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DK3111221T4 - Fremgangsmåder, kit og systemer til scoring af immunresponsen mod cancer ved samtidig påvisning af CD3, CD8, CD20 og FOXP3 - Google Patents

Fremgangsmåder, kit og systemer til scoring af immunresponsen mod cancer ved samtidig påvisning af CD3, CD8, CD20 og FOXP3 Download PDF

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Publication number
DK3111221T4
DK3111221T4 DK15706450.2T DK15706450T DK3111221T4 DK 3111221 T4 DK3111221 T4 DK 3111221T4 DK 15706450 T DK15706450 T DK 15706450T DK 3111221 T4 DK3111221 T4 DK 3111221T4
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DK
Denmark
Prior art keywords
foxp3
scoring
kits
cancer
systems
Prior art date
Application number
DK15706450.2T
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English (en)
Other versions
DK3111221T3 (da
Inventor
Noemi Sebastiao
William Day
Srinivas Chukka
Jim Martin
Michael Barnes
Joerg Bredno
Alisa Tubbs
Yao Nie
Ting Chen
Robert Ochs
Original Assignee
Ventana Med Syst Inc
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52589380&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3111221(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ventana Med Syst Inc filed Critical Ventana Med Syst Inc
Publication of DK3111221T3 publication Critical patent/DK3111221T3/da
Application granted granted Critical
Publication of DK3111221T4 publication Critical patent/DK3111221T4/da

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    • G01N33/5751—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G01N33/575—
    • G01N33/57515—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/016—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486—Counting the particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00138—Slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4739—Cyclin; Prad 1
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4742—Keratin; Cytokeratin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/7051—T-cell receptor (TcR)-CD3 complex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70517—CD8

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Signal Processing (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Computer Vision & Pattern Recognition (AREA)
DK15706450.2T 2014-02-24 2015-02-20 Fremgangsmåder, kit og systemer til scoring af immunresponsen mod cancer ved samtidig påvisning af CD3, CD8, CD20 og FOXP3 DK3111221T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461943939P 2014-02-24 2014-02-24
PCT/EP2015/053643 WO2015124737A1 (en) 2014-02-24 2015-02-20 Methods, kits, and systems for scoring the immune response to cancer by simultaneous detection of cd3, cd8, cd20 and foxp3

Publications (2)

Publication Number Publication Date
DK3111221T3 DK3111221T3 (da) 2019-01-07
DK3111221T4 true DK3111221T4 (da) 2022-04-19

Family

ID=52589380

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15706450.2T DK3111221T4 (da) 2014-02-24 2015-02-20 Fremgangsmåder, kit og systemer til scoring af immunresponsen mod cancer ved samtidig påvisning af CD3, CD8, CD20 og FOXP3

Country Status (8)

Country Link
US (2) US11079382B2 (da)
EP (1) EP3111221B2 (da)
JP (1) JP6605506B2 (da)
AU (1) AU2015220783B2 (da)
CA (1) CA2940115C (da)
DK (1) DK3111221T4 (da)
ES (1) ES2701092T5 (da)
WO (1) WO2015124737A1 (da)

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EP3779779A1 (en) 2014-08-04 2021-02-17 Ventana Medical Systems, Inc. Image analysis system using context features
WO2017171720A1 (en) * 2016-03-29 2017-10-05 Flagship Biosciences, Inc. Digital image analysis of inflammatory cells and mediators of inflammation
US10346975B2 (en) * 2016-06-06 2019-07-09 Case Western Reserve University Computerized analysis of computed tomography (CT) imagery to quantify tumor infiltrating lymphocytes (TILs) in non-small cell lung cancer (NSCLC)
EP3392799A1 (en) * 2017-04-21 2018-10-24 Koninklijke Philips N.V. Medical image detection
WO2018231204A1 (en) 2017-06-13 2018-12-20 Google Llc Augmented reality microscope for pathology
WO2019020556A1 (en) * 2017-07-24 2019-01-31 Ventana Medical Systems, Inc. METHODS AND SYSTEMS FOR ASSESSING INFILTRAT OF IMMUNE CELLS IN TUMOR SAMPLES
US10956795B2 (en) * 2017-09-15 2021-03-23 Case Western Reserve University Predicting recurrence in early stage non-small cell lung cancer (NSCLC) using spatial arrangement of clusters of tumor infiltrating lymphocytes and cancer nuclei
EP3710820B1 (en) 2017-11-13 2025-06-11 F. Hoffmann-La Roche AG Devices for sample analysis using epitachophoresis
JP7000139B2 (ja) * 2017-12-01 2022-01-19 キヤノン株式会社 画像情報処理装置および表示方法
DK3746790T3 (da) 2018-01-31 2023-12-11 Ventana Med Syst Inc Fremgangsmåder og systemer til evaluering af immuncelleinfiltrat i kolorektal stadie III cancer
IL310416B1 (en) * 2018-04-12 2025-12-01 Kite Pharma Inc Chimeric T-cell receptor therapy using tumor microenvironmental characteristics
JP2021515240A (ja) * 2018-04-12 2021-06-17 グーグル エルエルシーＧｏｏｇｌｅ ＬＬＣ 定量的バイオマーカデータのオーバレイを有する病理学用拡張現実顕微鏡
WO2019197509A1 (en) 2018-04-13 2019-10-17 Ventana Medical Systems, Inc. Systems for cell shape estimation
US20220177587A1 (en) 2018-09-19 2022-06-09 Alpine Immune Sciences, Inc. Methods and uses of variant cd80 fusion proteins and related constructs
EP3864403A1 (en) 2018-10-12 2021-08-18 F. Hoffmann-La Roche AG Detection methods for epitachophoresis workflow automation
US20210405057A1 (en) * 2018-11-09 2021-12-30 Pierian Biosciences, LLC Methods and compositions for determining the composition of a tumor microenvironment
JP6994586B2 (ja) * 2018-12-11 2022-01-14 株式会社日立ハイテク 自動分析装置
WO2020166469A1 (ja) * 2019-02-15 2020-08-20 コニカミノルタ株式会社 情報提供方法、情報提供装置及びプログラム
CN114269916A (zh) 2019-05-14 2022-04-01 豪夫迈·罗氏有限公司 用于样品分析的装置和方法
EP3753690A1 (en) 2019-06-21 2020-12-23 Koninklijke Philips N.V. Guard element for use in a hair-cutting unit
EP3756544A1 (en) 2019-06-26 2020-12-30 Koninklijke Philips N.V. System and method for correcting a sweat analyte measurement
EP4025608A1 (en) * 2019-09-04 2022-07-13 F. Hoffmann-La Roche AG Cd8 binding agents and uses thereof
CN114113616B (zh) * 2021-12-07 2022-08-23 深圳裕策生物科技有限公司 一种试剂盒及其染色方法
JPWO2024090265A1 (da) * 2022-10-28 2024-05-02

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Also Published As

Publication number Publication date
WO2015124737A1 (en) 2015-08-27
DK3111221T3 (da) 2019-01-07
CA2940115C (en) 2023-03-14
EP3111221B1 (en) 2018-10-10
US20210311060A1 (en) 2021-10-07
JP6605506B2 (ja) 2019-11-13
EP3111221B2 (en) 2022-01-19
AU2015220783B2 (en) 2021-02-04
JP2017511488A (ja) 2017-04-20
ES2701092T5 (es) 2022-05-12
US11079382B2 (en) 2021-08-03
CA2940115A1 (en) 2015-08-27
AU2015220783A1 (en) 2016-07-07
EP3111221A1 (en) 2017-01-04
US20160363593A1 (en) 2016-12-15
ES2701092T3 (es) 2019-02-20

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