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DK2185698T3 - Kinaseinhibitorer og anvendelser deraf - Google Patents

Kinaseinhibitorer og anvendelser deraf Download PDF

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Publication number
DK2185698T3
DK2185698T3 DK08797416.8T DK08797416T DK2185698T3 DK 2185698 T3 DK2185698 T3 DK 2185698T3 DK 08797416 T DK08797416 T DK 08797416T DK 2185698 T3 DK2185698 T3 DK 2185698T3
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kinase
peptide
seq
inhibiting
amino acid
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DK08797416.8T
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Alyssa Panitch
Brandon Seal
Brian Ward
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Purdue Research Foundation
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
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  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Claims (13)

1. Kinaseinhiberende sammensætning, der omfatter et kinaseinhiberende peptid til inhibering af vækst af et neoplasma, hvor det kinaseinhiberende peptid er et peptid med en aminosyresekvens valgt blandt gruppen bestående af HRRIKAWLKKIKALARQLGVAA [SEQ ID NO: 166]; WLRRIKAWLRRIKALARQLGVAA [SEQ ID NO: 113]; WLRRIKAWLRRALARQLGVA [SEQ ID NO: 177]; KAFAKLAARLYRKALARQLGVAA [SEQ ID NO: 173]; FAKLAARLYRKALARQLGVAA [SEQ ID NO: 163]; YARAAARQARAKALARQLGVAA [SEQ ID NO: 106]; YARAAARQARAKALNRQLGVA [SEQ ID NO: 28]; YARAAARQARAKALNRQLAVAA [SEQ ID NO: 100]; og YARAAARQARAKALNRQLAVA [SEQ ID NO: 64],
2. Kinaseinhiberende sammensætning ifølge krav 1, hvor det kinaseinhiberende peptid til inhibering af vækst af et neoplasma er et peptid med en aminosyresekvens HRRIKAWLKKIKALARQLGVAA [SEQ ID NO: 166],
3. Kinaseinhiberende sammensætning ifølge krav 1, hvor det kinaseinhiberende peptid til inhibering af vækst af et neoplasma er et peptid med en aminosyresekvens WLRRIKAWLRRIKALARQLGVAA [SEQ ID NO: 113],
4. Kinaseinhiberende sammensætning ifølge krav 1, hvor det kinaseinhiberende peptid til inhibering af vækst af et neoplasma er et peptid med en aminosyresekvens WLRRIKAWLRRALARQLGVA [SEQ ID NO: 177],
5. Kinaseinhiberende sammensætning ifølge krav 1 til anvendelse i en fremgangsmåde til behandling af et neoplasma valgt blandt gruppen bestående af et papillom, et adenom, et hydatidiformmodermærke, et fibrom, et chondrom, et osteom, et leiomyom, et rhabdomyom, et lipom, et hemangiom, et lymphangiom, et polycythaemia vera, en infektiøs mononucleose, et "godartet giiom”, et menin-giom, et ganglioneurom, et neurilemmom, et neurofibrom, et pigmenteret næves (modermærke), et pheochromocytom, en carcinoid tumor, et te ratom, et carei-nom, et adenocarcinom, et basaiceiiecarcinom, et choriocarcinom, et fibrosar-kom, et cbondrosarkom, et osteosarkom, et leiomyosarkom, et rhabdomyosar-kom, et liposarkom, et hemangiosarkom, et lymphangiosarkom, en myeiocytisk leukemi, en erythrocytisk leukemi, en lymphocytisk leukemi, et multipelt myelom, en monocytisk leukemi, et Ewing sarkom, et ondartet non-Hodgkin iymfom, et meduliobiastom, oligodendrogliom, et neurilemmaisarkom, ondartet melanom, thymon, en gliobiastom multiforme, et astrocytom, et ependymom, et meningeal-sarkom, et neuroblastom (schwannom), et neurofibrosarkom, et ondartet pheochromocytom, et retinoblastom, en carcinoid tumor, en nephroblastom (Wilms tumor), et teratocarcinom og et embryonaicarcinom med choriocarcinom.
8. Anvendelse af den kinaseinhiberende sammensætning ifølge krav 1 i fremstillingen af et medikament til behandling af et neoplasma valgt blandt gruppen bestående af et papillom, et adenom, et hydatidiformmodermærke, et fibrom, et chondrom, et osteom, et leiomyom, et rhabdomyom, et lipom, et hemangiom, et lymphangiom, et polycythaemia vera, en infektiøs mononucleose, et "godartet” giiom, et meningiom, et ganglioneurom, et neurilemmom, et neurofibrom, et pigmenteret nævus (modermærke), et pheochromocytom, en carcinoid tumor, et te ratom, et card nom, et adenocarcinom, et basaiceiiecarcinom, et choriocarci-nom, et fibrosarkom, et chondrosarkom, et osteosarkom, et leiomyosarkom, et rhabdomyosarkom, et liposarkom, et hemangiosarkom, et lymphangiosarkom, en myeiocytisk leukemi, en erythrocytisk leukemi, en lymphocytisk leukemi, et multipelt myelom, en monocytisk leukemi, et Ewing sarkom, et ondartet non-Hodgkin Iymfom, et meduliobiastom, oligodendrogliom, et neurilemmaisarkom, ondartet melanom, thymon, en gliobiastom multiforme, et astrocytom, et ependymom, et meningeaisarkom, et neuroblastom (schwannom), et neurofibrosarkom, et ondartet pheochromocytom, et retinoblastom, en carcinoid tumor, en nephroblastom (Wilms tumor), et teratocarcinom og et embryonaicarcinom med choriocarcinom.
7. Kinaseinhiberende sammensætning ifølge krav 1, hvor det kinaseinhibe-rende peptid er en cyclinafhængig kinaseinhibitor.
8. Kinaseinhiberende sammensætning ifølge krav 1, hvor sammensætningen inducerer programmeret celledød af mindst en celle i en cellepopulation.
9. Kinaseinhiberende sammensætning ifølge krav 1, hvor sammensætningen inhiberer hyperplasi af mindst en hyperplastisk celle i en cellepopulation.
10. Kinaseinhiberende sammensætning ifølge krav 1, hvor det kinaseinhiberende peptid til inhibering af vækst af et neoplasma er et peptid med en aminosy-resekvens KAFAKLAARLYRKALARQLGVAA [SEQ ID NO: 173],
11. Kinaseinhiberende sammensætning ifølge krav 1, hvor det kinaseinhiberende peptid til inhibering af vækst af et neoplasma er et peptid med en aminosy-resekvens FAKLAARLYRKALARQLGVAA [SEQ ID NO: 163],
12. Kinaseinhiberende sammensætning ifølge krav 1, hvor det kinaseinhiberende peptid til inhibering af vækst af et neoplasma er et peptid med en aminosy-resekvens YARAAARQARAKALARQLGVAA [SEQ ID NO: 106],
13. Kinaseinhiberende sammensætning ifølge krav 1, hvor det kinaseinhiberende peptid til inhibering af vækst af et neoplasma er et peptid med en aminosy-resekvens YARAAARQARAKALNRQLGVA [SEQ ID NO: 28].
14. Kinaseinhiberende sammensætning ifølge krav 1, hvor det kinaseinhiberende peptid til inhibering af vækst af et neoplasma er et peptid med en aminosy-resekvens YARAAARQARAKALNRQLAVAA [SEQ ID NO: 100],
15. Kinaseinhiberende sammensætning ifølge krav 1, hvor det kinaseinhibe-rende peptid til inhibering af vækst af et neoplasma er et peptid med en aminosy-resekvens YARAAARQARAKALNRQLAVA [SEQ ID NO: 64],
DK08797416.8T 2007-08-07 2008-08-07 Kinaseinhibitorer og anvendelser deraf DK2185698T3 (da)

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US96394107P 2007-08-07 2007-08-07
US99497007P 2007-09-24 2007-09-24
PCT/US2008/072525 WO2009021137A2 (en) 2007-08-07 2008-08-07 Kinase inhibitors and uses thereof

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EP (1) EP2185698B1 (da)
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US9447158B2 (en) 2016-09-20
US8741849B2 (en) 2014-06-03
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