DK175786B1 - Kloning og ekspression af sur fibroblastvækstfaktor - Google Patents

Kloning og ekspression af sur fibroblastvækstfaktor Download PDF

Info

Publication number: DK175786B1
Authority: DK; Denmark
Prior art keywords: afgf; human; dna; gene; bovine
Prior art date: 1986-07-11

Application number

DK198703587A

Other languages

Danish (da)

English (en)

Other versions

DK358787D0 (da

DK358787A (da

Inventor

David L Linemeyer

Guillermo Gimenez-Gallego

Linda J Kelly

A Thomas Kenneth Jr

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-11

Filing date

1987-07-10

Publication date

2005-02-21

1987-07-10 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1987-07-10 Publication of DK358787D0 publication Critical patent/DK358787D0/da

1988-01-12 Publication of DK358787A publication Critical patent/DK358787A/da

1998-08-11 Priority to DK199801023A priority Critical patent/DK175856B1/da

2005-02-21 Application granted granted Critical

2005-02-21 Publication of DK175786B1 publication Critical patent/DK175786B1/da

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Wood Science & Technology (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmacology & Pharmacy (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Dermatology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK198703587A 1986-07-11 1987-07-10 Kloning og ekspression af sur fibroblastvækstfaktor DK175786B1 (da)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DK199801023A DK175856B1 (da)	1986-07-11	1998-08-11	Nukleotid sekvens, ekspressionsplasmid og fremgangsmåde til oprensning af aFGF

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US88446086A	1986-07-11	1986-07-11
US88446086		1986-07-11
US5499187A	1987-06-04	1987-06-04
US5499187		1987-06-04

Publications (3)

Publication Number	Publication Date
DK358787D0 DK358787D0 (da)	1987-07-10
DK358787A DK358787A (da)	1988-01-12
DK175786B1 true DK175786B1 (da)	2005-02-21

Family

ID=26733717

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198703587A DK175786B1 (da)	1986-07-11	1987-07-10	Kloning og ekspression af sur fibroblastvækstfaktor

Country Status (12)

Country	Link
EP (1)	EP0259953B1 (es)
JP (2)	JPH0714347B2 (es)
KR (1)	KR960009725B1 (es)
AU (1)	AU614262B2 (es)
DE (1)	DE3789530T2 (es)
DK (1)	DK175786B1 (es)
ES (1)	ES2062982T3 (es)
FI (1)	FI98915C (es)
IE (1)	IE62101B1 (es)
IL (1)	IL83062A (es)
NZ (1)	NZ220917A (es)
PT (1)	PT85306B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3689845T3 (de) *	1985-09-12	2001-11-15	Scios Inc., Sunnyvale	Rekombinanter fibroblast-wachstumsfaktor.
DE3721081A1 (de) *	1987-06-26	1989-01-19	Progen Biotechnik Gmbh	Dna-sequenz, die codiert fuer ein zellteilungsfoerderndes polypeptid, sowie ein plasmid, ein wirtsorganismus und ein verfahren zur gewinnung dieses polypeptids
US5175147A (en) *	1988-08-19	1992-12-29	Takeda Chemical Industries, Ltd	Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract
US5656458A (en) *	1988-11-04	1997-08-12	Chiron Corporation	Expression and processing of amino terminus acetylated FGF's in yeast
EP0441886B1 (en) *	1988-11-04	1996-08-21	Chiron Corporation	Expression and processing of acetylated fgf's in yeast
EP0392605A1 (en) *	1989-04-13	1990-10-17	Merck & Co. Inc.	Method of enhancing acidic fibroblast growth factor expression
EP0406738A3 (en) *	1989-07-03	1991-08-14	Takeda Chemical Industries, Ltd.	Production of acidic fgf protein
JPH0343088A (ja) *	1989-09-29	1991-02-25	Takeda Chem Ind Ltd	ａＦＧＦ蛋白質の製造法
US5126323A (en) *	1989-11-16	1992-06-30	Genetics Institute, Inc.	Homogeneous purified k-fgf and compositions containing the same
US5726152A (en) *	1990-09-21	1998-03-10	Merck & Co., Inc.	Vascular endothelial cell growth factor II
CA2064331C (en) *	1991-03-28	2003-02-18	Marvin L. Bayne	Vascular endothelial cell growth factor c subunit
US5348941A (en) *	1992-04-01	1994-09-20	Merck & Co., Inc.	Stabilizers for fibroblast growth factors
ATE242330T1 (de) *	1993-01-15	2003-06-15	Inst Genetics Llc	Klonierung von enterokinase und verfahren zu deren verwendung
US6746859B1 (en)	1993-01-15	2004-06-08	Genetics Institute, Llc	Cloning of enterokinase and method of use
FR2724665B1 (fr) *	1994-09-16	1996-12-20	Rhone Poulenc Rorer Sa	Procede de production de proteines recombinantes, plasmides et cellules modifiees
JP2014193870A (ja) *	2014-04-23	2014-10-09	Eu Sol Biotech Co Ltd	ヒト酸性繊維芽細胞増殖因子の改変ペプチド

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4444760A (en) *	1983-06-17	1984-04-24	Merck & Co., Inc.	Purification and characterization of a protein fibroblast growth factor
DE3689845T3 (de) *	1985-09-12	2001-11-15	Scios Inc., Sunnyvale	Rekombinanter fibroblast-wachstumsfaktor.
US4935352A (en) *	1985-10-21	1990-06-19	Takeda Chemical Industries, Ltd.	Expression vector for animal cell line and use thereof
US4868113A (en) *	1986-03-03	1989-09-19	Rorer Biotechnology, Inc.	Recombinant DNA vector encoding human endothelial cell growth factor

1987
- 1987-07-01 NZ NZ220917A patent/NZ220917A/en unknown
- 1987-07-02 IL IL83062A patent/IL83062A/xx not_active IP Right Cessation
- 1987-07-08 FI FI873033A patent/FI98915C/fi not_active IP Right Cessation
- 1987-07-09 ES ES87306066T patent/ES2062982T3/es not_active Expired - Lifetime
- 1987-07-09 DE DE3789530T patent/DE3789530T2/de not_active Expired - Lifetime
- 1987-07-09 EP EP87306066A patent/EP0259953B1/en not_active Expired - Lifetime
- 1987-07-10 PT PT85306A patent/PT85306B/pt unknown
- 1987-07-10 IE IE187187A patent/IE62101B1/en not_active IP Right Cessation
- 1987-07-10 AU AU75544/87A patent/AU614262B2/en not_active Expired
- 1987-07-10 DK DK198703587A patent/DK175786B1/da not_active IP Right Cessation
- 1987-07-11 JP JP17212087A patent/JPH0714347B2/ja not_active Expired - Lifetime
- 1987-07-11 KR KR1019870007482A patent/KR960009725B1/ko not_active Expired - Fee Related
1994
- 1994-08-24 JP JP6199482A patent/JP2565666B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
KR880001817A (ko)	1988-04-27
FI873033A0 (fi)	1987-07-08
EP0259953B1 (en)	1994-04-06
DE3789530D1 (de)	1994-05-11
PT85306A (en)	1987-08-01
NZ220917A (en)	1991-05-28
IL83062A0 (en)	1987-12-31
DK358787D0 (da)	1987-07-10
IL83062A (en)	1993-07-08
EP0259953A1 (en)	1988-03-16
PT85306B (pt)	1990-03-30
JPH0714347B2 (ja)	1995-02-22
AU7554487A (en)	1988-01-14
KR960009725B1 (ko)	1996-07-23
JPS6394991A (ja)	1988-04-26
JP2565666B2 (ja)	1996-12-18
FI98915C (fi)	1997-09-10
IE871871L (en)	1988-01-11
DE3789530T2 (de)	1994-09-15
AU614262B2 (en)	1991-08-29
FI873033L (fi)	1988-01-12
FI98915B (fi)	1997-05-30
JPH07224096A (ja)	1995-08-22
IE62101B1 (en)	1994-12-14
DK358787A (da)	1988-01-12
ES2062982T3 (es)	1995-01-01

Publication	Publication Date	Title
DK175786B1 (da)	2005-02-21	Kloning og ekspression af sur fibroblastvækstfaktor
Van Eldik et al.	1988	Synthesis and expression of a gene coding for the calcium-modulated protein S100 beta and designed for cassette-based, site-directed mutagenesis.
EP0237966A2 (en)	1987-09-23	Human basic fibroblast growth factor
IL99984A (en)	1998-12-06	Chimeric fibroblast growth factors
US5223483A (en)	1993-06-29	Cysteine-modified acidic fibroblast growth factor
EP0363675B1 (en)	1993-12-15	New derivatives of human/bovine basic fibroblast growth factor
US5352589A (en)	1994-10-04	Deletion mutant of basic fibroblast growth factor and production thereof
US5401832A (en)	1995-03-28	Brain derived and recombinant acidic fibroblast growth factor
EP0319052B1 (en)	1995-01-25	Mutant acidic fibroblast growth factor
CS29191A3 (en)	1992-06-17	Covalent hybrids angiogenin/ribonuclease
US5409897A (en)	1995-04-25	Cysteine-modified acidic fibroblast growth factor and methods of use
CA2027075C (en)	2002-11-26	Mutein of hst-1 and production therof
DK175856B1 (da)	2005-04-11	Nukleotid sekvens, ekspressionsplasmid og fremgangsmåde til oprensning af aFGF
US5679550A (en)	1997-10-21	Hst-2 muteins, pharmaceutical compositions and kits comprising same, and preparation of same
CA1340639C (en)	1999-07-06	Mutant acidic fibroblast growth factor
EP0412526A2 (en)	1991-02-13	Expression vector for hirudin, hirudin fusion protein, transformed microorganism, and method for production of hirudin

Legal Events

Date	Code	Title	Description
2007-07-30	PUP	Patent expired