DK2144924T3 - Fusionsproteinvaccine - Google Patents
Fusionsproteinvaccine Download PDFInfo
- Publication number
- DK2144924T3 DK2144924T3 DK08724181.6T DK08724181T DK2144924T3 DK 2144924 T3 DK2144924 T3 DK 2144924T3 DK 08724181 T DK08724181 T DK 08724181T DK 2144924 T3 DK2144924 T3 DK 2144924T3
- Authority
- DK
- Denmark
- Prior art keywords
- fusion protein
- protein
- amino acid
- rib
- vaccine
- Prior art date
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- 238000011809 primate model Methods 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 108010004914 prolylarginine Proteins 0.000 description 1
- 108020001775 protein parts Proteins 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000003259 recombinant expression Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 238000006268 reductive amination reaction Methods 0.000 description 1
- 210000005000 reproductive tract Anatomy 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 235000017709 saponins Nutrition 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000001542 size-exclusion chromatography Methods 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 108010061238 threonyl-glycine Proteins 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 229940124856 vaccine component Drugs 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000005570 vertical transmission Effects 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 230000007923 virulence factor Effects 0.000 description 1
- 239000000304 virulence factor Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (12)
1. Fusionsprotein, der omfatter mindst to aminosyresekvenser, hvor de to aminosyresekvenser består af en første aminosyresekvens med mindst 90 % sekvensidentitet med en aminosyresekvens som vist i SEQ ID NO:2, fusioneret til en anden aminosyresekvens med mindst 90 % sekvensidentitet med en aminosyresekvens som vist i SEQ ID NO:4, hvor fusionsproteinet er i stand til at fremkalde beskyttende immunitet mod gruppe B-Streptococcus.
2. Fusionsprotein ifølge krav 1, hvor den første aminosyresekvens har mindst 95, 96, 97, 98 eller 99 % sekvensidentitet med en aminosyresekvens som vist i SEQ ID NO:2, eller hvor den anden aminosyresekvens har mindst 95, 96, 97, 98 eller 99 % sekvensidentitet med en aminosyresekvens som vist i SEQ ID NO:4.
3. Fusionsprotein ifølge krav 1, hvor fusionsproteinet omfatter en aminosyresekvens med mindst 90 % identitet med den i SEQ ID NO:6 viste aminosyresekvens.
4. Fusionsprotein ifølge krav 3, hvor fusionsproteinet omfatter en aminosyresekvens med mindst 95 % identitet med den i SEQ ID NO:6 viste aminosyresekvens.
5. Fusionsprotein ifølge et hvilket som helst af de foregående krav, hvor fusionsproteinet er modificeret ved glycosylering, amidering, carboxylering eller phosphorylering.
6. Vaccine, der omfatter en farmaceutisk effektiv mængde af et fusionsprotein ifølge et hvilket som helst af kravene 1-5, hvor vaccinepræparatet er i stand til at fremkalde beskyttende immunitet mod gruppe B-Streptococcus, idet det omfatter en farmaceutisk effektiv bærer.
7. Vaccine ifølge krav 6, som yderligere omfatter en adjuvans.
8. Vaccine ifølge et hvilket som helst af kravene 6-7, hvor fusionsproteinet er konjugeret til et polysaccharid til dannelse af en konjugeret vaccine.
9. Nukleotidsekvens, der mindst omfatter nukleotidsekvensen SEQ ID NO:1, som er koblet til SEQ ID NO:3, eller den i SEQ ID NO:5 viste nukleotidsekvens.
10. Nukleotidsekvens ifølge krav 9, hvor SEQ ID NO:1 og 3 er kemisk forbundet, konjugeret eller tværbundet.
11. Vektor, der omfatter nukleotidsekvensen ifølge krav 9-10.
12. Værtscelle, der omfatter vektoren ifølge krav 11.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0700919 | 2007-04-16 | ||
| US94047307P | 2007-05-29 | 2007-05-29 | |
| PCT/SE2008/000270 WO2008127179A1 (en) | 2007-04-16 | 2008-04-14 | Fusion protein vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2144924T3 true DK2144924T3 (da) | 2016-08-22 |
Family
ID=39864173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08724181.6T DK2144924T3 (da) | 2007-04-16 | 2008-04-14 | Fusionsproteinvaccine |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8313748B2 (da) |
| EP (1) | EP2144924B1 (da) |
| CN (1) | CN101855238B (da) |
| CA (1) | CA2684494C (da) |
| CY (1) | CY1117896T1 (da) |
| DK (1) | DK2144924T3 (da) |
| ES (1) | ES2586418T3 (da) |
| HR (1) | HRP20160995T1 (da) |
| HU (1) | HUE028253T2 (da) |
| LT (1) | LT2144924T (da) |
| PL (1) | PL2144924T3 (da) |
| PT (1) | PT2144924T (da) |
| RU (1) | RU2487890C2 (da) |
| SI (1) | SI2144924T1 (da) |
| WO (1) | WO2008127179A1 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014018904A1 (en) * | 2012-07-26 | 2014-01-30 | Genocea Biosciences, Inc. | Fused antigen vaccines and compositions against streptococcus pneumoniae |
| RU2015106791A (ru) | 2012-10-03 | 2016-11-20 | Глэксосмитиклайн Байолоджикалз Са | Иммуногенные композиции |
| CN103694323B (zh) * | 2013-12-09 | 2017-01-18 | 成都欧林生物科技股份有限公司 | 金黄色葡萄球菌MntC重组蛋白及其制备方法和应用 |
| RU2757426C2 (ru) * | 2015-10-21 | 2021-10-15 | МинерваКС Апс | Иммунногенный слитый белок |
| US10888610B2 (en) * | 2015-12-30 | 2021-01-12 | Minerv Ax Aps | Immunogenic complex for eliciting protective immunity against group b streptococcus |
| WO2018229708A1 (en) | 2017-06-16 | 2018-12-20 | Glaxosmithkline Biologicals Sa | Method of treatment |
| CN114728051A (zh) | 2019-11-22 | 2022-07-08 | 葛兰素史克生物有限公司 | 细菌糖糖缀合物疫苗的剂量和施用 |
| WO2021250626A2 (en) | 2020-06-12 | 2021-12-16 | Glaxosmithkline Biologicals Sa | Dock tag system |
| WO2021250625A2 (en) | 2020-06-12 | 2021-12-16 | Glaxosmithkline Biologicals Sa | Gbs ferritin nanoparticles |
| EP4066854A1 (en) | 2021-03-29 | 2022-10-05 | MinervaX | Immunogenic fusion protein |
| CN114437235B (zh) * | 2022-01-04 | 2024-02-09 | 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） | 马链球菌马亚种8种蛋白的重组融合蛋白及其制备方法和应用 |
| CN116478953B (zh) * | 2023-06-14 | 2023-09-12 | 四川大学华西医院 | 鲍曼不动杆菌DlaT重组蛋白、制备方法及应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4225579A (en) * | 1979-02-27 | 1980-09-30 | Israel Kleinberg | Means and method for improving defenses against caries |
| US4496538A (en) | 1982-07-06 | 1985-01-29 | Connaught Laboratories, Inc. | Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine |
| US4879213A (en) * | 1986-12-05 | 1989-11-07 | Scripps Clinic And Research Foundation | Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse |
| WO1994001031A1 (fr) | 1992-07-02 | 1994-01-20 | Paul Charvet | Appareil de cuisson dans l'huile a chauffage au gaz |
| DK0625043T3 (da) | 1992-09-16 | 2002-04-22 | Univ Tennessee Res Corp | Vaccine med rekombinant multivalent M-protein |
| IL107458A0 (en) * | 1992-11-02 | 1994-02-27 | Gen Hospital Corp | Conjugate vaccine against group b streptococcus |
| CN1046291C (zh) | 1993-03-19 | 1999-11-10 | G·林达尔 | Rib蛋白、其纯化方法、检测试剂盒及药物组合物 |
| US6355255B1 (en) * | 1998-12-07 | 2002-03-12 | Regents Of The University Of Minnesota | Streptococcal C5a peptidase vaccine |
| US6426074B1 (en) | 1997-03-19 | 2002-07-30 | The Brigham And Women's Hospital Inc. | Group B Streptococcus vaccine |
| GB9808932D0 (en) | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
| NZ541969A (en) * | 2003-03-13 | 2008-01-31 | Glaxosmithkline Biolog Sa | Purifying pneumolysin from Streptococcus pneumoniae in a single chromatographic step by binding it to a hydrophobic interaction column in the presence of detergent and high salt |
| WO2005028618A2 (en) * | 2003-09-15 | 2005-03-31 | Chiron Corporation | Immunogenic compositions for streptococcus agalactiae |
-
2008
- 2008-04-14 LT LTEP08724181.6T patent/LT2144924T/lt unknown
- 2008-04-14 PT PT87241816T patent/PT2144924T/pt unknown
- 2008-04-14 CA CA2684494A patent/CA2684494C/en active Active
- 2008-04-14 US US12/596,249 patent/US8313748B2/en active Active
- 2008-04-14 EP EP08724181.6A patent/EP2144924B1/en active Active
- 2008-04-14 HU HUE08724181A patent/HUE028253T2/en unknown
- 2008-04-14 RU RU2009142976/10A patent/RU2487890C2/ru active
- 2008-04-14 PL PL08724181T patent/PL2144924T3/pl unknown
- 2008-04-14 DK DK08724181.6T patent/DK2144924T3/da active
- 2008-04-14 SI SI200831661A patent/SI2144924T1/sl unknown
- 2008-04-14 ES ES08724181.6T patent/ES2586418T3/es active Active
- 2008-04-14 WO PCT/SE2008/000270 patent/WO2008127179A1/en active Application Filing
- 2008-04-14 CN CN200880020390.1A patent/CN101855238B/zh active Active
-
2016
- 2016-08-08 HR HRP20160995TT patent/HRP20160995T1/hr unknown
- 2016-08-09 CY CY20161100783T patent/CY1117896T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2009142976A (ru) | 2011-05-27 |
| CA2684494C (en) | 2016-07-05 |
| SI2144924T1 (sl) | 2016-12-30 |
| CN101855238A (zh) | 2010-10-06 |
| LT2144924T (lt) | 2016-10-10 |
| ES2586418T3 (es) | 2016-10-14 |
| EP2144924B1 (en) | 2016-05-11 |
| PL2144924T3 (pl) | 2017-06-30 |
| CN101855238B (zh) | 2014-09-17 |
| CA2684494A1 (en) | 2008-10-23 |
| PT2144924T (pt) | 2016-08-17 |
| HUE028253T2 (en) | 2017-02-28 |
| HRP20160995T1 (hr) | 2016-10-21 |
| CY1117896T1 (el) | 2017-05-17 |
| WO2008127179A8 (en) | 2009-07-23 |
| WO2008127179A1 (en) | 2008-10-23 |
| US20100062015A1 (en) | 2010-03-11 |
| EP2144924A4 (en) | 2010-08-25 |
| RU2487890C2 (ru) | 2013-07-20 |
| EP2144924A1 (en) | 2010-01-20 |
| US8313748B2 (en) | 2012-11-20 |
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