DK3166923T3 - Fremgangsmåde til fremstilling af substituerede phenylalkaner - Google Patents
Fremgangsmåde til fremstilling af substituerede phenylalkaner Download PDFInfo
- Publication number
- DK3166923T3 DK3166923T3 DK15818168.5T DK15818168T DK3166923T3 DK 3166923 T3 DK3166923 T3 DK 3166923T3 DK 15818168 T DK15818168 T DK 15818168T DK 3166923 T3 DK3166923 T3 DK 3166923T3
- Authority
- DK
- Denmark
- Prior art keywords
- production
- phenylalkanes
- substituted
- substituted phenylalkanes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462022815P | 2014-07-10 | 2014-07-10 | |
| US201562155913P | 2015-05-01 | 2015-05-01 | |
| PCT/US2015/039884 WO2016007823A1 (en) | 2014-07-10 | 2015-07-10 | Process for preparing substituted phenylalkanes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3166923T3 true DK3166923T3 (da) | 2023-04-11 |
Family
ID=55064941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15818168.5T DK3166923T3 (da) | 2014-07-10 | 2015-07-10 | Fremgangsmåde til fremstilling af substituerede phenylalkaner |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9556108B2 (da) |
| EP (1) | EP3166923B1 (da) |
| JP (1) | JP6502397B2 (da) |
| AU (1) | AU2015287663B2 (da) |
| BR (1) | BR112017000417B1 (da) |
| CA (1) | CA2954642C (da) |
| DK (1) | DK3166923T3 (da) |
| ES (1) | ES2940904T3 (da) |
| MX (1) | MX2017000023A (da) |
| PT (1) | PT3166923T (da) |
| WO (1) | WO2016007823A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112017000417B1 (pt) | 2014-07-10 | 2021-06-08 | SpecGx LLC | processo para preparação de fenilalcanos substituídos |
| WO2016057931A1 (en) | 2014-10-10 | 2016-04-14 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| GB2539442A (en) * | 2015-06-16 | 2016-12-21 | Azad Pharmaceutical Ingredients Ag | New synthesis of tapentadol-HCI intermediates |
| ES2908442T3 (es) * | 2015-07-10 | 2022-04-29 | SpecGx LLC | Un proceso de dos pasos para preparar fenilalquilaminas 3-sustituidas |
| WO2018009856A1 (en) | 2016-07-08 | 2018-01-11 | Cody Laboratories, Inc. | Method for catalytic preparation of hydromorphone, hydrocodone and other opiates |
| CN116496496B (zh) * | 2023-04-27 | 2024-11-05 | 中国石油大学(华东) | 一种基于三嗪共价框架材料（CTFs）制备单位点催化剂的制备方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2340812C2 (de) | 1973-08-11 | 1982-05-27 | Basf Ag, 6700 Ludwigshafen | Phenylpropanale sowie ein Verfahren zu deren Herstellung |
| DE4426245A1 (de) | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| DE60105144T2 (de) | 2000-04-20 | 2005-09-08 | F. Hoffmann-La Roche Ag | Pyrrolidin und piperidin derivate für die behandlung von neurodegenerativen erkrankungen |
| WO2003033456A1 (en) * | 2001-10-16 | 2003-04-24 | Dr. Reddy's Laboratories Ltd. | NOVEL β-PHENYL-α-OXYSUBSTITUTED PROPIONIC DERIVATIVES: PROCESS FOR ITS PREPARATION AND THEIR USE IN THE PREPARATION OF PHARMACEUTICALLY IMPORTANT COMPOUNDS |
| US7399858B2 (en) | 2002-11-11 | 2008-07-15 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof |
| US7321038B2 (en) | 2002-11-11 | 2008-01-22 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| US7323565B2 (en) | 2002-11-11 | 2008-01-29 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| JP4351859B2 (ja) * | 2003-04-14 | 2009-10-28 | 三菱レイヨン株式会社 | 光学活性β−アリ−ル化合物の製造法 |
| DE10328316A1 (de) * | 2003-06-23 | 2005-01-20 | Grünenthal GmbH | Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe |
| US7608709B2 (en) | 2005-07-25 | 2009-10-27 | National University Corporation Chiba University | 2, 3-bis(dialkylphosphino)pyrazine derivative, process of producing the same, and metal complex having the same as ligand |
| TWI401237B (zh) | 2006-07-24 | 2013-07-11 | ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備 | |
| US7399859B1 (en) | 2007-02-06 | 2008-07-15 | Cody Laboratories Inc. | Method for catalytic preparation of hydromorphone and hydrocodone |
| US9446995B2 (en) * | 2012-05-21 | 2016-09-20 | Illinois Institute Of Technology | Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions |
| EP2349560B1 (en) | 2008-11-14 | 2025-01-22 | University Of Kansas | Polymer-supported transition metal catalyst complexes and methods of use |
| EP2440562B1 (en) | 2009-06-11 | 2016-08-10 | Mallinckrodt LLC | Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer |
| CN102002065B (zh) | 2009-09-02 | 2014-09-10 | 上海特化医药科技有限公司 | 他喷他多的制备方法及其中间体 |
| WO2011067386A2 (de) | 2009-12-04 | 2011-06-09 | Basf Se | Verfahren zur herstellung von aliphatischen aldehyden |
| BR112012016059A2 (pt) * | 2009-12-29 | 2015-09-01 | Mapi Pharma Ltd | "compostos intermediários e processos para a preparação de tapentadol e compostos relacionados". |
| WO2011092719A2 (en) * | 2010-02-01 | 2011-08-04 | Ind-Swift Laboratories Limited | Process for the preparation of l-phenyl-3-dimethylaminopropane derivatives |
| WO2011107876A2 (en) | 2010-03-05 | 2011-09-09 | Actavis Group Ptc Ehf | Improved resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol |
| WO2011157390A2 (en) | 2010-06-15 | 2011-12-22 | Grünenthal GmbH | Process for the preparation of substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds |
| TWI396678B (zh) | 2010-12-07 | 2013-05-21 | Nat Univ Tsing Hua | 二級醇製備方法 |
| WO2012089181A1 (en) * | 2010-12-30 | 2012-07-05 | Zentiva, K.S. | O-substituted (2r,3r)-3-(3-hydroxyphenyl)-2-methyl-4-pentenoic acids and a method of obtaining the same |
| WO2012146978A2 (en) * | 2011-04-28 | 2012-11-01 | Actavis Group Ptc Ehf | A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof |
| US20130150622A1 (en) * | 2011-12-12 | 2013-06-13 | Boehringer Ingelheim International Gmbh | Stereoselective synthesis of tapentadol and its salts |
| JP2013221025A (ja) | 2012-04-19 | 2013-10-28 | Dainippon Sumitomo Pharma Co Ltd | ビフェニルアセトアミド誘導体の製造方法及びその中間体 |
| CA2873984A1 (en) | 2012-05-23 | 2013-11-28 | Stemergie Biotechnology Sa | Inhibitors of the activity of complex (iii) of the mitochondrial electron transport chain and use thereof |
| CN102936205B (zh) * | 2012-11-12 | 2014-06-18 | 合肥市新星医药化工有限公司 | 一种他喷他多的合成方法 |
| BR112017000417B1 (pt) | 2014-07-10 | 2021-06-08 | SpecGx LLC | processo para preparação de fenilalcanos substituídos |
-
2015
- 2015-07-10 BR BR112017000417-8A patent/BR112017000417B1/pt active IP Right Grant
- 2015-07-10 DK DK15818168.5T patent/DK3166923T3/da active
- 2015-07-10 WO PCT/US2015/039884 patent/WO2016007823A1/en active Application Filing
- 2015-07-10 ES ES15818168T patent/ES2940904T3/es active Active
- 2015-07-10 JP JP2016575070A patent/JP6502397B2/ja active Active
- 2015-07-10 US US14/796,069 patent/US9556108B2/en active Active
- 2015-07-10 CA CA2954642A patent/CA2954642C/en active Active
- 2015-07-10 AU AU2015287663A patent/AU2015287663B2/en active Active
- 2015-07-10 MX MX2017000023A patent/MX2017000023A/es unknown
- 2015-07-10 PT PT158181685T patent/PT3166923T/pt unknown
- 2015-07-10 EP EP15818168.5A patent/EP3166923B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112017000417A2 (pt) | 2017-11-07 |
| MX2017000023A (es) | 2017-05-01 |
| WO2016007823A1 (en) | 2016-01-14 |
| PT3166923T (pt) | 2023-06-02 |
| BR112017000417B1 (pt) | 2021-06-08 |
| AU2015287663B2 (en) | 2019-02-28 |
| US20160009635A1 (en) | 2016-01-14 |
| US9556108B2 (en) | 2017-01-31 |
| EP3166923B1 (en) | 2023-03-15 |
| ES2940904T3 (es) | 2023-05-12 |
| EP3166923A4 (en) | 2018-02-21 |
| JP2017520566A (ja) | 2017-07-27 |
| AU2015287663A1 (en) | 2017-01-12 |
| CA2954642A1 (en) | 2016-01-14 |
| CA2954642C (en) | 2023-04-11 |
| JP6502397B2 (ja) | 2019-04-17 |
| EP3166923A1 (en) | 2017-05-17 |
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