DK3386628T3 - Modulær kontinuerlig flowindretning - Google Patents

Modulær kontinuerlig flowindretning Download PDF

Info

Publication number: DK3386628T3
Authority: DK; Denmark
Prior art keywords: continuous flow; flow device; modular continuous; modular; flow
Prior art date: 2016-02-29

Application number

DK17707041.4T

Other languages

English (en)

Inventor

Kerry Gilmore

Peter H Seeberger

Bartholomäus Pieber

Sourav Chatterjee

Original Assignee

Max Planck Gesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-02-29

Filing date

2017-02-27

Publication date

2019-09-02

2017-02-27 Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft

2019-09-02 Application granted granted Critical

2019-09-02 Publication of DK3386628T3 publication Critical patent/DK3386628T3/da

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J19/12—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electromagnetic waves
- B01J19/122—Incoherent waves
- B01J19/126—Microwaves
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00002—Chemical plants
- B01J2219/00027—Process aspects
- B01J2219/00033—Continuous processes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00286—Reactor vessels with top and bottom openings
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00389—Feeding through valves
- B01J2219/00391—Rotary valves
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00389—Feeding through valves
- B01J2219/00391—Rotary valves
- B01J2219/00394—Rotary valves in multiple arrangements
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00389—Feeding through valves
- B01J2219/00409—Solenoids in combination with valves
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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- B01J2219/00418—Means for dispensing and evacuation of reagents using pressure
- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J2219/00277—Apparatus
- B01J2219/00479—Means for mixing reactants or products in the reaction vessels
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/0059—Sequential processes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00801—Means to assemble
- B01J2219/0081—Plurality of modules
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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- B01J2219/00801—Means to assemble
- B01J2219/0081—Plurality of modules
- B01J2219/00813—Fluidic connections
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
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- B01J2219/00869—Microreactors placed in parallel, on the same or on different supports
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00851—Additional features
- B01J2219/00871—Modular assembly
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00873—Heat exchange
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00889—Mixing
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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- B01J2219/00891—Feeding or evacuation
- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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- B01J2219/00925—Irradiation
- B01J2219/00934—Electromagnetic waves
- B01J2219/00941—Microwaves
- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
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- B01J2219/0095—Control aspects
- B01J2219/00952—Sensing operations
- B01J2219/00954—Measured properties
- B01J2219/00959—Flow
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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- B01J2219/00952—Sensing operations
- B01J2219/00954—Measured properties
- B01J2219/00963—Pressure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Toxicology (AREA)
General Health & Medical Sciences (AREA)
Electromagnetism (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Physical Or Chemical Processes And Apparatus (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK17707041.4T 2016-02-29 2017-02-27 Modulær kontinuerlig flowindretning DK3386628T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP16157958.6A EP3210667A1 (en)	2016-02-29	2016-02-29	Modular continuous flow device
PCT/EP2017/054536 WO2017148874A1 (en)	2016-02-29	2017-02-27	Modular continuous flow device

Publications (1)

Publication Number	Publication Date
DK3386628T3 true DK3386628T3 (da)	2019-09-02

Family

ID=55650058

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK17707041.4T DK3386628T3 (da)	2016-02-29	2017-02-27	Modulær kontinuerlig flowindretning

Country Status (10)

Country	Link
US (1)	US11731101B2 (da)
EP (2)	EP3210667A1 (da)
JP (1)	JP6682005B2 (da)
KR (1)	KR102630524B1 (da)
CN (1)	CN108698014B (da)
DK (1)	DK3386628T3 (da)
ES (1)	ES2744798T3 (da)
HU (1)	HUE045055T2 (da)
PT (1)	PT3386628T (da)
WO (1)	WO2017148874A1 (da)

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GB201902743D0 (en) *	2019-02-28	2019-04-17	Ge Healthcare Bio Sciences Ab	Improvements in and relating to optimizing the operation of a chromatography system
KR102143528B1 (ko) *	2019-06-25	2020-08-11	충남대학교산학협력단	고온 반응을 위한 연속식 미세유체 반응기 및 이를 이용한 인돌 유도체의 제조 방법
WO2021089632A1 (en) *	2019-11-04	2021-05-14	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Microwave-assisted method for synthesis of oligo- and polysaccharides on solid phase
EP3815778A1 (en) *	2019-11-04	2021-05-05	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Device for rapid automated synthesis of oligo- and polysaccharides
CN111298737B (zh) *	2020-03-12	2021-08-17	大连理工大学	一种多功能连续流动合成装置
WO2021227546A1 (zh) *	2020-05-12	2021-11-18	睿科集团(厦门)股份有限公司	一种多功能样品萃取流路及方法
JP7509408B2 (ja)	2020-07-14	2024-07-02	株式会社Dfc	合成物収集制御装置および合成物収集制御プログラム
EP4183770A1 (en)	2021-11-22	2023-05-24	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Continuous flow process for production of cationic lipids
CA3224056A1 (en)	2021-06-24	2022-12-29	Peter Seeberger	Continuous flow process for production of cationic lipids

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EP0215533B1 (en) *	1985-01-18	1993-12-15	Applied Biosystems, Inc.	A method of extracting nucleic acids from cells
US5346999A (en) *	1985-01-18	1994-09-13	Applied Biosystems, Inc.	Method of nucleic acid extraction
IE64511B1 (en) *	1988-03-11	1995-08-09	Takeda Chemical Industries Ltd	Automated synthesizing apparatus
WO1995012608A1 (en) *	1993-11-02	1995-05-11	Affymax Technologies N.V.	Synthesizing and screening molecular diversity
US6913934B2 (en) *	1998-08-13	2005-07-05	Symyx Technologies, Inc.	Apparatus and methods for parallel processing of multiple reaction mixtures
US7150994B2 (en) *	1999-03-03	2006-12-19	Symyx Technologies, Inc.	Parallel flow process optimization reactor
US7435392B2 (en) *	2000-02-03	2008-10-14	Acclavis, Llc	Scalable continuous production system
US6994827B2 (en) *	2000-06-03	2006-02-07	Symyx Technologies, Inc.	Parallel semicontinuous or continuous reactors
DE10034095C2 (de)	2000-07-13	2002-12-05	Gerhard Jesse	Dosierpumpe
US7413714B1 (en)	2000-07-16	2008-08-19	Ymc Co. Ltd.	Sequential reaction system
US6901334B2 (en) *	2001-12-17	2005-05-31	Rohm And Haas Company	Methods and systems for high throughput analysis
JP2006231160A (ja) *	2005-02-23	2006-09-07	Chemgenesis Inc	反応容器並列型自動合成装置
WO2008082457A1 (en) *	2006-12-27	2008-07-10	Exxonmobil Research And Engineering Company	Catalyst treatment apparatus and process
DE102007028116B3 (de) *	2007-06-19	2008-11-20	Siemens Ag	Mikrofluidiksystem zum Mischen von mindestens zwei Ausgangsstoffen
WO2009009804A2 (en) *	2007-07-06	2009-01-15	Erasmus, Maria, Christina, Gertruida	A system for and a method of heating water
US20120076692A1 (en) *	2010-09-23	2012-03-29	Siemens Medical Solutions Usa, Inc.	Modular Component Synthesis Unit
EP2751113B1 (en)	2011-08-29	2017-07-05	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Method and device for the synthesis of artemisinin
EP2826779A1 (en)	2013-07-15	2015-01-21	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives

2016
- 2016-02-29 EP EP16157958.6A patent/EP3210667A1/en not_active Withdrawn
2017
- 2017-02-27 CN CN201780014011.7A patent/CN108698014B/zh active Active
- 2017-02-27 US US16/080,708 patent/US11731101B2/en active Active
- 2017-02-27 EP EP17707041.4A patent/EP3386628B1/en active Active
- 2017-02-27 WO PCT/EP2017/054536 patent/WO2017148874A1/en active Application Filing
- 2017-02-27 PT PT17707041T patent/PT3386628T/pt unknown
- 2017-02-27 HU HUE17707041A patent/HUE045055T2/hu unknown
- 2017-02-27 DK DK17707041.4T patent/DK3386628T3/da active
- 2017-02-27 JP JP2018545475A patent/JP6682005B2/ja active Active
- 2017-02-27 ES ES17707041T patent/ES2744798T3/es active Active
- 2017-02-27 KR KR1020187028031A patent/KR102630524B1/ko active Active

Also Published As

Publication number	Publication date
US11731101B2 (en)	2023-08-22
CN108698014A (zh)	2018-10-23
EP3210667A1 (en)	2017-08-30
PT3386628T (pt)	2019-09-20
HUE045055T2 (hu)	2019-12-30
KR102630524B1 (ko)	2024-01-26
JP6682005B2 (ja)	2020-04-15
CN108698014B (zh)	2020-11-10
WO2017148874A1 (en)	2017-09-08
ES2744798T3 (es)	2020-02-26
EP3386628A1 (en)	2018-10-17
JP2019509885A (ja)	2019-04-11
KR20180117675A (ko)	2018-10-29
EP3386628B1 (en)	2019-06-12
US20210187468A1 (en)	2021-06-24

Publication	Publication Date	Title
DK3305266T3 (da)	2020-08-17	Stiftformig stimulationsindretning
EP3360118A4 (en)	2019-07-03	Flow alarm
DK3404169T3 (da)	2021-04-26	Gondolanordning
DK3302658T3 (da)	2019-12-02	Fluidafgivelsesindretninger
DK3160558T3 (da)	2020-04-27	Strømningsregulerende indåndingsanordning
EP3550189A4 (en)	2020-10-21	FLOW REGULATION DEVICE
DE112018006403A5 (de)	2020-10-29	Modulares fluggerät
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