DK2430051T3 - Sammensætninger indeholdende antistoffer til behandling af CD5+ HLA-DR+ B- eller T-cellerelaterede sygdomme - Google Patents
Sammensætninger indeholdende antistoffer til behandling af CD5+ HLA-DR+ B- eller T-cellerelaterede sygdomme Download PDFInfo
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- DK2430051T3 DK2430051T3 DK10720014.9T DK10720014T DK2430051T3 DK 2430051 T3 DK2430051 T3 DK 2430051T3 DK 10720014 T DK10720014 T DK 10720014T DK 2430051 T3 DK2430051 T3 DK 2430051T3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Oncology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Claims (17)
1. Mindst et CD5-antistof og mindst et HLA-DR-antistof, hvor det mindst ene CD5-antistof er et antistof, der omfatter: (i) en variabel letkæde, der omfatter CDR1 (L1) af sekvensen SEQ ID NO: 3, CDR2 (L2) af sekvensen SEQ ID NO: 4 og CDR3 (L3) af sekvensen SEQ ID NO: 5, og (ii) en variabel tungkæde, der omfatter CDR1 (H1) af sekvensen SEQ ID NO: 6, CDR2 (H2) af sekvensen SEQ ID NO: 7 og CDR3 (H3) af sekvensen SEQ ID NO: 8, og hvor det mindst ene HLA-DR-antistof er et antistof, der omfatter: (i) en variabel letkæde, der omfatter CDR1 (L1) af sekvensen SEQ ID NO: 11, CDR2 (L2) af sekvensen SEQ ID NO: 12 og CDR3 (L3) af sekvensen SEQ ID NO: 13, og (ii) en variabel tungkæde, der omfatter CDR1 (H1) af sekvensen SEQ ID NO: 14, CDR2 (H2) af sekvensen SEQ ID NO: 15 og CDR3 (H3) af sekvensen SEQ ID NO: 16, til anvendelse som et lægemiddel.
2. Mindst et CD5-antistof og mindst et HLA-DR-antistof til anvendelse ifølge krav 1, hvor det mindst ene CD5-antistof og det mindst ene HLA-DR-antistof udgøres af et bispecifikt antistof.
3. Mindst et CD5-antistof og mindst et HLA-DR-antistof til anvendelse ifølge krav 1 eller 2, hvor det mindst ene CD5-antistof er et antistof, der omfatter en variabel tungkæde ifølge SEQ ID NO: 2.
4. Mindst et CD5-antistof og mindst et HLA-DR-antistof til anvendelse ifølge et hvilket som helst af kravene 1 til 3, hvor det mindst ene CD5-antistof er et antistof, der omfatter en variabel letkæde ifølge SEQ ID NO: 1 og en variabel tungkæde ifølge SEQ ID NO: 2.
5. Mindst et CD5-antistof og mindst et HLA-DR-antistof til anvendelse ifølge et hvilket som helst af kravene 1 til 4, hvor det mindst ene HLA-DR-antistof er et antistof, der omfatter en variabel tungkæde ifølge SEQ ID NO: 10.
6. Mindst et CD5-antistof og mindst et HLA-DR-antistof til anvendelse ifølge et hvilket som helst af kravene 1 til 5, hvor det mindst ene HLA-DR-antistof er et antistof, der omfatter en variabel letkæde ifølge SEQ ID NO: 9 og en variabel tungkæde ifølge SEQ ID NO: 10.
7. Mindst et CD5-antistof og mindst et HLA-DR-antistof til anvendelse ifølge krav 2, hvor det bispecifikke antistof omfatter en variabel letkæde ifølge SEQ ID NO: 1, en variabel tungkæde ifølge SEQ ID NO: 2, en variabel letkæde ifølge SEQ ID NO: 9 og en variabel tungkæde ifølge SEQ ID NO: 10.
8. Mindst et CD5-antistof og mindst et HLA-DR-antistof til anvendelse ifølge et hvilket som helst af kravene 1 til 7, hvor antistoffet er konjugeret med eller fusioneret med et cytotoksisk middel.
9. Mindst et CD5-antistof og mindst et HLA-DR-antistof til anvendelse ifølge et hvilket som helst af kravene 1 til 8, hvor lægemidlet er til forebyggelse eller behandling af CD5+ HLA-DR+ B- eller T-cellerelaterede sygdomme, der er valgt fra gruppen bestående af B- eller T-cellemaligniteter, B- eller T-celle autoimmune sygdomme, transplantationssygdomme og transplantatafstødninger.
10. Mindst et CD5-antistof og mindst et HLA-DR-antistof til anvendelse ifølge et hvilket som helst af kravene 1 til 9, hvor det mindst ene CD5-bindende antistof og mindst et HLA-DR-antistof er kombineret med mindst en anden forbindelse til behandling af B- eller T-cellemaligniteter, autoimmune sygdomme, transplantationssygdomme og transplantatafstødninger.
11. Mindst et CD5-antistof og mindst et HLA-DR-antistof til anvendelse ifølge krav 10, hvor den mindst ene anden forbindelse til behandling af B- eller T-cellemaligniteter eller autoimmune sygdomme i et anti-CD20.
12. Mindst et CD5-antistof og mindst et HLA-DR-antistof til anvendelse ifølge krav 10, hvor den mindst ene anden forbindelse til behandling af transplantationssygdomme og transplantatafstødninger er et anti-CD3.
13. Mindst et CD5-antistof og mindst et HLA-antistof til anvendelse ifølge et hvilket som helst af kravene 9 til 11, hvor B- eller T-cellermaligniteterne er valgt fra gruppen bestående af kronisk lymfatisk leukæmi, kappecellelymfom, nogle diffuse storcellet B-celle-lymfomer, kronisk lymfatisk T-celleleukæmi og T-celleleukæmi hos voksne (ATL).
14. Mindst et CD5-antistof og mindst et HLA-DR-antistof til anvendelse ifølge et hvilket som helst af kravene 9 til 11, hvor den B- eller T-celle autoimmune sygdom er valgt fra gruppen bestående af reumatoid artritis, psoriasis, systemisk lupus erythematosus, Castelmans sygdom, kronisk thyroiditis og multipel sklerose.
15. Mindst et CD5-antistof og mindst et HLA-DR-antistof til anvendelse ifølge krav 9, 10 og 12, hvor den B- eller T-cellerelaterede sygdom er en graft-versus-host-sygdom eller en aktivering af værtens T-celle efter transplantatafstødninger.
16. Mindst et CD5-antistof og mindst et HLA-DR-antistof til anvendelse ifølge et hvilket som helst af kravene 1 til 15, hvor det mindst ene CD5-antistof og det mindst ene HLA-DR-antistof er formuleret i en farmaceutisk sammensætning.
17. Mindst et CD5-antistof og mindst et HLA-DR-antistof til anvendelse ifølge et hvilket som helst af kravene 1 til 16, hvor det mindst ene CD5-antistof og det mindst ene HLA-DR-antistof er formuleret i et kombineret præparat til samtidig, separat eller sekventiel anvendelse.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09305434 | 2009-05-14 | ||
| PCT/EP2010/056664 WO2010145895A1 (en) | 2009-05-14 | 2010-05-14 | Compositions containing antibodies for treating cd5+ hla-dr+ b or t cell related diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2430051T3 true DK2430051T3 (da) | 2016-07-04 |
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Family Applications (1)
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| DK10720014.9T DK2430051T3 (da) | 2009-05-14 | 2010-05-14 | Sammensætninger indeholdende antistoffer til behandling af CD5+ HLA-DR+ B- eller T-cellerelaterede sygdomme |
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| US (1) | US8679500B2 (da) |
| EP (1) | EP2430051B1 (da) |
| DK (1) | DK2430051T3 (da) |
| ES (1) | ES2584916T3 (da) |
| PL (1) | PL2430051T3 (da) |
| PT (1) | PT2430051T (da) |
| WO (1) | WO2010145895A1 (da) |
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| WO2012160215A1 (en) * | 2011-05-26 | 2012-11-29 | Fundacio Clinic Per A La Recerca Biomedica | Soluble protein cd5 or cd6 for the treatment of cancer or tumor or for use as an adjuvant |
| EP2543680A1 (en) | 2011-07-07 | 2013-01-09 | Centre National de la Recherche Scientifique | Multispecific mutated antibody Fab fragments |
| US11369663B2 (en) | 2016-06-07 | 2022-06-28 | Washington University | Detection of CD5 and methods and compositions for modulating CD5 |
| AU2018374283A1 (en) | 2017-11-29 | 2020-06-04 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of CD5+ cells |
| JP7649139B2 (ja) | 2018-05-03 | 2025-03-19 | ジェンマブ ビー．ブイ． | 抗体バリアントの組み合わせおよびその使用 |
| AU2019401647A1 (en) * | 2018-12-21 | 2021-07-08 | Multitude Inc. | Antibodies specific to MUC18 |
| MX2021012961A (es) | 2019-04-24 | 2021-11-25 | Heidelberg Pharma Res Gmbh | Conjugados de anticuerpo y farmaco de amatoxina y usos de los mismos. |
| EP3980034A4 (en) * | 2019-06-05 | 2024-02-28 | Heidelberg Pharma Research GmbH | T-CELL DEPLETION THERAPIES |
| US20230075244A1 (en) * | 2020-02-20 | 2023-03-09 | The Feinstein Institutes For Medical Research | Agonist antibodies against endoglin and uses thereof |
| CN116249551A (zh) * | 2020-08-21 | 2023-06-09 | 希望之城 | 抗cd5抗体组合物及其用途 |
| WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| US20240398982A1 (en) | 2023-05-31 | 2024-12-05 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2024258967A1 (en) | 2023-06-13 | 2024-12-19 | Synthis Therapeutics, Inc. | Anti-cd5 antibodies and their uses |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| US20250127728A1 (en) | 2023-10-05 | 2025-04-24 | Capstan Therapeutics, Inc. | Constrained Ionizable Cationic Lipids and Lipid Nanoparticles |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10162870A1 (de) * | 2001-12-20 | 2003-07-10 | Alexander Cherkasky | Fusionsproteinen gegen B-Zell-Tumoren |
| EP1479760A1 (de) * | 2003-05-19 | 2004-11-24 | ProBioGen AG | Künstliches Immunorgan |
| JP5214252B2 (ja) * | 2005-03-03 | 2013-06-19 | イミューノメディクス、インコーポレイテッド | ヒト化ｌ２４３抗体 |
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- 2010-05-14 US US13/320,097 patent/US8679500B2/en not_active Expired - Fee Related
- 2010-05-14 PT PT107200149T patent/PT2430051T/pt unknown
- 2010-05-14 EP EP10720014.9A patent/EP2430051B1/en active Active
- 2010-05-14 DK DK10720014.9T patent/DK2430051T3/da active
- 2010-05-14 ES ES10720014.9T patent/ES2584916T3/es active Active
- 2010-05-14 PL PL10720014T patent/PL2430051T3/pl unknown
- 2010-05-14 WO PCT/EP2010/056664 patent/WO2010145895A1/en active Application Filing
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| US20120121598A1 (en) | 2012-05-17 |
| PL2430051T3 (pl) | 2017-04-28 |
| ES2584916T3 (es) | 2016-09-30 |
| PT2430051T (pt) | 2016-07-11 |
| US8679500B2 (en) | 2014-03-25 |
| WO2010145895A1 (en) | 2010-12-23 |
| EP2430051A1 (en) | 2012-03-21 |
| EP2430051B1 (en) | 2016-03-23 |
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