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DK2483289T4 - Fremgangsmåder til forebyggelse og fjernelse af trisulfidbindinger - Google Patents

Fremgangsmåder til forebyggelse og fjernelse af trisulfidbindinger Download PDF

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Publication number
DK2483289T4
DK2483289T4 DK10763112.9T DK10763112T DK2483289T4 DK 2483289 T4 DK2483289 T4 DK 2483289T4 DK 10763112 T DK10763112 T DK 10763112T DK 2483289 T4 DK2483289 T4 DK 2483289T4
Authority
DK
Denmark
Prior art keywords
trisulphide
bonds
prevention
removal
methods
Prior art date
Application number
DK10763112.9T
Other languages
English (en)
Other versions
DK2483289T3 (da
Inventor
David Evans
R Blake Pepinsky
Dingyi Wen
Rashmi Rohit Kshirsagar
Karin Lucas
Original Assignee
Biogen Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43016606&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2483289(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogen Ma Inc filed Critical Biogen Ma Inc
Publication of DK2483289T3 publication Critical patent/DK2483289T3/da
Application granted granted Critical
Publication of DK2483289T4 publication Critical patent/DK2483289T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
DK10763112.9T 2009-10-02 2010-10-01 Fremgangsmåder til forebyggelse og fjernelse af trisulfidbindinger DK2483289T4 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24837709P 2009-10-02 2009-10-02
US25044309P 2009-10-09 2009-10-09
US25903509P 2009-11-06 2009-11-06
US31907310P 2010-03-30 2010-03-30
PCT/US2010/051189 WO2011041721A1 (en) 2009-10-02 2010-10-01 Methods of preventing and removing trisulfide bonds

Publications (2)

Publication Number Publication Date
DK2483289T3 DK2483289T3 (da) 2019-06-11
DK2483289T4 true DK2483289T4 (da) 2025-05-19

Family

ID=43016606

Family Applications (1)

Application Number Title Priority Date Filing Date
DK10763112.9T DK2483289T4 (da) 2009-10-02 2010-10-01 Fremgangsmåder til forebyggelse og fjernelse af trisulfidbindinger

Country Status (4)

Country Link
US (2) US9005926B2 (da)
EP (1) EP2483289B2 (da)
DK (1) DK2483289T4 (da)
WO (1) WO2011041721A1 (da)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2483289T4 (da) 2009-10-02 2025-05-19 Biogen Ma Inc Fremgangsmåder til forebyggelse og fjernelse af trisulfidbindinger
DK2707383T3 (da) * 2011-05-13 2018-07-23 Biogen Ma Inc Fremgangsmåder til forebyggelse og fjernelse af trisulfidbindinger
BR112017001403A2 (pt) * 2014-07-24 2017-11-21 Genentech Inc métodos para conjugar um agente com uma fração de tiol em uma proteína que contém pelo menos uma ligação trissulfeto
DK3334760T3 (da) 2015-08-12 2021-04-19 Pfizer Antistofcysteiner med kappe og uden kappe, og deres anvendelse i antistof-lægemiddel-konjugering
WO2017186654A1 (en) 2016-04-28 2017-11-02 Merck Patent Gmbh Method for reducing the trisulfide level in proteins
CN109154014A (zh) * 2016-05-10 2019-01-04 豪夫迈·罗氏有限公司 重组产生多肽期间减少三硫键的方法
US12486318B2 (en) 2016-06-15 2025-12-02 Yale University Anti-guanosine antibody as a molecular delivery vehicle
EP3672981A4 (en) 2017-08-22 2021-09-15 Biogen MA Inc. PROCESSES FOR PURIFYING ANTIBODIES PRESENTING REDUCED AGGREGATES WITH HIGH MOLECULAR WEIGHT
US12304970B2 (en) 2018-02-01 2025-05-20 Yale University Nuclear localization signals, compositions formed therefrom, and methods of use thereof for delivery of cargo to the nucleus
CN110824096B (zh) * 2018-08-13 2022-11-29 齐鲁制药有限公司 一种蛋白错配二硫键的分析方法
WO2020037016A1 (en) * 2018-08-15 2020-02-20 Bristol-Myers Squibb Company Protein fragmentation control strategy by re-oxidation in downstream chromatography
AU2021400324A1 (en) * 2020-12-20 2023-07-13 Regeneron Pharmaceuticals, Inc. Methods for identification of scrambled disulfides in biomolecules

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DK2483289T4 (da) 2009-10-02 2025-05-19 Biogen Ma Inc Fremgangsmåder til forebyggelse og fjernelse af trisulfidbindinger
DK2707383T3 (da) 2011-05-13 2018-07-23 Biogen Ma Inc Fremgangsmåder til forebyggelse og fjernelse af trisulfidbindinger

Also Published As

Publication number Publication date
US10308706B2 (en) 2019-06-04
DK2483289T3 (da) 2019-06-11
WO2011041721A1 (en) 2011-04-07
US20120264916A1 (en) 2012-10-18
EP2483289A1 (en) 2012-08-08
EP2483289B1 (en) 2019-03-20
EP2483289B2 (en) 2025-03-26
US9005926B2 (en) 2015-04-14
US20150274808A1 (en) 2015-10-01

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