[go: up one dir, main page]

DK1948822T3 - Multikomponent-nukleinsyreenzymer og fremgangsmåder til deres anvendelse - Google Patents

Multikomponent-nukleinsyreenzymer og fremgangsmåder til deres anvendelse

Info

Publication number
DK1948822T3
DK1948822T3 DK06790343.5T DK06790343T DK1948822T3 DK 1948822 T3 DK1948822 T3 DK 1948822T3 DK 06790343 T DK06790343 T DK 06790343T DK 1948822 T3 DK1948822 T3 DK 1948822T3
Authority
DK
Denmark
Prior art keywords
methods
mnazymes
nucleic acid
acid enzymes
multicomponent nucleic
Prior art date
Application number
DK06790343.5T
Other languages
English (en)
Inventor
Donald John Birkett
Tram Bich Doan
Elisa Mokany
Alison Velyian Todd
Original Assignee
Johnson & Johnson Res Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson & Johnson Res Pty Ltd filed Critical Johnson & Johnson Res Pty Ltd
Application granted granted Critical
Publication of DK1948822T3 publication Critical patent/DK1948822T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/337—Ribozyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/205—Aptamer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/125—Sandwich assay format

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK06790343.5T 2005-10-07 2006-10-06 Multikomponent-nukleinsyreenzymer og fremgangsmåder til deres anvendelse DK1948822T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72456705P 2005-10-07 2005-10-07
US72629105P 2005-10-13 2005-10-13
PCT/AU2006/001473 WO2007041774A1 (en) 2005-10-07 2006-10-06 Multicomponent nucleic acid enzymes and methods for their use

Publications (1)

Publication Number Publication Date
DK1948822T3 true DK1948822T3 (da) 2011-10-17

Family

ID=37942211

Family Applications (2)

Application Number Title Priority Date Filing Date
DK06790343.5T DK1948822T3 (da) 2005-10-07 2006-10-06 Multikomponent-nukleinsyreenzymer og fremgangsmåder til deres anvendelse
DK11167771.2T DK2385141T3 (da) 2005-10-07 2006-10-06 Flerkomponentnukleinsyreenzymer og fremgangsmåder til anvendelse heraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK11167771.2T DK2385141T3 (da) 2005-10-07 2006-10-06 Flerkomponentnukleinsyreenzymer og fremgangsmåder til anvendelse heraf

Country Status (14)

Country Link
US (2) US8394946B2 (da)
EP (2) EP1948822B1 (da)
JP (1) JP5665272B2 (da)
KR (1) KR101379621B1 (da)
CN (1) CN103789311A (da)
AT (1) ATE516369T1 (da)
AU (2) AU2006302729B2 (da)
BR (1) BRPI0616466B1 (da)
CA (1) CA2625263C (da)
DK (2) DK1948822T3 (da)
ES (1) ES2431076T3 (da)
IL (1) IL190501A (da)
NZ (1) NZ567403A (da)
WO (1) WO2007041774A1 (da)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2255599C (en) 1996-04-25 2006-09-05 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
AU7299301A (en) 2000-06-21 2002-01-02 Bioarray Solutions Ltd Multianalyte molecular analysis using application-specific random particle arrays
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
ES2712173T3 (es) 2001-10-15 2019-05-09 Bioarray Solutions Ltd Análisis multiplexado de loci polimórficos mediante consulta simultánea y detección mediada por enzimas
US7041453B2 (en) * 2002-08-22 2006-05-09 Bioarray Solutions Ltd. Molecular constructs and methods of use for detection of biochemical reactions
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
US7927796B2 (en) 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
CN1882699A (zh) 2003-09-22 2006-12-20 佰尔瑞溶液有限公司 带有多个能共价结合生物分子的官能基团的表面固定化多电解质
EP1692298A4 (en) 2003-10-28 2008-08-13 Bioarray Solutions Ltd OPTIMIZATION OF GENE EXPRESSION ANALYSIS USING IMMOBILIZED CATCHES
JP2007509629A (ja) 2003-10-29 2007-04-19 バイオアレイ ソリューションズ リミテッド 二本鎖ｄｎａの切断による複合核酸分析
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
AU2006302729B2 (en) 2005-10-07 2011-02-03 Speedx Pty Ltd Multicomponent nucleic acid enzymes and methods for their use
CN101365808B (zh) 2005-12-07 2012-04-25 泰博特克药品有限公司 用于评估hiv病毒适应度的方法、质粒载体和引物
WO2008054834A2 (en) * 2006-02-03 2008-05-08 Columbia University Binary deoxyribozyme probes for nucleic acid analysis
EP2013561B1 (en) * 2006-03-31 2012-06-27 Columbia University Binary probes for fluorescent analysis of nucleic acids
BRPI0718137B1 (pt) * 2006-10-06 2016-05-10 Johnson & Johnson Res Pty Ltd comutadores moleculares e métodos para seu uso
KR100896987B1 (ko) * 2007-03-14 2009-05-14 한국과학기술연구원 앱타머를 이용한 표적 단백질 검출 방법 및 검출키트
AU2008235256B2 (en) * 2007-04-05 2014-05-15 Speedx Pty Ltd Nucleic acid enzymes and complexes and methods for their use
US8409803B2 (en) 2007-04-06 2013-04-02 Speedx Pty Ltd. Respiratory syncytial virus (RSV) viral load detection assay
US8043810B2 (en) * 2007-05-02 2011-10-25 Eagle Eye Research, Inc. Analyte detection using autocatalytic chain reactions
US8551768B2 (en) 2008-11-21 2013-10-08 The Trustees Of Columbia University In The City Of New York Split DNA enzyme for visual single nucleotide polymorphism typing
WO2010088404A1 (en) 2009-01-28 2010-08-05 Columbia University Microarrays of binary nucleic acid probes for detecting nucleic acid analytes
AU2010221419B2 (en) 2009-03-02 2015-10-01 Alnylam Pharmaceuticals, Inc. Nucleic acid chemical modifications
EP2425023B1 (en) 2009-04-27 2015-12-23 Pacific Biosciences of California, Inc. Real-time sequencing methods and systems
US8916349B2 (en) 2009-11-23 2014-12-23 Becton, Dickinson And Company Assay method for target nucleic acid by signal amplification using probe hybridization and restriction
US9102938B2 (en) 2010-04-01 2015-08-11 Alnylam Pharmaceuticals, Inc. 2′ and 5′ modified monomers and oligonucleotides
US8859266B2 (en) * 2010-04-28 2014-10-14 University Of Central Florida Research Foundation, Inc. Binary probe system for sensitive detection of target analytes
WO2012034130A2 (en) * 2010-09-10 2012-03-15 Qiagen Methods and compositions for nucleic acid detection
SG188497A1 (en) 2010-09-22 2013-05-31 Alios Biopharma Inc Substituted nucleotide analogs
MX2013003681A (es) 2010-10-01 2013-11-20 Moderna Therapeutics Inc Ácidos nucleicos manipulados y métodos de uso de los mismos.
JP6092114B2 (ja) * 2010-11-19 2017-03-08 スピーデクス ピーティーワイ リミテッド シグナル増幅
AU2012206750A1 (en) 2011-01-10 2013-07-18 Noxxon Pharma Ag Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same
DE12722942T1 (de) * 2011-03-31 2021-09-30 Modernatx, Inc. Freisetzung und formulierung von manipulierten nukleinsäuren
JP6355555B2 (ja) 2011-04-01 2018-07-11 キアゲン Ｗｎｔ／ｂ−カテニンシグナル伝達経路に関する遺伝子発現シグネチャーおよびその使用
MX349801B (es) * 2011-09-09 2017-08-14 Speedx Pty Ltd Sustratos de enzimas de ácido nucleico.
AU2012358804B2 (en) 2011-12-22 2018-04-19 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
DK2817421T3 (da) 2012-02-20 2018-03-05 Speedx Pty Ltd Detektion af nukleinsyrer
EP2828277A1 (en) 2012-03-21 2015-01-28 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
EP2827876A4 (en) 2012-03-22 2015-10-28 Alios Biopharma Inc PHARMACEUTICAL COMBINATIONS WITH A THIONUCLEOTIDE ANALOG
AU2013202354A1 (en) * 2012-06-18 2014-01-16 Speedx Pty Ltd Target detection and signal amplification
AU2012307021B2 (en) * 2012-09-10 2014-10-30 Speedx Pty Ltd Nucleic acid enzyme substrates
US9476090B2 (en) * 2013-05-21 2016-10-25 Stc.Unm Signal propagation biomolecules, devices and methods
WO2014200905A2 (en) 2013-06-10 2014-12-18 President And Fellows Of Harvard College Early developmental genomic assay for characterizing pluripotent stem cell utility and safety
WO2014197965A1 (en) * 2013-06-12 2014-12-18 The Governing Council Of The University Of Toronto Catalytic nucleic acid and gold nanoparticles for detection of biomolecules
EP3305913A4 (en) * 2015-05-29 2018-10-31 Toppan Printing Co., Ltd. Nucleic acid detection method, nucleic acid quantitative determination method, nucleic acid base sequence identification method, nucleic acid mutation or polymorphism identification method, nucleic acid detection kit, and reaction chip
CN108026569B (zh) * 2015-07-17 2021-08-24 卢米耐克斯公司 用于催化性测定的方法和组合物
EP3351251A4 (en) * 2015-09-16 2019-05-22 Tohoku University Nucleic Acid MOLECULE
WO2017195137A1 (en) * 2016-05-10 2017-11-16 Nicolas Arab Compositions and methods for identifying, quantifying, and/or characterizing an analyte
US20190360019A1 (en) * 2016-11-16 2019-11-28 Universal Biosensors Pty Ltd Cleavage event transduction methods and products
EP3372691A1 (en) * 2017-03-06 2018-09-12 Technische Universität Braunschweig Arrangement for detecting and amplifying a signal based on a single target molecule and method for detecting and amplifying a signal based on a single target molecule
EP3610036B1 (en) 2017-04-11 2025-07-02 SpeeDx Pty Ltd Detection cascades
WO2019030383A1 (en) 2017-08-10 2019-02-14 Katholieke Universiteit Leuven ENZYME SENSOR OF NUCLEIC ACIDS
US11313001B2 (en) 2017-11-06 2022-04-26 The Regents Of The University Of Michigan Compositions and methods for detection of microorganisms
SG11201912883WA (en) 2017-12-21 2020-01-30 Speedx Pty Ltd Nucleic acid ratio determination
JP7423603B2 (ja) 2018-08-09 2024-01-29 スピードックス・プロプライエタリー・リミテッド 核酸の多重検出
CN109097468A (zh) * 2018-08-14 2018-12-28 南通市第人民医院 Opcml基因启动子甲基化水平的检测试剂盒及其应用
CN109837353A (zh) * 2018-12-05 2019-06-04 重庆医科大学 基于DNA纳米自主装对沙门菌invA基因检测的方法
KR20230098259A (ko) 2020-10-29 2023-07-03 비오까르띠 엔브이 멀티플렉스 핵산 검출을 위한 제네릭 카트리지 및 방법
WO2022232683A2 (en) * 2021-04-30 2022-11-03 The Regents Of The University Of California Multicomponent xnazyme-based nucleic acid detection system
CN113025691B (zh) * 2021-05-26 2021-08-06 广东品博易视生物科技有限公司 一种预放大核酸及其应用
CN115637287A (zh) * 2022-06-14 2023-01-24 青岛科技大学 用于检测单碱基基因突变的MNAzyme生物传感器
EP4310195A1 (en) * 2022-07-18 2024-01-24 Moirai Biodesign, S.L. Method for nucleic acid detection using signal-mediated amplification of rna technology and rna aptamers

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000159A (en) 1974-06-28 1976-12-28 Phillips Petroleum Company Preparation of n,n-disubstituted thioamides
US5176995A (en) 1985-03-28 1993-01-05 Hoffmann-La Roche Inc. Detection of viruses by amplification and hybridization
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4800159A (en) * 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5424413A (en) 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
ATE217347T1 (de) * 1992-12-04 2002-05-15 Univ Yale Diagnose mittels signalverstärkung durch ein ribozym
WO1998049346A1 (en) 1997-04-29 1998-11-05 The Scripps Research Institute Enzymatic dna molecules
US7141665B1 (en) * 1998-04-29 2006-11-28 The Scripps Research Institute Enzymatic DNA molecules
US5807718A (en) * 1994-12-02 1998-09-15 The Scripps Research Institute Enzymatic DNA molecules
US5545729A (en) * 1994-12-22 1996-08-13 Hybridon, Inc. Stabilized ribozyme analogs
EP0822992A4 (en) 1995-02-27 2000-08-09 Intelligene Ltd DETECTION OF BIOMOLECULES
ATE414169T1 (de) 1998-03-05 2008-11-15 Johnson & Johnson Res Pty Ltd Methoden zur detektion von nukleinsäuren unter verwendung von zymogenen und dazugehörige kits
EP1063296A1 (en) * 1998-03-12 2000-12-27 Taisho Pharmaceutical Co., Ltd Nucleic acid enzyme showing allosteric rna-cleaving activity on target rna
DE19811618C1 (de) * 1998-03-17 2000-08-31 Andreas Jenne Ribozym codierende DNA und ein Oligonucleotidsubstrat enthaltende Zusammensetzung und Verfahren zur Messung von Transkriptionsraten
US6361941B1 (en) 1998-03-27 2002-03-26 Johnson & Johnson Research Pty Limited Catalytic nucleic acid-based diagnostic methods
DE19915141C2 (de) 1999-03-26 2002-11-21 Artus Ges Fuer Molekularbiolog Detektion von Nucleinsäure-Amplifikaten
CA2400415A1 (en) * 2000-03-06 2001-09-13 Ribozyme Pharmaceuticals, Inc. Nucleic acid sensor molecules
JP3595843B2 (ja) * 2000-10-13 2004-12-02 独立行政法人産業技術総合研究所 Ｒｎａ分子を認識することにより他の特定の標的ｒｎａに対する切断活性を獲得する核酸酵素
AU2002367785A1 (en) 2001-11-05 2003-11-03 Sirna Therapeutics, Inc Allosteric nucleic acid sensor molecules
WO2005051174A2 (en) 2003-11-21 2005-06-09 The Trustees Of Columbia University In The City Of New York Nucleic acid aptamer-based compositions and methods
US20070254282A1 (en) 2004-01-29 2007-11-01 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Catalytic Polynucleotide and Its Use for Determination of Analytes
US7553945B2 (en) * 2005-08-03 2009-06-30 Bowling Green State University RNA complexes and methods of their production
AU2006302729B2 (en) 2005-10-07 2011-02-03 Speedx Pty Ltd Multicomponent nucleic acid enzymes and methods for their use
US20120101267A1 (en) * 2005-10-07 2012-04-26 Alison Velyian Todd Multicomponent nucleic acid enzymes with cleavage, ligase or other activity and methods for their use
CN101365808B (zh) 2005-12-07 2012-04-25 泰博特克药品有限公司 用于评估hiv病毒适应度的方法、质粒载体和引物
WO2008054834A2 (en) 2006-02-03 2008-05-08 Columbia University Binary deoxyribozyme probes for nucleic acid analysis
BRPI0718137B1 (pt) * 2006-10-06 2016-05-10 Johnson & Johnson Res Pty Ltd comutadores moleculares e métodos para seu uso
AU2008235256B2 (en) 2007-04-05 2014-05-15 Speedx Pty Ltd Nucleic acid enzymes and complexes and methods for their use
US8409803B2 (en) * 2007-04-06 2013-04-02 Speedx Pty Ltd. Respiratory syncytial virus (RSV) viral load detection assay
EP2188394B1 (en) 2007-08-13 2015-06-24 University of Strathclyde Identification of nucleic acid sequences
US20110207132A1 (en) 2008-08-04 2011-08-25 University Of Maryland Probes and methods for detecting analytes
US9602380B2 (en) 2014-03-28 2017-03-21 Futurewei Technologies, Inc. Context-aware dynamic policy selection for load balancing behavior

Also Published As

Publication number Publication date
JP5665272B2 (ja) 2015-02-04
US8945836B2 (en) 2015-02-03
ES2431076T3 (es) 2013-11-25
US20130123480A1 (en) 2013-05-16
AU2011202017A1 (en) 2011-05-26
HK1116836A1 (en) 2009-01-02
US8394946B2 (en) 2013-03-12
BRPI0616466B1 (pt) 2021-01-26
CA2625263C (en) 2016-12-13
EP1948822B1 (en) 2011-07-13
AU2011202017B2 (en) 2012-02-02
US20070231810A1 (en) 2007-10-04
JP2009509551A (ja) 2009-03-12
AU2006302729B2 (en) 2011-02-03
EP1948822A1 (en) 2008-07-30
ATE516369T1 (de) 2011-07-15
DK2385141T3 (da) 2013-10-28
KR20080071130A (ko) 2008-08-01
KR101379621B1 (ko) 2014-04-11
IL190501A (en) 2014-11-30
IL190501A0 (en) 2008-11-03
EP2385141A1 (en) 2011-11-09
EP1948822A4 (en) 2009-10-28
EP2385141B1 (en) 2013-08-07
BRPI0616466A2 (pt) 2011-06-21
NZ567403A (en) 2011-03-31
CA2625263A1 (en) 2007-04-19
CN103789311A (zh) 2014-05-14
AU2006302729A1 (en) 2007-04-19
WO2007041774A1 (en) 2007-04-19

Similar Documents

Publication Publication Date Title
DK1948822T3 (da) Multikomponent-nukleinsyreenzymer og fremgangsmåder til deres anvendelse
WO2007035953A3 (en) Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
ATE458832T1 (de) Paralleles scoring von polymorphismen mittels amplifikation und fehlerkorrektur
ATE550441T1 (de) Verfahren, zusammensetzungen und kits zur isothermischen amplifikation von nukleinsäuren
WO2007123744A3 (en) Systems and devices for sequence by synthesis analysis
WO2009092035A3 (en) Methods and compositions for the analysis of biological molecules
WO2010026488A3 (en) Methods and kits for nucleic acid sequencing
WO2008051530A3 (en) Polymerase enzymes and reagents for enhanced nucleic acid sequencing
WO2009105670A3 (en) Substrates for multiplexed assays and uses thereof
WO2009117327A3 (en) Compositions and methods for analysis of nucleic acid molecules during amplification reactions
EP1969146A4 (en) PROCESS FOR THE ALLOCATION OF NUCLEIC ACIDS AND FOR THE IDENTIFICATION OF FINE-STRUCTURED VARIATIONS IN NUCLEIC ACIDS AND AID THEREFOR
ATE515488T1 (de) Click-chemie zur herstellung von reportermolekülen
EA201170933A1 (ru) Анализ нуклеиновых кислот, полученных из единичных клеток
WO2011056866A3 (en) Methods and kits for 3'-end-tagging of rna
EP4450642A3 (en) Single molecule nucleic acid sequence analysis processes and compositions
DK1726664T3 (da) Detektionssystem til PCR-assay
BR0205268A (pt) Processos e composições para a mplificação de sequências de rna
WO2009151691A3 (en) Genetic polymorphisms associated wiith venous thrombosis, methods of detection and uses thereof
NO20072722L (no) Preparater og fremgangsmate for a rense nukleinsyrer fra stabiliseringsreagenser
WO2005056837A3 (en) Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
WO2010036359A3 (en) Methods of polymerase activity assay
WO2006088623A3 (en) Selection probe amplification
WO2008076856A3 (en) Reagents and methods for detecting cyp2d6 polymorphisms
WO2009012363A3 (en) Nucleotides and aptamers containing boronic acid groups having biased binding to glycosylated proteins, and uses thereof
WO2005083127A3 (en) Genetic polymorphisms associated with stroke, methods of detection and uses thereof