DK21588A - 4-arylcarbonyl-1-((4-morpholinyl)-alkyl)-1h-indoler, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende disse forbindelser - Google Patents

4-arylcarbonyl-1-((4-morpholinyl)-alkyl)-1h-indoler, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende disse forbindelser

Info

Publication number: DK21588A
Authority: DK; Denmark
Prior art keywords: indoles; arylcarbonyl; morpholinyl; procedures; alkyl
Prior art date: 1987-02-11

Application number

DK021588A

Other languages

English (en)

Other versions

DK167921B1 (da

DK21588D0 (da

Inventor

Ambra Thomas Edward D

Malcolm Rice Bell

Original Assignee

Sterling Drug Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-02-11

Filing date

1988-01-19

Publication date

1988-08-12

1988-01-19 Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc

1988-01-19 Publication of DK21588D0 publication Critical patent/DK21588D0/da

1988-08-12 Publication of DK21588A publication Critical patent/DK21588A/da

1994-01-03 Application granted granted Critical

1994-01-03 Publication of DK167921B1 publication Critical patent/DK167921B1/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK021588A 1987-02-11 1988-01-19 4-arylcarbonyl-1-oe(4-morpholinyl)-lavere alkylaa-1h-indoler, fremgangsmaade til fremstilling heraf, analgetiske praeparater indeholdende saadanne forbindelser og anvendelsen af disse forbindelser til fremstilling af farmaceutiske praeparater mod smerte DK167921B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/013,313 US4840950A (en)	1987-02-11	1987-02-11	4-arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles
US1331387		1987-02-11

Publications (3)

Publication Number	Publication Date
DK21588D0 DK21588D0 (da)	1988-01-19
DK21588A true DK21588A (da)	1988-08-12
DK167921B1 DK167921B1 (da)	1994-01-03

Family

ID=21759325

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK021588A DK167921B1 (da)	1987-02-11	1988-01-19	4-arylcarbonyl-1-oe(4-morpholinyl)-lavere alkylaa-1h-indoler, fremgangsmaade til fremstilling heraf, analgetiske praeparater indeholdende saadanne forbindelser og anvendelsen af disse forbindelser til fremstilling af farmaceutiske praeparater mod smerte

Country Status (21)

Country	Link
US (1)	US4840950A (da)
EP (1)	EP0278265B1 (da)
JP (1)	JP2561939B2 (da)
KR (1)	KR960007523B1 (da)
AR (1)	AR243184A1 (da)
AT (1)	ATE80386T1 (da)
AU (1)	AU596494B2 (da)
CA (1)	CA1299180C (da)
DE (1)	DE3874361T2 (da)
DK (1)	DK167921B1 (da)
ES (1)	ES2052608T3 (da)
FI (1)	FI88152C (da)
GR (1)	GR3005855T3 (da)
IE (1)	IE63264B1 (da)
IL (1)	IL84922A (da)
MX (1)	MX174421B (da)
NO (1)	NO169713C (da)
NZ (1)	NZ223146A (da)
PH (1)	PH25902A (da)
PT (1)	PT86527B (da)
ZA (1)	ZA879723B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5081122A (en) *	1990-03-05	1992-01-14	Sterling Drug Inc.	Antiglaucoma compositions containing 4-arylcarbonyl-1-(4-morpholinyl)-lower-alkyl)-1H-indoles and method of use thereof
US8604031B2 (en)	2006-05-18	2013-12-10	Mannkind Corporation	Intracellular kinase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3182071A (en) *	1961-06-27	1965-05-04	Warner Lambert Pharmaceutical	Acylated indole derivatives
US3215699A (en) *	1961-06-27	1965-11-02	Warner Lambert Pharmaceutical	Substituted acetylphenyl hydrazones of 2,3-piperidine diones
US3487091A (en) *	1967-12-18	1969-12-30	American Home Prod	1-(benzyl- or substituted-benzyl)-3-(2-substituted-ethyl) indoles
GB1374414A (en) *	1972-06-12	1974-11-20	Sterling Drug Inc	1-acyl-3-amino-alkyl-indoles and their preparation
GB1436771A (en) *	1973-02-16	1976-05-26	Labaz	Indole derivatives and process for preparing the same
US4581354A (en) *	1984-08-06	1986-04-08	Sterling Drug Inc.	3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use
PH23498A (en) *	1984-08-06	1989-08-16	Sterling Drug Inc	3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof

1987
- 1987-02-11 US US07/013,313 patent/US4840950A/en not_active Expired - Lifetime
- 1987-12-22 IL IL84922A patent/IL84922A/xx not_active IP Right Cessation
- 1987-12-29 ZA ZA879723A patent/ZA879723B/xx unknown
1988
- 1988-01-04 PH PH36317A patent/PH25902A/en unknown
- 1988-01-08 IE IE4788A patent/IE63264B1/en not_active IP Right Cessation
- 1988-01-11 NZ NZ223146A patent/NZ223146A/en unknown
- 1988-01-12 FI FI880117A patent/FI88152C/fi not_active IP Right Cessation
- 1988-01-12 PT PT86527A patent/PT86527B/pt not_active IP Right Cessation
- 1988-01-13 MX MX010085A patent/MX174421B/es unknown
- 1988-01-19 EP EP88100694A patent/EP0278265B1/en not_active Expired - Lifetime
- 1988-01-19 AT AT88100694T patent/ATE80386T1/de not_active IP Right Cessation
- 1988-01-19 KR KR1019880000361A patent/KR960007523B1/ko not_active IP Right Cessation
- 1988-01-19 DE DE8888100694T patent/DE3874361T2/de not_active Expired - Lifetime
- 1988-01-19 DK DK021588A patent/DK167921B1/da not_active IP Right Cessation
- 1988-01-19 NO NO880206A patent/NO169713C/no not_active IP Right Cessation
- 1988-01-19 ES ES88100694T patent/ES2052608T3/es not_active Expired - Lifetime
- 1988-01-19 AU AU10387/88A patent/AU596494B2/en not_active Expired
- 1988-01-20 JP JP63010552A patent/JP2561939B2/ja not_active Expired - Lifetime
- 1988-01-20 AR AR88309876A patent/AR243184A1/es active
- 1988-01-26 CA CA000557313A patent/CA1299180C/en not_active Expired - Lifetime
1992
- 1992-10-01 GR GR920401725T patent/GR3005855T3/el unknown

Also Published As

Publication number	Publication date
IL84922A (en)	1992-03-29
MX10085A (es)	1993-09-01
MX174421B (es)	1994-05-16
DK167921B1 (da)	1994-01-03
NO169713B (no)	1992-04-21
FI88152C (fi)	1993-04-13
DE3874361D1 (de)	1992-10-15
AR243184A1 (es)	1993-07-30
ATE80386T1 (de)	1992-09-15
JPS63216865A (ja)	1988-09-09
GR3005855T3 (da)	1993-06-07
AU596494B2 (en)	1990-05-03
DK21588D0 (da)	1988-01-19
KR960007523B1 (ko)	1996-06-05
NO169713C (no)	1992-07-29
IL84922A0 (en)	1988-06-30
ES2052608T3 (es)	1994-07-16
IE63264B1 (en)	1995-04-05
IE880047L (en)	1988-08-11
AU1038788A (en)	1988-08-18
ZA879723B (en)	1988-06-23
FI880117A0 (fi)	1988-01-12
US4840950A (en)	1989-06-20
EP0278265A1 (en)	1988-08-17
NO880206D0 (no)	1988-01-19
NO880206L (no)	1988-08-12
EP0278265B1 (en)	1992-09-09
FI88152B (fi)	1992-12-31
FI880117A (fi)	1988-08-12
JP2561939B2 (ja)	1996-12-11
DE3874361T2 (de)	1993-03-25
CA1299180C (en)	1992-04-21
NZ223146A (en)	1990-01-29
PT86527B (pt)	1991-12-31
KR880009962A (ko)	1988-10-06
PH25902A (en)	1991-12-19
PT86527A (en)	1988-02-01

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Legal Events

Date	Code	Title	Description
1994-01-03	B1	Patent granted (law 1993)
2008-02-04	PUP	Patent expired