DK171682B1 - Væksthormon-frigørende peptid og pharmaceutisk acceptable salte deraf, sammensætning med indhold deraf samt fremgangsmåde til fremstilling af peptider - Google Patents

Væksthormon-frigørende peptid og pharmaceutisk acceptable salte deraf, sammensætning med indhold deraf samt fremgangsmåde til fremstilling af peptider Download PDF

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Publication number: DK171682B1
Authority: DK; Denmark
Prior art keywords: arg; leu; ala; ser; gln
Prior art date: 1985-01-17

Application number

DK018086A

Other languages

Danish (da)

English (en)

Other versions

DK18086D0 (da

DK18086A (da

Inventor

David Howard Coy

William Andrew Murphy

Original Assignee

Univ Tulane

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-01-17

Filing date

1986-01-15

Publication date

1997-03-10

1986-01-15 Application filed by Univ Tulane filed Critical Univ Tulane

1986-01-15 Publication of DK18086D0 publication Critical patent/DK18086D0/da

1986-07-18 Publication of DK18086A publication Critical patent/DK18086A/da

1997-03-10 Application granted granted Critical

1997-03-10 Publication of DK171682B1 publication Critical patent/DK171682B1/da

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206010061902 Pancreatic neoplasm Diseases 0.000 description 1
NQRYJNQNLNOLGT-UHFFFAOYSA-O Piperidinium(1+) Chemical compound C1CC[NH2+]CC1 NQRYJNQNLNOLGT-UHFFFAOYSA-O 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
102100021923 Prolow-density lipoprotein receptor-related protein 1 Human genes 0.000 description 1
101710202113 Prolow-density lipoprotein receptor-related protein 1 Proteins 0.000 description 1
RWRDLPDLKQPQOW-UHFFFAOYSA-O Pyrrolidinium ion Chemical compound C1CC[NH2+]C1 RWRDLPDLKQPQOW-UHFFFAOYSA-O 0.000 description 1
229920005654 Sephadex Polymers 0.000 description 1
BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
206010052428 Wound Diseases 0.000 description 1
208000027418 Wounds and injury Diseases 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
230000002745 absorbent Effects 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
229910052784 alkaline earth metal Inorganic materials 0.000 description 1
150000001342 alkaline earth metals Chemical class 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
150000003862 amino acid derivatives Chemical class 0.000 description 1
238000010171 animal model Methods 0.000 description 1
238000003556 assay Methods 0.000 description 1
239000011324 bead Substances 0.000 description 1
WGQKYBSKWIADBV-UHFFFAOYSA-O benzylaminium Chemical compound [NH3+]CC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-O 0.000 description 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 1
238000009534 blood test Methods 0.000 description 1
210000004899 c-terminal region Anatomy 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000011575 calcium Substances 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
KFGRVLINLVVMJA-MITYVQBRSA-N chembl440262 Chemical compound C([C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O)C1=CC=C(O)C=C1 KFGRVLINLVVMJA-MITYVQBRSA-N 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
238000004440 column chromatography Methods 0.000 description 1
125000005265 dialkylamine group Chemical group 0.000 description 1
125000005131 dialkylammonium group Chemical group 0.000 description 1
POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000002124 endocrine Effects 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
235000021050 feed intake Nutrition 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
125000005519 fluorenylmethyloxycarbonyl group Chemical group 0.000 description 1
239000012634 fragment Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
230000035876 healing Effects 0.000 description 1
244000144980 herd Species 0.000 description 1
IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
210000004731 jugular vein Anatomy 0.000 description 1
229940070765 laurate Drugs 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
239000008176 lyophilized powder Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
235000013622 meat product Nutrition 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
230000003278 mimic effect Effects 0.000 description 1
YNAVUWVOSKDBBP-UHFFFAOYSA-O morpholinium Chemical compound [H+].C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-O 0.000 description 1
OIBISEAEGMVEPG-UHFFFAOYSA-N n-[(4-methylphenyl)methyl]hydroxylamine Chemical compound CC1=CC=C(CNO)C=C1 OIBISEAEGMVEPG-UHFFFAOYSA-N 0.000 description 1
229940105631 nembutal Drugs 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
229940049964 oleate Drugs 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
238000012856 packing Methods 0.000 description 1
210000000496 pancreas Anatomy 0.000 description 1
201000002528 pancreatic cancer Diseases 0.000 description 1
WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
239000012071 phase Substances 0.000 description 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
239000006187 pill Substances 0.000 description 1
230000001817 pituitary effect Effects 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
229920005990 polystyrene resin Polymers 0.000 description 1
239000011148 porous material Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000002953 preparative HPLC Methods 0.000 description 1
238000002203 pretreatment Methods 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
238000000746 purification Methods 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
229960001153 serine Drugs 0.000 description 1
229910000077 silane Inorganic materials 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
238000012360 testing method Methods 0.000 description 1
125000005207 tetraalkylammonium group Chemical group 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
125000005208 trialkylammonium group Chemical group 0.000 description 1
GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical class CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Endocrinology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Fodder In General (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK018086A 1985-01-17 1986-01-15 Væksthormon-frigørende peptid og pharmaceutisk acceptable salte deraf, sammensætning med indhold deraf samt fremgangsmåde til fremstilling af peptider DK171682B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US69208285A	1985-01-17	1985-01-17
US69208285		1985-01-17

Publications (3)

Publication Number	Publication Date
DK18086D0 DK18086D0 (da)	1986-01-15
DK18086A DK18086A (da)	1986-07-18
DK171682B1 true DK171682B1 (da)	1997-03-10

Family

ID=24779183

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK018086A DK171682B1 (da)	1985-01-17	1986-01-15	Væksthormon-frigørende peptid og pharmaceutisk acceptable salte deraf, sammensætning med indhold deraf samt fremgangsmåde til fremstilling af peptider

Country Status (13)

Country	Link
EP (1)	EP0188214A3 (fi)
JP (1)	JPS61210099A (fi)
AU (1)	AU590738B2 (fi)
CA (1)	CA1271600A (fi)
DK (1)	DK171682B1 (fi)
ES (1)	ES8703894A1 (fi)
FI (1)	FI860200A (fi)
IE (1)	IE860131L (fi)
IL (1)	IL77534A (fi)
NO (1)	NO169173C (fi)
NZ (1)	NZ214792A (fi)
PT (1)	PT81845B (fi)
ZA (1)	ZA86338B (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5565606A (en) *	1986-10-21	1996-10-15	Hoechst Aktiengesellschaft	Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method
DE3742633A1 (de) *	1987-12-16	1989-06-29	Hoechst Ag	Peptide mit beeinflussender wirkung auf die hypophyse von saeugern
IL86102A (en) *	1987-05-11	1994-04-12	Univ Tulane	Alkylated peptides that release growth hormone and their use
US5002931A (en) *	1987-05-22	1991-03-26	The Salk Institute For Biological Studies	GRF analogs VII
US4959352A (en) *	1987-09-18	1990-09-25	Hoffmann-La Roche Inc.	Cyclic growth hormone releasing factor analogs and method for the manufacture thereof
ATE106895T1 (de) *	1987-09-18	1994-06-15	Hoffmann La Roche	Zyklische grf-analoga.
US5084442A (en) *	1988-09-06	1992-01-28	Hoffmann-La Roche Inc.	Cyclic growth hormone releasing factor analogs and method for the manufacture thereof
US5756458A (en) *	1989-06-16	1998-05-26	Pharmacia & Upjohn Company	Stabilized potent GRF analogs
EP0544706A4 (en) *	1990-06-29	1993-10-13	Hoffmann-La Roche Inc.	Histidine substituted growth hormone releasing factor analogs
ZA922746B (en) *	1991-04-26	1992-12-30	Lilly Co Eli	Superactive grf analogs
US5550212A (en) *	1993-12-17	1996-08-27	The Administrators Of The Tulane Educational Fund	Analogues of hGH-RH(1-29)NH2 having antagonistic activity
AU5441096A (en) *	1995-04-14	1996-10-30	The Administrators Of The Tulane Eductional Fund	Analogs of growth hormone-releasing factor
JP3576170B2 (ja) *	1995-05-26	2004-10-13	セラテクノロジーズ・インコーポレーテッド	生物学的活性が増加したキメラ脂肪体プロｇｒｆ類似体
JP2004520395A (ja)	2001-02-02	2004-07-08	コンジュケム，インコーポレーテッド	長期持続性成長ホルモン放出因子誘導体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4517181A (en) *	1982-09-15	1985-05-14	The Salk Institute For Biological Studies	Mammalian PGRF
NZ204456A (en) *	1982-06-16	1987-05-29	Salk Inst For Biological Studi	Synthetic pancreatic growth-hormone releasing factor
US4518586A (en) *	1983-01-13	1985-05-21	The Salk Institute For Biological Studies	GRF Analogs III
IL70530A (en) *	1983-01-13	1986-09-30	Salk Inst For Biological Studi	Synthetic peptides having growth hormone releasing factor activity and compositions containing them
AU575843B2 (en) *	1983-08-10	1988-08-11	The Administrators Of The Tulane Eductional Fund	Growth hormone releasing peptides
US4528190A (en) *	1983-10-25	1985-07-09	The Salk Institute For Biological Studies	GRF Analogs IV
US4649131A (en) *	1984-09-24	1987-03-10	Hoffmann-La Roche Inc.	Growth hormone releasing factor analogs

1986
- 1986-01-06 CA CA000499013A patent/CA1271600A/en not_active Expired - Lifetime
- 1986-01-07 EP EP86100127A patent/EP0188214A3/en not_active Withdrawn
- 1986-01-07 IL IL77534A patent/IL77534A/xx not_active IP Right Cessation
- 1986-01-10 NZ NZ214792A patent/NZ214792A/xx unknown
- 1986-01-15 PT PT81845A patent/PT81845B/pt not_active IP Right Cessation
- 1986-01-15 DK DK018086A patent/DK171682B1/da active
- 1986-01-16 NO NO860149A patent/NO169173C/no unknown
- 1986-01-16 IE IE860131A patent/IE860131L/xx unknown
- 1986-01-16 AU AU52299/86A patent/AU590738B2/en not_active Ceased
- 1986-01-16 ZA ZA86338A patent/ZA86338B/xx unknown
- 1986-01-16 FI FI860200A patent/FI860200A/fi not_active Application Discontinuation
- 1986-01-17 ES ES550989A patent/ES8703894A1/es not_active Expired
- 1986-01-17 JP JP61006591A patent/JPS61210099A/ja active Pending

Also Published As

Publication number	Publication date
FI860200A (fi)	1986-07-18
IE860131L (en)	1986-07-17
NO169173B (no)	1992-02-10
FI860200A0 (fi)	1986-01-16
AU590738B2 (en)	1989-11-16
EP0188214A3 (en)	1989-05-24
ZA86338B (en)	1987-08-26
ES550989A0 (es)	1987-03-16
EP0188214A2 (en)	1986-07-23
CA1271600A (en)	1990-07-10
DK18086D0 (da)	1986-01-15
AU5229986A (en)	1986-07-24
PT81845A (en)	1986-02-01
NZ214792A (en)	1989-01-27
NO860149L (no)	1986-07-18
PT81845B (pt)	1987-11-30
NO169173C (no)	1992-05-20
IL77534A (en)	1991-01-31
ES8703894A1 (es)	1987-03-16
JPS61210099A (ja)	1986-09-18
DK18086A (da)	1986-07-18

Publication	Publication Date	Title
US4411890A (en)	1983-10-25	Synthetic peptides having pituitary growth hormone releasing activity
US5847066A (en)	1998-12-08	Analogs of growth hormone-releasing factor
US5084555A (en)	1992-01-28	An octapeptide bombesin analog
US5877277A (en)	1999-03-02	Octapeptide bombesin analogs
DK167361B1 (da)	1993-10-18	Grf-analoge peptider, farmaceutisk acceptable salte heraf og fremgangsmaader til fremstilling af disse
AU636301B2 (en)	1993-04-29	Cyclic grf-analogs ii
IL101452A (en)	1996-11-14	Analogs of the factor that releases the growth hormone, their preparation and the pharmaceutical preparations that contain them
US5717062A (en)	1998-02-10	Cyclic analogs of PTH and PTHrP
US5416073A (en)	1995-05-16	Growth hormone-releasing peptides and method of treating animals, therewith
EP1405861A2 (en)	2004-04-07	Analogs of parathyroid hormone
DK171682B1 (da)	1997-03-10	Væksthormon-frigørende peptid og pharmaceutisk acceptable salte deraf, sammensætning med indhold deraf samt fremgangsmåde til fremstilling af peptider
EP0083864B1 (en)	1987-05-13	Synthetic peptides having pituitary growth hormone releasing activity
EP0018072B1 (en)	1983-01-26	Synthetic peptides having pituitary growth hormone releasing activity
AU1154783A (en)	1983-07-15	Synthetic peptides having pituitary growth hormone releasing activity
AU757222B2 (en)	2003-02-06	Antagonistic analogs of GH-RH inhibiting IGF-I and -II
US5112808A (en)	1992-05-12	Alkylated hormone-releasing peptides and method of treatig mammals therewith
EP0307860B1 (en)	1994-06-08	Cyclic GRF-analogs
AU613364B2 (en)	1991-08-01	Novel alkylated growth hormone-releasing peptides and method of treating mammals therewith
US4959352A (en)	1990-09-25	Cyclic growth hormone releasing factor analogs and method for the manufacture thereof
FI101884B (fi)	1998-09-15	Luteinisoivaa hormonia vapauttavan hormonin (LHRH) antagonistipeptidej ä