DK290986A - 2-arylimidazolforbindelser, laegemidler indeholdende disse forbindelser og deres fremstilling - Google Patents

2-arylimidazolforbindelser, laegemidler indeholdende disse forbindelser og deres fremstilling Download PDF

Info

Publication number: DK290986A
Authority: DK; Denmark
Prior art keywords: compounds; preparation; arylimidazole; pharmaceuticals containing; pharmaceuticals
Prior art date: 1985-06-21

Application number

DK290986A

Other languages

Danish (da)

English (en)

Other versions

DK290986D0 (da

Inventor

Erich Mueller

Norbert Hauel

Klaus Noll

Berthold Narr

Joachim Heider

Manfred Psiorz

Andreas Bomhard

Jacques Van Meel

Willi Diederen

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-06-21

Filing date

1986-06-20

Publication date

1986-12-22

1986-06-20 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1986-06-20 Publication of DK290986D0 publication Critical patent/DK290986D0/da

1986-12-22 Publication of DK290986A publication Critical patent/DK290986A/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK290986A 1985-06-21 1986-06-20 2-arylimidazolforbindelser, laegemidler indeholdende disse forbindelser og deres fremstilling DK290986A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19853522230 DE3522230A1 (de)	1985-06-21	1985-06-21	Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (2)

Publication Number	Publication Date
DK290986D0 DK290986D0 (da)	1986-06-20
DK290986A true DK290986A (da)	1986-12-22

Family

ID=6273829

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK290986A DK290986A (da)	1985-06-21	1986-06-20	2-arylimidazolforbindelser, laegemidler indeholdende disse forbindelser og deres fremstilling

Country Status (12)

Country	Link
EP (1)	EP0209707A3 (fi)
JP (1)	JPS62471A (fi)
AU (1)	AU5893286A (fi)
DE (1)	DE3522230A1 (fi)
DK (1)	DK290986A (fi)
ES (3)	ES8800907A1 (fi)
FI (1)	FI862623A (fi)
GR (1)	GR861583B (fi)
HU (1)	HUT42452A (fi)
NO (1)	NO862477L (fi)
PT (1)	PT82789B (fi)
ZA (1)	ZA864602B (fi)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LU85544A1 (fr) *	1984-09-19	1986-04-03	Cird	Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique
GB8510758D0 (en) *	1985-04-27	1985-06-05	Wellcome Found	Compounds
DE3634066A1 (de) *	1986-10-07	1988-04-21	Boehringer Mannheim Gmbh	Neue 5-alkylbenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel
ZA889365B (en) *	1987-12-22	1990-08-29	Lilly Co Eli	Hydrates of andinotropic agent
GB8804016D0 (en) *	1988-02-22	1988-03-23	Boots Co Plc	Therapeutic agents
IL94390A (en) *	1989-05-30	1996-03-31	Merck & Co Inc	The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
US5064825A (en) *	1989-06-01	1991-11-12	Merck & Co., Inc.	Angiotensin ii antagonists
JPH06759B2 (ja) *	1989-09-22	1994-01-05	ファイザー製薬株式会社	新規なベンゾイミダゾール化合物
US5208240A (en) *	1991-03-12	1993-05-04	Merrell Dow Pharmaceuticals Inc.	8-substituted purines as selective adenosine receptor agents
US5506361A (en) *	1991-05-08	1996-04-09	Theupjohn Company	Imidazobenzoquinones and composition for preventing or treating hypertension or congestive heart failure containing the same
JPH05112533A (ja) *	1991-05-08	1993-05-07	Upjohn Co:The	イミダゾベンゾキノン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤
US5821258A (en) *	1994-12-27	1998-10-13	Mitsui Chemicals, Inc.	Phenylbenzimidazole derivatives
CA2225465A1 (en) *	1995-08-02	1997-02-13	Newcastle University Ventures Limited	Benzimidazole compounds
WO2000026192A1 (de)	1998-11-03	2000-05-11	Basf Aktiengesellschaft	Substituierte 2-phenylbenzimidazole, deren herstellung und anwendung
CA2350734C (en) *	1998-11-17	2006-10-10	Basf Aktiengesellschaft	2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof
DE19918211A1 (de) *	1999-04-22	2000-10-26	Basf Ag	Cycloalkylsubstituierte Benzimidazole, deren Herstellung und Anwendung
US6448281B1 (en)	2000-07-06	2002-09-10	Boehringer Ingelheim (Canada) Ltd.	Viral polymerase inhibitors
EP2335700A1 (en)	2001-07-25	2011-06-22	Boehringer Ingelheim (Canada) Ltd.	Hepatitis C virus polymerase inhibitors with a heterobicylic structure
JP4637481B2 (ja)	2001-10-19	2011-02-23	オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド	Ｃｄｓ１／ｃｈｋ２阻害剤および癌治療における化学療法または放射線療法の補助剤としての２−フェニルベンズイミダゾールおよびイミダゾ−［４，５］−ピリジン
WO2003087062A2 (en) *	2002-04-05	2003-10-23	Cadila Healthcare Limited	4-(heterocyclyl)-benzenesulfoximine compounds for the treatment of inflammation
JP4334476B2 (ja) *	2002-07-29	2009-09-30	株式会社静岡カフェイン工業所	１，３アゾール誘導体及び同誘導体を含む血栓症治療のための医薬組成物
US7223785B2 (en)	2003-01-22	2007-05-29	Boehringer Ingelheim International Gmbh	Viral polymerase inhibitors
US7098231B2 (en)	2003-01-22	2006-08-29	Boehringer Ingelheim International Gmbh	Viral polymerase inhibitors
DE602004006852D1 (de)	2003-04-17	2007-07-19	Janssen Pharmaceutica Nv	2-phenyl-benzimidazol und 2-phenyl-imidazo-4,5ü-pyridin-derivate als checkpoint-kinase-cds1 (chk2)-hemmer zur behandlung von krebs
SG150511A1 (en)	2004-02-20	2009-03-30	Boehringer Ingelheim Int	Viral polymerase inhibitors
ES2362102T3 (es)	2004-06-30	2011-06-28	Janssen Pharmaceutica Nv	Eteres de bencimidazol e imidazopiridina sustituidos con arilo como agentes anticáncer.
TWI375673B (en)	2005-04-11	2012-11-01	Abbott Lab	1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
US7728026B2 (en)	2005-04-11	2010-06-01	Abbott Laboratories, Inc.	2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors
CA2618682C (en)	2005-08-12	2011-06-21	Boehringer Ingelheim International Gmbh	Viral polymerase inhibitors
CA2628461C (en)	2005-11-15	2013-09-24	Abbott Laboratories	Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors
EP2012780B1 (en)	2006-05-02	2012-04-11	Abbott Laboratories	Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors
US8067613B2 (en)	2007-07-16	2011-11-29	Abbott Laboratories	Benzimidazole poly(ADP ribose)polymerase inhibitors
WO2010083199A1 (en)	2009-01-19	2010-07-22	Abbott Laboratories	Benzthiazole inhibitors of poly(adp-ribose)polymerase
EP3006429B1 (en) *	2010-12-24	2019-02-06	Sumitomo Chemical Co., Ltd.	Fused heterocyclic compound and use for pest control thereof
CN105246876B (zh) *	2013-02-28	2017-06-16	住友化学株式会社	稠合杂环化合物及其有害生物防除用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1089853A (en) *	1965-02-25	1967-11-08	Merck & Co Inc	Substituted benzimidazoles and compositions containing them
US3669979A (en) *	1967-12-14	1972-06-13	Gaf Corp	Novel process for the production of 2-benzothiazolyl-phenol and derivatives thereof employing phosphorus trichloride as a catalyst
DE2305339C3 (de) *	1973-02-03	1980-05-08	Dr. Karl Thomae Gmbh, 7950 Biberach	Imidazo [4,5-b] pyridine, ihre Herstellung und ihre Verwendung als Cardiötonica
DE2927988A1 (de) *	1979-07-11	1981-02-05	Thomae Gmbh Dr K	Neue 8-phenyl-purine, deren herstellung und deren verwendung als arzneimittel
DE2927987A1 (de) *	1979-07-11	1981-02-05	Thomae Gmbh Dr K	Neue 2-alkoxyphenyl-imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine, deren herstellung und deren verwendung als arzneimittel
DD147317A1 (de) *	1979-11-23	1981-04-01	Gerald Igel	Einrichtung zur elektrischen stimulation des herzens
DE3037464A1 (de) *	1980-10-03	1982-05-19	Dr. Karl Thomae Gmbh, 7950 Biberach	6-hydroxy-2-phenyl-imidazo 4,5-b zu pyridine, ihre herstellung und diese sie enthaltende arzneimittel
DE3044497A1 (de) *	1980-11-26	1982-06-24	Dr. Karl Thomae Gmbh, 7950 Biberach	Neues verfahren zur herstellung von imidazo(4,5-b)pyridinen und -pyrimidinen
ES517193A0 (es) *	1981-11-10	1983-12-01	Wellcome Found	Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.
RO86850B (ro) *	1982-05-03	1985-05-31	Eli Lilly And Company	Procedeu pentru prepararea unor 2-fenilimidazo [4,5 c] piridine
DE3224512A1 (de) *	1982-07-01	1984-01-05	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3324115A1 (de) *	1983-07-05	1985-01-17	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
US4515796A (en) *	1983-09-08	1985-05-07	Eli Lilly And Company	Certain naphthalenyl imidazo compounds and their pharmaceutical use
DE3340076A1 (de) *	1983-11-05	1985-05-15	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue purinderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3346575A1 (de) *	1983-12-23	1985-07-04	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue benzimidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
ZA851236B (en) *	1984-02-24	1986-09-24	Lilly Co Eli	2-arylimidazo 4,5-cpyridines

1985
- 1985-06-21 DE DE19853522230 patent/DE3522230A1/de not_active Withdrawn
1986
- 1986-06-11 EP EP86107969A patent/EP0209707A3/de not_active Withdrawn
- 1986-06-18 GR GR861583A patent/GR861583B/el unknown
- 1986-06-19 FI FI862623A patent/FI862623A/fi not_active IP Right Cessation
- 1986-06-19 PT PT82789A patent/PT82789B/pt unknown
- 1986-06-20 NO NO862477A patent/NO862477L/no unknown
- 1986-06-20 AU AU58932/86A patent/AU5893286A/en not_active Abandoned
- 1986-06-20 ZA ZA864602A patent/ZA864602B/xx unknown
- 1986-06-20 ES ES556338A patent/ES8800907A1/es not_active Expired
- 1986-06-20 HU HU862615A patent/HUT42452A/hu unknown
- 1986-06-20 JP JP61144658A patent/JPS62471A/ja active Pending
- 1986-06-20 DK DK290986A patent/DK290986A/da not_active Application Discontinuation
- 1986-12-04 ES ES557241A patent/ES8705864A1/es not_active Expired
- 1986-12-04 ES ES557240A patent/ES8705863A1/es not_active Expired

Also Published As

Publication number	Publication date
DK290986D0 (da)	1986-06-20
ES8705863A1 (es)	1987-05-16
FI862623A (fi)	1986-12-22
ES8800907A1 (es)	1987-12-01
AU5893286A (en)	1986-12-24
DE3522230A1 (de)	1987-01-02
ES557241A0 (es)	1987-05-16
ES8705864A1 (es)	1987-05-16
EP0209707A2 (de)	1987-01-28
GR861583B (en)	1986-10-21
FI862623A0 (fi)	1986-06-19
JPS62471A (ja)	1987-01-06
ES556338A0 (es)	1987-12-01
ZA864602B (en)	1988-02-24
PT82789A (de)	1986-07-01
PT82789B (de)	1988-05-17
EP0209707A3 (de)	1989-02-01
ES557240A0 (es)	1987-05-16
NO862477L (no)	1986-12-22
HUT42452A (en)	1987-07-28
NO862477D0 (no)	1986-06-20

Publication	Publication Date	Title
DK290986A (da)	1986-12-22	2-arylimidazolforbindelser, laegemidler indeholdende disse forbindelser og deres fremstilling
DK362787A (da)	1988-01-17	Benzensulfonamido-indanylforbindelser, laegemidler indeholdende disse forbindelser og fremgangsmaade til deres fremstilling
DK288184D0 (da)	1984-06-12	13alfa-alkylgonaner, deres fremstilling og farmaceutiske praeparater indeholdende disse
DK231687A (da)	1987-11-08	Heterocykliske forbindelser, deres fremstilling og anvendelse, samt laegemidler indeholdende disse forbindelser
DK209585D0 (da)	1985-05-10	Pyrrolobenzimidazoler, fremgangsmaade til deres fremstilling og laegemidler indeholdende disse forbindelser samt mellemprodukter
DK201086D0 (da)	1986-05-01	Antivirale forbindelser, deres fremstilling og anvendelse og laegemidler indeholdende saadanne forbindelser
DK213085A (da)	1985-11-18	Aminotetralinderivater, laegemidler indeholdende disse og fremgangsmaade til forbindelsernes fremstilling
DK446386D0 (da)	1986-09-17	Proteinhydrolysater, fremgangsmaader til fremstilling deraf og laegemidler, der indeholder disse hydrolysater
DK163923C (da)	1992-09-14	2-phenyl-3-aminomethyl-imidazooe1,2-aaapyridinderivater og farmaceutisk praeparat indeholdende saadanne forbindelser
DK162986C (da)	1992-06-01	4-substituerede 2-amino-5-hydroxypyrimidin-forbindelser og farmaceutiske praeparater indeholdende disse
DK610284A (da)	1985-06-29	2-phenyl-imidazolderivater, deres fremstilling og laegemidler indeholdende disse forbindelser
DK518687A (da)	1988-04-05	Imidazo-benzoxazinoner, deres fremstilling og laegemidler indholdende forbindelserne
DK590185D0 (da)	1985-12-18	Imidazoderivater, deres fremstilling og laegemiddel indeholdende saadanne forbindelser
DK166583C (da)	1993-10-25	1-pyrimidinyloxy-3-alkylamino-2-propanoler, deres fremstilling og farmaceutiske praeparater indeholdende disse
DK592685A (da)	1986-06-22	Imidazoderivater, deres fremstilling og laegemiddel indeholdende saadanne forbindelser
DK166279C (da)	1993-08-23	3,4-dihydro-2h-benzooebaapyranderivater, deres fremstilling og laegemidler indeholdende disse forbindelser
DK457787A (da)	1988-03-04	Sulfonamidoethylforbindelser, laegemidler indeholdende disse forbindelser og fremgangsmaade til deres fremstilling
DK307385A (da)	1986-01-06	Morpholinolforbindelser, deres fremstilling og farmaceutiske anvendelse
DK572785D0 (da)	1985-12-11	Imidazolderivater, laegemidler indeholdende disse forbindelser og fremgangsmaader til deres fremstilling
DK488385D0 (da)	1985-10-24	N6-bicycloadenosinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende saadanne forbindelser
DK21785D0 (da)	1985-01-17	Dihydropyridinforbindelser og farmaceutiske praeparater indeholdende disse
DK81185D0 (da)	1985-02-22	Carboxicam-enolester-forbindelser og farmaceutiske praeparater indeholdende disse
DK162092C (da)	1992-02-24	Basisk substituerede 3-phenyl-quinolin-2-on-derivater, deres fremstilling og anvendelse samt laegemiddel indeholdende disse derivater
DK189786D0 (da)	1986-04-24	4-aminoalkylidensubstituerede 3-aryl-5(4h)-isoxazoloner, fremgangsmaader til fremstilling deraf, samt laegemidler indeholdende disse forbindelser og deres anvendelse
DK352586D0 (da)	1986-07-24	11-methylen-oestr-15-ener, fremgangsmaader til deres fremstilling og farmaceutiske praeparater indeholdende disse oestrener

Legal Events

Date	Code	Title	Description
1989-02-13	AHB	Application shelved due to non-payment