DK2331092T3 - Fremgangsmåder og sammensætninger til indgivelse af 3-halopyruvat og associerede forbindelser til behandling af cancer - Google Patents
Fremgangsmåder og sammensætninger til indgivelse af 3-halopyruvat og associerede forbindelser til behandling af cancerInfo
- Publication number
- DK2331092T3 DK2331092T3 DK09808532.7T DK09808532T DK2331092T3 DK 2331092 T3 DK2331092 T3 DK 2331092T3 DK 09808532 T DK09808532 T DK 09808532T DK 2331092 T3 DK2331092 T3 DK 2331092T3
- Authority
- DK
- Denmark
- Prior art keywords
- halopyruvate
- administering
- cancer
- compositions
- treatment
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9079308P | 2008-08-21 | 2008-08-21 | |
US9740808P | 2008-09-16 | 2008-09-16 | |
US16523909P | 2009-03-31 | 2009-03-31 | |
PCT/US2009/004789 WO2010021750A2 (en) | 2008-08-21 | 2009-08-21 | Methods and compositions for administration of 3-halopyruvate and related compounds for the treatment of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2331092T3 true DK2331092T3 (da) | 2014-05-19 |
Family
ID=41707605
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK09808532.7T DK2331092T3 (da) | 2008-08-21 | 2009-08-21 | Fremgangsmåder og sammensætninger til indgivelse af 3-halopyruvat og associerede forbindelser til behandling af cancer |
Country Status (6)
Country | Link |
---|---|
US (2) | US9492417B2 (da) |
EP (1) | EP2331092B1 (da) |
DK (1) | DK2331092T3 (da) |
ES (1) | ES2464729T3 (da) |
PL (1) | PL2331092T3 (da) |
WO (1) | WO2010021750A2 (da) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010021750A2 (en) | 2008-08-21 | 2010-02-25 | The Johns Hopkins University | Methods and compositions for administration of 3-halopyruvate and related compounds for the treatment of cancer |
WO2013103840A1 (en) * | 2012-01-05 | 2013-07-11 | Guilford Frederick Timothy | Anti-cancer composition and method utilizing 3-bp and liposomal reduced glutathione |
JP6552509B2 (ja) * | 2014-01-14 | 2019-07-31 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 選択的atp阻害剤をカプセル化するシクロデキストリン組成物およびその使用 |
WO2017079563A1 (en) | 2015-11-06 | 2017-05-11 | The Johns Hopkins University | Methods of treating liver fibrosis by administering 3-bromopyruvate |
WO2020152487A1 (en) | 2018-11-13 | 2020-07-30 | The Nielsen Compy (Us), Llc | Methods and apparatus to perform image analyses in a computing environment |
WO2024119187A1 (en) * | 2022-12-02 | 2024-06-06 | Kodiscovery, Llc | Heavy isotope 3-bp molecules, compositions, and treatments |
Family Cites Families (40)
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US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4337760A (en) | 1978-10-13 | 1982-07-06 | Adolf Schwimmer | Method for the treatment of tumors with β-glucuronidase activity dependent pharmaceuticals |
DE3360633D1 (en) | 1982-02-12 | 1985-10-03 | Unitika Ltd | Anti-cancer device |
US4737323A (en) | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
US5800820A (en) | 1989-01-10 | 1998-09-01 | Repligen Corporation | Methods and compositions for treatment of angiogenic diseases |
US5759837A (en) | 1989-01-17 | 1998-06-02 | John Hopkins University | Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway |
US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
IT1263831B (it) | 1993-01-29 | 1996-09-04 | Paolo Chiesi | Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina |
WO1994023697A1 (en) | 1993-04-22 | 1994-10-27 | Depotech Corporation | Cyclodextrin liposomes encapsulating pharmacologic compounds and methods for their use |
HU213200B (en) | 1993-05-12 | 1997-03-28 | Chinoin Gyogyszer Es Vegyeszet | The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production |
IL115849A0 (en) | 1994-11-03 | 1996-01-31 | Merz & Co Gmbh & Co | Tangential filtration preparation of liposomal drugs and liposome product thereof |
WO1997004104A2 (en) | 1995-07-14 | 1997-02-06 | The Johns Hopkins University | Tumor type ii hexokinase transcription regulatory regions |
US5854067A (en) | 1996-01-19 | 1998-12-29 | Board Of Regents, The University Of Texas System | Hexokinase inhibitors |
US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
US6214879B1 (en) | 1998-03-24 | 2001-04-10 | Virginia Commonwealth University | Allosteric inhibitors of pyruvate kinase |
DE19814815C2 (de) | 1998-04-02 | 2000-10-12 | Gerhard Steffan | Sterinverknüpfte, anionische Cyclodextrinderivate und deren Verwendung in Arzneimittelformulierungen |
US6284786B1 (en) | 1999-02-16 | 2001-09-04 | The Center For The Improvement Of Human Functioning, Int'l., Inc. | Treatment of cancer using lipoic acid in combination with ascorbic acid |
US20020006915A1 (en) | 2000-02-15 | 2002-01-17 | Mack Strong Vivian E. | Use of COX-2 inhibitors to treat sepsis, complications thereof, and EP receptor modulation |
US6448030B1 (en) | 2000-02-18 | 2002-09-10 | University Of Nevada-Las Vegas | Method for predicting the efficacy of anti-cancer drugs |
WO2001068667A1 (en) | 2000-03-14 | 2001-09-20 | The Johns Hopkins University School Of Medicine | Arrest of proliferation of highly glycolytic tumors |
US6670330B1 (en) | 2000-05-01 | 2003-12-30 | Theodore J. Lampidis | Cancer chemotherapy with 2-deoxy-D-glucose |
WO2002033118A2 (en) | 2000-08-03 | 2002-04-25 | The Texas A & M University System | Isocitrate lyase enzyme from mycobacterium tuberculosis and inhibitory agents to combat persistent infection |
US7381713B2 (en) | 2000-12-04 | 2008-06-03 | Sioan-Kettering Institute For Cancer Research | Treatment of cancer by reduction of intracellular energy and pyrimidines |
US7547673B2 (en) | 2001-09-13 | 2009-06-16 | The Johns Hopkins University | Therapeutics for cancer using 3-bromopyruvate and other selective inhibitors of ATP production |
EP1553924B1 (en) | 2002-06-26 | 2010-12-08 | MediGene AG | Novel method of stabilizing diagnostic and therapeutic compounds in a cationic carrier system |
US7071163B2 (en) | 2002-08-05 | 2006-07-04 | Mirus Bio Corporation | Compounds for targeting hepatocytes in vivo |
BRPI0406667A (pt) | 2003-01-10 | 2005-12-20 | Threshold Pharmaceuticals Inc | Método para o tratamento de câncer, e, formulação terapeuticamente aceitável de 2-dg |
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CN101200457A (zh) | 2003-02-26 | 2008-06-18 | 贝林格尔英格海姆法玛两合公司 | 二氢蝶啶酮、其制法及作为药物制剂的用途 |
CA2928387A1 (en) | 2004-05-03 | 2005-11-17 | Merrimack Pharmaceuticals, Inc. | Drug delivery liposomes containing anionic polyols or anionic sugars |
WO2006010073A1 (en) * | 2004-07-08 | 2006-01-26 | Threshold Pharmaceuticals, Inc. | Prevention of cancer |
WO2006020403A2 (en) | 2004-07-28 | 2006-02-23 | Board Of Regents, The University Of Texas System | 3-halo-2-oxopropionate salts and esters as novel anticancer agents |
US7754693B2 (en) | 2006-02-16 | 2010-07-13 | Young Hee Ko | Composition and method for the efficacious and safe administration of halopyruvate for the treatment of cancer |
EP2255818B1 (en) | 2008-02-19 | 2018-08-22 | Earnest Medicine Co., Ltd. | Oral or enteral composition useful for recovery of physical functions |
WO2010021750A2 (en) | 2008-08-21 | 2010-02-25 | The Johns Hopkins University | Methods and compositions for administration of 3-halopyruvate and related compounds for the treatment of cancer |
US9968583B2 (en) | 2009-03-30 | 2018-05-15 | Eisai R & D Management Co., Ltd. | Method of manufacture of liposome composition |
WO2012118376A1 (en) | 2011-03-01 | 2012-09-07 | To-Bbb Holding B.V. | Advanced active liposomal loading of poorly water-soluble substances |
WO2014004651A1 (en) | 2012-06-26 | 2014-01-03 | The Johns Hopkins University | Multifunctional tunable biomaterials for tissue engineering |
WO2014121235A2 (en) | 2013-02-01 | 2014-08-07 | Zoneone Pharma, Inc. | Transformation of drug cyclodextrin complex compositions into compositions of mixtures of lipid vesicle encapsulated drug and cyclodextrin drug complexes |
JP6552509B2 (ja) | 2014-01-14 | 2019-07-31 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 選択的atp阻害剤をカプセル化するシクロデキストリン組成物およびその使用 |
-
2009
- 2009-08-21 WO PCT/US2009/004789 patent/WO2010021750A2/en active Application Filing
- 2009-08-21 ES ES09808532.7T patent/ES2464729T3/es active Active
- 2009-08-21 US US12/583,598 patent/US9492417B2/en active Active
- 2009-08-21 EP EP09808532.7A patent/EP2331092B1/en not_active Revoked
- 2009-08-21 PL PL09808532T patent/PL2331092T3/pl unknown
- 2009-08-21 DK DK09808532.7T patent/DK2331092T3/da active
-
2016
- 2016-10-03 US US15/284,014 patent/US10130598B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2331092B1 (en) | 2014-03-19 |
EP2331092A4 (en) | 2011-10-12 |
US9492417B2 (en) | 2016-11-15 |
PL2331092T3 (pl) | 2014-08-29 |
WO2010021750A2 (en) | 2010-02-25 |
EP2331092A2 (en) | 2011-06-15 |
US10130598B2 (en) | 2018-11-20 |
WO2010021750A3 (en) | 2010-07-08 |
ES2464729T3 (es) | 2014-06-03 |
US20100137434A1 (en) | 2010-06-03 |
US20170224641A1 (en) | 2017-08-10 |
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