DK317287D0 - Reduktase-inhibitorer - Google Patents

Reduktase-inhibitorer

Info

Publication number: DK317287D0
Authority: DK; Denmark
Prior art keywords: reductase inhibitors; reductase; inhibitors
Prior art date: 1986-06-23

Application number

DK317287A

Other languages

English (en)

Other versions

DK317287A (da

Inventor

Edward S Inamine

David R Houck

Otto D Hensens

Ta-Jyh Lee

Wasyl Halczenko

George D Hartman

Robert L Smith

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-23

Filing date

1987-06-22

Publication date

1987-06-22

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27357040&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK317287(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1987-06-22 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1987-06-22 Publication of DK317287D0 publication Critical patent/DK317287D0/da

1987-12-24 Publication of DK317287A publication Critical patent/DK317287A/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/365—Nocardia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK317287A 1986-06-23 1987-06-22 Hmg-coa-reduktaseinhibitorer samt et farmaceutisk praeparat, der indeholder disse DK317287A (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US87704186A	1986-06-23	1986-06-23
US193387A	1987-01-09	1987-01-09
US4813687A	1987-05-15	1987-05-15

Publications (2)

Publication Number	Publication Date
DK317287D0 true DK317287D0 (da)	1987-06-22
DK317287A DK317287A (da)	1987-12-24

Family

ID=27357040

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK317287A DK317287A (da)	1986-06-23	1987-06-22	Hmg-coa-reduktaseinhibitorer samt et farmaceutisk praeparat, der indeholder disse

Country Status (7)

Country	Link
EP (1)	EP0251625B1 (da)
KR (1)	KR880000586A (da)
AU (1)	AU7455987A (da)
CA (1)	CA1340331C (da)
DE (1)	DE3770345D1 (da)
DK (1)	DK317287A (da)
PT (1)	PT85109A (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4833258A (en) *	1987-02-17	1989-05-23	Merck & Co., Inc.	Intermediates useful in the preparation of HMG-COA reductase inhibitors
US4795811A (en) *	1987-06-22	1989-01-03	Merck & Co., Inc.	Intermediates for preparing HMG-CoA reductase inhibitors
PT88364A (pt) *	1987-09-02	1989-07-31	Merck & Co Inc	Process for preparing novel hmg-coa reductase inhibitors
DE3869282D1 (de) *	1987-09-02	1992-04-23	Merck & Co Inc	Inhibitoren von hmg-coa-reduktase.
US4841074A (en) *	1987-12-11	1989-06-20	Merck & Co., Inc.	Intermediates and processes for 6-carboxy HMG-CoA reductase inhibitors
US4857547A (en) *	1988-01-07	1989-08-15	Merck & Co., Inc.	Novel HMG-CoA reductase inhibitors
US4866090A (en) *	1988-01-07	1989-09-12	Merck & Co., Inc.	Novel HMG-CoA reductase inhibitors
US4857546A (en) *	1988-01-07	1989-08-15	Merck & Co., Inc.	Novel HMG-CoA reductase inhibitors
US4866068A (en) *	1988-02-01	1989-09-12	Merck & Co., Inc.	Novel HMG-CoA reductase inhibitors
US4946864A (en) *	1988-02-01	1990-08-07	Merck & Co., Inc.	Novel HMG-CoA reductase inhibitors
US5049696A (en) *	1988-04-11	1991-09-17	Merck & Co., Inc.	Antihypercholesterolemic compounds
US4997755A (en) *	1988-04-15	1991-03-05	Merck & Co., Inc.	HMG-CoA reductase inhibitors produced by Nocardia sp. (MA 6455)
EP0337548A3 (en) *	1988-04-15	1991-08-14	Merck & Co. Inc.	HMG-COA reductase inhibitors produced by nocardia SP. (MA6455)(ATCC 53695)
FI893004A (fi) *	1988-06-29	1989-12-30	Merck & Co Inc	5-oxygenerade hmg-coa-reduktas -inhibitorer.
US4916239A (en) *	1988-07-19	1990-04-10	Merck & Co., Inc.	Process for the lactonization of mevinic acids and analogs thereof
CA2009043A1 (en) *	1989-02-01	1990-08-01	Michael J. Ferris	Process for the preparation of 6-alpha-hydroxymethyl lovastatin derivatives
US5001148A (en) *	1989-06-07	1991-03-19	E. R. Squibb & Sons, Inc.	Mevinic acid derivatives
IL90847A0 (en) *	1989-06-09	1990-02-09	Merck & Co Inc	3-keto hmg-coa reductase inhibitors and pharmaceutical compositions containing them
GB8915280D0 (en) *	1989-07-04	1989-08-23	British Bio Technology	Compounds
FI94339C (fi)	1989-07-21	1995-08-25	Warner Lambert Co	Menetelmä farmaseuttisesti käyttökelpoisen /R-(R,R)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5089523A (en) *	1990-05-11	1992-02-18	E. R. Squibb & Sons, Inc.	Fluorinated derivatives of mevinic acids
US5264455A (en) *	1990-07-06	1993-11-23	E. R. Squibb & Sons, Inc.	Sulfur-substituted mevinic acid derivatives
GB9100174D0 (en) *	1991-01-04	1991-02-20	British Bio Technology	Compounds
GB9111192D0 (en) *	1991-05-23	1991-07-17	British Bio Technology	Synthetic process
US5286746A (en) *	1991-12-20	1994-02-15	E. R. Squibb & Sons, Inc.	Sulfur-substituted mevinic acid derivatives
US6043064A (en) *	1993-10-22	2000-03-28	Bristol-Myers Squibb Company	Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
SI9800046A (sl) *	1998-02-18	1999-08-31	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
AU4543699A (en) *	1998-06-08	1999-12-30	Advanced Medicine, Inc.	Multibinding inhibitors of hmg-coa reductase
PL346392A1 (en) *	1999-06-29	2002-02-11	Kaneka Corp	Process for selective lactonization
US20210008084A1 (en)	2017-10-16	2021-01-14	Tsinghua University	Mevalonate pathway inhibitor and pharmaceutical composition thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5835144A (ja) *	1981-08-27	1983-03-01	Sankyo Co Ltd	Ｍｂ−５３０ｂ誘導体およびその製造法
US4611068A (en) *	1984-11-19	1986-09-09	Merck Frosst Canada, Inc.	Process for the preparation of HMG-CoA reductase inhibitors and intermediate compounds employed therein

1987
- 1987-06-17 PT PT85109A patent/PT85109A/pt unknown
- 1987-06-19 CA CA000540097A patent/CA1340331C/en not_active Expired - Fee Related
- 1987-06-22 DK DK317287A patent/DK317287A/da not_active Application Discontinuation
- 1987-06-22 AU AU74559/87A patent/AU7455987A/en not_active Abandoned
- 1987-06-22 DE DE8787305527T patent/DE3770345D1/de not_active Expired - Fee Related
- 1987-06-22 EP EP87305527A patent/EP0251625B1/en not_active Expired - Lifetime
- 1987-06-22 KR KR1019870006305A patent/KR880000586A/ko not_active Application Discontinuation

Also Published As

Publication number	Publication date
DE3770345D1 (de)	1991-07-04
EP0251625A3 (en)	1989-01-25
CA1340331C (en)	1999-01-26
PT85109A (en)	1987-07-01
AU7455987A (en)	1987-12-24
DK317287A (da)	1987-12-24
EP0251625A2 (en)	1988-01-07
EP0251625B1 (en)	1991-05-29
KR880000586A (ko)	1988-03-28

Publication	Publication Date	Title
DK317287D0 (da)	1987-06-22	Reduktase-inhibitorer
DE3681991D1 (de)	1991-11-21	Hmg-coa-reduktase-hemmungskoerper.
ATE97652T1 (de)	1993-12-15	Peptidasehemmungsmittel.
DK674387A (da)	1988-06-23	Proteaseinhibitorer
DK226888A (da)	1988-10-30	Steroid 5-alfa-reduktase inhibitor
DE3864608D1 (de)	1991-10-10	Hmg-coa-reduktasehemmer.
DK640388D0 (da)	1988-11-16	Pyrimidinderivater
DK247889D0 (da)	1989-05-22	Pyrimidinderivater
DE68904083D1 (de)	1993-02-11	Hmg-coa-reduktaseinhibitoren.
BR8907457A (pt)	1991-04-02	Inibidores de interleucina-1
DE68901091D1 (de)	1992-05-07	Hmg-coa-reduktaseinhibitoren.
MX9203768A (es)	1992-07-01	Inhibidores novedosos de reductasa 3-hidroxi-metilglutaril-coenzima a.
DE3674131D1 (de)	1990-10-18	Substituierte dihalo-statin-reninhemmungsmittel.
DK0409676T3 (da)	1995-03-27	Acetylcholinesterase-inhibitorer
DK349586A (da)	1987-03-19	Enzyminhibitor
DK584288D0 (da)	1988-10-20	Saerlig fremgangsmaade
FI101796B1 (fi)	1998-08-31	Uusia -glukosidaasi-inhibiittoreita
DK227388D0 (da)	1988-04-26	Pyrimidinderivater
NO864337D0 (no)	1986-10-30	Dopamin-beta-hydrolase-inhibitorer.
DK174087D0 (da)	1987-04-06	Angiotensinkonverterende enzyminhibitor
DK314988D0 (da)	1988-06-09	Saerlig fremgangsmaade
NO860960L (no)	1986-09-15	Avsetningsinhibitorer.
DK440887A (da)	1988-02-29	Dopamin-beta-hydroxylase-inhibitorer
DK69489A (da)	1989-08-17	Aspartattranscarbamylase-inhibitorer
NO872985L (no)	1988-01-22	Inhibitor for polyuretanpropergoler.

Legal Events

Date	Code	Title	Description
1990-02-05	AHB	Application shelved due to non-payment