DK3095441T3 - Hurtigt opløsende doseringsform af en oral vaccine under anvendelse af stivelse - Google Patents

Hurtigt opløsende doseringsform af en oral vaccine under anvendelse af stivelse Download PDF

Info

Publication number: DK3095441T3
Authority: DK; Denmark
Prior art keywords: starch; dosage form; oral vaccine; dissolving dosage; quick dissolving
Prior art date: 2010-10-08

Application number

DK16178493.9T

Other languages

English (en)

Inventor

Rosie Mclaughlin

Wei Tian

Original Assignee

Scherer Technologies Llc R P

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-10-08

Filing date

2011-10-11

Publication date

2021-01-11

2011-10-11 Application filed by Scherer Technologies Llc R P filed Critical Scherer Technologies Llc R P

2021-01-11 Application granted granted Critical

2021-01-11 Publication of DK3095441T3 publication Critical patent/DK3095441T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Virology (AREA)
Immunology (AREA)
Microbiology (AREA)
Zoology (AREA)
Mycology (AREA)
Organic Chemistry (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Inorganic Chemistry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Medicinal Preparation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK16178493.9T 2010-10-08 2011-10-11 Hurtigt opløsende doseringsform af en oral vaccine under anvendelse af stivelse DK3095441T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US39123810P	2010-10-08	2010-10-08
EP11779263.0A EP2624815B8 (en)	2010-10-08	2011-10-11	Oral vaccine fast-dissolving dosage form using starch

Publications (1)

Publication Number	Publication Date
DK3095441T3 true DK3095441T3 (da)	2021-01-11

Family

ID=44908091

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK11779263.0T DK2624815T3 (da)	2010-10-08	2011-10-11	Oral vaccine i hurtigt opløsende doseringsform under anvendelse af stivelse
DK16178493.9T DK3095441T3 (da)	2010-10-08	2011-10-11	Hurtigt opløsende doseringsform af en oral vaccine under anvendelse af stivelse

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK11779263.0T DK2624815T3 (da)	2010-10-08	2011-10-11	Oral vaccine i hurtigt opløsende doseringsform under anvendelse af stivelse

Country Status (18)

Country	Link
US (1)	US9956169B2 (da)
EP (2)	EP3095441B1 (da)
JP (2)	JP6061859B2 (da)
KR (1)	KR101751964B1 (da)
CN (2)	CN103347494A (da)
AR (1)	AR083361A1 (da)
AU (1)	AU2011312107B2 (da)
BR (1)	BR112013009255B1 (da)
CA (1)	CA2813146C (da)
DK (2)	DK2624815T3 (da)
ES (2)	ES2602506T3 (da)
HK (1)	HK1253541A1 (da)
HU (1)	HUE052853T2 (da)
MX (2)	MX386380B (da)
PL (1)	PL3095441T3 (da)
PT (1)	PT3095441T (da)
RU (2)	RU2639447C2 (da)
WO (1)	WO2012048333A1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX386380B (es) *	2010-10-08	2025-03-18	Scherer Technologies Llc R P	Forma de dosis de disolución rápida de vacuna oral que usa almidón.
US11033493B2 (en)	2013-12-02	2021-06-15	Intelgenx Corp.	Film dosage form with extended release mucoadhesive particles
US9668970B2 (en) *	2013-12-02	2017-06-06	Intelgenx Corp.	Film dosage form with extended release mucoadhesive particles
US10272038B2 (en)	2013-12-02	2019-04-30	Intelgenx Corp.	Film dosage form with extended release mucoadhesive particles
TWI745278B (zh)	2014-10-10	2021-11-11	以色列商艾畢克生物實驗有限公司	發泡性降低之疫苗組合物
CN104530489B (zh) *	2015-02-05	2017-07-07	湖南尔康制药股份有限公司	一种速溶于水的淀粉成膜组合物
CN109224191A (zh) *	2018-07-23	2019-01-18	西安交通大学医学院第附属医院	一种用于静脉输液用的无菌输液港辅助植入装置
US11523988B2 (en) *	2018-11-29	2022-12-13	Catalent U.K. Swindon Zydis Limited	Oral dispersible vaccine comprising virosomes
PL3791395T3 (pl)	2019-07-31	2022-01-24	Catalent U.K. Swindon Zydis Limited	Gęstościomierz przepływowy do dozowania formulacji farmaceutycznej
BR112023003769A2 (pt)	2020-09-17	2023-03-28	Catalent Uk Swindon Zydis Ltd	Uso de tensoativo com formulações de dosagem a base de gelatina de peixe de alto peso molecular para melhorar as características de fluxo
GB2615464B (en)	2020-10-08	2025-01-01	Catalent Uk Swindon Zydis Ltd	Stable oral dispersible formulation for epinephrine and salts or solvates thereof
US11672761B2 (en)	2020-11-16	2023-06-13	Orcosa Inc.	Rapidly infusing platform and compositions for therapeutic treatment in humans

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1548022A (en)	1976-10-06	1979-07-04	Wyeth John & Brother Ltd	Pharmaceutial dosage forms
US5079018A (en) *	1989-08-14	1992-01-07	Neophore Technologies, Inc.	Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
IT1250421B (it)	1991-05-30	1995-04-07	Recordati Chem Pharm	Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.
BR9405996A (pt) *	1993-03-11	1995-12-19	Secretech Inc	Mucoadesivos poliméricos na distribuição de imunógenos em superfícies mucosais
GB9517062D0 (en) *	1995-08-18	1995-10-25	Scherer Ltd R P	Pharmaceutical compositions
AU7682896A (en) *	1995-10-13	1997-04-30	Zynaxis, Inc.	Solid, orally administrable viral vaccines and methods of preparation
GB9700878D0 (en) *	1997-01-17	1997-03-05	Scherer Ltd R P	Dosage forms and method for ameliorating male erectile dysfunction
US5976577A (en) *	1997-07-11	1999-11-02	Rp Scherer Corporation	Process for preparing fast dispersing solid oral dosage form
EP1579851A3 (en) *	1997-08-29	2009-09-02	Corixa Corporation	Rapid release encapsulated bioactive agents for inducing or potentiating an immune response and methods of use thereof
GB9722682D0 (en) *	1997-10-27	1997-12-24	Scherer Ltd R P	Pharmaceutical products
US20040265377A1 (en)	1997-10-27	2004-12-30	Harry Seager	Solid dispersing vaccine composition for oral delivery
GB9901819D0 (en) *	1999-01-27	1999-03-17	Scherer Corp R P	Pharmaceutical compositions
GB9908014D0 (en) *	1999-04-08	1999-06-02	Scherer Corp R P	Pharmaceutical compositions
WO2001034801A2 (en)	1999-11-12	2001-05-17	Fibrogen, Inc.	Recombinant gelatin in vaccines
EP1120109A3 (en) *	2000-01-24	2002-07-10	Pfizer Products Inc.	Rapidly disintegrating and fast dissolving solid dosage form
GB0020089D0 (en)	2000-08-15	2000-10-04	Smithkline Beecham Biolog	Vaccine Composition
US6509040B1 (en)	2001-06-22	2003-01-21	R.P. Scherer Corporation	Fast dispersing dosage forms essentially free of mammalian gelatin
GB0210397D0 (en) *	2002-05-07	2002-06-12	Ferring Bv	Pharmaceutical formulations
DE60307082T4 (de) *	2002-05-07	2015-04-30	Ferring B.V.	In der mundhöhle dispergierbare phamarzeutische zusammensetzung mit desmopressin
KR20050052467A (ko) *	2002-08-12	2005-06-02	다이나박스 테크놀로지 코퍼레이션	면역조절 조성물, 이의 제조방법 및 이의 이용방법
AU2003280324A1 (en) *	2002-11-26	2004-06-18	Alk-Abello A/S	Pharmaceutical allergen product
US8012505B2 (en) *	2003-02-28	2011-09-06	Alk-Abello A/S	Dosage form having a saccharide matrix
JP2006525308A (ja) *	2003-05-02	2006-11-09	ワーナー−ランバートカンパニーリミティドライアビリティーカンパニー	耐熱性および耐湿性が改善された変性デンプンを含有する速溶性の経口消耗フィルム
AU2004281634B2 (en)	2003-09-03	2011-01-27	Dendritherapeutics, Inc.	Multiplex vaccines
US7972621B2 (en) *	2004-06-03	2011-07-05	R.P. Scherer Technologies, Llc	Process for formulating fast dispersing dosage forms comprising at least one fish gelatin selected on the basis of molecular weight
US20090155351A1 (en)	2005-10-04	2009-06-18	Alk-Abello A/S	Solid Vaccine Formulation
US20070166239A1 (en) *	2006-01-13	2007-07-19	Haixiang Lin	Mucosal immunogenic substances comprising a polyinosinic acid - polycytidilic acid based adjuvant
WO2008002663A2 (en) *	2006-06-28	2008-01-03	The Board Of Trustees Of The Leland Stanford Junior University	Immunogenic protein constructs
US20110059130A1 (en) *	2007-08-20	2011-03-10	Fraunhofer Usa, Inc.	Prophylactic and therapeutic influenza vaccines, antigens, compositions and methods
EP2247284B1 (en) *	2008-02-28	2017-04-19	R.P. Scherer Technologies, LLC	Process to minimize polymorphism
JP2011526888A (ja) *	2008-07-01	2011-10-20	ザ・ジョンズ・ホプキンス・ユニバーシティ	治療薬を標的送達するための経口速溶性薄膜
WO2010036970A2 (en) *	2008-09-25	2010-04-01	Fraunhofer Usa, Inc.	Influenza vaccines, antigens, compositions, and methods
KR101074271B1 (ko) *	2009-06-25	2011-10-17	(주)차바이오앤디오스텍	불쾌한 맛을 효과적으로 은폐한 경구용 속용 필름
US8545879B2 (en) *	2009-08-31	2013-10-01	Wilmington Pharmaceuticals, Llc	Fast disintegrating compositions of meloxicam
KR101612073B1 (ko) *	2009-10-30	2016-04-14	아이엑스 바이오파마 리미티드	신속 용해 고체 투약 제형
GB201009273D0 (en)	2010-06-03	2010-07-21	Glaxosmithkline Biolog Sa	Novel vaccine
RU2539209C2 (ru) *	2010-07-08	2015-01-20	Вм. Ригли Дж. Компани	Кондитерское изделие и способ его изготовления
MX386380B (es) *	2010-10-08	2025-03-18	Scherer Technologies Llc R P	Forma de dosis de disolución rápida de vacuna oral que usa almidón.

2011
- 2011-10-11 MX MX2017004866A patent/MX386380B/es unknown
- 2011-10-11 JP JP2013533011A patent/JP6061859B2/ja active Active
- 2011-10-11 AR ARP110103727A patent/AR083361A1/es not_active Application Discontinuation
- 2011-10-11 US US13/270,411 patent/US9956169B2/en active Active
- 2011-10-11 WO PCT/US2011/055689 patent/WO2012048333A1/en active Application Filing
- 2011-10-11 EP EP16178493.9A patent/EP3095441B1/en active Active
- 2011-10-11 CN CN2011800590592A patent/CN103347494A/zh active Pending
- 2011-10-11 RU RU2013119946A patent/RU2639447C2/ru not_active Application Discontinuation
- 2011-10-11 KR KR1020137011905A patent/KR101751964B1/ko active Active
- 2011-10-11 DK DK11779263.0T patent/DK2624815T3/da active
- 2011-10-11 CN CN201810325584.8A patent/CN108434089B/zh active Active
- 2011-10-11 EP EP11779263.0A patent/EP2624815B8/en active Active
- 2011-10-11 HU HUE16178493A patent/HUE052853T2/hu unknown
- 2011-10-11 MX MX2013003875A patent/MX347101B/es active IP Right Grant
- 2011-10-11 ES ES11779263.0T patent/ES2602506T3/es active Active
- 2011-10-11 BR BR112013009255-6A patent/BR112013009255B1/pt active IP Right Grant
- 2011-10-11 DK DK16178493.9T patent/DK3095441T3/da active
- 2011-10-11 PL PL16178493T patent/PL3095441T3/pl unknown
- 2011-10-11 AU AU2011312107A patent/AU2011312107B2/en active Active
- 2011-10-11 PT PT161784939T patent/PT3095441T/pt unknown
- 2011-10-11 ES ES16178493T patent/ES2842290T3/es active Active
- 2011-10-11 CA CA2813146A patent/CA2813146C/en active Active
2016
- 2016-09-09 JP JP2016176393A patent/JP6403738B2/ja active Active
2017
- 2017-10-25 RU RU2017137357A patent/RU2017137357A/ru unknown
2018
- 2018-10-08 HK HK18112743.5A patent/HK1253541A1/zh unknown

Also Published As

Publication number	Publication date
ES2602506T3 (es)	2017-02-21
KR101751964B1 (ko)	2017-06-28
WO2012048333A1 (en)	2012-04-12
EP3095441A1 (en)	2016-11-23
PL3095441T3 (pl)	2021-06-14
JP2016199605A (ja)	2016-12-01
CN108434089B (zh)	2020-06-16
HK1253541A1 (zh)	2019-06-21
HUE052853T2 (hu)	2021-05-28
AR083361A1 (es)	2013-02-21
RU2013119946A (ru)	2014-11-20
BR112013009255A2 (pt)	2016-07-26
MX347101B (es)	2017-04-12
AU2011312107A1 (en)	2013-05-02
CN103347494A (zh)	2013-10-09
EP2624815B1 (en)	2016-08-10
EP2624815A1 (en)	2013-08-14
EP3095441B1 (en)	2020-12-02
ES2842290T3 (es)	2021-07-13
JP6061859B2 (ja)	2017-01-18
RU2639447C2 (ru)	2017-12-21
MX2013003875A (es)	2013-06-24
PT3095441T (pt)	2021-01-14
BR112013009255B1 (pt)	2021-02-23
CA2813146A1 (en)	2012-04-12
MX386380B (es)	2025-03-18
CN108434089A (zh)	2018-08-24
KR20140091461A (ko)	2014-07-21
JP2013539766A (ja)	2013-10-28
RU2017137357A3 (da)	2019-04-25
AU2011312107B2 (en)	2016-06-23
RU2017137357A (ru)	2019-04-25
US20120087944A1 (en)	2012-04-12
JP6403738B2 (ja)	2018-10-10
DK2624815T3 (da)	2016-11-07
US9956169B2 (en)	2018-05-01
CA2813146C (en)	2018-12-18
EP2624815B8 (en)	2016-09-21

Publication	Publication Date	Title
DK3095441T3 (da)	2021-01-11	Hurtigt opløsende doseringsform af en oral vaccine under anvendelse af stivelse
IL245328A0 (en)	2016-06-30	Pharmaceutical composition
SMT201600350B (it)	2016-11-10	Composizioni farmaceutiche
DK3170508T3 (da)	2020-01-02	Vaccineformuleringer
DK2498756T3 (da)	2019-11-25	Tabletformuleringer af neratinibmaleat
EP2623065A4 (en)	2014-04-02	Dental mill blank
DK3284467T3 (da)	2020-01-20	Nikotinholdige farmaceutiske sammensætninger
DK2528602T4 (da)	2020-04-27	Formuleringer af bendamustin
DK4159204T3 (da)	2024-05-21	Hidtil ukendt farmaceutisk sammensætning
DK3603704T3 (da)	2023-07-24	Indgivelse af medikament
GT201200303A (es)	2014-04-29	Formulaciones farmacéuticas
DK4104848T3 (da)	2024-01-02	Sikker indgivelse af desmopressin
FI20105639A0 (fi)	2010-06-07	Mikroselluloosan valmistus
CO6940426A2 (es)	2014-05-09	Formulaciones farmacéuticas
EP2595653A4 (en)	2014-03-12	INFLUENZA VACCINE
DK2815752T3 (da)	2020-07-20	Oral farmaceutisk sammensætning
BRPI0922653A2 (pt)	2016-01-05	preparação farmacêutica
DK2648696T3 (da)	2020-05-04	Ny indgivelsesform af racecadotril
CO6801722A2 (es)	2013-11-29	Composiciones farmacéuticas
DK3498313T3 (da)	2023-01-09	Rørformede proteser
DK2571843T3 (da)	2018-01-29	Forbedret fremstilling af chalcon-derivater
BR112012022411A2 (pt)	2016-07-05	articulador
BR112014015885A2 (pt)	2017-06-13	preparação farmacêutica
FR2978964B1 (fr)	2015-02-20	Composition vaccinale anti-il-6
EP2763699A4 (en)	2015-05-20	VACCINE