DK1828151T3 - Malonamidderivater som inhibitorer af gamma-sekretase til behandlingen af alzheimer's sygdom - Google Patents
Malonamidderivater som inhibitorer af gamma-sekretase til behandlingen af alzheimer's sygdomInfo
- Publication number
- DK1828151T3 DK1828151T3 DK05811672.4T DK05811672T DK1828151T3 DK 1828151 T3 DK1828151 T3 DK 1828151T3 DK 05811672 T DK05811672 T DK 05811672T DK 1828151 T3 DK1828151 T3 DK 1828151T3
- Authority
- DK
- Denmark
- Prior art keywords
- alzheimer
- inhibitors
- disease
- treatment
- gamma secretase
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 title 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- WRIRWRKPLXCTFD-UHFFFAOYSA-N malonamide Chemical class NC(=O)CC(N)=O WRIRWRKPLXCTFD-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106395 | 2004-12-08 | ||
| EP05100816 | 2005-02-07 | ||
| PCT/EP2005/012834 WO2006061136A2 (en) | 2004-12-08 | 2005-12-01 | Malonamide derivatives as inhibitors of gamma-secretase for the treatment of alzheimer’s disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1828151T3 true DK1828151T3 (da) | 2011-05-16 |
Family
ID=36293585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05811672.4T DK1828151T3 (da) | 2004-12-08 | 2005-12-01 | Malonamidderivater som inhibitorer af gamma-sekretase til behandlingen af alzheimer's sygdom |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7211573B2 (da) |
| EP (1) | EP1828151B1 (da) |
| JP (1) | JP4979590B2 (da) |
| KR (1) | KR100890678B1 (da) |
| CN (1) | CN101072760B (da) |
| AR (1) | AR053987A1 (da) |
| AT (1) | ATE504580T1 (da) |
| AU (1) | AU2005313582B8 (da) |
| BR (1) | BRPI0518615A2 (da) |
| CA (1) | CA2589196A1 (da) |
| DE (1) | DE602005027388D1 (da) |
| DK (1) | DK1828151T3 (da) |
| HK (1) | HK1114840A1 (da) |
| IL (1) | IL183293A0 (da) |
| MX (1) | MX2007006504A (da) |
| NO (1) | NO20072609L (da) |
| NZ (1) | NZ555184A (da) |
| PL (1) | PL1828151T3 (da) |
| PT (1) | PT1828151E (da) |
| RU (1) | RU2402538C2 (da) |
| TW (1) | TWI349005B (da) |
| WO (1) | WO2006061136A2 (da) |
| ZA (1) | ZA200705018B (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101096476B1 (ko) | 2006-09-20 | 2011-12-20 | 에프. 호프만-라 로슈 아게 | 4-옥소-2,3,4,5-테트라히드로-벤조[ｂ][1,4]디아제핀 유도체 |
| CA2676160A1 (en) | 2007-02-02 | 2008-08-07 | F. Hoffmann-La Roche Ag | 6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl derivatives |
| US8741889B2 (en) * | 2008-01-11 | 2014-06-03 | Hoffmann-La Roche Inc | Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor |
| JP5612482B2 (ja) * | 2008-01-11 | 2014-10-22 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 癌の処理のためのγ−セクレターゼインヒビターの使用 |
| WO2016198366A1 (en) | 2015-06-11 | 2016-12-15 | F. Hoffmann-La Roche Ag | Targeted notch pathway inhibitors |
| US11339157B1 (en) | 2017-10-24 | 2022-05-24 | Bayer Aktiengesellschaft | 4H-pyrrolo[3,2-c]pyridin-4-one derivatives |
| US20220017456A1 (en) * | 2018-11-07 | 2022-01-20 | Chugai Seiyaku Kabushiki Kaisha | O-substituted serine derivative production method |
| JP7641913B2 (ja) | 2019-04-24 | 2025-03-07 | バイエル・アクチエンゲゼルシヤフト | ４ｈ－ピロロ［３，２－ｃ］ピリジン－４－オン化合物 |
| US20220378762A1 (en) | 2019-04-24 | 2022-12-01 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| US20240307362A1 (en) | 2019-04-24 | 2024-09-19 | Bayer Aktiengesellschaft | 4H-PYRROLO[3,2-c]PYRIDIN-4-ONE COMPOUNDS |
| CN112300019A (zh) * | 2019-07-31 | 2021-02-02 | 华东师范大学 | 一种邻乙酰氨基苯丁酸类化合物的制备方法 |
| EP4126861A1 (en) | 2020-03-31 | 2023-02-08 | Bayer Aktiengesellschaft | 3-(anilino)-2-[3-(3-alkoxy-pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one derivatives as egfr inhibitors for the treatment of cancer |
| EP4305020A1 (en) | 2021-03-09 | 2024-01-17 | Basf Se | Malonamides and their use as herbicides |
| AU2022332622A1 (en) * | 2021-08-25 | 2024-03-07 | Basf Se | Herbicidal malonamides |
| IL311001A (en) * | 2021-08-31 | 2024-04-01 | Basf Se | Herbicidal malonamides containing a compressed ring system |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002241368A (ja) * | 1997-02-18 | 2002-08-28 | Shionogi & Co Ltd | 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物 |
| EP1089977A1 (en) * | 1998-06-22 | 2001-04-11 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| GB0012671D0 (en) | 2000-05-24 | 2000-07-19 | Merck Sharp & Dohme | Therapeutic agents |
| AU2003240681B2 (en) * | 2002-05-29 | 2008-10-09 | F. Hoffmann-La Roche Ag | N-acylaminobenzene derivatives as selective monoamine oxidase B inhibitors |
| TW200502221A (en) * | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| NZ541324A (en) | 2003-02-04 | 2008-10-31 | Hoffmann La Roche | Malonamide derivatives as gamma-secretase inhibitors |
| US7060698B2 (en) | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| EP1711470B1 (en) | 2003-09-09 | 2009-04-15 | F. Hoffmann-La Roche Ag | Malonamide derivatives blocking the activtiy of gamma-secretase |
| PT1673347E (pt) | 2003-10-06 | 2015-11-02 | Hoffmann La Roche | Derivados de dibenzo-azepina e benzo-diazepina substituídos, úteis como inibidores de secretase gama |
-
2005
- 2005-11-30 US US11/289,176 patent/US7211573B2/en not_active Expired - Fee Related
- 2005-12-01 KR KR1020077015604A patent/KR100890678B1/ko not_active IP Right Cessation
- 2005-12-01 NZ NZ555184A patent/NZ555184A/en not_active IP Right Cessation
- 2005-12-01 JP JP2007544779A patent/JP4979590B2/ja not_active Expired - Fee Related
- 2005-12-01 EP EP05811672A patent/EP1828151B1/en active Active
- 2005-12-01 CN CN2005800421635A patent/CN101072760B/zh not_active Expired - Fee Related
- 2005-12-01 CA CA002589196A patent/CA2589196A1/en not_active Abandoned
- 2005-12-01 AT AT05811672T patent/ATE504580T1/de active
- 2005-12-01 DK DK05811672.4T patent/DK1828151T3/da active
- 2005-12-01 AU AU2005313582A patent/AU2005313582B8/en not_active Ceased
- 2005-12-01 DE DE602005027388T patent/DE602005027388D1/de active Active
- 2005-12-01 RU RU2007120211/04A patent/RU2402538C2/ru not_active IP Right Cessation
- 2005-12-01 PT PT05811672T patent/PT1828151E/pt unknown
- 2005-12-01 MX MX2007006504A patent/MX2007006504A/es active IP Right Grant
- 2005-12-01 WO PCT/EP2005/012834 patent/WO2006061136A2/en active Application Filing
- 2005-12-01 BR BRPI0518615-3A patent/BRPI0518615A2/pt not_active IP Right Cessation
- 2005-12-01 PL PL05811672T patent/PL1828151T3/pl unknown
- 2005-12-07 AR ARP050105106A patent/AR053987A1/es unknown
- 2005-12-07 TW TW094143269A patent/TWI349005B/zh not_active IP Right Cessation
-
2007
- 2007-05-17 IL IL183293A patent/IL183293A0/en unknown
- 2007-05-24 NO NO20072609A patent/NO20072609L/no not_active Application Discontinuation
- 2007-06-04 ZA ZA200705018A patent/ZA200705018B/xx unknown
-
2008
- 2008-04-29 HK HK08104728.3A patent/HK1114840A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070086979A (ko) | 2007-08-27 |
| TWI349005B (en) | 2011-09-21 |
| ATE504580T1 (de) | 2011-04-15 |
| EP1828151B1 (en) | 2011-04-06 |
| AU2005313582A8 (en) | 2011-06-16 |
| PL1828151T3 (pl) | 2011-09-30 |
| CN101072760B (zh) | 2011-12-28 |
| WO2006061136A2 (en) | 2006-06-15 |
| ZA200705018B (en) | 2010-04-28 |
| RU2402538C2 (ru) | 2010-10-27 |
| CN101072760A (zh) | 2007-11-14 |
| HK1114840A1 (en) | 2008-11-14 |
| RU2007120211A (ru) | 2009-01-20 |
| IL183293A0 (en) | 2007-09-20 |
| KR100890678B1 (ko) | 2009-03-26 |
| TW200626568A (en) | 2006-08-01 |
| AU2005313582B8 (en) | 2011-06-16 |
| AU2005313582B2 (en) | 2011-06-02 |
| PT1828151E (pt) | 2011-06-16 |
| CA2589196A1 (en) | 2006-06-15 |
| AU2005313582A1 (en) | 2006-06-15 |
| JP2008522994A (ja) | 2008-07-03 |
| AR053987A1 (es) | 2007-05-30 |
| NZ555184A (en) | 2010-01-29 |
| US7211573B2 (en) | 2007-05-01 |
| MX2007006504A (es) | 2007-06-22 |
| BRPI0518615A2 (pt) | 2008-11-25 |
| US20060122168A1 (en) | 2006-06-08 |
| DE602005027388D1 (de) | 2011-05-19 |
| EP1828151A2 (en) | 2007-09-05 |
| NO20072609L (no) | 2007-06-19 |
| JP4979590B2 (ja) | 2012-07-18 |
| WO2006061136A3 (en) | 2006-08-03 |
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