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DK297185D0 - PREPARATION OF BIOLOGICAL ACTIVE PROTEINS, COMPOSED BY MULTIPLE SUBSTANCES, BY RECOMBINANT METHODOLOGY - Google Patents

PREPARATION OF BIOLOGICAL ACTIVE PROTEINS, COMPOSED BY MULTIPLE SUBSTANCES, BY RECOMBINANT METHODOLOGY

Info

Publication number
DK297185D0
DK297185D0 DK297185A DK297185A DK297185D0 DK 297185 D0 DK297185 D0 DK 297185D0 DK 297185 A DK297185 A DK 297185A DK 297185 A DK297185 A DK 297185A DK 297185 D0 DK297185 D0 DK 297185D0
Authority
DK
Denmark
Prior art keywords
preparation
biological active
active proteins
recombinant methodology
hormone
Prior art date
Application number
DK297185A
Other languages
Danish (da)
Other versions
DK171489B1 (en
DK297185A (en
Inventor
Vemuri B Reddy
Nancy Hsiung
Anton K Beck
Edward George Bernstine
Original Assignee
Integrated Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24187868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK297185(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Integrated Genetics Inc filed Critical Integrated Genetics Inc
Publication of DK297185A publication Critical patent/DK297185A/en
Publication of DK297185D0 publication Critical patent/DK297185D0/en
Application granted granted Critical
Publication of DK171489B1 publication Critical patent/DK171489B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Steroid Compounds (AREA)

Abstract

A biologically active secreted protein composed of a plurality of subunits is prepared by a recombinant methodology. Each subunit is synthesized by a cell having an autonomously replicating expression vector i.e. a plasmid or virus containing heterologous DNA encoding for the subunit. The preferred host is a eukaryotic cell. The secreted protein is a hormone such as hCG, luteinizing hormone (LH), follicle stimulating hormone (FSH) or thyroid stimulating hormone (TSH).
DK297185A 1983-11-02 1985-07-01 A method for producing a biologically active, post-translationally modified protein hormone composed of multiple subunits, eukaryotic cell transfected with one or more expression vectors and capable of producing such a hormone, expression vector comprising heterologous DNA encoding the subunits of the hormone, a set of expression vectors, each vector comprising DK171489B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US54821183A 1983-11-02 1983-11-02
US54821183 1983-11-02
PCT/US1984/001771 WO1985001959A1 (en) 1983-11-02 1984-10-31 Production of heterodimeric human fertlity hormones
US8401771 1984-10-31

Publications (3)

Publication Number Publication Date
DK297185A DK297185A (en) 1985-07-01
DK297185D0 true DK297185D0 (en) 1985-07-01
DK171489B1 DK171489B1 (en) 1996-11-25

Family

ID=24187868

Family Applications (2)

Application Number Title Priority Date Filing Date
DK297185A DK171489B1 (en) 1983-11-02 1985-07-01 A method for producing a biologically active, post-translationally modified protein hormone composed of multiple subunits, eukaryotic cell transfected with one or more expression vectors and capable of producing such a hormone, expression vector comprising heterologous DNA encoding the subunits of the hormone, a set of expression vectors, each vector comprising
DK297285A DK297285D0 (en) 1983-11-02 1985-07-01 PREPARATION OF HETERODIMER HUMAN FERTILITY HORMONES BY RECOMBINANT METHODOLOGY

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK297285A DK297285D0 (en) 1983-11-02 1985-07-01 PREPARATION OF HETERODIMER HUMAN FERTILITY HORMONES BY RECOMBINANT METHODOLOGY

Country Status (8)

Country Link
EP (3) EP0578328B1 (en)
AT (2) ATE190461T1 (en)
DE (4) DE3486469T2 (en)
DK (2) DK171489B1 (en)
LU (1) LU90770I2 (en)
MX (1) MX9203334A (en)
NL (1) NL300044I2 (en)
WO (1) WO1985001959A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639639A (en) * 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
US4923805A (en) * 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
JPS60145098A (en) * 1984-01-09 1985-07-31 Suntory Ltd Preparation of polypeptide adduct with saccharide
AU5993186A (en) * 1985-06-04 1987-01-07 Biotechnology Research Partners Limited Autoantigen vaccines
CA1340740C (en) * 1987-12-08 1999-09-14 Eileen R. Mulvihill Co-expression in eukaryotic cells
US5648254A (en) * 1988-01-15 1997-07-15 Zymogenetics, Inc. Co-expression in eukaryotic cells
DE69029799T2 (en) * 1989-02-21 1997-05-28 Washington University, St. Louis, Mo. MODIFIED FORMS OF REPRODUCTION HORMONES
US5705478A (en) * 1989-02-21 1998-01-06 Washington University Covalently linked β subunits of the glycoprotein hormones as antagonists
US6225449B1 (en) 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
US5792460A (en) * 1989-02-21 1998-08-11 Washington University Modified glycoprotein hormones having a CTP at the amino terminus
US6028177A (en) * 1991-10-04 2000-02-22 Washington University Methods of detecting single-chain forms of the glycoprotein hormone quartet
IT1250075B (en) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca PHARMACEUTICAL COMPOSITIONS CONTAINING GONADOTROPINE.
US6737515B2 (en) 1993-11-19 2004-05-18 Washington University Follicle stimulating hormone-glycosylation analogs
US6238890B1 (en) 1994-02-18 2001-05-29 Washington University Single chain forms of the glycoprotein hormone quartet
MX9601320A (en) * 1994-08-12 1997-05-31 Univ Washington Single-chain forms of the glycoprotein hormone quartet.
CA2173750C (en) * 1994-08-12 2011-03-22 Irving Boime Single-chain forms of the glycoprotein hormone quartet
US6635256B1 (en) 1998-10-19 2003-10-21 Washington University Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
US6103501A (en) * 1997-11-17 2000-08-15 Washington University Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
EP1013281A1 (en) 1998-12-15 2000-06-28 Applied Research Systems ARS Holding N.V. hCG therapy for the treatment of breast cancer
TWI277425B (en) 1999-04-13 2007-04-01 Lilly Co Eli Pulmonary administration of dry powder formulations for treating infertility
MXPA04004289A (en) * 2001-11-08 2005-03-31 William R Moyle Protein knobs.
US7081446B2 (en) 2002-01-31 2006-07-25 The Trustees Of Columbia University In The City Of New York Long-acting follicle stimulating hormone analogues and uses thereof
BRPI0613042A2 (en) 2005-07-15 2010-12-14 Serono Lab jnk inhibitors for the treatment of endometriosis
KR20080044836A (en) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. KUN inhibitors for the treatment of endometriosis
CN101304736A (en) 2005-09-07 2008-11-12 雪兰诺实验室公司 IKK Inhibitors for Endometriosis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2048894A (en) * 1979-05-11 1980-12-17 Gist Brocades Nv Plasmid
US4419446A (en) * 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations

Also Published As

Publication number Publication date
EP0160699A1 (en) 1985-11-13
DK171489B1 (en) 1996-11-25
EP0578328A1 (en) 1994-01-12
DE10199035I2 (en) 2006-03-16
EP0578328B1 (en) 1999-12-29
DE10199035I1 (en) 2001-11-08
DK297285A (en) 1985-07-01
DE10199028I1 (en) 2001-09-20
NL300044I1 (en) 2001-07-02
DE3486474T2 (en) 2000-08-03
EP0957167A1 (en) 1999-11-17
ATE190461T1 (en) 2000-04-15
EP0160699B1 (en) 1992-08-12
ATE169334T1 (en) 1998-08-15
DE3486474D1 (en) 2000-02-03
DE3486469D1 (en) 1998-09-10
NL300044I2 (en) 2001-12-01
DE3486469T2 (en) 1999-04-15
EP0160699A4 (en) 1987-10-20
DK297285D0 (en) 1985-07-01
DE10199028I2 (en) 2004-07-01
WO1985001959A1 (en) 1985-05-09
MX9203334A (en) 1992-09-01
LU90770I2 (en) 2001-07-03
DK297185A (en) 1985-07-01

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