DK3464260T3 - Forbindelser, der indeholder ureamotiver, og derivater deraf som antibakterielle lægemidler - Google Patents
Forbindelser, der indeholder ureamotiver, og derivater deraf som antibakterielle lægemidler Download PDFInfo
- Publication number
- DK3464260T3 DK3464260T3 DK17728481.7T DK17728481T DK3464260T3 DK 3464260 T3 DK3464260 T3 DK 3464260T3 DK 17728481 T DK17728481 T DK 17728481T DK 3464260 T3 DK3464260 T3 DK 3464260T3
- Authority
- DK
- Denmark
- Prior art keywords
- ureamotives
- derivatives
- compounds containing
- antibacterial medicines
- medicines
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/30—Derivatives containing the group >N—CO—N aryl or >N—CS—N—aryl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/38—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16171906 | 2016-05-30 | ||
| PCT/EP2017/063014 WO2017207556A2 (en) | 2016-05-30 | 2017-05-30 | Urea motif containing compounds and derivatives thereof as antibacterial drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3464260T3 true DK3464260T3 (da) | 2021-12-20 |
Family
ID=56087197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17728481.7T DK3464260T3 (da) | 2016-05-30 | 2017-05-30 | Forbindelser, der indeholder ureamotiver, og derivater deraf som antibakterielle lægemidler |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12187696B2 (da) |
| EP (1) | EP3464260B8 (da) |
| JP (1) | JP7129085B2 (da) |
| CN (1) | CN109890804A (da) |
| CA (1) | CA3023040A1 (da) |
| DK (1) | DK3464260T3 (da) |
| ES (1) | ES2901164T3 (da) |
| HU (1) | HUE057798T2 (da) |
| PL (1) | PL3464260T3 (da) |
| SG (1) | SG11201809537VA (da) |
| WO (1) | WO2017207556A2 (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3331852B1 (en) * | 2015-08-17 | 2020-12-23 | National Taiwan University | Substituted malonamides and their use as antibacterial drugs |
| CN108785306B (zh) * | 2018-09-09 | 2021-02-19 | 东北农业大学 | 索拉非尼在制备抑菌及干预致病菌生物被膜的药物中的用途 |
| CN109456261A (zh) * | 2018-12-05 | 2019-03-12 | 西安交通大学 | 一种基于vegfr-2抑制剂索拉菲尼的光亲合探针分子及其制备方法 |
| CN113061126A (zh) * | 2021-03-16 | 2021-07-02 | 无锡海伦生物科技有限公司 | 基于卤素中间体的索拉非尼光亲和探针分子的制备方法及应用 |
| US11648248B1 (en) | 2022-01-12 | 2023-05-16 | King Abdulaziz University | Potent antimicrobial compounds with a pyridazine nucleus |
| TW202339708A (zh) * | 2022-04-13 | 2023-10-16 | 國立臺灣大學 | 抗微生物組合物、醫藥組合物及其用途 |
| EP4554576A2 (en) * | 2022-07-15 | 2025-05-21 | University of Southern California | Bifunctional photocrosslinking probes for covalent capture of protein-nucleic acid complexes in cells |
| CN117180254A (zh) * | 2023-08-25 | 2023-12-08 | 华中科技大学协和深圳医院 | Sc-43用于制备抗革兰氏阳性细菌感染药物中的应用 |
| WO2025083280A1 (en) * | 2023-10-19 | 2025-04-24 | Universitat De Barcelona | Sorafenib analogs for use in the treatment of cancer |
| EP4674846A1 (en) | 2024-07-02 | 2026-01-07 | Technische Universität München | Urea motif containing compounds as antibacterial drugs against multiresistant mycobacteria |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL254871A (da) * | 1959-08-14 | |||
| US3579578A (en) * | 1966-07-08 | 1971-05-18 | Givaudan Corp | 3,4-dihalo-3' and 4'-lower alkylcarbanilides |
| US3503886A (en) * | 1967-10-27 | 1970-03-31 | Mary C Noel | Antiseptic compositions |
| KR970002877B1 (ko) | 1987-07-17 | 1997-03-12 | 더 누트라스웨트 캄파니 | 고성능 감미제 |
| JPH10109912A (ja) * | 1996-10-04 | 1998-04-28 | Akio Suganuma | 抗菌組成物 |
| US6207679B1 (en) * | 1997-06-19 | 2001-03-27 | Sepracor, Inc. | Antimicrobial agents uses and compositions related thereto |
| US6093742A (en) * | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| US7517880B2 (en) * | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| CA2353557A1 (en) | 1998-12-04 | 2000-06-08 | Influx, Inc. | Inhibitors of multidrug transporters |
| WO2002055661A2 (en) * | 2000-11-17 | 2002-07-18 | Smithkline Beecham Corporation | Fatty acid synthase inhibitors |
| KR20030080509A (ko) * | 2002-04-09 | 2003-10-17 | 주식회사 엘지생명과학 | 우레아, 티오우레아 및 설파마이드 유도체를 함유하는항균제 조성물 |
| WO2005009944A1 (en) * | 2003-07-09 | 2005-02-03 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| EP1804785A2 (en) * | 2004-10-27 | 2007-07-11 | Neurogen Corporation | Diaryl ureas as cb1 antagonists |
| EP1991215A1 (en) | 2006-03-09 | 2008-11-19 | Cenix Bioscience GmbH | Use of inhibitors of scavenger receptor class proteins for the treatment of infectious diseases |
| FR2901792A1 (fr) * | 2006-06-06 | 2007-12-07 | Negma Lerads Soc Par Actions S | DERIVES ACTIVATEURS DE PPARs, PROCEDE DE PREPARATION ET APPLICATION EN THERAPEUTIQUE |
| GB2449973B8 (en) | 2007-05-31 | 2010-01-06 | Syntopix Group Plc | Antibacterial & anti-acne formulations containing dialkyl sulphosuccinates |
| WO2009035951A2 (en) * | 2007-09-11 | 2009-03-19 | Arete Therapeutics, Inc. | Soluble epoxide hydrolase inhibitors |
| US8252841B2 (en) * | 2007-10-19 | 2012-08-28 | The Board Of Regents Of The University Of Texas System | Methods of inhibiting bacterial virulence and compounds relating thereto |
| EP2385831A4 (en) * | 2009-01-09 | 2014-03-26 | Uab Research Foundation | SMALL MOLECULAR HEMMER OF NADS, NAMNAT AND NMNAT |
| CN103130686B (zh) * | 2011-12-02 | 2016-09-14 | 天津市国际生物医药联合研究院 | N,n′-不对称二芳基取代脲类化合物及其制备方法和用途 |
| WO2013142628A2 (en) * | 2012-03-20 | 2013-09-26 | Fred Hutchinson Cancer Research Center | Antibiotic compounds and compositions, and methods for identification thereof |
| US9951097B2 (en) | 2012-12-04 | 2018-04-24 | The Board Of Trustees Of The University Of Illinois | Antibacterial compounds targeting isoprenoid biosynthesis |
| WO2015051149A1 (en) | 2013-10-04 | 2015-04-09 | The Trustees Of Columbia University In The City Of New York | Sorafenib analogs and uses thereof |
| US9387186B2 (en) * | 2014-05-22 | 2016-07-12 | Muhammad Iqbal Choudhary | Thiourea derivatives |
-
2017
- 2017-05-30 DK DK17728481.7T patent/DK3464260T3/da active
- 2017-05-30 JP JP2018562297A patent/JP7129085B2/ja active Active
- 2017-05-30 EP EP17728481.7A patent/EP3464260B8/en active Active
- 2017-05-30 ES ES17728481T patent/ES2901164T3/es active Active
- 2017-05-30 CA CA3023040A patent/CA3023040A1/en active Pending
- 2017-05-30 SG SG11201809537VA patent/SG11201809537VA/en unknown
- 2017-05-30 WO PCT/EP2017/063014 patent/WO2017207556A2/en not_active Ceased
- 2017-05-30 PL PL17728481T patent/PL3464260T3/pl unknown
- 2017-05-30 CN CN201780034569.1A patent/CN109890804A/zh active Pending
- 2017-05-30 HU HUE17728481A patent/HUE057798T2/hu unknown
- 2017-05-30 US US16/304,521 patent/US12187696B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP7129085B2 (ja) | 2022-09-01 |
| EP3464260B8 (en) | 2022-02-16 |
| CN109890804A (zh) | 2019-06-14 |
| EP3464260A2 (en) | 2019-04-10 |
| US20210009550A1 (en) | 2021-01-14 |
| CA3023040A1 (en) | 2017-12-07 |
| JP2019524644A (ja) | 2019-09-05 |
| WO2017207556A4 (en) | 2018-03-22 |
| PL3464260T3 (pl) | 2022-01-31 |
| WO2017207556A3 (en) | 2018-01-11 |
| SG11201809537VA (en) | 2018-12-28 |
| US12187696B2 (en) | 2025-01-07 |
| ES2901164T3 (es) | 2022-03-21 |
| WO2017207556A2 (en) | 2017-12-07 |
| EP3464260B1 (en) | 2021-10-27 |
| HUE057798T2 (hu) | 2022-06-28 |
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