DK31088A - Blodkoaguleringsnedsaettende peptidderivater - Google Patents

Blodkoaguleringsnedsaettende peptidderivater

Info

Publication number: DK31088A
Authority: DK; Denmark
Prior art keywords: peptide derivatives; reducing peptide; coagulator; blood; blood coagulator
Prior art date: 1987-01-23

Application number

DK031088A

Other languages

English (en)

Other versions

DK173757B1 (da

DK31088D0 (da

Inventor

John L Krstenansky

Simon J T Mao

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-01-23

Filing date

1988-01-22

Publication date

1988-07-24

1988-01-22 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1988-01-22 Publication of DK31088D0 publication Critical patent/DK31088D0/da

1988-07-24 Publication of DK31088A publication Critical patent/DK31088A/da

2001-09-10 Application granted granted Critical

2001-09-10 Publication of DK173757B1 publication Critical patent/DK173757B1/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Tropical Medicine & Parasitology (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Toxicology (AREA)
Zoology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)

DK198800310A 1987-01-23 1988-01-22 Blodkoaguleringsnedsættende peptidderivater DK173757B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US641787A	1987-01-23	1987-01-23
US641787		1987-01-23
US5316287A	1987-05-21	1987-05-21
US5316287		1987-05-21

Publications (3)

Publication Number	Publication Date
DK31088D0 DK31088D0 (da)	1988-01-22
DK31088A true DK31088A (da)	1988-07-24
DK173757B1 DK173757B1 (da)	2001-09-10

Family

ID=26675603

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198800310A DK173757B1 (da)	1987-01-23	1988-01-22	Blodkoaguleringsnedsættende peptidderivater

Country Status (19)

Country	Link
EP (1)	EP0276014B1 (da)
JP (1)	JP2709817B2 (da)
KR (1)	KR960014105B1 (da)
CN (1)	CN88100260A (da)
AR (1)	AR245140A1 (da)
AT (1)	ATE110743T1 (da)
AU (1)	AU601801B2 (da)
CA (1)	CA1341032C (da)
DE (1)	DE3851238T2 (da)
DK (1)	DK173757B1 (da)
ES (1)	ES2063740T3 (da)
FI (1)	FI89060C (da)
HU (1)	HU199159B (da)
IE (1)	IE63547B1 (da)
IL (1)	IL85159A (da)
NO (1)	NO174105C (da)
NZ (1)	NZ223236A (da)
PH (1)	PH26263A (da)
PT (1)	PT86600B (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6005071A (en) *	1987-01-23	1999-12-21	Merrell Pharmaceuticals Inc.	Anticoagulant peptides
US5789540A (en) *	1987-01-23	1998-08-04	Merrell Pharmaceuticals Inc.	Anticoagulant peptides
US5236898A (en) *	1987-05-21	1993-08-17	Merrell Dow Pharmaceuticals Inc.	Cyclic anticoagulant peptides
US5192745A (en) *	1987-05-21	1993-03-09	Merrell Dow Pharmaceuticals Inc.	Cyclic anticoagulant peptides
US5256559A (en) *	1988-03-04	1993-10-26	Biogen, Inc.	Methods and compositions for inhibiting platelet aggregation
NZ228995A (en) *	1988-05-10	1992-03-26	Merrell Dow Pharma	Hirudin peptide derivatives and pharmaceutical compositions
JPH04503660A (ja) *	1988-12-05	1992-07-02	バイオジェンインコーポレイテッド	血小板凝集抑制の方法及び組成物
US5232912A (en) *	1988-12-07	1993-08-03	Merrell Dow Pharmaceuticals Inc.	Anticoagulant peptides
AU630132B2 (en) *	1988-12-07	1992-10-22	Merrell Dow Pharmaceuticals Inc.	Anticoagulant peptides
US5196404B1 (en) *	1989-08-18	1996-09-10	Biogen Inc	Inhibitors of thrombin
US5240913A (en) *	1989-08-18	1993-08-31	Biogen, Inc.	Inhibitors of thrombin
ZA907743B (en) *	1989-10-03	1991-07-31	Merrell Dow Pharma	Radiolabeled anticoagulant peptides
CA2026376C (en) *	1989-10-03	2002-01-01	John L. Krstenansky	Anticoagulant peptides
US5192747A (en) *	1989-10-03	1993-03-09	Merrell Dow Pharmaceuticals Inc.	Anticoagulant peptides
CA2035917C (en) *	1990-02-13	2001-10-02	John L. Krstenansky	Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
DE4005591A1 (de) *	1990-02-22	1991-09-05	Behringwerke Ag	Die blutgerinnung inhibierende peptide, verfahren zu ihrer herstellung und ihre verwendung
US6060451A (en) *	1990-06-15	2000-05-09	The National Research Council Of Canada	Thrombin inhibitors based on the amino acid sequence of hirudin
AU640502B2 (en) *	1990-07-24	1993-08-26	Merrell Dow Pharmaceuticals Inc.	Analogs of hirudin having antiplatelet activity
US5574012A (en) *	1990-07-24	1996-11-12	Merrell Pharmaceuticals Inc.	Analogs of hirudin having anti-platelet activity
CA2086243C (en) *	1990-07-24	2001-10-02	John L. Krstenansky	Anticoagulant peptides
US5242810A (en) *	1990-12-07	1993-09-07	Biogen, Inc.	Bifunctional inhibitors of thrombin and platelet activation
DE4103649A1 (de) *	1991-02-07	1992-08-13	Basf Ag	Neue antikoagulatorisch wirksame peptide
US5767235A (en) *	1991-03-05	1998-06-16	Nippon Mining Company Limited	Anticoagulant hirudin variants and methods for their production
ATE142642T1 (de) *	1991-03-05	1996-09-15	Japan Energy Corp	Hirudinanalog oder dessen salz, dessen herstellung und das als aktiven bestandteil enthaltende antikoagulanz
IT1250689B (it) *	1991-07-22	1995-04-21	Marco Gerna	Analoghi dell'irudina e procedimento per la loro preparazione
PT100757A (pt) *	1991-07-31	1993-10-29	Pasteur Institut	Polipeptidos aptos para induzir "in vivo"anticorpos capazes de inibir a invasao de globulos vermelhos por merozoitos de "p.falciparum", produtos aparentados e sua aplicacao na producao de composicoes de vacinacao
EP0702696B1 (en) *	1993-06-11	2003-07-30	Merrell Pharmaceuticals Inc.	Trifunctional antithrombin and antiplatelet peptides
GB9426038D0 (en)	1994-12-22	1995-02-22	Iaf Biochem Int	Low molecular weight bicyclic thrombin inhibitors
US6057314A (en) *	1995-12-21	2000-05-02	Biochem Pharma Inc.	Low molecular weight bicyclic thrombin inhibitors
US5831003A (en) *	1996-06-28	1998-11-03	Bayer Corporation	Peptides which bind to prothrombin and thrombin
GB0209249D0 (en) *	2002-04-23	2002-06-05	Evolutec Ltd	Anticoagulants
GB0711779D0 (en) *	2007-06-18	2007-07-25	Univ Singapore	Thrombin inhibitor
CN102757479B (zh) *	2012-05-09	2014-04-30	北京林业大学	高活性降血压肽及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3445517C2 (de) *	1984-12-13	1993-11-18	Ciba Geigy	Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
DE3445532A1 (de) *	1984-12-13	1986-06-19	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3506992A1 (de) *	1985-02-27	1986-08-28	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
MY101203A (en) *	1985-12-12	1991-08-17	Ucp Gen Pharma Ag	Production of thrombin iinhibitors.

1988
- 1988-01-15 CA CA000556652A patent/CA1341032C/en not_active Expired - Fee Related
- 1988-01-19 JP JP63007651A patent/JP2709817B2/ja not_active Expired - Fee Related
- 1988-01-19 NZ NZ223236A patent/NZ223236A/xx unknown
- 1988-01-21 IL IL85159A patent/IL85159A/xx not_active IP Right Cessation
- 1988-01-21 AR AR88309880A patent/AR245140A1/es active
- 1988-01-21 KR KR1019880000432A patent/KR960014105B1/ko not_active IP Right Cessation
- 1988-01-22 HU HU88258A patent/HU199159B/hu unknown
- 1988-01-22 PH PH36388A patent/PH26263A/en unknown
- 1988-01-22 NO NO880268A patent/NO174105C/no unknown
- 1988-01-22 AT AT88100934T patent/ATE110743T1/de not_active IP Right Cessation
- 1988-01-22 AU AU10729/88A patent/AU601801B2/en not_active Ceased
- 1988-01-22 DE DE3851238T patent/DE3851238T2/de not_active Expired - Fee Related
- 1988-01-22 DK DK198800310A patent/DK173757B1/da not_active IP Right Cessation
- 1988-01-22 ES ES88100934T patent/ES2063740T3/es not_active Expired - Lifetime
- 1988-01-22 PT PT86600A patent/PT86600B/pt not_active IP Right Cessation
- 1988-01-22 EP EP88100934A patent/EP0276014B1/en not_active Expired - Lifetime
- 1988-01-22 IE IE16788A patent/IE63547B1/en not_active IP Right Cessation
- 1988-01-22 FI FI880286A patent/FI89060C/fi not_active IP Right Cessation
- 1988-01-23 CN CN198888100260A patent/CN88100260A/zh active Pending

Also Published As

Publication number	Publication date
JPS63215698A (ja)	1988-09-08
AU1072988A (en)	1988-07-28
IE63547B1 (en)	1995-05-17
PT86600B (pt)	1991-12-31
DK173757B1 (da)	2001-09-10
FI880286A (fi)	1988-07-24
AU601801B2 (en)	1990-09-20
PT86600A (pt)	1988-02-01
PH26263A (en)	1992-04-01
FI89060B (fi)	1993-04-30
DE3851238T2 (de)	1995-03-16
HU199159B (en)	1990-01-29
KR880009045A (ko)	1988-09-13
NO880268D0 (no)	1988-01-22
IL85159A (en)	1993-04-04
DK31088D0 (da)	1988-01-22
FI89060C (fi)	1993-08-10
NO174105B (no)	1993-12-06
NZ223236A (en)	1989-11-28
NO880268L (no)	1988-07-25
AR245140A1 (es)	1993-12-30
CN88100260A (zh)	1988-11-09
FI880286A0 (fi)	1988-01-22
IE880167L (en)	1988-07-23
HUT46339A (en)	1988-10-28
EP0276014A3 (en)	1990-05-16
NO174105C (no)	1994-03-16
DE3851238D1 (de)	1994-10-06
EP0276014B1 (en)	1994-08-31
CA1341032C (en)	2000-06-20
IL85159A0 (en)	1988-06-30
ATE110743T1 (de)	1994-09-15
KR960014105B1 (ko)	1996-10-14
EP0276014A2 (en)	1988-07-27
JP2709817B2 (ja)	1998-02-04
ES2063740T3 (es)	1995-01-16

Publication	Publication Date	Title
DK31088A (da)	1988-07-24	Blodkoaguleringsnedsaettende peptidderivater
DK22588D0 (da)	1988-01-19	Peptidderivater
NO179394C (no)	1996-10-02	Blod-prövetakingssett
FI88259B (fi)	1993-01-15	Kirurgisk reparationsanordning
BR8703588A (pt)	1988-03-22	Oxigenador sanguineo
DK540289A (da)	1990-05-01	Protein
DK532787A (da)	1988-04-14	Peptidderivater
DK555088A (da)	1989-04-08	Blodtagningsventil
DK299087D0 (da)	1987-06-12	Proteins and derivatives thereof
BR8807112A (pt)	1989-10-31	Forceps cirurgico
DK275788D0 (da)	1988-05-20	Protein
DK565089D0 (da)	1989-11-10	Hudpraeparater
BR8900714A (pt)	1989-10-17	Agrafadora cirurgica
DK250088A (da)	1988-11-08	Ophthalmologisk praeparat
DK109590A (da)	1990-07-02	Biologisk aktivt protein
DK444288D0 (da)	1988-08-09	Humant reg - protein
DK4390D0 (da)	1990-01-08	Peptidderivater
DK178089A (da)	1989-10-15	Proteinoprensningsfremgangsmaade
DK125687A (da)	1987-10-16	Patientkran-chassis
DK679488A (da)	1989-06-08	Peptidderivater
KR890015994U (ko)	1989-08-18	휴지 걸이
KR900008052U (ko)	1990-05-01	개량 휴지걸이
KR900002318U (ko)	1990-02-06	치질 환자용 팬티
DE3990085T1 (de)	1990-01-11	Ophthalmologisches instrument
BR8704479A (pt)	1987-12-29	Especulo cirurgico

Legal Events

Date	Code	Title	Description
2001-09-10	B1	Patent granted (law 1993)
2004-09-06	PBP	Patent lapsed	Country of ref document: DK