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DK3233892T3 - Modificerede kappa-letkæde-bindende polypeptider - Google Patents

Modificerede kappa-letkæde-bindende polypeptider Download PDF

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Publication number
DK3233892T3
DK3233892T3 DK15822920.3T DK15822920T DK3233892T3 DK 3233892 T3 DK3233892 T3 DK 3233892T3 DK 15822920 T DK15822920 T DK 15822920T DK 3233892 T3 DK3233892 T3 DK 3233892T3
Authority
DK
Denmark
Prior art keywords
light chain
kappa light
binding polypeptides
chain binding
modified kappa
Prior art date
Application number
DK15822920.3T
Other languages
English (en)
Inventor
Gustav Rodrigo
Mats Ander
Tomas Bjorkman
Original Assignee
Cytiva Bioprocess R & D Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE1451564A external-priority patent/SE538570C2/en
Application filed by Cytiva Bioprocess R & D Ab filed Critical Cytiva Bioprocess R & D Ab
Application granted granted Critical
Publication of DK3233892T3 publication Critical patent/DK3233892T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/24—Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DK15822920.3T 2014-12-17 2015-12-11 Modificerede kappa-letkæde-bindende polypeptider DK3233892T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1451564A SE538570C2 (en) 2014-12-17 2014-12-17 Modified kappa light chain-binding polypeptides
SE1451563 2014-12-17
PCT/EP2015/079389 WO2016096644A1 (en) 2014-12-17 2015-12-11 Modified kappa light chain-binding polypeptides

Publications (1)

Publication Number Publication Date
DK3233892T3 true DK3233892T3 (da) 2024-04-08

Family

ID=55080083

Family Applications (2)

Application Number Title Priority Date Filing Date
DK15822919.5T DK3233891T3 (da) 2014-12-17 2015-12-11 Modificerede kappa-letkæde-bindende polypeptider
DK15822920.3T DK3233892T3 (da) 2014-12-17 2015-12-11 Modificerede kappa-letkæde-bindende polypeptider

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK15822919.5T DK3233891T3 (da) 2014-12-17 2015-12-11 Modificerede kappa-letkæde-bindende polypeptider

Country Status (7)

Country Link
US (3) US10208092B2 (da)
EP (2) EP3233891B1 (da)
JP (5) JP6843438B2 (da)
CN (3) CN107108700B (da)
DK (2) DK3233891T3 (da)
ES (2) ES2975669T3 (da)
WO (2) WO2016096643A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107108700B (zh) * 2014-12-17 2023-02-17 思拓凡生物工艺研发有限公司 修饰的κ轻链-结合多肽
EP3252158A4 (en) * 2015-01-26 2018-07-18 Kaneka Corporation Mutant immunoglobulin kappa chain variable region-binding peptide
JPWO2016121701A1 (ja) * 2015-01-26 2017-11-09 株式会社カネカ 免疫グロブリンκ鎖可変領域含有タンパク質精製用アフィニティー分離マトリックス
JP6950957B2 (ja) 2015-10-22 2021-10-13 プロテノバ株式会社 イムノグロブリン結合ポリペプチド
WO2017191748A1 (ja) * 2016-05-02 2017-11-09 株式会社カネカ 改変型免疫グロブリンκ鎖可変領域結合性ペプチド
WO2017195638A1 (ja) 2016-05-09 2017-11-16 株式会社カネカ 抗体またはκ鎖可変領域含有抗体断片の精製方法
WO2017195641A1 (ja) * 2016-05-11 2017-11-16 株式会社カネカ アフィニティ分離マトリックスの製造方法およびアフィニティ分離マトリックス
CN106279419A (zh) * 2016-08-08 2017-01-04 吴江近岸蛋白质科技有限公司 一种抗体结合蛋白Protein L及其制备方法
WO2019059400A1 (ja) 2017-09-25 2019-03-28 Jsr株式会社 イムノグロブリン結合タンパク質、及びそれを用いたアフィニティー担体
CN111148753B (zh) * 2017-09-25 2024-02-23 Jsr株式会社 免疫球蛋白结合蛋白质和使用其的亲和载体
WO2020066270A1 (ja) * 2018-09-28 2020-04-02 株式会社カネカ κ鎖可変領域を含む抗体および／または抗体断片の製造方法
CN114761030A (zh) * 2019-11-01 2022-07-15 休斯敦系统大学 具有诱导的抗肿瘤免疫的溶瘤病毒疗法
CN111057153B (zh) * 2019-12-06 2021-09-07 广州康盛生物科技股份有限公司 一种免疫球蛋白结合蛋白及其制备方法和应用
GB202112386D0 (en) * 2021-08-31 2021-10-13 Cytiva Bioprocess R & D Ab Modified kappa light chain-binding polypeptides
US20250002543A1 (en) 2021-10-25 2025-01-02 Tosoh Corporation Immunoglobulin-binding protein
KR102637595B1 (ko) * 2022-05-03 2024-02-16 아미코젠주식회사 알칼리내성이 증가된 면역글로불린-결합 단백질 변이체 및 이의 용도
AU2023288640A1 (en) * 2022-06-22 2024-12-12 Cytiva Bioprocess R&D Ab Kappa light chain-binding convection matrix
CN115820704B (zh) * 2022-12-22 2023-06-16 武汉爱博泰克生物科技有限公司 表达蛋白l的重组质粒及其应用与重组蛋白l的表达方法
WO2024165378A2 (en) * 2023-02-06 2024-08-15 Cytiva Bioprocess R&D Ab Optimization of elution conditions

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9201331D0 (sv) * 1992-04-28 1992-04-28 Hightech Receptor C O Active Protein l och hybridproteiner daerav
AU5874999A (en) * 1998-09-14 2000-04-03 Affitech As Immunoglobulin binding protein
SE0200943D0 (sv) 2002-03-25 2002-03-25 Amersham Biosciences Ab Mutant protein
AU2003903317A0 (en) 2003-06-27 2003-07-10 Proteome Systems Intellectual Property Pty Ltd Method of isolating a protein
GB0323238D0 (en) 2003-10-03 2003-11-05 Domantis Ltd Synthetic LG binding domains of protein L
US20070275873A1 (en) 2004-04-29 2007-11-29 Heidner Hans W Methods and Compositions Comprising Protein L Immunoglobulin Binding Domains for Cell-Specific Targeting
CN106422418B (zh) 2006-09-29 2022-03-01 思拓凡生物工艺研发有限公司 用于抗体分离的包含来自金黄色葡萄球菌a蛋白的结构域c的层析配体
WO2012087230A1 (en) * 2010-12-20 2012-06-28 Ge Healthcare Bio-Sciences Ab Affinity chromatography matrix
CN103852465A (zh) * 2012-11-30 2014-06-11 通用电气公司 检测标记蛋白的方法和装置
CN104837536B (zh) 2012-12-14 2018-01-02 通用电气医疗集团生物工艺研发股份公司 清洁填充床层析柱的方法
JP6369807B2 (ja) * 2014-10-21 2018-08-08 株式会社プロテイン・エクスプレス プロテインｌ変異体
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
CN107108700B (zh) * 2014-12-17 2023-02-17 思拓凡生物工艺研发有限公司 修饰的κ轻链-结合多肽
EP3252158A4 (en) * 2015-01-26 2018-07-18 Kaneka Corporation Mutant immunoglobulin kappa chain variable region-binding peptide
GB201503578D0 (en) * 2015-03-03 2015-04-15 Ge Healthcare Bio Sciences Ab Sanitization method for affinity chromatography matrices
JP6950957B2 (ja) * 2015-10-22 2021-10-13 プロテノバ株式会社 イムノグロブリン結合ポリペプチド
GB2569585A (en) * 2017-12-20 2019-06-26 Ge Healthcare Bio Sciences Ab A method for preparation of a separation matrix
CN111057153B (zh) * 2019-12-06 2021-09-07 广州康盛生物科技股份有限公司 一种免疫球蛋白结合蛋白及其制备方法和应用

Also Published As

Publication number Publication date
EP3233891B1 (en) 2024-03-13
CN107108700B (zh) 2023-02-17
CN107108701B (zh) 2022-02-11
US10208092B2 (en) 2019-02-19
WO2016096644A1 (en) 2016-06-23
CN107108700A (zh) 2017-08-29
EP3233892A1 (en) 2017-10-25
JP2022164689A (ja) 2022-10-27
WO2016096643A1 (en) 2016-06-23
JP2017537632A (ja) 2017-12-21
EP3233892B1 (en) 2024-03-13
US20170327545A1 (en) 2017-11-16
US20170320919A1 (en) 2017-11-09
CN107108701A (zh) 2017-08-29
US11136357B2 (en) 2021-10-05
ES2975669T3 (es) 2024-07-11
JP6843438B2 (ja) 2021-03-17
US20190144511A1 (en) 2019-05-16
ES2977457T3 (es) 2024-08-23
US10208091B2 (en) 2019-02-19
DK3233891T3 (da) 2024-04-08
JP7204086B2 (ja) 2023-01-16
EP3233891A1 (en) 2017-10-25
CN116731129A (zh) 2023-09-12
JP2018505657A (ja) 2018-03-01
JP2024100775A (ja) 2024-07-26
JP2020202855A (ja) 2020-12-24

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