DK3134413T3 - SUBSTITUTED [1,2,4] TRIAZOLO [1,5-A] PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS - Google Patents

SUBSTITUTED [1,2,4] TRIAZOLO [1,5-A] PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS Download PDF

Info

Publication number: DK3134413T3
Authority: DK; Denmark
Prior art keywords: triazolo; pyrimidin; substituted; compounds; pde2 inhibitors
Prior art date: 2014-04-23

Application number

DK15721086.5T

Other languages

Danish (da)

Inventor

James Breitenbucher

Graeme Freestone

Laurent Gomez

Robert Lemus

Kiev Ly

Margaret Mccarrick

William Vernier

Troy Vickers

Original Assignee

Dart Neuroscience Cayman Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-04-23

Filing date

2015-04-22

Publication date

2019-10-14

2015-04-22 Application filed by Dart Neuroscience Cayman Ltd filed Critical Dart Neuroscience Cayman Ltd

2019-10-14 Application granted granted Critical

2019-10-14 Publication of DK3134413T3 publication Critical patent/DK3134413T3/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

DK15721086.5T 2014-04-23 2015-04-22 SUBSTITUTED [1,2,4] TRIAZOLO [1,5-A] PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS DK3134413T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201461983387P	2014-04-23	2014-04-23
PCT/US2015/027102 WO2015164508A1 (en)	2014-04-23	2015-04-22	Substituted [1,2,4] triazolo [1,5-a] pyrimidin-7-yl compounds as pde2 inhibitors

Publications (1)

Publication Number	Publication Date
DK3134413T3 true DK3134413T3 (en)	2019-10-14

Family

ID=53055118

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK19194930.4T DK3597649T3 (en)	2014-04-23	2015-04-22	COMPOSITIONS CONTAINING SUBSTITUTED [1,2,4] TRIAZOLO [1,5-A] PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS
DK15721086.5T DK3134413T3 (en)	2014-04-23	2015-04-22	SUBSTITUTED [1,2,4] TRIAZOLO [1,5-A] PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK19194930.4T DK3597649T3 (en)	2014-04-23	2015-04-22	COMPOSITIONS CONTAINING SUBSTITUTED [1,2,4] TRIAZOLO [1,5-A] PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS

Country Status (23)

Country	Link
US (5)	US9932345B2 (en)
EP (2)	EP3134413B1 (en)
JP (1)	JP6626449B2 (en)
KR (1)	KR102471058B1 (en)
CN (2)	CN106459062A (en)
AU (2)	AU2015249753B2 (en)
BR (1)	BR112016024713B1 (en)
CA (1)	CA2938294C (en)
DK (2)	DK3597649T3 (en)
ES (2)	ES2902806T3 (en)
HR (1)	HRP20212035T1 (en)
HU (1)	HUE057317T2 (en)
IL (2)	IL248292A (en)
MA (1)	MA50375A (en)
MX (1)	MX358004B (en)
NZ (1)	NZ725161A (en)
PL (1)	PL3597649T3 (en)
PT (1)	PT3597649T (en)
RU (1)	RU2659070C9 (en)
SG (1)	SG11201606216UA (en)
SI (1)	SI3597649T1 (en)
TW (1)	TWI664181B (en)
WO (1)	WO2015164508A1 (en)

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2015
- 2015-04-22 EP EP15721086.5A patent/EP3134413B1/en active Active
- 2015-04-22 SI SI201531770T patent/SI3597649T1/en unknown
- 2015-04-22 HU HUE19194930A patent/HUE057317T2/en unknown
- 2015-04-22 KR KR1020167032113A patent/KR102471058B1/en active Active
- 2015-04-22 US US15/306,069 patent/US9932345B2/en active Active
- 2015-04-22 DK DK19194930.4T patent/DK3597649T3/en active
- 2015-04-22 DK DK15721086.5T patent/DK3134413T3/en active
- 2015-04-22 ES ES19194930T patent/ES2902806T3/en active Active
- 2015-04-22 NZ NZ725161A patent/NZ725161A/en unknown
- 2015-04-22 ES ES15721086T patent/ES2759246T3/en active Active
- 2015-04-22 PL PL19194930T patent/PL3597649T3/en unknown
- 2015-04-22 HR HRP20212035TT patent/HRP20212035T1/en unknown
- 2015-04-22 WO PCT/US2015/027102 patent/WO2015164508A1/en active Application Filing
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- 2015-04-22 MA MA050375A patent/MA50375A/en unknown
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- 2015-04-22 EP EP19194930.4A patent/EP3597649B8/en active Active
- 2015-04-22 CN CN201580030165.6A patent/CN106459062A/en active Pending
- 2015-04-22 CN CN201910367854.6A patent/CN110092788B/en active Active
- 2015-04-22 AU AU2015249753A patent/AU2015249753B2/en active Active
- 2015-04-22 SG SG11201606216UA patent/SG11201606216UA/en unknown
- 2015-04-23 TW TW104113093A patent/TWI664181B/en active
2016
- 2016-10-10 IL IL248292A patent/IL248292A/en active IP Right Grant
2017
- 2017-08-30 IL IL254224A patent/IL254224B/en active IP Right Grant
2018
- 2018-02-26 US US15/905,672 patent/US10501465B2/en active Active
2019
- 2019-11-25 US US16/694,869 patent/US11186582B2/en active Active
- 2019-12-20 AU AU2019283994A patent/AU2019283994C1/en active Active
2022
- 2022-06-27 US US17/850,668 patent/US20230192698A1/en not_active Abandoned
2024
- 2024-03-22 US US18/613,695 patent/US20250092047A1/en active Pending

Also Published As

Publication number	Publication date
HRP20212035T1 (en)	2022-04-01
US10501465B2 (en)	2019-12-10
EP3597649B1 (en)	2021-10-13
PL3597649T3 (en)	2022-04-04
WO2015164508A1 (en)	2015-10-29
MX358004B (en)	2018-07-31
AU2019283994A1 (en)	2020-01-23
EP3134413B1 (en)	2019-09-11
KR102471058B1 (en)	2022-11-25
TWI664181B (en)	2019-07-01
RU2659070C9 (en)	2018-08-24
KR20160145745A (en)	2016-12-20
BR112016024713B1 (en)	2023-05-02
IL254224B (en)	2019-01-31
RU2016143387A3 (en)	2018-05-23
CN110092788B (en)	2022-02-25
AU2015249753A1 (en)	2016-11-03
US20250092047A1 (en)	2025-03-20
ES2759246T3 (en)	2020-05-08
CN106459062A (en)	2017-02-22
SG11201606216UA (en)	2016-09-29
AU2015249753B2 (en)	2019-10-10
MX2016013860A (en)	2017-05-12
CA2938294C (en)	2023-02-21
TW201625625A (en)	2016-07-16
EP3134413A1 (en)	2017-03-01
JP6626449B2 (en)	2019-12-25
SI3597649T1 (en)	2022-04-29
NZ725161A (en)	2017-10-27
MA50375A (en)	2021-05-26
IL248292A (en)	2017-09-28
CN110092788A (en)	2019-08-06
CA2938294A1 (en)	2015-10-29
EP3597649A1 (en)	2020-01-22
US20200095256A1 (en)	2020-03-26
RU2016143387A (en)	2018-05-23
BR112016024713A2 (en)	2017-08-15
US11186582B2 (en)	2021-11-30
ES2902806T3 (en)	2022-03-29
AU2019283994B2 (en)	2021-05-27
US20170057967A1 (en)	2017-03-02
HUE057317T2 (en)	2022-04-28
WO2015164508A4 (en)	2015-12-23
AU2019283994C1 (en)	2021-12-09
US20230192698A1 (en)	2023-06-22
US9932345B2 (en)	2018-04-03
RU2659070C2 (en)	2018-06-28
US20180179216A1 (en)	2018-06-28
DK3597649T3 (en)	2022-01-10
IL254224A0 (en)	2017-10-31
JP2017513808A (en)	2017-06-01
PT3597649T (en)	2022-01-21
EP3597649B8 (en)	2022-02-16

Publication	Publication Date	Title
DK3134413T3 (en)	2019-10-14	SUBSTITUTED [1,2,4] TRIAZOLO [1,5-A] PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS
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