[go: up one dir, main page]

DK3297637T3 - Benzen-1,3,5-tricarboxamidderivater og anvendelser deraf - Google Patents

Benzen-1,3,5-tricarboxamidderivater og anvendelser deraf Download PDF

Info

Publication number
DK3297637T3
DK3297637T3 DK16797375.9T DK16797375T DK3297637T3 DK 3297637 T3 DK3297637 T3 DK 3297637T3 DK 16797375 T DK16797375 T DK 16797375T DK 3297637 T3 DK3297637 T3 DK 3297637T3
Authority
DK
Denmark
Prior art keywords
benzene
tricarboxamide
derivatives
tricarboxamide derivatives
Prior art date
Application number
DK16797375.9T
Other languages
English (en)
Inventor
Yizhou Dong
Bin Li
Original Assignee
Ohio State Innovation Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ohio State Innovation Foundation filed Critical Ohio State Innovation Foundation
Application granted granted Critical
Publication of DK3297637T3 publication Critical patent/DK3297637T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5123Organic compounds, e.g. fats, sugars
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/64Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/78Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK16797375.9T 2015-05-21 2016-05-20 Benzen-1,3,5-tricarboxamidderivater og anvendelser deraf DK3297637T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562164891P 2015-05-21 2015-05-21
PCT/US2016/033514 WO2016187531A1 (en) 2015-05-21 2016-05-20 Benzene-1,3,5-tricarboxamide derivatives and uses thereof

Publications (1)

Publication Number Publication Date
DK3297637T3 true DK3297637T3 (da) 2021-08-02

Family

ID=57320926

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16797375.9T DK3297637T3 (da) 2015-05-21 2016-05-20 Benzen-1,3,5-tricarboxamidderivater og anvendelser deraf

Country Status (5)

Country Link
US (1) US10369122B2 (da)
EP (2) EP3297637B1 (da)
DK (1) DK3297637T3 (da)
ES (1) ES2880103T3 (da)
WO (1) WO2016187531A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016171198A1 (ja) * 2015-04-21 2016-10-27 国立大学法人東京大学 微粒子検出システム及び微粒子検出プログラム
US10281374B2 (en) * 2015-11-04 2019-05-07 Diagnostic Biosystems Method of pretreatment of biological samples for an analyte-staining assay method
US10379015B2 (en) 2017-06-04 2019-08-13 Diagnostic Biosystems Method for labeling concentration density differentials of an analyte in a biological sample
US11622942B2 (en) 2017-11-14 2023-04-11 Ohio State Innovation Foundation Benzene-1,3,5-tricarboxamide derived ester lipids and uses thereof
MY207334A (en) * 2019-03-08 2025-02-19 Massachusetts Inst Technology Synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
US20220323594A1 (en) * 2019-08-09 2022-10-13 Nutcracker Therapeutics, Inc. Lipidated cationic peptide-peg compositions for nucleic acid delivery
EP4010350A4 (en) 2019-08-09 2023-11-22 Nutcracker Therapeutics, Inc. Methods and apparatuses for manufacturing for removing material from a therapeutic composition
JP7791822B2 (ja) 2020-01-09 2025-12-24 ガイド セラピューティクス,エルエルシー ナノマテリアル
US20230295257A1 (en) * 2020-07-24 2023-09-21 Strand Therapeutics Inc. Lipid nanoparticle comprising modified nucleotides
US20230293706A1 (en) * 2020-08-07 2023-09-21 Nutcracker Therapeutics, Inc. Multicomponent Delivery Systems for Polyanionic Cargo Compound Delivery
CN114315606B (zh) * 2020-12-29 2023-12-26 李斌 一种脂样分子及其应用
MX2023008333A (es) * 2021-01-20 2023-08-21 Beam Therapeutics Inc Nanomateriales.
CA3203628A1 (en) 2021-01-20 2022-07-28 Beam Therapeutics Inc. Nanomaterials comprising a biodegradable feature
WO2023274265A1 (zh) * 2021-06-29 2023-01-05 江苏恒瑞医药股份有限公司 苯酰胺类化合物及其用途
CZ310443B6 (cs) * 2021-07-19 2025-06-25 Ústav organické chemie a biochemie AV ČR, v. v. i. Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití
US20250295755A1 (en) 2021-10-22 2025-09-25 Sail Biomedicines, Inc. Mrna vaccine composition
AU2022398450A1 (en) 2021-11-23 2024-06-06 Sail Biomedicines, Inc. A bacteria-derived lipid composition and use thereof
EP4452930A1 (en) * 2021-12-20 2024-10-30 Beam Therapeutics Inc. Ionizable amine and ester lipids and lipid nanoparticles
JP2025500373A (ja) 2021-12-20 2025-01-09 セイル バイオメディシンズ インコーポレイテッド Mrna治療用組成物
US20250188140A1 (en) * 2022-03-08 2025-06-12 Ohio State Innovation Foundation Ccl5 mrna nanoparticle and methods of use thereof
CA3255274A1 (en) 2022-04-26 2023-11-02 Strand Therapeutics Inc. Lipid nanoparticles including a Venezuelan equine encephalitis (VEE) replica and their uses
WO2024019936A1 (en) 2022-07-20 2024-01-25 Beam Therapeutics Inc. Nanomaterials comprising triols
EP4615424A1 (en) 2022-11-10 2025-09-17 Sail Biomedicines, Inc. Rna compositions comprising lipid nanoparticles or lipid reconstructed natural messenger packs
WO2024159172A1 (en) 2023-01-27 2024-08-02 Senda Biosciences, Inc. A modified lipid composition and uses thereof
WO2024220625A1 (en) 2023-04-19 2024-10-24 Sail Biomedicines, Inc. Delivery of polynucleotides from lipid nanoparticles comprising rna and ionizable lipids
WO2024220752A2 (en) 2023-04-19 2024-10-24 Sail Biomedicines, Inc. Rna therapeutic compositions
WO2024220712A2 (en) 2023-04-19 2024-10-24 Sail Biomedicines, Inc. Vaccine compositions
WO2025106915A1 (en) 2023-11-17 2025-05-22 Sail Biomedicines, Inc. Circular polyribonucleotides encoding glucagon-like peptide 1 (glp-1) and uses thereof
WO2025106930A1 (en) 2023-11-17 2025-05-22 Sail Biomedicines, Inc. Circular polyribonucleotides encoding glucagon-like peptide 2 (glp-2) and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4411649A (en) * 1979-07-12 1983-10-25 Baxter Travenol Laboratories, Inc. Fluid flow control system
US4507466A (en) * 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
EP0796840A3 (de) * 1996-03-22 1999-01-27 Witco Vinyl Additives GmbH Stabilisatoren für chlorhaltige Polymere
GB9905771D0 (en) 1999-03-12 1999-05-05 Isis Innovation Compounds
CN1174023C (zh) 2002-04-12 2004-11-03 武汉大学 一种聚酰胺-胺树型高分子及其制备方法和用途
WO2006001835A2 (en) 2003-12-30 2006-01-05 The Regents Of The University Of California Aromatic triamide-lanthanide complexes
KR20150000461A (ko) 2011-10-27 2015-01-02 메사추세츠 인스티튜트 오브 테크놀로지 약물 캡슐화 마이크로스피어를 형성할 수 있는, n-말단 상에 관능화된 아미노산 유도체

Also Published As

Publication number Publication date
EP3297637B1 (en) 2021-05-26
US10369122B2 (en) 2019-08-06
EP3297637A1 (en) 2018-03-28
WO2016187531A1 (en) 2016-11-24
EP3297637A4 (en) 2019-01-23
US20180147166A1 (en) 2018-05-31
ES2880103T3 (es) 2021-11-23
EP3939571A1 (en) 2022-01-19

Similar Documents

Publication Publication Date Title
DK3297637T3 (da) Benzen-1,3,5-tricarboxamidderivater og anvendelser deraf
NO2023013I1 (no) Combination of foslevodopa and foscarbidopa, each in all forms protected by the basic patent
DK3580561T3 (da) Hla-baserede metoder, sammensætninger og anvendelse heraf
DK3676297T3 (da) Forbindelser, sammensætninger og fremgangsmåder
DK3452463T3 (da) Amidsubstituerede pyridinyltriazolderivater og anvendelser deraf
DK3407888T3 (da) Pyridopyrroloquinoxalinforbindelser, deres sammensætninger og anvendelser
DK3328849T3 (da) 1,1,1-trifluor-3-hydroxypropan-2-yl-carbamat-derivater og 1,1,1-trifluor-4-hydroxybutan-2-yl-carbamat-derivater som magl-inhibitorer
HUE058009T2 (hu) 1,3-Tiazol-2-il szubsztituált benzamid-származékok
DK3307707T3 (da) Halogensubstituerede phenoxyphenylamidiner og anvendelsen deraf som fungicider
DK3154594T3 (da) Fap-aktiverede, terapeutiske midler og anvendelser i forbindelser dermed
DK3557998T3 (da) Sammensætninger, kompositioner og anvendelsesmetoder
BR112016018521A2 (pt) composição, e, kit.
EP3313530A4 (en) 4,6-PYRIMIDINYLENE DERIVATIVES AND USE THEREOF
DK3408326T3 (da) Elastomerartikler, sammensætninger og fremgangsmåder til fremstilling deraf
DK3236991T3 (da) Fgf21-derivater og anvendelser deraf
EP3535204A4 (en) SELF-SERVICE STORAGE FACILITY, MANUFACTURING, AND METHODOLOGY
DK3253762T3 (da) 9h-pyrrolo-dipyridinderivater.
DK3494119T3 (da) Forbindelser og sammensætninger og anvendelser deraf
EP3713931C0 (en) 3-OXO-6-HETEROARYL-2-PHENYL-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDE
LT3402792T (lt) Chinolin-2-ono dariniai
DK3612579T3 (da) Pultrudat, fremstilling og anvendelse heraf
LT3457851T (lt) Sobetiromo dariniai
PL3135110T3 (pl) Pochodne 1,7-diarylo-1,6-heptadieno-3,5-dionu, sposób ich wytwarzania i ich zastosowanie
DK3365321T3 (da) Solabegron-zwitterion og anvendelser deraf
DK3337506T3 (da) Kombinationer og anvendelser deraf