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DK3384052T3 - Kliniske korrelater for immunterapieffekt - Google Patents

Kliniske korrelater for immunterapieffekt Download PDF

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Publication number
DK3384052T3
DK3384052T3 DK16871163.8T DK16871163T DK3384052T3 DK 3384052 T3 DK3384052 T3 DK 3384052T3 DK 16871163 T DK16871163 T DK 16871163T DK 3384052 T3 DK3384052 T3 DK 3384052T3
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Prior art keywords
clinical correlates
immunotherapy effect
immunotherapy
effect
correlates
Prior art date
Application number
DK16871163.8T
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English (en)
Inventor
John Connolly
Han Chong Toh
Richard Hopkins
Original Assignee
Agency Science Tech & Res
Singapore Health Serv Pte Ltd
Tessa Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Agency Science Tech & Res, Singapore Health Serv Pte Ltd, Tessa Therapeutics Ltd filed Critical Agency Science Tech & Res
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Publication of DK3384052T3 publication Critical patent/DK3384052T3/da

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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DK16871163.8T 2015-12-04 2016-09-09 Kliniske korrelater for immunterapieffekt DK3384052T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201509979S 2015-12-04
PCT/SG2016/050441 WO2017095324A1 (en) 2015-12-04 2016-09-09 Clinical correlates of immunotherapy efficacy

Publications (1)

Publication Number Publication Date
DK3384052T3 true DK3384052T3 (da) 2020-06-02

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DK16871163.8T DK3384052T3 (da) 2015-12-04 2016-09-09 Kliniske korrelater for immunterapieffekt

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US (2) US10342865B2 (da)
EP (2) EP3699294A1 (da)
JP (1) JP6793746B2 (da)
KR (1) KR101968452B1 (da)
CN (1) CN108884497A (da)
DK (1) DK3384052T3 (da)
ES (1) ES2795440T3 (da)
PT (1) PT3384052T (da)
SG (1) SG11201804683RA (da)
TW (1) TW201720451A (da)
WO (1) WO2017095324A1 (da)

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DE102007008342B4 (de) * 2007-02-20 2016-09-01 Robert Bosch Automotive Steering Gmbh Verfahren zur Stabilisierung eines Fahrzeugverbundes
CN112748247A (zh) * 2020-12-23 2021-05-04 复旦大学附属华山医院 抗体结合剂在制备白癜风病期辅助检测产品中的应用及白癜风病期鉴定用的检测试剂盒
WO2022197933A1 (en) 2021-03-18 2022-09-22 The Broad Institute, Inc. Compositions and methods for characterizing lymphoma and related conditions
CN114941031A (zh) * 2022-01-28 2022-08-26 中国医学科学院北京协和医院 早期胃癌预后差异基因与复发预测模型

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO784197A0 (en) 1997-07-10 1997-08-07 Csl Limited Treatment of nasopharyngeal carcinoma
EP1777523A1 (en) 2005-10-19 2007-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method
EP2203746B1 (en) * 2007-09-24 2013-03-06 Technion Research & Development Foundation Ltd. T cell subpopulations capable of treating cancer
CN109517897A (zh) * 2011-04-28 2019-03-26 南加利福尼亚大学 人类髓源抑制性细胞癌症标记
FR3008369B1 (fr) 2013-07-12 2015-06-26 Renault Sa Commande du couple transmis a une roue motrice d'un vehicule a motorisation hybride
WO2015043614A1 (en) * 2013-09-26 2015-04-02 Biontech Ag Methods and compositions for prediction of therapeutic efficacy of cancer treatments and cancer prognosis
CN114107424A (zh) 2014-10-08 2022-03-01 诺华股份有限公司 预测针对嵌合抗原受体疗法的治疗应答性的生物标志及其用途

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