[go: up one dir, main page]

DK2035548T3 - Vurdering af embryokvalitet på basis af blastomer deling og bevævgelse - Google Patents

Vurdering af embryokvalitet på basis af blastomer deling og bevævgelse

Info

Publication number
DK2035548T3
DK2035548T3 DK07722668.6T DK07722668T DK2035548T3 DK 2035548 T3 DK2035548 T3 DK 2035548T3 DK 07722668 T DK07722668 T DK 07722668T DK 2035548 T3 DK2035548 T3 DK 2035548T3
Authority
DK
Denmark
Prior art keywords
determining
division period
embryo quality
inter
extent
Prior art date
Application number
DK07722668.6T
Other languages
English (en)
Inventor
Niels B Ramsing
Joergen Berntsen
Original Assignee
Unisense Fertilitech As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43414894&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2035548(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/DK2006/000581 external-priority patent/WO2007042044A1/en
Application filed by Unisense Fertilitech As filed Critical Unisense Fertilitech As
Application granted granted Critical
Publication of DK2035548T3 publication Critical patent/DK2035548T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0604—Whole embryos; Culture medium therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
    • A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/06—Bioreactors or fermenters specially adapted for specific uses for in vitro fertilization
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/38—Pediatrics
    • G01N2800/385—Congenital anomalies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Developmental Biology & Embryology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Surgery (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Computer Hardware Design (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
DK07722668.6T 2006-06-16 2007-06-15 Vurdering af embryokvalitet på basis af blastomer deling og bevævgelse DK2035548T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US81411506P 2006-06-16 2006-06-16
DKPA200600821 2006-06-16
PCT/DK2006/000581 WO2007042044A1 (en) 2005-10-14 2006-10-16 Determination of a change in a cell population
DKPA200700571 2007-04-19
PCT/DK2007/000291 WO2007144001A2 (en) 2006-06-16 2007-06-15 Embryo quality assessment based on blastomere division and movement

Publications (1)

Publication Number Publication Date
DK2035548T3 true DK2035548T3 (da) 2010-11-22

Family

ID=43414894

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07722668.6T DK2035548T3 (da) 2006-06-16 2007-06-15 Vurdering af embryokvalitet på basis af blastomer deling og bevævgelse

Country Status (8)

Country Link
US (4) US20100041090A1 (da)
EP (2) EP2035548B1 (da)
JP (2) JP5731748B2 (da)
CN (2) CN101495619B (da)
AT (1) ATE477499T1 (da)
DE (1) DE602007008419D1 (da)
DK (1) DK2035548T3 (da)
WO (1) WO2007144001A2 (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2549205T3 (es) 2005-10-14 2015-10-26 Unisense Fertilitech A/S Determinación de un cambio en una población de células
DK2173853T3 (da) 2007-06-29 2011-07-04 Unisense Fertilitech As Indretning, system og fremgangsmåde til at overvåge og/eller dyrke mikroskopiske objekter
GB0719037D0 (en) 2007-09-28 2007-11-07 Vitrolife Sweden Ab Sampling needle
US20110111447A1 (en) * 2008-07-05 2011-05-12 Unisense Fertilitech A/S One to one identification system
CN104293646A (zh) 2009-08-22 2015-01-21 里兰斯坦福初级大学理事会 成像并评估胚胎、卵母细胞和干细胞
GB201006046D0 (en) * 2010-04-12 2010-05-26 Ge Healthcare Uk Ltd System and method for determining motion of a biological object
JP5962828B2 (ja) * 2010-06-30 2016-08-03 大日本印刷株式会社 体外培養による胚の製造方法、並びに胚を選別するための方法、装置、及びシステム
JP5807288B2 (ja) * 2010-06-30 2015-11-10 大日本印刷株式会社 体外培養による胚の製造方法、並びに胚を選別するための方法、装置、及びシステム
AU2011312464B2 (en) * 2010-09-27 2016-05-19 Ares Trading S.A. Apparatus, method, and system for the automated imaging and evaluation of embryos, oocytes, and stem cells
GR1007617B (el) * 2011-01-24 2012-06-20 Ιδρυμα Τεχνολογιας Και Ερευνας - Ιτε, Χρηση μη-γραμμικων απεικονιστικων τεχνικων για την αξιολογηση της ποιοτητας εμβρυων προεμφυτευτικου σταδιου και την προωθηση επιτυχους εγκυμοσυνης
CN103460038A (zh) 2011-02-23 2013-12-18 里兰斯坦福初级大学理事会 检测人类胚胎中的非整倍性的方法
WO2012163363A1 (en) 2011-05-31 2012-12-06 Unisense Fertilitech A/S Embryo quality assessment based on blastomere cleavage and morphology
US20140128667A1 (en) * 2011-07-02 2014-05-08 Unisense Fertilitech A/S Adaptive embryo selection criteria optimized through iterative customization and collaboration
US20140017717A1 (en) * 2012-05-31 2014-01-16 Auxogyn, Inc. In vitro embryo blastocyst prediction methods
EP2855664B1 (en) 2012-05-31 2017-10-04 Unisense Fertilitech A/S Embryo quality assessment based on blastocyst development
WO2014001312A1 (en) * 2012-06-25 2014-01-03 Unisense Fertilitech A/S Method and apparatus
CN110688985A (zh) * 2012-08-30 2020-01-14 尤尼森斯繁殖技术公司 体外培养胚胎的自动化监控
WO2014121200A1 (en) 2013-02-01 2014-08-07 Auxogyn, Inc. Abnormal syngamy phenotypes observed with time lapse imaging for early identification of embryos with lower developmental potential
EP2961336B1 (en) 2013-02-28 2024-03-27 Ares Trading S.A. Apparatus, method, and system for automated, non-invasive cell activity tracking
JP2014193145A (ja) * 2013-03-01 2014-10-09 Naoki Yamashita 胚盤胞培養液中のノルエピネフリン量によるヒト胚盤胞の評価方法
ES2691918T3 (es) * 2013-06-18 2018-11-29 Inserm - Institut National De La Santé Et De La Recherche Médicale Métodos para determinar la calidad de un embrión
US10942170B2 (en) 2014-03-20 2021-03-09 Ares Trading S.A. Quantitative measurement of human blastocyst and morula morphology developmental kinetics
WO2015192352A1 (zh) * 2014-06-19 2015-12-23 湖南光琇高新生命科技有限公司 一种根据分裂行为对体外受精治疗胚胎进行评估的等级分类方法
US11494578B1 (en) * 2015-09-21 2022-11-08 Ares Trading S.A. Systems and methods for automated assessment of embryo quality using image based features
US10510143B1 (en) * 2015-09-21 2019-12-17 Ares Trading S.A. Systems and methods for generating a mask for automated assessment of embryo quality
JP2018014991A (ja) * 2016-07-13 2018-02-01 ソニー株式会社 情報処理装置、情報処理方法及び情報処理システム
JP2018022216A (ja) * 2016-08-01 2018-02-08 ソニー株式会社 情報処理装置、情報処理方法、及びプログラム
US11282201B2 (en) 2016-11-02 2022-03-22 Sony Corporation Information processing device, information processing method and information processing system
JP6977293B2 (ja) * 2017-03-31 2021-12-08 ソニーグループ株式会社 情報処理装置、情報処理方法、プログラム及び観察システム
JP7100431B2 (ja) * 2017-07-14 2022-07-13 株式会社ニコン 受精卵判定装置、受精卵判定システム、及び受精卵判定プログラム
DE112018004960T5 (de) 2017-10-26 2020-07-23 Sony Corporation Informationsverarbeitungseinrichtung, informationsverarbeitungsverfahren, programm und beobachtungssystem
JP6732722B2 (ja) * 2017-12-11 2020-08-05 憲隆 福永 胚選抜システム
WO2020004237A1 (ja) * 2018-06-20 2020-01-02 Ｊｃｒファーマ株式会社 初期胚を選別するための解析ソフトウエア及び装置
GB201810634D0 (en) * 2018-06-28 2018-08-15 Vitrolife As Methods and apparatus for assessing embryo development
CN109214437A (zh) * 2018-08-22 2019-01-15 湖南自兴智慧医疗科技有限公司 一种基于机器学习的ivf-et早孕胚胎发育预测系统
AU2020341837A1 (en) * 2019-09-06 2022-04-21 The Brigham And Women's Hospital, Inc. Automated evaluation of quality assurance metrics for assisted reproduction procedures
CN116758539B (zh) * 2023-08-17 2023-10-31 武汉互创联合科技有限公司 一种基于数据增强的胚胎图像卵裂球识别方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3618734A (en) * 1969-06-10 1971-11-09 Res Foundation Of Children S H Specimen incubator
DE2940446C2 (de) * 1979-10-05 1982-07-08 B. Braun Melsungen Ag, 3508 Melsungen Züchtung von tierischen Zellen in Suspensions- und Monolayerkulturen in Fermentationsgefäßen
US4724543A (en) * 1985-09-10 1988-02-09 Beckman Research Institute, City Of Hope Method and apparatus for automatic digital image analysis
JP2559760B2 (ja) * 1987-08-31 1996-12-04 株式会社日立製作所 細胞搬送方法
US5196168A (en) * 1991-12-19 1993-03-23 Eastman Kodak Company Incubator with positioning device for slide elements
AU658079B2 (en) * 1992-09-28 1995-03-30 Becton Dickinson & Company Cell culture insert
US5763279A (en) * 1993-09-09 1998-06-09 Synthecon, Inc. Gas permeable bioreactor and method of use
US5968340A (en) * 1997-04-07 1999-10-19 Marine Biological Laboratory Polarographic self-referencing probe and method for using
US6228636B1 (en) * 1998-09-21 2001-05-08 Matsushita Electric Industrial Co., Ltd. Incubator
DE19903506C2 (de) * 1999-01-29 2002-04-04 Inst Chemo Biosensorik Verfahren, Gefäß und Vorrichtung zur Überwachung der Stoffwechselaktivität von Zellkulturen in flüssigen Medien
US6391577B1 (en) * 1999-03-03 2002-05-21 Susan R. Mikkelsen Rapid electrochemical assay for antibiotic and cytotoxic drug susceptibility in microorganisms
JP3442357B2 (ja) * 2000-08-25 2003-09-02 株式会社日立製作所 両生類卵母細胞試料導入装置、両生類卵母細胞試料導入システム、両生類卵母細胞試料導入方法、両生類卵母細胞の製造方法、両生類卵母細胞及びそれを販売又は譲渡する方法、スクリーニング用のセンサーとして用いる方法、容器、及び解析方法
US6434320B1 (en) * 2000-10-13 2002-08-13 Comtrak Technologies, Llc Method of searching recorded digital video for areas of activity
US6555365B2 (en) * 2000-12-07 2003-04-29 Biocrystal, Ltd. Microincubator comprising a cell culture apparatus and a transparent heater
US7015031B2 (en) * 2002-01-24 2006-03-21 Genx International, Inc. Biological specimen-culturing system and method with onboard specimen development sensors
JP4287287B2 (ja) * 2002-02-13 2009-07-01 レイファイ コーポレイション 空間時間信号の取得、圧縮、及び特徴づけのための方法及び装置
US7326565B2 (en) * 2002-11-19 2008-02-05 Sanyo Electric Co., Ltd. Storage apparatus
US20060201883A1 (en) * 2003-02-19 2006-09-14 Hofmeister William H Polymer matrixes having nanoscale channels and uses
US7372985B2 (en) * 2003-08-15 2008-05-13 Massachusetts Institute Of Technology Systems and methods for volumetric tissue scanning microscopy
US7239719B2 (en) * 2003-08-22 2007-07-03 Bbn Technologies Corp. Automatic target detection and motion analysis from image data
US20050118563A1 (en) * 2003-08-28 2005-06-02 Geoffrey Sher Method for determining embryo quality
US20070015289A1 (en) * 2003-09-19 2007-01-18 Kao H P Dispenser array spotting
JP3950972B2 (ja) * 2003-11-14 2007-08-01 国立大学法人名古屋大学 生物試料の生物発光測定装置
EP1702052A4 (en) * 2003-12-19 2009-02-18 Univ Waterloo CULTIVATED CELL AND METHOD AND DEVICE FOR CELL CULTURE
US7336401B2 (en) * 2003-12-19 2008-02-26 Xerox Corporation Systems and methods for estimating an image marking process using event mapping of scanned image attributes
JP4333426B2 (ja) * 2004-03-19 2009-09-16 ソニー株式会社 化合物半導体の製造方法、及び半導体装置の製造方法
ES2549205T3 (es) * 2005-10-14 2015-10-26 Unisense Fertilitech A/S Determinación de un cambio en una población de células
US20080056952A1 (en) * 2006-08-25 2008-03-06 Angros Lee H Analytic plates with markable portions and methods of use

Also Published As

Publication number Publication date
ATE477499T1 (de) 2010-08-15
US20130102837A1 (en) 2013-04-25
JP5732110B2 (ja) 2015-06-10
JP5731748B2 (ja) 2015-06-10
CN101495619B (zh) 2014-01-08
WO2007144001A3 (en) 2008-06-05
US20130225917A1 (en) 2013-08-29
CN103074410A (zh) 2013-05-01
JP2013198503A (ja) 2013-10-03
EP2035548A2 (en) 2009-03-18
US20120309043A1 (en) 2012-12-06
CN103074410B (zh) 2016-12-07
DE602007008419D1 (de) 2010-09-23
CN101495619A (zh) 2009-07-29
EP2282210A1 (en) 2011-02-09
EP2035548B1 (en) 2010-08-11
WO2007144001A2 (en) 2007-12-21
JP2009539387A (ja) 2009-11-19
US20100041090A1 (en) 2010-02-18

Similar Documents

Publication Publication Date Title
DK2035548T3 (da) Vurdering af embryokvalitet på basis af blastomer deling og bevævgelse
NZ598293A (en) Imaging and evaluating embryos, oocytes, and stem cells
EA201100120A1 (ru) Способы и системы для оценки клинического бесплодия
DK2621344T3 (da) Apparat, fremgangsmåde og system til automatisk billeddannelse og evaluering af embryoner, oocytter og stamceller
EP1734112A4 (en) PROCESS FOR PROLIFERATION OF A PLURIPOTENTIAL STEM CELL
DK2274419T3 (da) Fremgangsmåder til fremstilling af hårmikrofollikler og de novopapiller og anvendelse heraf til in vitro-test og in vivo-implantationer
DK2727998T3 (da) Fremgangsmåder til oprensning af pancreatiske endodermceller afledt fra humane embryoniske stamceller
DK2311282T3 (da) Fremgangsmåde og apparat til at udføre ændring i betjenende High Speed Downlink Shared Channel-celle.
DE602006019133D1 (de) Verfahren zur nicht-invasiven glucosemessung
EP1815244A4 (en) CELL CULTURE DEVICE
NO20090953L (no) Kontinuerlig dyrkingsanordning med bevegelig beholder og tilvirking av en dyrking pa en kontinuerlig mate
DK1984744T3 (da) Fremgangsmåder og sæt til diagnostisering af væksthormonmangel
DE602007006672D1 (de) Testverfahren und kit zur vorhersage des implantationserfolgs bei unterstützter befruchtung
ATE480615T1 (de) Verfahren zur proliferation von stammzellen
EP1857542A4 (en) METHOD FOR IN VITRO-AMPLIFICATION OF ADULTER STEM CELLS
GB2484873A (en) Differentiation of human embryonic stem cells
GB0600038D0 (en) Method and apparatus for the automatic identification of birds by their vocalizations
EP1929730A4 (en) Method and apparatus for instant messaging
EP2343361A4 (en) CELL CULTURE KIT, TEST PROCEDURE AND MANUFACTURING PROCESS FOR THE CELL CULTURE KIT
DK1858405T3 (da) Apparat til måling af hjerneparametre
DK1907628T3 (da) Kunstgræsstruktur og fremgangsmåde til fremstilling deraf
BRPI0923830A2 (pt) Método para identificar o presente nível de risco fetal durante trabalho de parto, e , aparelho para identificar o nível de risco fetal durante o trabalho de parto.
BRPI0506839A (pt) composições e métodos para induzir a cardiomiogênese
DE602007004143D1 (de) Verfahren zur Beurteilung der Lebensfähigkeit von Embryos
EP2021464A4 (en) METHOD FOR CULTURING HUMAN EMBRYONIC STEM CELLS