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DK179788D0 - N-aryl-piperazinalkanamidderivater, fremgangsmaade til fremstilling deraf, praeparater indeholdende samme samt anvendelse af saadanne derivater til fremstilling af farmaceutisk aktive praeparater - Google Patents

N-aryl-piperazinalkanamidderivater, fremgangsmaade til fremstilling deraf, praeparater indeholdende samme samt anvendelse af saadanne derivater til fremstilling af farmaceutisk aktive praeparater

Info

Publication number
DK179788D0
DK179788D0 DK179788A DK179788A DK179788D0 DK 179788 D0 DK179788 D0 DK 179788D0 DK 179788 A DK179788 A DK 179788A DK 179788 A DK179788 A DK 179788A DK 179788 D0 DK179788 D0 DK 179788D0
Authority
DK
Denmark
Prior art keywords
6alkyl
derivatives
preparing
preparations
piperazinal
Prior art date
Application number
DK179788A
Other languages
English (en)
Other versions
DK174878B1 (da
DK179788A (da
Inventor
Georges Henri Paul Van Daele
Freddy Francois Vlaeminck
Marc Gustaaf Celine Verdonck
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of DK179788D0 publication Critical patent/DK179788D0/da
Publication of DK179788A publication Critical patent/DK179788A/da
Priority to DK200300404A priority Critical patent/DK175244B1/da
Application granted granted Critical
Publication of DK174878B1 publication Critical patent/DK174878B1/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK198801797A 1987-04-01 1988-03-30 Anvendelse af N-aryl-piperazinalkanamidderivater til fremstilling af et medikament til forbedring af søvn DK174878B1 (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK200300404A DK175244B1 (da) 1987-04-01 2003-03-17 N-aryl-piperazinalkanamidderivater, farmaceutiske sammensætninger indeholdende disse samt fremgangsmåder til fremstilling deraf

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3412987A 1987-04-01 1987-04-01
US3412987 1987-04-01

Publications (3)

Publication Number Publication Date
DK179788D0 true DK179788D0 (da) 1988-03-30
DK179788A DK179788A (da) 1988-10-02
DK174878B1 DK174878B1 (da) 2004-01-12

Family

ID=21874492

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198801797A DK174878B1 (da) 1987-04-01 1988-03-30 Anvendelse af N-aryl-piperazinalkanamidderivater til fremstilling af et medikament til forbedring af søvn

Country Status (21)

Country Link
EP (2) EP0727421B1 (da)
JP (1) JP2574377B2 (da)
KR (1) KR960016539B1 (da)
AT (2) ATE207474T1 (da)
AU (1) AU609790B2 (da)
CA (1) CA1315790C (da)
DE (2) DE3855520T2 (da)
DK (1) DK174878B1 (da)
ES (2) ES2167510T3 (da)
FI (1) FI97617C (da)
GR (1) GR3020983T3 (da)
HK (1) HK1006020A1 (da)
HU (2) HUT57740A (da)
IE (1) IE81057B1 (da)
IL (1) IL85919A (da)
NO (1) NO178660C (da)
NZ (1) NZ223847A (da)
PH (1) PH25507A (da)
PT (1) PT87118B (da)
RU (1) RU2014328C1 (da)
ZA (1) ZA882352B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840896A (en) * 1989-11-22 1998-11-24 Janssen Pharmaceutica, N.V. Method of preventing or limiting reperfusion damage
CA2044143C (en) * 1989-11-22 2002-11-19 Herman Van Belle Method of preventing or limiting reperfusion damage
JP2660086B2 (ja) * 1990-07-03 1997-10-08 明治製菓株式会社 脳及び心機能障害改善剤
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines
ATE174913T1 (de) * 1992-07-31 1999-01-15 Bristol Myers Squibb Co Diphenyl oxazole-, thiazole- und imidazole- derivate als inhibitoren der wiederaufnahme des adenosins
SE9202266D0 (sv) * 1992-07-31 1992-07-31 Kabi Pharmacia Ab Novel piperazine carboxamides
ES2151960T3 (es) * 1994-04-20 2001-01-16 Lonza Ag Procedimiento para la preparacion de derivados de acido 2-piperazincarboxilicos.
CA2234342A1 (en) * 1997-04-10 1998-10-10 Kyowa Hakko Kogyo Co., Ltd. Pancreatitis remedy
JP2002504134A (ja) * 1997-06-16 2002-02-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 疼痛を治療するためのドラフラジン類似体の使用
UA89503C2 (uk) 2004-09-13 2010-02-10 Х. Луннбек А/С Заміщені похідні аніліну
ES2639621T3 (es) 2004-12-30 2017-10-27 Janssen Pharmaceutica N.V. Derivados de fenilamida del ácido 4-(bencil)-piperazina-1-carboxílico y compuestos relacionados como moduladores de la amida hidrolasa de ácidos grasos (FAAH) para el tratamiento de la ansiedad, el dolor y otras afecciones
UA108233C2 (uk) 2010-05-03 2015-04-10 Модулятори активності гідролази амідів жирних кислот
CN110511220B (zh) * 2018-05-22 2022-04-01 上海挚盟医药科技有限公司 作为钾通道调节剂的对二氨基苯衍生物、其制备方法及其在医药上的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795375A1 (de) * 1968-09-21 1972-01-05 Boehringer Mannheim Gmbh Basische AEther und Verfahren zur Herstellung derselben
US4766125A (en) * 1981-06-23 1988-08-23 Janssen Pharmaceutica N.V. N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia

Also Published As

Publication number Publication date
IE81057B1 (en) 1999-12-29
FI881525A (fi) 1988-10-02
IE880989L (en) 1988-10-01
EP0285219A2 (en) 1988-10-05
EP0285219B1 (en) 1996-09-11
EP0285219A3 (en) 1991-07-03
KR960016539B1 (ko) 1996-12-14
HUT57740A (en) 1991-12-30
CA1315790C (en) 1993-04-06
AU1384788A (en) 1988-10-06
PT87118A (pt) 1988-04-01
DK174878B1 (da) 2004-01-12
PH25507A (en) 1991-07-24
IL85919A0 (en) 1988-09-30
EP0727421A1 (en) 1996-08-21
FI97617B (fi) 1996-10-15
FI881525A0 (fi) 1988-03-31
GR3020983T3 (en) 1996-12-31
KR880012566A (ko) 1988-11-28
DE3856501D1 (de) 2001-11-29
JP2574377B2 (ja) 1997-01-22
NO881407L (no) 1988-10-03
RU2014328C1 (ru) 1994-06-15
PT87118B (pt) 1992-07-31
NO178660B (no) 1996-01-29
ES2091183T3 (es) 1996-11-01
JPS63290869A (ja) 1988-11-28
ATE142627T1 (de) 1996-09-15
DE3856501T2 (de) 2004-04-29
NO178660C (no) 1996-05-08
ES2167510T3 (es) 2002-05-16
ATE207474T1 (de) 2001-11-15
HU211129A9 (en) 1995-10-30
NZ223847A (en) 1989-12-21
NO881407D0 (no) 1988-03-29
DE3855520T2 (de) 1997-02-06
DK179788A (da) 1988-10-02
EP0727421B1 (en) 2001-10-24
FI97617C (fi) 1997-01-27
HK1006020A1 (en) 1999-02-05
IL85919A (en) 1992-12-01
DE3855520D1 (de) 1996-10-17
ZA882352B (en) 1989-12-27
AU609790B2 (en) 1991-05-09

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