DK3458460T3 - Imidazoler som histondemethylase-inhibitorer - Google Patents
Imidazoler som histondemethylase-inhibitorer Download PDFInfo
- Publication number
- DK3458460T3 DK3458460T3 DK17723710.4T DK17723710T DK3458460T3 DK 3458460 T3 DK3458460 T3 DK 3458460T3 DK 17723710 T DK17723710 T DK 17723710T DK 3458460 T3 DK3458460 T3 DK 3458460T3
- Authority
- DK
- Denmark
- Prior art keywords
- histondemethylase
- imidazoles
- inhibitors
- histondemethylase inhibitors
- Prior art date
Links
- 150000002460 imidazoles Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16170238.6A EP3246330A1 (en) | 2016-05-18 | 2016-05-18 | Imidazoles as histone demethylase inhibitors |
| PCT/EP2017/062009 WO2017198780A1 (en) | 2016-05-18 | 2017-05-18 | Imidazoles as histone demethylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3458460T3 true DK3458460T3 (da) | 2021-03-01 |
Family
ID=56014931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17723710.4T DK3458460T3 (da) | 2016-05-18 | 2017-05-18 | Imidazoler som histondemethylase-inhibitorer |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10562914B2 (da) |
| EP (2) | EP3246330A1 (da) |
| JP (1) | JP6972024B2 (da) |
| CN (1) | CN109641918B (da) |
| AU (1) | AU2017266325B2 (da) |
| CA (1) | CA3063785A1 (da) |
| DK (1) | DK3458460T3 (da) |
| WO (1) | WO2017198780A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3246330A1 (en) | 2016-05-18 | 2017-11-22 | Istituto Europeo di Oncologia S.r.l. | Imidazoles as histone demethylase inhibitors |
| DK3661510T3 (da) | 2017-08-03 | 2025-01-02 | Oryzon Genomics Sa | Fremgangsmåder til behandling af adfærdsændringer |
| CN113631164A (zh) | 2019-03-20 | 2021-11-09 | 奥莱松基因组股份有限公司 | 使用kdm1a抑制剂如化合物伐菲德司他治疗注意缺陷多动症的方法 |
| SG11202109159VA (en) | 2019-03-20 | 2021-10-28 | Oryzon Genomics Sa | Methods of treating borderline personality disorder |
| JP2022546908A (ja) | 2019-07-05 | 2022-11-10 | オリゾン・ゲノミクス・ソシエダッド・アノニマ | Ｋｄｍ１ａ阻害剤を使用した小細胞肺がんの個別化された処置のためのバイオマーカーおよび方法 |
| IT202000007873A1 (it) | 2020-04-14 | 2021-10-14 | St Europeo Di Oncologia S R L | Molecole per uso nel trattamento delle infezioni virali |
| WO2022058405A2 (en) | 2020-09-16 | 2022-03-24 | Ifom - Istituto Firc Di Oncologia Molecolare | Histone deacetylase inhibitors and uses thereof |
| MX2023011779A (es) | 2021-04-08 | 2023-11-22 | Oryzon Genomics Sa | Combinaciones de inhibidores de lsd1 para el tratamiento de canceres mieloides. |
| EP4522137A1 (en) | 2022-05-09 | 2025-03-19 | Oryzon Genomics, S.A. | Methods of treating nf1-mutant tumors using lsd1 inhibitors |
| CN119546292A (zh) | 2022-05-09 | 2025-02-28 | 奥莱松基因组股份有限公司 | 使用lsd1抑制剂治疗恶性周围神经鞘瘤(mpnst)的方法 |
| WO2024110649A1 (en) | 2022-11-24 | 2024-05-30 | Oryzon Genomics, S.A. | Combinations of lsd1 inhibitors and menin inhibitors for treating cancer |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5204018A (en) | 1990-02-01 | 1993-04-20 | Hoffmann-La Roche Inc. | Liquid crystals |
| GB0321003D0 (en) * | 2003-09-09 | 2003-10-08 | Angeletti P Ist Richerche Bio | Compounds, compositions and uses |
| CA2594665A1 (en) | 2005-01-19 | 2006-07-27 | Biolipox Ab | Thienopyrroles useful in the treatment of inflammation |
| US20090247766A1 (en) * | 2008-03-27 | 2009-10-01 | University Of Southern California | Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof |
| US8389580B2 (en) | 2009-06-02 | 2013-03-05 | Duke University | Arylcyclopropylamines and methods of use |
| CN102985402B (zh) | 2010-04-20 | 2015-04-29 | 罗马大学 | 反苯环丙胺衍生物作为组蛋白去甲基酶lsd1和/或lsd2的抑制剂 |
| US9061966B2 (en) | 2010-10-08 | 2015-06-23 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| GB201017345D0 (en) | 2010-10-14 | 2010-11-24 | Proximagen Ltd | Receptor antagonists |
| US9067949B2 (en) | 2011-01-19 | 2015-06-30 | Albany Molecular Research, Inc. | Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia |
| CN103842332B (zh) | 2011-08-09 | 2016-08-17 | 武田药品工业株式会社 | 环丙胺化合物 |
| ES2821548T3 (es) | 2011-08-15 | 2021-04-26 | Univ Utah Res Found | Análogos de (E)-N'-(1-feniletiliden) benzohidrazida sustituida como inhibidores de desmetilasas de histonas |
| EP2740474A1 (en) | 2012-12-05 | 2014-06-11 | Instituto Europeo di Oncologia S.r.l. | Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a |
| WO2014164867A1 (en) * | 2013-03-11 | 2014-10-09 | Imago Biosciences | Kdm1a inhibitors for the treatment of disease |
| EP2969007B1 (en) | 2013-03-14 | 2019-05-08 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| US10005769B2 (en) | 2013-06-18 | 2018-06-26 | 4Sc Ag | 2,3-dihydrobenzofuran-5YL compounds as DYRK kinase inhibitors |
| CN104278008B (zh) * | 2013-07-12 | 2020-08-21 | 北京宏冠再生医学科技有限公司 | 一种通过小分子化合物处理来制备多潜能干细胞的方法、试剂盒和用途 |
| WO2016007731A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Imidazopyridines and imidazopyrazines as lsd1 inhibitors |
| EP2993175A1 (en) | 2014-09-05 | 2016-03-09 | IEO - Istituto Europeo di Oncologia Srl | Thienopyrroles as histone demethylase inhibitors |
| EP3246330A1 (en) | 2016-05-18 | 2017-11-22 | Istituto Europeo di Oncologia S.r.l. | Imidazoles as histone demethylase inhibitors |
-
2016
- 2016-05-18 EP EP16170238.6A patent/EP3246330A1/en not_active Withdrawn
-
2017
- 2017-05-18 US US16/301,875 patent/US10562914B2/en active Active
- 2017-05-18 AU AU2017266325A patent/AU2017266325B2/en active Active
- 2017-05-18 CN CN201780044641.9A patent/CN109641918B/zh active Active
- 2017-05-18 DK DK17723710.4T patent/DK3458460T3/da active
- 2017-05-18 CA CA3063785A patent/CA3063785A1/en active Pending
- 2017-05-18 EP EP17723710.4A patent/EP3458460B1/en active Active
- 2017-05-18 JP JP2018560892A patent/JP6972024B2/ja active Active
- 2017-05-18 WO PCT/EP2017/062009 patent/WO2017198780A1/en unknown
-
2019
- 2019-12-20 US US16/722,554 patent/US10961255B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017266325B2 (en) | 2021-07-08 |
| US10562914B2 (en) | 2020-02-18 |
| EP3458460A1 (en) | 2019-03-27 |
| JP6972024B2 (ja) | 2021-11-24 |
| CN109641918B (zh) | 2021-12-21 |
| US20190152987A1 (en) | 2019-05-23 |
| CN109641918A (zh) | 2019-04-16 |
| WO2017198780A1 (en) | 2017-11-23 |
| EP3458460B1 (en) | 2020-12-09 |
| US10961255B2 (en) | 2021-03-30 |
| CA3063785A1 (en) | 2017-11-23 |
| EP3246330A1 (en) | 2017-11-22 |
| AU2017266325A1 (en) | 2019-01-17 |
| US20200299303A1 (en) | 2020-09-24 |
| JP2019519520A (ja) | 2019-07-11 |
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