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DK3027598T3 - Oxoquinazolinyl-butanamidderivater - Google Patents

Oxoquinazolinyl-butanamidderivater Download PDF

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Publication number
DK3027598T3
DK3027598T3 DK14739045.4T DK14739045T DK3027598T3 DK 3027598 T3 DK3027598 T3 DK 3027598T3 DK 14739045 T DK14739045 T DK 14739045T DK 3027598 T3 DK3027598 T3 DK 3027598T3
Authority
DK
Denmark
Prior art keywords
butanamidderivater
quinazolinyl
oxo
quinazolinyl butanamidderivater
Prior art date
Application number
DK14739045.4T
Other languages
English (en)
Inventor
Dieter Dorsch
Hans-Peter Buchstaller
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK3027598T3 publication Critical patent/DK3027598T3/da

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK14739045.4T 2013-07-31 2014-07-10 Oxoquinazolinyl-butanamidderivater DK3027598T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13003815 2013-07-31
PCT/EP2014/001895 WO2015014442A1 (en) 2013-07-31 2014-07-10 Oxoquinazolinyl-butanamide derivatives

Publications (1)

Publication Number Publication Date
DK3027598T3 true DK3027598T3 (da) 2017-05-22

Family

ID=48915813

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14739045.4T DK3027598T3 (da) 2013-07-31 2014-07-10 Oxoquinazolinyl-butanamidderivater

Country Status (25)

Country Link
US (1) US9901577B2 (da)
EP (1) EP3027598B1 (da)
JP (1) JP6423875B2 (da)
KR (1) KR102331389B1 (da)
CN (1) CN105392784B (da)
AR (1) AR097087A1 (da)
AU (1) AU2014298955B2 (da)
BR (1) BR112016001645B1 (da)
CA (1) CA2919905C (da)
DK (1) DK3027598T3 (da)
ES (1) ES2632988T3 (da)
HR (1) HRP20171053T1 (da)
HU (1) HUE032846T2 (da)
IL (1) IL243734B (da)
LT (1) LT3027598T (da)
MX (1) MX359656B (da)
NZ (1) NZ716593A (da)
PL (1) PL3027598T3 (da)
PT (1) PT3027598T (da)
RS (1) RS56211B1 (da)
RU (1) RU2669393C2 (da)
SG (1) SG11201600743WA (da)
SI (1) SI3027598T1 (da)
WO (1) WO2015014442A1 (da)
ZA (1) ZA201601333B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2948067A1 (en) 2014-05-07 2015-11-12 Merck Patent Gmbh Heterocyclyl-butanamide derivatives
SG11201803584RA (en) * 2015-11-02 2018-05-30 Merck Patent Gmbh 1,4-dicarbonyl-piperidyl derivatives
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
GB201615282D0 (en) * 2016-09-08 2016-10-26 Univ Bath Tankyrase inhibitors
HUE054382T2 (hu) 2016-12-30 2021-09-28 Mitobridge Inc Poli-ADP ribóz polimeráz (PARP) inhibitorok
AU2018392616B2 (en) 2017-12-21 2023-10-12 Abbvie Biotechnology Ltd Quinazolinones as PARP14 inhibitors
CN109180702B (zh) * 2018-10-29 2021-11-30 四川大学 一种噻吩并嘧啶酮化合物及其用途
AU2019392502A1 (en) 2018-12-03 2021-07-22 Merck Patent Gmbh 4-heteroarylcarbonyl-N-(phenyl or heteroaryl) piperidine-1-carboxamides as inhibitors of tankyrases
IL296533B1 (en) * 2020-03-19 2025-12-01 Merck Patent Gmbh Tetrazole derivatives, their preparation and pharmaceutical compositions containing them
MX2024001925A (es) 2021-08-13 2024-07-09 Glaxosmithkline Ip Dev Ltd Quimeras dirigidas a la citotoxicidad para células que expresan ccr2.
WO2023161881A1 (en) * 2022-02-25 2023-08-31 Glaxosmithkline Intellectual Property Development Limited Cytotoxicity targeting chimeras for ccr2-expressing cells
WO2025111705A1 (en) * 2023-11-30 2025-06-05 Waverley Pharma Inc. Quinazolinone derivatives as poly (adp ribose) polymerase 1 (parp-1) inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9202915D0 (en) * 1992-02-12 1992-03-25 Wellcome Found Chemical compounds
AU6348401A (en) * 2000-05-26 2001-12-11 Novirio Pharmaceuticals Ltd Methods of treating hepatitis delta virus infection with beta-l-2'- deoxy-nucleosides
AUPR201600A0 (en) 2000-12-11 2001-01-11 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivative
JPWO2002094790A1 (ja) 2001-05-23 2004-09-09 三菱ウェルファーマ株式会社 縮合ヘテロ環化合物およびその医薬用途
JP4027406B2 (ja) * 2003-03-12 2007-12-26 クドス ファーマシューティカルズ リミテッド フタラジノン誘導体
JP4969443B2 (ja) 2004-06-30 2012-07-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Parp阻害剤としてのキナゾリノン誘導体
AR070221A1 (es) * 2008-01-23 2010-03-25 Astrazeneca Ab Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas.
CN101492425A (zh) * 2009-02-27 2009-07-29 无锡市凯奥善生物医药科技有限公司 一类parp抑制剂的化合物
EP2731942B1 (en) 2011-07-13 2015-09-23 Novartis AG Novel 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors
EP2890696A1 (en) * 2012-08-29 2015-07-08 Amgen, Inc. Quinazolinone compounds and derivatives thereof

Also Published As

Publication number Publication date
CN105392784A (zh) 2016-03-09
CA2919905A1 (en) 2015-02-05
LT3027598T (lt) 2017-06-12
AR097087A1 (es) 2016-02-17
KR102331389B1 (ko) 2021-11-26
RS56211B1 (sr) 2017-11-30
NZ716593A (en) 2021-07-30
ES2632988T3 (es) 2017-09-18
ZA201601333B (en) 2019-12-18
JP6423875B2 (ja) 2018-11-14
CA2919905C (en) 2021-08-10
RU2669393C2 (ru) 2018-10-11
BR112016001645B1 (pt) 2023-04-11
KR20160037985A (ko) 2016-04-06
IL243734A0 (en) 2016-04-21
BR112016001645A2 (pt) 2017-08-01
MX359656B (es) 2018-10-05
JP2016525556A (ja) 2016-08-25
PT3027598T (pt) 2017-07-17
US9901577B2 (en) 2018-02-27
PL3027598T3 (pl) 2017-09-29
EP3027598B1 (en) 2017-04-12
EP3027598A1 (en) 2016-06-08
WO2015014442A1 (en) 2015-02-05
MX2016001136A (es) 2016-04-29
HRP20171053T1 (hr) 2017-10-06
US20160184310A1 (en) 2016-06-30
HUE032846T2 (en) 2017-11-28
RU2016106952A (ru) 2017-09-04
AU2014298955B2 (en) 2018-03-01
AU2014298955A1 (en) 2016-03-10
HK1222391A1 (zh) 2017-06-30
SG11201600743WA (en) 2016-02-26
BR112016001645A8 (pt) 2020-01-21
SI3027598T1 (sl) 2017-08-31
IL243734B (en) 2019-09-26
RU2016106952A3 (da) 2018-05-14
CN105392784B (zh) 2018-10-09

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