DK175701B1 - Fremgangsmåde til fremstilling af polypeptider - Google Patents

Fremgangsmåde til fremstilling af polypeptider Download PDF

Info

Publication number: DK175701B1
Authority: DK; Denmark
Prior art keywords: yeast; dna; promoter; gene; plasmid
Prior art date: 1988-05-04

Application number

DK198902175A

Other languages

Danish (da)

English (en)

Other versions

DK217589A (da

DK217589D0 (da

Inventor

Jutta Heim

Kenji Takabayashi

Hansjoerg Treichler

Dieter Heinrich Wolf

Original Assignee

Novartis Ag

Ucp Gen Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-05-04

Filing date

1989-05-03

Publication date

2005-01-24

1988-05-04 Priority claimed from GB888810524A external-priority patent/GB8810524D0/en

1988-05-27 Priority claimed from GB888812627A external-priority patent/GB8812627D0/en

1989-03-29 Priority claimed from GB898907110A external-priority patent/GB8907110D0/en

1989-05-03 Application filed by Novartis Ag, Ucp Gen Pharma Ag filed Critical Novartis Ag

1989-05-03 Publication of DK217589D0 publication Critical patent/DK217589D0/da

1989-11-05 Publication of DK217589A publication Critical patent/DK217589A/da

2005-01-24 Application granted granted Critical

2005-01-24 Publication of DK175701B1 publication Critical patent/DK175701B1/da

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Mycology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Tropical Medicine & Parasitology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Liquid Crystal Substances (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)

DK198902175A 1988-05-04 1989-05-03 Fremgangsmåde til fremstilling af polypeptider DK175701B1 (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
GB888810524A GB8810524D0 (en)	1988-05-04	1988-05-04	Improvements in production of polypeptides
GB8810524		1988-05-04
GB8812627		1988-05-27
GB888812627A GB8812627D0 (en)	1988-05-27	1988-05-27	Improvements in production of polypeptides
GB8907110		1989-03-29
GB898907110A GB8907110D0 (en)	1988-05-04	1989-03-29	Improvements in the production of polypeptides

Publications (3)

Publication Number	Publication Date
DK217589D0 DK217589D0 (da)	1989-05-03
DK217589A DK217589A (da)	1989-11-05
DK175701B1 true DK175701B1 (da)	2005-01-24

Family

ID=27263890

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198902175A DK175701B1 (da)	1988-05-04	1989-05-03	Fremgangsmåde til fremstilling af polypeptider

Country Status (16)

Country	Link
EP (1)	EP0341215B1 (hu)
JP (1)	JPH0824565B2 (hu)
AT (1)	ATE124086T1 (hu)
AU (1)	AU614121B2 (hu)
CA (1)	CA1340016C (hu)
DE (1)	DE68923123T2 (hu)
DK (1)	DK175701B1 (hu)
ES (1)	ES2072918T3 (hu)
FI (1)	FI103129B (hu)
HU (1)	HU218731B (hu)
IE (1)	IE66044B1 (hu)
IL (1)	IL90170A (hu)
MX (1)	MX169508B (hu)
NO (1)	NO180593C (hu)
NZ (1)	NZ228955A (hu)
PT (1)	PT90436B (hu)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8809860D0 (en) *	1988-04-26	1988-06-02	Ciba Geigy Ag	Process for production of polypeptides
FR2645174B1 (fr) *	1989-03-31	1994-01-07	Transgene Sa	Souches de levure ameliorees pour la production de proteines heterologues matures en particulier d'hirudine et procede de preparation d'hirudine correspondant
FR2645175B1 (fr) *	1989-03-31	1994-02-18	Transgene Sa	Souche de saccharomyces cerevisiaeproductrice d'une proteine heterologue et procede de preparation de ladite proteine heterologue par fermentation de ladite souche
US5879926A (en) *	1989-03-31	1999-03-09	Transgene S.A.	Yeast strains for the production of mature heterologous proteins, especially hirudin
WO1991008229A1 (de) *	1989-12-01	1991-06-13	Basf Aktiengesellschaft	Hirudinpolyalkylenglykolkonjugate
US5580734A (en) *	1990-07-13	1996-12-03	Transkaryotic Therapies, Inc.	Method of producing a physical map contigous DNA sequences
MY106504A (en) *	1990-07-13	1995-06-30	Transkaryotic Therapies Inc	Library screening method.
EP0548267A4 (en) *	1990-09-04	1994-11-23	Salk Inst Biotech Ind	Production of insulin-like growth factor-1 in methylotrophic yeast cells
US5612198A (en) *	1990-09-04	1997-03-18	The Salk Institute	Production of insulin-like growth factor-1 in methylotrophic yeast cells
AU648124B2 (en)	1990-11-08	1994-04-14	Japan Energy Corporation	Hirudine mutant, production thereof, anticoagulant, secretory vector, microorganism transformed by said vector, and production of product from said microorganism
SG84484A1 (en) *	1991-02-25	2001-11-20	Ciba Geigy Ag	Improved yeast vectors
CA2105064A1 (en) *	1991-04-01	1992-10-02	Martin Anthony Gleeson	Genes which influence pichia proteolytic activity, and uses therefor
HU214698B (hu) *	1992-04-09	1998-06-29	Gyógyszerkutató Intézet Kft.	Eljárás rekombináns deszulfátó-hirudin HV-1 peptidek előállítására
SG49859A1 (en) *	1992-09-04	2002-03-19	Ucp Gen Pharma Ag	Process for the production of protease inhibitors
TW282490B (hu) *	1992-12-15	1996-08-01	Ciba Geigy Ag
EP0663009A1 (en) *	1993-08-04	1995-07-19	Novartis AG	High molecular weight desulphatohirudin
DE4404168A1 (de) *	1994-02-10	1995-08-17	Hoechst Ag	Hirudinderivate und Verfahren zu deren Herstellung
JP3732516B2 (ja) *	1995-02-09	2006-01-05	ノバルティス・アクチエンゲゼルシャフト	タンパク質の製造法
ATE353953T1 (de) *	1995-03-20	2007-03-15	Novozymes As	Wirtszelle, die reduzierte mengen einer metalloprotease exprimiert und methoden zur verwendung dieser wirtszelle zur proteinproduktion
DE19529997C1 (de) *	1995-08-16	1997-04-10	Hoechst Ag	Verfahren zur Inaktivierung von Carboxypeptidase Y in hirudinhaltigen Kulturbrühen
WO1997012045A1 (en) *	1995-09-27	1997-04-03	Chiron Corporation	Method of making a protease deficient host
DE69624087T2 (de)	1996-01-31	2003-06-05	Sumitomo Bakelite Co. Ltd., Tokio/Tokyo	Verfahren zur Herstellung von in Epoxyharz eingekapselter Halbleitervorrichtung
FR2768743B1 (fr)	1997-09-23	2001-09-14	Bio Merieux	Procede de lyse de micro-organisme
GB2338236B (en)	1998-06-13	2003-04-09	Aea Technology Plc	Microbiological cell processing
US7795205B2 (en)	2004-04-12	2010-09-14	Canyon Pharmaceuticals, Inc.	Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
ES2550761T3 (es) *	2009-11-25	2015-11-12	Novo Nordisk A/S	Método para producción de polipéptidos
EP3696274A4 (en)	2017-10-10	2021-07-28	Ajinomoto Co., Inc.	PROTEIN MANUFACTURING PROCESS
KR20230023751A (ko)	2020-06-11	2023-02-17	아지노모토 가부시키가이샤	단백질의 제조법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3342139A1 (de) *	1983-11-22	1985-05-30	Ciba-Geigy Ag, Basel	Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
JPS62224284A (ja) *	1986-03-25	1987-10-02	Agency Of Ind Science & Technol	微生物
GB8809860D0 (en) *	1988-04-26	1988-06-02	Ciba Geigy Ag	Process for production of polypeptides
GB8817160D0 (en) *	1988-07-19	1988-08-24	Ciba Geigy Ag	Novel proteins
GB8817161D0 (en) *	1988-07-19	1988-08-24	Ciba Geigy Ag	Modified proteins

1989
- 1989-04-28 AU AU33828/89A patent/AU614121B2/en not_active Expired
- 1989-05-01 DE DE68923123T patent/DE68923123T2/de not_active Expired - Lifetime
- 1989-05-01 AT AT89810335T patent/ATE124086T1/de not_active IP Right Cessation
- 1989-05-01 EP EP89810335A patent/EP0341215B1/en not_active Expired - Lifetime
- 1989-05-01 ES ES89810335T patent/ES2072918T3/es not_active Expired - Lifetime
- 1989-05-02 JP JP1112294A patent/JPH0824565B2/ja not_active Expired - Lifetime
- 1989-05-02 MX MX015887A patent/MX169508B/es unknown
- 1989-05-02 PT PT90436A patent/PT90436B/pt not_active IP Right Cessation
- 1989-05-02 CA CA000598488A patent/CA1340016C/en not_active Expired - Lifetime
- 1989-05-02 NZ NZ228955A patent/NZ228955A/en unknown
- 1989-05-03 IE IE145189A patent/IE66044B1/en not_active IP Right Cessation
- 1989-05-03 FI FI892114A patent/FI103129B/fi not_active IP Right Cessation
- 1989-05-03 DK DK198902175A patent/DK175701B1/da not_active IP Right Cessation
- 1989-05-03 HU HU077/89A patent/HU218731B/hu unknown
- 1989-05-03 NO NO891837A patent/NO180593C/no not_active IP Right Cessation
- 1989-05-03 IL IL9017089A patent/IL90170A/en active IP Right Grant

Also Published As

Publication number	Publication date
AU3382889A (en)	1989-11-09
DK217589A (da)	1989-11-05
DK217589D0 (da)	1989-05-03
MX169508B (es)	1993-07-08
FI892114A (fi)	1989-11-05
IL90170A0 (en)	1989-12-15
ATE124086T1 (de)	1995-07-15
PT90436B (pt)	1994-11-30
EP0341215A2 (en)	1989-11-08
FI103129B1 (fi)	1999-04-30
EP0341215B1 (en)	1995-06-21
NO180593B (no)	1997-02-03
JPH0824565B2 (ja)	1996-03-13
PT90436A (pt)	1989-11-30
JPH02104279A (ja)	1990-04-17
IE66044B1 (en)	1995-12-13
IL90170A (en)	1995-12-31
EP0341215A3 (en)	1992-01-15
NO891837L (no)	1989-11-06
NO891837D0 (no)	1989-05-03
CA1340016C (en)	1998-08-25
HU218731B (hu)	2000-11-28
DE68923123D1 (de)	1995-07-27
NZ228955A (en)	1991-06-25
HUT54210A (en)	1991-01-28
NO180593C (no)	1997-05-14
AU614121B2 (en)	1991-08-22
DE68923123T2 (de)	1995-11-30
FI892114A0 (fi)	1989-05-03
FI103129B (fi)	1999-04-30
IE891451L (en)	1989-11-04
ES2072918T3 (es)	1995-08-01

Publication	Publication Date	Title
DK175701B1 (da)	2005-01-24	Fremgangsmåde til fremstilling af polypeptider
Farquhar et al.	1991	Protein disulfide isomerase is essential for viability in Saccharomyces cerevisiae
EP0578746B1 (en)	2002-07-03	GENES WHICH INFLUENCE $i(PICHIA) PROTEOLYTIC ACTIVITY, AND USES THEREFOR
Lodi et al.	1993	Isolation of the DLD gene of Saccharomyces cerevisiae encoding the mitochondrial enzyme D-lactate ferricytochrome c oxidoreductase
HU204097B (en)	1991-11-28	Process for producing cloning system relating to kluyveromyces species
NO314151B1 (no)	2003-02-03	Pichia pastoris sur fosfatasegen
EP1002095A1 (en)	2000-05-24	Improved protein expression strains
EP0362183B1 (en)	1993-06-16	Process for the production of human lysozyme
EP0340170A2 (en)	1989-11-02	Process for the production of polypeptides
EP0592358B1 (en)	2000-10-11	Process for the production of protease inhibitors
US6103515A (en)	2000-08-15	Production of polypeptides by use of novel protease deficient yeast strains
JPH06343471A (ja)	1994-12-20	ポリペプチドの製造方法
KR0161148B1 (ko)	1998-11-16	재조합 메탄올 자화 효모를 사용한 이종 단백질의 생산방법
DD283839A5 (de)	1990-10-24	Verfahren zur herstellung eines hefestammes ohne carboxyteptidase-ysc alpha-aktivitaet

Legal Events

Date	Code	Title	Description
2009-05-18	PUP	Patent expired