DK3585808T3 - Modificerede serpiner til behandlingen af bradykinin formidlet sygdom - Google Patents
Modificerede serpiner til behandlingen af bradykinin formidlet sygdom Download PDFInfo
- Publication number
- DK3585808T3 DK3585808T3 DK18711233.9T DK18711233T DK3585808T3 DK 3585808 T3 DK3585808 T3 DK 3585808T3 DK 18711233 T DK18711233 T DK 18711233T DK 3585808 T3 DK3585808 T3 DK 3585808T3
- Authority
- DK
- Denmark
- Prior art keywords
- serpines
- bradykinine
- modified
- treatment
- mediated disease
- Prior art date
Links
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17157527 | 2017-02-23 | ||
| PCT/EP2018/054490 WO2018154044A1 (en) | 2017-02-23 | 2018-02-23 | Modified serpins for the treatment of bradykinin-mediated disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3585808T3 true DK3585808T3 (da) | 2022-01-31 |
Family
ID=58162468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18711233.9T DK3585808T3 (da) | 2017-02-23 | 2018-02-23 | Modificerede serpiner til behandlingen af bradykinin formidlet sygdom |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US11851474B2 (da) |
| EP (1) | EP3585808B1 (da) |
| DK (1) | DK3585808T3 (da) |
| WO (1) | WO2018154044A1 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201322091D0 (en) * | 2013-12-13 | 2014-01-29 | Cambridge Entpr Ltd | Modified serpins for the treatment of bleeding disorders |
| CN112315897A (zh) * | 2020-11-04 | 2021-02-05 | 深圳前海鹰岗生物科技有限公司 | 一种抑制细胞炎症反应释放治疗痛风急性发作的聚合物微针及制备方法 |
| EP4052723A1 (en) * | 2021-03-02 | 2022-09-07 | Grifols Worldwide Operations Limited | Alpha-1 antitrypsin dosing regimen |
| CN113917154B (zh) * | 2021-09-22 | 2023-11-24 | 北京松果天目健康管理有限公司 | 尿蛋白标志物在制备糖尿病肾病临床早期检测的试剂盒中的应用 |
| CN116549599A (zh) * | 2022-01-30 | 2023-08-08 | 江苏众红生物工程创药研究院有限公司 | 激肽及其衍生物在治疗vci、psci或csvd中的应用 |
| CN117820464A (zh) * | 2023-12-29 | 2024-04-05 | 中国农业科学院兰州兽医研究所 | 多房棘球蚴丝氨酸蛋白酶抑制剂及其制备方法和在制备肠道炎症的药物中的应用 |
| WO2026021603A1 (zh) * | 2024-07-25 | 2026-01-29 | 吉林大学第一医院 | Serpina3蛋白变异体或其编码序列以及它们的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| FR2599752B1 (fr) | 1986-06-10 | 1989-11-03 | Transgene Sa | Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine |
| US5910486A (en) | 1994-09-06 | 1999-06-08 | Uab Research Foundation | Methods for modulating protein function in cells using, intracellular antibody homologues |
| AU1618901A (en) * | 1999-11-18 | 2001-05-30 | John D. Bolla | Treatment of rosacea |
| CA2552894A1 (en) * | 2004-01-09 | 2005-08-04 | University Of Utah Research Foundation | Methods of using high affinity atiii variants |
| WO2006090282A2 (en) | 2005-02-28 | 2006-08-31 | Universite De Lausanne | Recombinant inhibitor proteins of an hk14 protease and use thereof |
| PT2398500T (pt) | 2009-02-20 | 2019-06-14 | 2 Bbb Medicines B V | Sistema de entrega de medicamentos à base de glutationas |
| EP2238984A1 (en) * | 2009-04-08 | 2010-10-13 | Institut National De La Recherche Agronomique (Inra) | Caspasin inhibitor peptides |
| US8557961B2 (en) * | 2010-04-02 | 2013-10-15 | Amunix Operating Inc. | Alpha 1-antitrypsin compositions and methods of making and using same |
| GB201322091D0 (en) * | 2013-12-13 | 2014-01-29 | Cambridge Entpr Ltd | Modified serpins for the treatment of bleeding disorders |
-
2018
- 2018-02-23 US US16/487,858 patent/US11851474B2/en active Active
- 2018-02-23 WO PCT/EP2018/054490 patent/WO2018154044A1/en not_active Ceased
- 2018-02-23 DK DK18711233.9T patent/DK3585808T3/da active
- 2018-02-23 EP EP18711233.9A patent/EP3585808B1/en active Active
-
2023
- 2023-12-05 US US18/530,002 patent/US20240132573A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3585808B1 (en) | 2021-11-10 |
| WO2018154044A1 (en) | 2018-08-30 |
| US20240132573A1 (en) | 2024-04-25 |
| US11851474B2 (en) | 2023-12-26 |
| EP3585808A1 (en) | 2020-01-01 |
| US20200010533A1 (en) | 2020-01-09 |
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