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DK2475372T4 - Fremgangsmåde til fremstilling af micro-RNA og dets terapeutiske anvendelse - Google Patents

Fremgangsmåde til fremstilling af micro-RNA og dets terapeutiske anvendelse Download PDF

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Publication number
DK2475372T4
DK2475372T4 DK10757747.0T DK10757747T DK2475372T4 DK 2475372 T4 DK2475372 T4 DK 2475372T4 DK 10757747 T DK10757747 T DK 10757747T DK 2475372 T4 DK2475372 T4 DK 2475372T4
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rna
micro
preparation
therapeutic use
therapeutic
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DK10757747.0T
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DK2475372T3 (da
Inventor
Flemming Velin
Svend Lindenberg
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Velin Pharma As
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/141—MicroRNAs, miRNAs
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DK10757747.0T 2009-09-10 2010-09-10 Fremgangsmåde til fremstilling af micro-RNA og dets terapeutiske anvendelse DK2475372T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09169937 2009-09-10
PCT/EP2010/063313 WO2011029903A1 (en) 2009-09-10 2010-09-10 Method for the preparation of micro-rna and its therapeutic application

Publications (2)

Publication Number Publication Date
DK2475372T3 DK2475372T3 (da) 2017-10-23
DK2475372T4 true DK2475372T4 (da) 2020-11-30

Family

ID=42147287

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DK10757747.0T DK2475372T4 (da) 2009-09-10 2010-09-10 Fremgangsmåde til fremstilling af micro-RNA og dets terapeutiske anvendelse

Country Status (8)

Country Link
US (1) US9078914B2 (da)
EP (1) EP2475372B2 (da)
JP (1) JP5902088B2 (da)
CN (1) CN102573856B (da)
AU (1) AU2010294197C9 (da)
CA (1) CA2773619C (da)
DK (1) DK2475372T4 (da)
WO (1) WO2011029903A1 (da)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US9078914B2 (en) 2009-09-10 2015-07-14 Velin-Pharma A/S Method for the preparation of micro-RNA and its therapeutic application
EP2354246A1 (en) 2010-02-05 2011-08-10 febit holding GmbH miRNA in the diagnosis of ovarian cancer
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
CN103038349B (zh) 2010-06-04 2015-08-12 得克萨斯系统大学董事会 调节通过miR-378实现的代谢
US10385314B2 (en) * 2010-08-16 2019-08-20 Exostem Biotec Ltd. Methods of generating oligodendrocytes and cell populations comprising same
JP2014504857A (ja) 2010-12-15 2014-02-27 ミラゲン セラピューティクス ロックドヌクレオチドを含むｍｉｃｒｏＲＮＡ阻害剤
AU2012275556B2 (en) 2011-06-27 2016-02-04 Eisai R&D Management Co., Ltd. MicroRNA biomarkers indicative of Alzheimer's Disease
CN102296112B (zh) * 2011-08-09 2013-06-05 南京医科大学 人类非梗阻性无精子症相关的精浆微小核糖核酸标志物及其应用
US20140274789A1 (en) * 2011-08-11 2014-09-18 Andreas Keller Complex sets of mirnas as non-invasive biomarkers for psoriasis
US20140302068A1 (en) * 2011-09-09 2014-10-09 The Regents Of The University Of Colorado MicroRNA Biomarkers for Diagnosing Parkinson's Disease
EP2763703B1 (en) 2011-10-06 2018-02-14 Miragen Therapeutics, Inc. Control of whole body energy homeostasis by microrna regulation
CN104080911A (zh) * 2011-11-30 2014-10-01 不来梅大学 miRNA在胎盘组织中的表达
ITRM20110685A1 (it) 2011-12-23 2013-06-24 Internat Ct For Genetic En Gineering And Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci
US11286463B2 (en) 2012-03-08 2022-03-29 Advanced ReGen Medical Technologies, LLC Reprogramming of aged adult stem cells
US9334498B2 (en) 2012-05-10 2016-05-10 Uab Research Foundation Methods and compositions for modulating MIR-204 activity
WO2013184527A1 (en) 2012-06-05 2013-12-12 Capricor, Inc. Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
HK1209781A1 (en) 2012-06-21 2016-04-08 MiRagen Therapeutics, Inc. Oligonucleotide-based inhibitors comprising locked nucleic acid motif
CN102727909B (zh) * 2012-06-28 2014-06-04 中国人民解放军总医院 一种抑制原发性肝癌生长和转移的新方法
CN102787117A (zh) * 2012-07-20 2012-11-21 苏州大学 微小rna用于调控b7-h2基因表达
US9828603B2 (en) 2012-08-13 2017-11-28 Cedars Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
CN103667282A (zh) * 2012-08-30 2014-03-26 苏州博泰安生物科技有限公司 前列腺癌分子标志物miR-628-3P及其应用
EP2916853B1 (en) * 2012-11-09 2020-05-06 Velin-Pharma A/S Compositions for pulmonary delivery
CN103861122B (zh) * 2012-12-07 2016-05-04 中国科学院上海生命科学研究院 负向调控I型干扰素通路的miRNA分子及其应用
CN103173448A (zh) * 2013-02-07 2013-06-26 上海市胸科医院 早期肺腺癌miRNA特异表达谱及其反转录引物和用途
WO2014152646A1 (en) * 2013-03-14 2014-09-25 The Trustees Of Princeton University Micrornas as functional mediators and biomarkers of bone metastasis
WO2014152932A1 (en) * 2013-03-14 2014-09-25 Board Of Regents, The University Of Texas System Mirna for treating cancer and for use with adoptive immunotherapies
CN103157117B (zh) * 2013-03-19 2014-07-02 广州中国科学院先进技术研究所 一种调控肿瘤对trail耐受性的药物
JP6137894B2 (ja) * 2013-03-22 2017-05-31 国立大学法人京都大学 リポソーム−エキソソームハイブリッドベシクル及びその調製法
CN103194542B (zh) * 2013-04-28 2014-03-26 夏彦恺 人类胎儿生长受限相关的血清微小核糖核酸标志物及其应用
CN103205430B (zh) * 2013-04-28 2015-04-15 夏彦恺 人类重度子痫前期发生相关的血清微小核糖核酸标志物及其应用
WO2014189850A1 (en) 2013-05-20 2014-11-27 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Detection and treatment of irritable bowel syndrome
US9879260B2 (en) 2013-08-20 2018-01-30 The Board Of Regents Of The University Of Texas System Micro-RNA regulation of bone loss
WO2015042435A1 (en) * 2013-09-20 2015-03-26 Academia Sinica Treating diseases associated with pgc1-alpha by modulating micrornas mir-130a and mir-130b
EP3068884A4 (en) * 2013-11-13 2017-06-14 The Texas A&M University System Micro-rnas that modulate lymphangiogenesis and inflammatory pathways in lymphatic vessel cells
WO2015081263A1 (en) 2013-11-26 2015-06-04 Central Biomedia, Inc. Method and diet for immune enhanced donor blood
CN103623431B (zh) * 2013-12-05 2015-04-22 南京大学 miR181s在制备治疗急性肠炎药物中的应用
RU2548816C1 (ru) * 2013-12-16 2015-04-20 Мамонтова Марина Васильевна Способ выделения микрорнк из биологических жидкостей
WO2015091892A1 (en) * 2013-12-19 2015-06-25 Comprehensive Biomarker Center Gmbh Mirnas as non-invasive biomarkers for parkinson's disease
JP6353073B2 (ja) 2013-12-20 2018-07-04 アドヴァンスド リジェン メディカル テクノロジーズ，エルエルシー 細胞回復のための組成物並びにその作製及び使用方法
US10772911B2 (en) 2013-12-20 2020-09-15 Advanced ReGen Medical Technologies, LLC Cell free compositions for cellular restoration and methods of making and using same
EP3628334B1 (en) 2014-03-21 2023-06-28 Genzyme Corporation Gene therapy for retinitis pigmentosa
KR101667650B1 (ko) * 2014-03-31 2016-10-20 숙명여자대학교산학협력단 ｍｉＲ-192, ｍｉＲ-215 또는 ｍｉＲ-194를 포함하는 인간 상염색체 우성 다낭신 치료용 약학 조성물
CN103937826B (zh) * 2014-04-04 2016-04-06 东华大学 一种中枢神经系统中特异表达miR-505的载体的制备方法
BR112016028958A2 (pt) * 2014-06-13 2017-10-31 Univ Wien Bodenkultur método in vitro para diagnóstico de osteoporose ou determinação do risco de fraturas osteoporóticas ou monitoramento do tratamento em um indivíduo compreendendo as etapas de coleta de amostra de sangue, de medição do nível de micrornas e de comparação do nível de mirnas com o nível da amostra de referência e composição para tratamento
JP6566612B2 (ja) * 2014-06-27 2019-08-28 国立大学法人北海道大学 免疫体質又は免疫応答型を判定するためのバイオマーカー及び免疫応答型制御剤
JP6385732B2 (ja) * 2014-06-27 2018-09-05 国立大学法人北海道大学 免疫応答制御剤
CN105368822A (zh) * 2014-08-29 2016-03-02 香港大学 一种miRNA标记物、其方法和应用
CN105457039A (zh) * 2014-09-10 2016-04-06 洪挺祯 促进伤口愈合的制剂及其制备方法及使用方法
CN104306988B (zh) * 2014-09-25 2017-02-15 中国医学科学院基础医学研究所 miR‑431在制备治疗肌肉疾病的药物中的用途
US11357799B2 (en) 2014-10-03 2022-06-14 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
CN104491878A (zh) * 2014-12-19 2015-04-08 青岛大学 一种含有miRNA-324的药物组合物及其用途
BR112017015618A2 (pt) 2015-01-20 2018-04-10 Miragen Therapeutics Inc inibidores de mir-92 e usos destes.
CN104830858A (zh) * 2015-03-05 2015-08-12 中国人民解放军第四军医大学 一种与浆液性卵巢癌发生发展机制相关的microRNA分子及其应用
CN105647919A (zh) * 2015-04-01 2016-06-08 四川大学华西医院 一种microRNA-129-5p的检测试剂盒和检测方法
CN104940954B (zh) * 2015-06-23 2017-12-26 同济大学 MicroRNA‑7在制备抗胶质化药物中的应用
WO2017004381A1 (en) * 2015-06-30 2017-01-05 St. Jude Children's Research Hospital, Inc. Method for treating schizophrenia
CN107920995A (zh) * 2015-07-02 2018-04-17 路易斯威尔大学研究基金会 用于递送miRNA的源自可食用植物的微囊泡组合物和用于治疗癌症的方法
CN105497915A (zh) * 2015-07-21 2016-04-20 青岛大学附属医院 miR-223-3p或miR-885-5p模拟物在制备治疗急性痛风性关节炎药物中的应用
CN105363042B (zh) * 2015-10-21 2022-05-06 圣诺生物医药技术(苏州)有限公司 一种药物组合物及其应用
CN105288658B (zh) * 2015-10-30 2018-08-28 中国人民解放军第三军医大学 miR-18a-5p抑制剂在制备防治骨质疏松药物中的应用
US10980826B2 (en) 2015-11-06 2021-04-20 Toray Industries, Inc. Pharmaceutical composition for treating and/or preventing cancer
WO2017099238A1 (ja) 2015-12-10 2017-06-15 東レ株式会社 癌の治療及び／又は予防用医薬組成物
US11253551B2 (en) 2016-01-11 2022-02-22 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
WO2017131208A1 (ja) 2016-01-28 2017-08-03 東レ株式会社 癌の治療及び／又は予防用医薬組成物
CN105854017A (zh) * 2016-03-01 2016-08-17 扬州大学 一种治疗β-地中海贫血的试剂及其应用
JP6999575B2 (ja) * 2016-04-29 2022-01-18 アドヴァンスド リジェン メディカル テクノロジーズ，エルエルシー マイクロｒｎａ組成物並びにその作製及び使用方法
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
JP6984415B2 (ja) 2016-08-09 2021-12-22 東レ株式会社 癌の治療用及び／又は予防用医薬組成物
IT201600093825A1 (it) * 2016-09-19 2018-03-19 Fondazione St Italiano Tecnologia Composizione farmaceutica di miRNA e suoi usi terapeutici.
EP3515459A4 (en) 2016-09-20 2020-08-05 Cedars-Sinai Medical Center CELLS DERIVED FROM CARDIOSPHERES AND THEIR EXTRACELLULAR VESICLES TO DELAY OR REVERSE AGING AND AGE-RELATED DISORDERS
WO2018139759A1 (ko) * 2017-01-26 2018-08-02 주식회사 바이오오케스트라 마이크로 rna를 이용한 알츠하이머병 진단방법
CA3059910A1 (en) 2017-04-19 2018-10-25 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
US20200165617A1 (en) * 2017-05-09 2020-05-28 New York University Micrornas for treatment of neuropathic pain
CN107412250B (zh) * 2017-05-11 2019-03-05 南京北恒生物科技有限公司 miR-193a-3p的应用
WO2018205978A1 (zh) * 2017-05-11 2018-11-15 北京捷腾生物科技有限公司 预防口腔癌的方法
CN107287319B (zh) * 2017-07-13 2021-07-02 青岛大学 miRNA-485-5p核苷酸类似物及其反义核苷酸的应用和应用其的产品
KR101956315B1 (ko) 2017-07-19 2019-03-08 국민대학교 산학협력단 파킨슨병 바이오마커로서의 miR494 및 이를 이용한 진단키트
CN107419022B (zh) * 2017-08-17 2021-03-16 武汉大学 与绝经后骨质疏松相关的miRNA标志物和试剂盒
CN107693535A (zh) * 2017-09-05 2018-02-16 上海市光华中西医结合医院 一种microRNA的应用
CN109722473A (zh) * 2017-10-31 2019-05-07 中国科学院深圳先进技术研究院 与骨代谢疾病相关的miRNA标志物miR-19b的应用
KR102189991B1 (ko) * 2017-11-27 2020-12-11 (주)프로스테믹스 miRNA를 포함하는 상처 치료 또는 피부 개선용 조성물
WO2019126068A1 (en) 2017-12-20 2019-06-27 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
US10717981B2 (en) 2018-01-18 2020-07-21 Advanced ReGen Medical Technologies, LLC Therapeutic compositions and methods of making and using the same
EP3749344A4 (en) 2018-02-05 2022-01-26 Cedars-Sinai Medical Center METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS
CN108853132A (zh) * 2018-05-22 2018-11-23 深圳先进技术研究院 一种miR-340调控IL-17A表达的用途
WO2020014566A2 (en) * 2018-07-13 2020-01-16 Yale University Compositions and methods for treating endometriosis
EP4424380A3 (en) 2018-08-08 2024-11-20 Theramir Ltd Microrna-based therapy targeted against lcp-1 positive cancers
CN110038026B (zh) * 2019-03-27 2021-08-17 浙江大学 mmu-miR-218-5p在制备抑制胚胎着床的药物中的应用
CN110075122B (zh) * 2019-05-09 2021-04-20 复旦大学附属中山医院 一种肝癌治疗性外泌体药物
US11198908B2 (en) 2019-06-17 2021-12-14 Biorchestra Co., Ltd. Method for diagnosis of Alzheimer's disease using microRNA
CN114423413A (zh) * 2019-07-02 2022-04-29 俄亥俄州国家创新基金会 利用皮肤-脑轴的神经退行性疾病疗法
KR102323535B1 (ko) * 2019-07-10 2021-11-08 주식회사 엠디헬스케어 당뇨병성 신증 진단용 조성물
IT201900017234A1 (it) * 2019-09-25 2021-03-25 Int Centre For Genetic Engineering And Biotechnology Anti-miRNA per il trattamento del leiomioma
CN110791560B (zh) * 2019-11-06 2021-09-14 中国医学科学院医药生物技术研究所 一种用于阿尔茨海默病诊断和/或治疗的miRNA标志物
WO2021105407A1 (en) * 2019-11-29 2021-06-03 Novadip Biosciences miRNA-BASED PHARMACEUTICAL COMPOSITIONS AND USES THEREOF FOR THE PREVENTION AND THE TREATMENT OF TISSUE DISORDERS
CN111330008B (zh) * 2020-02-11 2021-02-05 四川大学 miR-93抑制剂在制备修复牙本质的药物中的用途
CN111529713B (zh) * 2020-05-11 2021-10-22 山东大学 一种AuNPs/miR-140复合物及其制备方法和应用
CN111840310B (zh) * 2020-07-27 2021-11-26 中国农业科学院兰州兽医研究所 ssc-miR-151-3p在制备调节猪繁殖与呼吸综合征病毒复制的药物中的应用
KR102371833B1 (ko) * 2020-09-14 2022-03-08 서울대학교산학협력단 GDF11 유전자의 발현을 조절하는 microRNA 및 이를 함유하는 조성물
CN112410414B (zh) * 2020-10-09 2022-07-08 嘉兴市妇幼保健院 孕妇血清外泌体miRNA标志物在制备胎儿先心病早期诊断产品中的应用及试剂盒
CN112359040B (zh) * 2020-11-02 2021-09-14 广东省科学院动物研究所 调节let-7基因表达量的制剂在制备调节蜜蜂糖反应性行为制剂中的应用
CN112402440A (zh) * 2020-11-18 2021-02-26 西安组织工程与再生医学研究所 miR-325核酸类似物在制备治疗血窦内皮细胞病理性功能异常相关产品中的应用
CN112458165A (zh) * 2020-12-27 2021-03-09 中山大学孙逸仙纪念医院 一种阿尔茨海默病的预测标志物、检测试剂盒及应用
CN114438187B (zh) * 2021-01-29 2022-08-26 浙江大学医学院附属妇产科医院 一种诊断早期流产的miRNA标志物及其应用
CN114214328A (zh) * 2021-12-17 2022-03-22 川北医学院附属医院 一种核酸药物及其应用
IL319217A (en) 2022-09-02 2025-04-01 Leibniz Inst F?R Immuntherapie Lit Therapeutic use of miR155 SNP rs377265631
WO2025054607A1 (en) * 2023-09-07 2025-03-13 The Regents Of The University Of California Compositions and methods for treating sarcopenia
CN117683883B (zh) * 2024-01-11 2024-12-20 山东中医药大学 miR-126-5p在不明原因复发性自然流产诊治中的应用
CN118105400B (zh) * 2024-03-14 2024-08-20 南京市妇幼保健院 一种人子宫内膜间充质干细胞外泌体来源的微小RNA miR-30b及其应用
CN119040464B (zh) * 2024-10-16 2025-04-18 合肥工业大学 一种口腔鳞状细胞癌诊断生物标志物hsa-miR-331-3p及其应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US622690A (en) 1899-04-11 howell
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4522803A (en) 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US5707331A (en) 1995-05-05 1998-01-13 John R. Wells Automatic multiple-decanting centrifuge
JP4038331B2 (ja) 1997-08-16 2008-01-23 オルソゲン アーゲー 治療効果を有するタンパク質を誘導するための方法
DE19903876B4 (de) * 1999-02-01 2006-09-28 Orthogen Gentechnologie Gmbh Verfahren zur in-vitro-Bildung und Anreicherung von Interleukin-1 Rezeptor-Antagonisten
US6398972B1 (en) 1999-04-12 2002-06-04 Harvest Technologies Corporation Method for producing platelet rich plasma and/or platelet concentrate
JP2002174633A (ja) * 2000-12-08 2002-06-21 Erc:Kk 血清の保存方法
DE10213780A1 (de) * 2002-03-22 2003-11-27 Orthogen Ag Verfahren und Mittel zur Herstellung therapeutisch interessanter Blutzusammensetzungen
ES2432745T3 (es) 2002-09-19 2013-12-05 Harvest Technologies Corporation Unidad estéril desechable
JP4399453B2 (ja) 2003-05-19 2010-01-13 ハーベスト・テクノロジーズ・コーポレイション 液体成分を分離するための方法および装置
BRPI0512814A (pt) 2004-07-01 2008-04-08 Univ Pittsburgh Of The Commmmo exosomas imunossupressivas
JP2008511678A (ja) * 2004-09-02 2008-04-17 イェール ユニバーシティ マイクロｒｎａによるオンコジーンの調節
DE102006005016A1 (de) * 2006-02-03 2007-08-16 Orthogen Ag Konditionierte Blutzusammensetzung und Verfahren zu deren Herstellung
WO2008088858A2 (en) * 2007-01-17 2008-07-24 The Johns Hopkins University Compositions and methods featuring micronas for treating neoplasia
JP2008182921A (ja) * 2007-01-29 2008-08-14 Osaka Univ 磁性粒子を用いた遺伝子導入方法
WO2008095096A2 (en) 2007-01-31 2008-08-07 Immune Disease Institute Let-7 microrna and mimetics thereof as therapeutics for cancer
WO2008097230A1 (en) 2007-02-09 2008-08-14 Harvest Technologies Corporation Tissue graft composition comprising autologous bone marrow and purified autologous thrombin
EP2136846A4 (en) 2007-03-26 2011-04-13 Crc For Asthma And Airways Ltd THERAPEUTIC OBJECTIVES AND MOLECULES
US20090124566A1 (en) * 2007-06-07 2009-05-14 Duke University Methods and compositions for the treatment of erythrocyte diseases
JP5399011B2 (ja) * 2007-06-28 2014-01-29 三菱化学メディエンス株式会社 組織傷害あるいは細胞増殖性疾患の検出方法
CA2733676A1 (en) * 2007-08-10 2009-02-19 British Columbia Cancer Agency Branch Microrna compositions and methods for the treatment of myelogenous leukemia
EP3048177A1 (en) * 2007-09-06 2016-07-27 The Ohio State University Research Foundation Microrna signatures in human ovarian cancer
US20090136942A1 (en) * 2007-09-18 2009-05-28 Oncomedx, Inc. Analysis of Extracellular RNA
CA2707157A1 (en) * 2007-11-30 2009-06-04 The Ohio State University Research Foundation Microrna expression profiling and targeting in peripheral blood in lung cancer
WO2009104051A2 (en) 2007-12-31 2009-08-27 Lu Patrick Y Combinational therapeutics for treatment of prostate cancer using epoxy encapsulated magnetic particles and rnai medicine
CN102014934B (zh) * 2008-02-22 2014-08-20 新加坡科技研究局 间充质干细胞颗粒
US20110160290A1 (en) * 2008-05-21 2011-06-30 Muneesh Tewari Use of extracellular rna to measure disease
US20120093936A1 (en) 2009-04-07 2012-04-19 Velin-Pharma A/S Method and device for treatment of conditions associated with inflammation or undesirable activation of the immune system
US9078914B2 (en) 2009-09-10 2015-07-14 Velin-Pharma A/S Method for the preparation of micro-RNA and its therapeutic application

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