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DK319780A - Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner - Google Patents

Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner

Info

Publication number
DK319780A
DK319780A DK319780A DK319780A DK319780A DK 319780 A DK319780 A DK 319780A DK 319780 A DK319780 A DK 319780A DK 319780 A DK319780 A DK 319780A DK 319780 A DK319780 A DK 319780A
Authority
DK
Denmark
Prior art keywords
ins
amino acid
insulin
ser
formulae
Prior art date
Application number
DK319780A
Other languages
English (en)
Inventor
K Breddam
F Widmer
J T Johansen
Original Assignee
Forenede Bryggerier As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forenede Bryggerier As filed Critical Forenede Bryggerier As
Priority to DK319780A priority Critical patent/DK319780A/da
Priority to ZA815066A priority patent/ZA815066B/xx
Priority to HU813205A priority patent/HU185668B/hu
Priority to US06/364,856 priority patent/US4645740A/en
Priority to PCT/DK1981/000074 priority patent/WO1982000301A1/en
Priority to IE1660/81A priority patent/IE51620B1/en
Priority to EP81303383A priority patent/EP0045187B1/en
Priority to JP56502653A priority patent/JPS642360B2/ja
Priority to DE8181303383T priority patent/DE3166608D1/de
Priority to CA000382347A priority patent/CA1175372A/en
Priority to AU74508/81A priority patent/AU543687B2/en
Priority to AT81303383T priority patent/ATE9820T1/de
Priority to ES504462A priority patent/ES8300858A1/es
Publication of DK319780A publication Critical patent/DK319780A/da
Priority to SU823414346A priority patent/SU1554766A3/ru
Priority to DK130082A priority patent/DK148714C/da
Priority to NO820958A priority patent/NO156654C/no
Priority to ES514463A priority patent/ES514463A0/es
Priority to DK320483A priority patent/DK149616C/da
Priority to SU843825251A priority patent/SU1611217A3/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK319780A 1980-07-24 1980-07-24 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner DK319780A (da)

Priority Applications (19)

Application Number Priority Date Filing Date Title
DK319780A DK319780A (da) 1980-07-24 1980-07-24 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
CA000382347A CA1175372A (en) 1980-07-24 1981-07-23 Process for enzymatic replacement of the b-30 amino acid in insulins
AU74508/81A AU543687B2 (en) 1980-07-24 1981-07-23 A process for enzymatic replacement of the b-30 amino acid ininsulins
US06/364,856 US4645740A (en) 1980-07-24 1981-07-23 Process for enzymatic replacement of the B-30 amino acid in insulins
PCT/DK1981/000074 WO1982000301A1 (en) 1980-07-24 1981-07-23 Enzymatic replacement of the b-30 amino acid in insulins
IE1660/81A IE51620B1 (en) 1980-07-24 1981-07-23 A process for enzymatic replacement of the b-30 amino acid in insulins
EP81303383A EP0045187B1 (en) 1980-07-24 1981-07-23 A process for enzymatic replacement of the b-30 amino acid in insulins
JP56502653A JPS642360B2 (da) 1980-07-24 1981-07-23
DE8181303383T DE3166608D1 (en) 1980-07-24 1981-07-23 A process for enzymatic replacement of the b-30 amino acid in insulins
ZA815066A ZA815066B (en) 1980-07-24 1981-07-23 A process for enzymatic replacement of the b-30 amino acid in insulins
HU813205A HU185668B (en) 1980-07-24 1981-07-23 Process for the enzymatic substitution of aminoacid in position b-30 of
AT81303383T ATE9820T1 (de) 1980-07-24 1981-07-23 Verfahren zur enzymatischen substitution der b-30-aminosaeure in den insulinen.
ES504462A ES8300858A1 (es) 1980-07-24 1981-07-23 Procedimiento de tratamiento de insulinas
SU823414346A SU1554766A3 (ru) 1980-07-24 1982-03-23 Способ получени человеческого инсулина формулы I @ -Т @ -ОН или его производных
DK130082A DK148714C (da) 1980-07-24 1982-03-23 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
NO820958A NO156654C (no) 1980-07-24 1982-03-23 Fremgangsmaate for enzymatisk erstatning av b-30-aminosyren i insuliner.
ES514463A ES514463A0 (es) 1980-07-24 1982-07-28 "procedimiento de escision enzimatica de derivados de insulina".
DK320483A DK149616C (da) 1980-07-24 1983-07-12 Fremgangsmaade til fremstilling af insuliner
SU843825251A SU1611217A3 (ru) 1980-07-24 1984-12-18 Способ получени инсулина человека

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK319780A DK319780A (da) 1980-07-24 1980-07-24 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner

Publications (1)

Publication Number Publication Date
DK319780A true DK319780A (da) 1982-01-25

Family

ID=8120166

Family Applications (1)

Application Number Title Priority Date Filing Date
DK319780A DK319780A (da) 1980-07-24 1980-07-24 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner

Country Status (14)

Country Link
US (1) US4645740A (da)
EP (1) EP0045187B1 (da)
JP (1) JPS642360B2 (da)
AT (1) ATE9820T1 (da)
AU (1) AU543687B2 (da)
CA (1) CA1175372A (da)
DE (1) DE3166608D1 (da)
DK (1) DK319780A (da)
ES (2) ES8300858A1 (da)
HU (1) HU185668B (da)
IE (1) IE51620B1 (da)
SU (2) SU1554766A3 (da)
WO (1) WO1982000301A1 (da)
ZA (1) ZA815066B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3101382A1 (de) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
WO1983001074A1 (en) * 1981-09-15 1983-03-31 Andresen, Finn, Hede Enzymatic preparation of human insulin or b-30 esters thereof
JPS58500739A (ja) * 1981-05-20 1983-05-12 ノルデイスク インシユリンラボラトリユ−ム インシユリン誘導体の製造法
DK353781A (da) * 1981-08-10 1983-02-11 Novo Industri As Fremgangsmaade til fremstilling af insulinderivater
EP0087238A1 (en) * 1982-02-08 1983-08-31 Biogen N.V. Am improved method for preparing human insulin from non-human insulin
DE3209184A1 (de) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
NL8201650A (nl) * 1982-04-21 1983-11-16 Akzo Nv Semisynthetische bereiding van humane insuline.
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
US5580751A (en) * 1990-09-14 1996-12-03 Carlsberg A/S Process for the preparation of C-terminally amidated peptides
DK220890D0 (da) * 1990-09-14 1990-09-14 Ole Buchardt Fremgangsmaade til fremstilling af c-terminalt amiderede peptider
JP3014764B2 (ja) * 1993-09-17 2000-02-28 ノボ ノルディスク アクティーゼルスカブ アシル化インスリン
US6011007A (en) * 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
US6869930B1 (en) 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
AU1112597A (en) * 1996-07-25 1998-02-20 Firma "Nika-Universal" Binary techniques for producing biologically active peptides
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
US4182654A (en) * 1974-09-18 1980-01-08 Pierce Chemical Company Production of polypeptides using polynucleotides
JPS6339237B2 (da) * 1979-04-06 1988-08-04 Karuruberugu Baiotekunorojii Ltd As
JPS55138391A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd New synthetic method of peptide derivative
DK146482C (da) * 1979-04-13 1986-10-06 Shionogi & Co Fremgangsmaade til fremstilling af et b30-threonin-insulin
IE50892B1 (en) * 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters

Also Published As

Publication number Publication date
ATE9820T1 (de) 1984-10-15
EP0045187B1 (en) 1984-10-10
EP0045187A1 (en) 1982-02-03
US4645740A (en) 1987-02-24
HU185668B (en) 1985-03-28
ES8306182A1 (es) 1983-06-01
AU7450881A (en) 1982-02-16
SU1554766A3 (ru) 1990-03-30
CA1175372A (en) 1984-10-02
ES514463A0 (es) 1983-06-01
ES504462A0 (es) 1982-12-01
JPS642360B2 (da) 1989-01-17
AU543687B2 (en) 1985-04-26
ES8300858A1 (es) 1982-12-01
ZA815066B (en) 1983-03-30
JPS57501161A (da) 1982-07-08
IE51620B1 (en) 1987-01-21
WO1982000301A1 (en) 1982-02-04
DE3166608D1 (en) 1984-11-15
IE811660L (en) 1982-01-24
SU1611217A3 (ru) 1990-11-30

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