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DK171419B1 - Mikrobielt fremstillet humant Interleukin-1, fremgangsmåder til fremstilling deraf samt farmaceutiske preparater indeholdende dette, og dets anvendelse i behandling og profylakse - Google Patents

Mikrobielt fremstillet humant Interleukin-1, fremgangsmåder til fremstilling deraf samt farmaceutiske preparater indeholdende dette, og dets anvendelse i behandling og profylakse Download PDF

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Publication number
DK171419B1
DK171419B1 DK077387A DK77387A DK171419B1 DK 171419 B1 DK171419 B1 DK 171419B1 DK 077387 A DK077387 A DK 077387A DK 77387 A DK77387 A DK 77387A DK 171419 B1 DK171419 B1 DK 171419B1
Authority
DK
Denmark
Prior art keywords
human interleukin
interleukin
buffered
solution
gradient
Prior art date
Application number
DK077387A
Other languages
Danish (da)
English (en)
Other versions
DK77387D0 (da
DK77387A (da
Inventor
Alvin Seth Stern
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK77387D0 publication Critical patent/DK77387D0/da
Publication of DK77387A publication Critical patent/DK77387A/da
Application granted granted Critical
Publication of DK171419B1 publication Critical patent/DK171419B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK077387A 1986-02-18 1987-02-16 Mikrobielt fremstillet humant Interleukin-1, fremgangsmåder til fremstilling deraf samt farmaceutiske preparater indeholdende dette, og dets anvendelse i behandling og profylakse DK171419B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/830,406 US5831022A (en) 1986-02-18 1986-02-18 Purification of recombinant human IL-1α
US83040686 1986-02-18

Publications (3)

Publication Number Publication Date
DK77387D0 DK77387D0 (da) 1987-02-16
DK77387A DK77387A (da) 1987-08-19
DK171419B1 true DK171419B1 (da) 1996-10-21

Family

ID=25256938

Family Applications (1)

Application Number Title Priority Date Filing Date
DK077387A DK171419B1 (da) 1986-02-18 1987-02-16 Mikrobielt fremstillet humant Interleukin-1, fremgangsmåder til fremstilling deraf samt farmaceutiske preparater indeholdende dette, og dets anvendelse i behandling og profylakse

Country Status (10)

Country Link
US (1) US5831022A (fr)
JP (1) JP2590085B2 (fr)
BE (1) BE1000636A5 (fr)
CH (1) CH676008A5 (fr)
DE (1) DE3704868C2 (fr)
DK (1) DK171419B1 (fr)
FR (1) FR2595714B1 (fr)
GB (1) GB2186580B (fr)
IT (1) IT1202565B (fr)
NL (1) NL8700397A (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE92766T1 (de) * 1987-12-18 1993-08-15 Immunex Corp Oertliche wundheilmittel, die interleukin-1proteine enthalten.
EP0644203A1 (fr) * 1988-07-29 1995-03-22 Otsuka Pharmaceutical Co., Ltd. Dérivés de l'il-1 alpha et médicament contre la thrombocytopénie
IT1226713B (it) * 1988-08-05 1991-02-05 Eniricerche Spa Procedimento per la preparazione di interleuchina 1 beta umana ricombinante in forma omogenea.
NZ295998A (en) * 1994-10-24 1999-10-28 Ophidian Pharm Inc Neutralizing antitoxins against clostridium difficile and clostidium botulinum toxins

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401756A (en) * 1981-04-14 1983-08-30 Immunex Corporation Process for preparing human interleukin 2
CA1341562C (fr) * 1982-03-31 2007-11-27 Tadatsugu Taniguchi Gene codant pour un polypeptide ayant une activite interleukine 2, adn recombinant portant ledit gene, lignees cellulaires possedant ledit adn recombinant et procede pour la preparation d'interleukine 2 en utilisant lesdites cellules
GR79124B (fr) * 1982-12-22 1984-10-02 Genentech Inc
FR2550802B1 (fr) * 1983-08-17 1986-04-11 Inst Nat Sante Rech Med Procede de production d'interleukine 1 humaine et medicaments correspondants
CA1340853C (fr) * 1983-12-23 1999-12-21 Hsiang-Fu Kung Purification d'une interleukine-2 recombinante
JPS60149386A (ja) * 1984-01-17 1985-08-06 Dainippon Pharmaceut Co Ltd インタ−ロイキン１をコ−ドする伝令リボ核酸及びその調製法
JPS60197629A (ja) * 1984-03-16 1985-10-07 Chemo Sero Therapeut Res Inst ＨＢｓ抗原の精製方法
DE3419995A1 (de) * 1984-05-29 1985-12-05 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von human-interleukin-2 und mittel zur durchfuehrung dieses verfahrens
JPS617296A (ja) * 1984-06-19 1986-01-13 イミユネツクス、コ−ポレ−シヨン インタ−ロイキン１の遺伝子の精製、クロ−ニング及び特性づけ
CA1341433C (fr) * 1984-06-19 2003-06-24 Douglas P. Cerretti Purification de l'interleukine 1
DE3432196A1 (de) * 1984-09-01 1986-03-06 Boehringer Ingelheim International GmbH, 6507 Ingelheim Neues mechanisches aufschlussverfahren von bakterienzellen zur isolierung von rekombinant hergestellten peptiden
DE3683186D1 (de) * 1985-04-25 1992-02-13 Hoffmann La Roche Rekombinantes humaninterleukin-1.
US4675387A (en) * 1985-07-26 1987-06-23 E. I. Du Pont De Nemours And Company Method for extracting protein with organic acid
US5008374A (en) * 1986-03-14 1991-04-16 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and drugs
US4801686A (en) * 1986-09-04 1989-01-31 Immunex Corporation Purification of recombinant interleukin-1

Also Published As

Publication number Publication date
IT1202565B (it) 1989-02-09
DK77387D0 (da) 1987-02-16
IT8719420A0 (it) 1987-02-18
BE1000636A5 (fr) 1989-02-28
US5831022A (en) 1998-11-03
GB2186580B (en) 1990-08-22
JP2590085B2 (ja) 1997-03-12
GB8703663D0 (en) 1987-03-25
DE3704868C2 (de) 1995-09-21
FR2595714A1 (fr) 1987-09-18
JPS62209097A (ja) 1987-09-14
FR2595714B1 (fr) 1990-05-18
DK77387A (da) 1987-08-19
CH676008A5 (fr) 1990-11-30
DE3704868A1 (de) 1987-08-20
NL8700397A (nl) 1987-09-16
GB2186580A (en) 1987-08-19

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Legal Events

Date Code Title Description
A0 Application filed
B1 Patent granted (law 1993)
PBP Patent lapsed