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DK328687A - Fremgangsmaade til halogenering af ergotalkaloider i 2-stilling, saaledes halogenerede derivater og disses anvendelse - Google Patents

Fremgangsmaade til halogenering af ergotalkaloider i 2-stilling, saaledes halogenerede derivater og disses anvendelse

Info

Publication number
DK328687A
DK328687A DK328687A DK328687A DK328687A DK 328687 A DK328687 A DK 328687A DK 328687 A DK328687 A DK 328687A DK 328687 A DK328687 A DK 328687A DK 328687 A DK328687 A DK 328687A
Authority
DK
Denmark
Prior art keywords
halogening
ergotal
kaloids
halogened
derivatives
Prior art date
Application number
DK328687A
Other languages
English (en)
Other versions
DK328687D0 (da
Inventor
Gabor Megyeri
Tibor Keve
Jr Lajos Kovacs
Bela Stefko
Erik Bogsch
Anna Kassai
Ferenc Trischler
Gabor Szepesi
Maria Gazdag
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of DK328687D0 publication Critical patent/DK328687D0/da
Publication of DK328687A publication Critical patent/DK328687A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK328687A 1986-06-27 1987-06-26 Fremgangsmaade til halogenering af ergotalkaloider i 2-stilling, saaledes halogenerede derivater og disses anvendelse DK328687A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU862690A HU196394B (en) 1986-06-27 1986-06-27 Process for preparing 2-halogenated ergoline derivatives

Publications (2)

Publication Number Publication Date
DK328687D0 DK328687D0 (da) 1987-06-26
DK328687A true DK328687A (da) 1987-12-28

Family

ID=10960659

Family Applications (1)

Application Number Title Priority Date Filing Date
DK328687A DK328687A (da) 1986-06-27 1987-06-26 Fremgangsmaade til halogenering af ergotalkaloider i 2-stilling, saaledes halogenerede derivater og disses anvendelse

Country Status (19)

Country Link
US (1) US4816587A (da)
EP (1) EP0251732B1 (da)
JP (1) JPH085879B2 (da)
AR (1) AR243194A1 (da)
AT (1) ATE88705T1 (da)
AU (1) AU597673B2 (da)
BG (1) BG48811A3 (da)
CA (1) CA1301163C (da)
CS (1) CS264295B2 (da)
DD (1) DD264430A5 (da)
DE (1) DE3785613T2 (da)
DK (1) DK328687A (da)
ES (1) ES2054672T3 (da)
FI (1) FI89048C (da)
HU (1) HU196394B (da)
PL (1) PL151562B1 (da)
SU (1) SU1528320A3 (da)
UA (1) UA5571A1 (da)
YU (1) YU46557B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
DE4033496A1 (de) * 1990-10-20 1992-04-23 Sandoz Ag Neue ergolinderivate, ihre herstellung und verwendung
ES2137354T3 (es) * 1993-01-12 1999-12-16 Biogen Inc Moleculas de anticuerpo anti-vla4 recombinante.
US6723550B1 (en) 1997-07-15 2004-04-20 Genencor International, Inc. Proteases from gram-positive organisms
US20030157642A1 (en) * 1997-07-15 2003-08-21 Caldwell Robert M. Increasing production of proteins in gram-positive microorganisms
US6521421B1 (en) * 1997-07-16 2003-02-18 Genencor International, Inc. Expression vectors encoding Bacillus subtilis disulfide bond isomerase and methods of secreting proteins in gram-positive microorganisms using the same
US6521440B1 (en) 1997-09-15 2003-02-18 Genencor International, Inc. Proteases from gram-positive organisms
US6316241B1 (en) * 1997-11-20 2001-11-13 Genencor International, Inc. Alpha/beta hydrolase-fold enzymes
FR2786099B1 (fr) * 1998-11-24 2000-12-29 Aventis Laboratoire Nouvelle application therapeutique de la 1,6-dimethyl-8beta- hydroxymethyl-10alpha-methoxyergoline
AU2002258525A1 (en) * 2001-03-13 2002-09-24 Sierra Sciences, Inc. Telomerase expression repressor proteins and methods of using the same
DE60238987D1 (de) 2001-03-15 2011-03-03 Neogenix Oncology Inc Behandlung von bauchspeicheldrüsenkrebs mit einem monoklonalen antikörper
EP2023141B1 (en) 2001-07-02 2014-04-09 Sekisui Medical Co., Ltd. Assay reagent comprising carrier particle latex
CA2478458A1 (en) * 2004-08-20 2006-02-20 Michael Panzara Treatment of pediatric multiple sclerosis
SI2558499T1 (sl) 2010-04-16 2017-08-31 Biogen MA Inc., Protitelesa proti VLA-4
US8889768B2 (en) 2010-06-11 2014-11-18 Basf Se Laser-transparent PBT with organic additives
KR101889111B1 (ko) 2010-06-11 2018-08-16 바스프 에스이 유기 첨가제를 포함하는 레이저-투명 ｐｂｔ
CN105560244B (zh) * 2014-10-10 2019-01-11 上海交通大学 一种γ-分泌酶抑制剂及其应用
BR112017010498A2 (pt) 2014-11-19 2017-12-26 Axon Neuroscience Se anticorpos tau humanizados em doença de alzheimer
WO2017217406A1 (ja) 2016-06-14 2017-12-21 デンカ株式会社 液体試料検査キット用膜担体、液体試料検査キット及び液体試料検査キットの製造方法
KR20190127665A (ko) 2017-03-28 2019-11-13 덴카 주식회사 막 담체와 이를 이용한 액체 시료 검사 키트 및 그 제조 방법
KR102547418B1 (ko) 2017-03-28 2023-06-23 덴카 주식회사 막 담체 및 이를 이용한 액체 시료 검사 키트
KR20210027352A (ko) 2018-06-04 2021-03-10 바이오젠 엠에이 인코포레이티드 감소된 효과기 기능을 갖는 항-ｖｌａ-4 항체
US20230365552A1 (en) * 2022-05-12 2023-11-16 The Florida State University Research Foundation, Inc. Lysergic acid derivatives and methods
WO2024145546A1 (en) * 2022-12-31 2024-07-04 Ceruvia Lifesciences Llc Process for synthesizing 2-bromolysergic acid diethylamide via controlled bromination of lysergic acid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901894A (en) * 1974-06-06 1975-08-26 Lilly Co Eli 8-thiomethylergolines
US3992422A (en) * 1975-08-14 1976-11-16 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes
US4098790A (en) * 1976-09-15 1978-07-04 Eli Lilly And Company Ergoline chlorination process
YU216177A (en) * 1977-09-09 1984-02-29 Rudolf Rucman Process for preparing 2-bromo ergosine
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
YU39849B (en) * 1978-09-26 1985-04-30 Lek Tovarna Farmacevtskih Process for preparing 2-bromo-ergolene and 2-bromo-ergoline compounds
HU193317B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing 2-bromo-alpha-ergochristin
HU193782B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof
HU193780B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 2-halogeno-6-methyl-ergol-9-ene derivatives and acid additional salts thereof
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds

Also Published As

Publication number Publication date
FI872852A (fi) 1987-12-28
UA5571A1 (uk) 1994-12-28
CS479187A2 (en) 1988-09-16
AR243194A1 (es) 1993-07-30
US4816587A (en) 1989-03-28
FI872852A0 (fi) 1987-06-26
PL151562B1 (en) 1990-09-28
SU1528320A3 (ru) 1989-12-07
FI89048C (fi) 1993-08-10
EP0251732A2 (en) 1988-01-07
HUT44541A (en) 1988-03-28
BG48811A3 (en) 1991-05-15
DK328687D0 (da) 1987-06-26
DD264430A5 (de) 1989-02-01
CS264295B2 (en) 1989-06-13
HU196394B (en) 1988-11-28
JPH085879B2 (ja) 1996-01-24
DE3785613D1 (de) 1993-06-03
ATE88705T1 (de) 1993-05-15
CA1301163C (en) 1992-05-19
YU119987A (en) 1988-06-30
DE3785613T2 (de) 1993-08-12
YU46557B (sh) 1993-11-16
JPS6314783A (ja) 1988-01-21
FI89048B (fi) 1993-04-30
EP0251732A3 (en) 1989-05-10
AU7476387A (en) 1988-01-07
PL266477A1 (en) 1988-07-21
ES2054672T3 (es) 1994-08-16
EP0251732B1 (en) 1993-04-28
AU597673B2 (en) 1990-06-07

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