EP2667898A1 (en) * 2011-01-26 2013-12-04 Cenix Bioscience GmbH Delivery system and conjugates for compound delivery via naturally occurring intracellular transport routes
AU2013222334A1 (en) * 2012-02-23 2014-09-11 President And Fellows Of Harvard College Modified microbial toxin receptor for delivering agents into cells
ES2808726T3 (es) * 2013-03-12 2021-03-01 Molecular Templates Inc Inmunotoxinas de unión a CD20 para inducir la internalización celular y procedimientos que usan las mismas

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