DK1697356T3 - Pyrido[2,3-d]pyrimidin-2,4-diaminer som PDE 2-inhibitorer - Google Patents

Pyrido[2,3-d]pyrimidin-2,4-diaminer som PDE 2-inhibitorer

Info

Publication number: DK1697356T3
Authority: DK; Denmark
Prior art keywords: pde; pyrido; diamines; pyrimidine; inhibitors
Prior art date: 2003-12-16

Application number

DK04801323T

Other languages

English (en)

Inventor

Thomas Arthur Beyer

Robert James Chambers

Mei Li

Andrew Ian Morrell

David Duane Thompson

Kelvin Lam

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-16

Filing date

2004-12-06

Publication date

2009-01-12

2004-12-06 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2009-01-12 Application granted granted Critical

2009-01-12 Publication of DK1697356T3 publication Critical patent/DK1697356T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Endocrinology (AREA)
Hematology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

DK04801323T 2003-12-16 2004-12-06 Pyrido[2,3-d]pyrimidin-2,4-diaminer som PDE 2-inhibitorer DK1697356T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US52999403P	2003-12-16	2003-12-16
PCT/IB2004/004013 WO2005061497A1 (en)	2003-12-16	2004-12-06	Pyrido[2,3-d]pyrimidine-2,4-diamines as pde 2 inhibitors

Publications (1)

Publication Number	Publication Date
DK1697356T3 true DK1697356T3 (da)	2009-01-12

Family

ID=34710150

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04801323T DK1697356T3 (da)	2003-12-16	2004-12-06	Pyrido[2,3-d]pyrimidin-2,4-diaminer som PDE 2-inhibitorer

Country Status (39)

Country	Link
US (1)	US20070135457A1 (da)
EP (1)	EP1697356B1 (da)
JP (1)	JP4073944B2 (da)
KR (1)	KR100816179B1 (da)
CN (1)	CN100439366C (da)
AP (1)	AP2006003632A0 (da)
AR (1)	AR046766A1 (da)
AT (1)	ATE387446T1 (da)
AU (1)	AU2004303609A1 (da)
BR (1)	BRPI0417663A (da)
CA (1)	CA2549510A1 (da)
CL (1)	CL2008001920A1 (da)
DE (1)	DE602004012154T2 (da)
DK (1)	DK1697356T3 (da)
EA (1)	EA010424B1 (da)
EC (1)	ECSP066643A (da)
ES (1)	ES2299888T3 (da)
GE (1)	GEP20094720B (da)
GT (1)	GT200400268A (da)
HN (1)	HN2004000538A (da)
HR (1)	HRP20080142T3 (da)
IL (1)	IL175813A0 (da)
IS (1)	IS8474A (da)
MA (1)	MA28270A1 (da)
MX (1)	MXPA06006777A (da)
NL (1)	NL1027787C2 (da)
NO (1)	NO20063231L (da)
PE (1)	PE20050681A1 (da)
PL (1)	PL1697356T3 (da)
PT (1)	PT1697356E (da)
RS (1)	RS50575B (da)
SI (1)	SI1697356T1 (da)
SV (1)	SV2005001979A (da)
TN (1)	TNSN06186A1 (da)
TW (1)	TWI291961B (da)
UA (1)	UA83091C2 (da)
UY (1)	UY28671A1 (da)
WO (1)	WO2005061497A1 (da)
ZA (1)	ZA200604970B (da)

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EP1960372B1 (en) *	2005-12-15	2015-12-09	Rigel Pharmaceuticals, Inc.	Kinase inhibitors and their uses
US20100143488A1 (en) *	2006-09-21	2010-06-10	Toshiki Oguro	Promoter of hard tissue regeneration
WO2009116577A1 (ja) *	2008-03-18	2009-09-24	日産化学工業株式会社	１－（置換フェニル）－１－置換シリルエーテル、アルコールまたはケトンの製造方法および中間体
WO2010062366A1 (en) *	2008-10-31	2010-06-03	Arginetix, Inc.	Compositions and methods of treating endothelial disorders
WO2011011312A1 (en)	2009-07-22	2011-01-27	Merck Sharp & Dohme Corp.	Quinolinone pde2 inhibitors
US8440710B2 (en)	2009-10-15	2013-05-14	Hoffmann-La Roche Inc.	HSL inhibitors useful in the treatment of diabetes
US9540379B2 (en)	2011-01-31	2017-01-10	Boehringer Ingelheim International Gmbh	(1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases
EA201391558A1 (ru)	2011-04-20	2014-05-30	Глэксо Груп Лимитед	Тетрагидропиразоло[1,5-а]пиримидины как противотуберкулезные соединения
MY173949A (en)	2012-04-25	2020-02-28	Takeda Pharmaceuticals Co	Nitrogenated heterocyclic compound
JP6205356B2 (ja)	2012-07-13	2017-09-27	武田薬品工業株式会社	複素環化合物
US20140045856A1 (en)	2012-07-31	2014-02-13	Boehringer Ingelheim International Gmbh	4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes
EP2975031A4 (en)	2013-03-14	2017-04-19	Takeda Pharmaceutical Company Limited	Heterocyclic compound
US10053468B2 (en)	2013-07-03	2018-08-21	Takeda Pharmaceutical Company Limited	Heterocyclic compound
WO2015002230A1 (ja)	2013-07-03	2015-01-08	武田薬品工業株式会社	アミド化合物
EP3026051A4 (en) *	2013-07-24	2017-03-08	Takeda Pharmaceutical Company Limited	Heterocyclic compound
EP3087060B1 (en)	2013-12-23	2020-05-13	Merck Sharp & Dohme Corp.	Pyrimidone carboxamide compounds as pde2 inhibitors
JP6696904B2 (ja)	2014-01-08	2020-05-20	イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−ＣｅｌｌｕｌａｒＴｈｅｒａｐｉｅｓ，Ｉｎｃ．	製剤および医薬組成物
EP3174408B1 (en) *	2014-08-01	2018-12-05	Firmenich SA	Solid dispersion of amide flavor compounds
HK1243935A1 (zh)	2014-12-06	2018-07-27	Intra-Cellular Therapies, Inc.	有机化合物
WO2016090380A1 (en)	2014-12-06	2016-06-09	Intra-Cellular Therapies, Inc.	Organic compounds
WO2016145614A1 (en)	2015-03-17	2016-09-22	Merck Sharp & Dohme Corp.	Triazolyl pyrimidinone compounds as pde2 inhibitors
EP3285581B1 (en)	2015-03-26	2021-08-11	Merck Sharp & Dohme Corp.	Pyrazolyl pyrimidinone compounds as pde2 inhibitors
WO2016179059A1 (en)	2015-05-05	2016-11-10	Merck Sharp & Dohme Corp.	Heteroaryl-pyrimidinone compounds as pde2 inhibitors
WO2016183741A1 (en)	2015-05-15	2016-11-24	Merck Sharp & Dohme Corp.	Pyrimidinone amide compounds as pde2 inhibitors
WO2016191935A1 (en)	2015-05-29	2016-12-08	Merck Sharp & Dohme Corp.	6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors
WO2016192083A1 (en) *	2015-06-04	2016-12-08	Merck Sharp & Dohme Corp.	Dihydropyrazolopyrimidinone compounds as pde2 inhibitors
US10647727B2 (en)	2015-06-25	2020-05-12	Merck Sharp & Dohme Corp.	Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors
WO2017000276A1 (en)	2015-07-01	2017-01-05	Merck Sharp & Dohme Corp.	Bicyclic heterocyclic compounds as pde2 inhibitors
WO2017000277A1 (en)	2015-07-01	2017-01-05	Merck Sharp & Dohme Corp.	Substituted triazolo bicycliccompounds as pde2 inhibitors
EP3156405A1 (en)	2015-10-13	2017-04-19	Boehringer Ingelheim International GmbH	Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
GB201700814D0 (en)	2017-01-17	2017-03-01	Liverpool School Tropical Medicine	Compounds
AU2018371216B2 (en)	2017-11-23	2024-09-19	Oslo University Hospital Hf	Treatment of tachycardia
CN109758458B (zh) *	2019-03-05	2021-02-23	中国人民解放军陆军军医大学第二附属医院	抑制Crif1与PKA相互作用的化合物的应用
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US3288792A (en) *	1962-07-05	1966-11-29	Burroughs Wellcome Co	Method of preparing 2, 4-diamino-6-alkylpyrido (2, 3-d) pyrimidines
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2004
- 2004-12-06 RS RSP-2008/0172A patent/RS50575B/sr unknown
- 2004-12-06 AP AP2006003632A patent/AP2006003632A0/xx unknown
- 2004-12-06 CA CA002549510A patent/CA2549510A1/en not_active Abandoned
- 2004-12-06 GE GEAP20049461A patent/GEP20094720B/en unknown
- 2004-12-06 UA UAA200606683A patent/UA83091C2/ru unknown
- 2004-12-06 HR HR20080142T patent/HRP20080142T3/xx unknown
- 2004-12-06 ES ES04801323T patent/ES2299888T3/es not_active Expired - Lifetime
- 2004-12-06 US US10/595,766 patent/US20070135457A1/en not_active Abandoned
- 2004-12-06 DK DK04801323T patent/DK1697356T3/da active
- 2004-12-06 DE DE602004012154T patent/DE602004012154T2/de not_active Expired - Fee Related
- 2004-12-06 BR BRPI0417663-4A patent/BRPI0417663A/pt not_active IP Right Cessation
- 2004-12-06 AT AT04801323T patent/ATE387446T1/de not_active IP Right Cessation
- 2004-12-06 KR KR1020067011800A patent/KR100816179B1/ko not_active Expired - Fee Related
- 2004-12-06 EP EP04801323A patent/EP1697356B1/en not_active Expired - Lifetime
- 2004-12-06 PT PT04801323T patent/PT1697356E/pt unknown
- 2004-12-06 AU AU2004303609A patent/AU2004303609A1/en not_active Abandoned
- 2004-12-06 PL PL04801323T patent/PL1697356T3/pl unknown
- 2004-12-06 WO PCT/IB2004/004013 patent/WO2005061497A1/en not_active Ceased
- 2004-12-06 SI SI200430637T patent/SI1697356T1/sl unknown
- 2004-12-06 CN CNB2004800376743A patent/CN100439366C/zh not_active Expired - Fee Related
- 2004-12-06 EA EA200600973A patent/EA010424B1/ru not_active IP Right Cessation
- 2004-12-06 MX MXPA06006777A patent/MXPA06006777A/es active IP Right Grant
- 2004-12-06 JP JP2006544574A patent/JP4073944B2/ja not_active Expired - Fee Related
- 2004-12-15 NL NL1027787A patent/NL1027787C2/nl not_active IP Right Cessation
- 2004-12-15 UY UY28671A patent/UY28671A1/es not_active Application Discontinuation
- 2004-12-15 TW TW093138972A patent/TWI291961B/zh active
- 2004-12-15 GT GT200400268A patent/GT200400268A/es unknown
- 2004-12-15 AR ARP040104668A patent/AR046766A1/es not_active Application Discontinuation
- 2004-12-16 HN HN2004000538A patent/HN2004000538A/es unknown
- 2004-12-16 SV SV2004001979A patent/SV2005001979A/es not_active Application Discontinuation
2005
- 2005-01-03 PE PE2005000028A patent/PE20050681A1/es not_active Application Discontinuation
2006
- 2006-05-18 IS IS8474A patent/IS8474A/is unknown
- 2006-05-22 IL IL175813A patent/IL175813A0/en unknown
- 2006-06-15 EC EC2006006643A patent/ECSP066643A/es unknown
- 2006-06-15 ZA ZA200604970A patent/ZA200604970B/en unknown
- 2006-06-16 MA MA29113A patent/MA28270A1/fr unknown
- 2006-06-16 TN TNP2006000186A patent/TNSN06186A1/fr unknown
- 2006-07-11 NO NO20063231A patent/NO20063231L/no not_active Application Discontinuation
2008
- 2008-06-27 CL CL200801920A patent/CL2008001920A1/es unknown

Also Published As

Publication number	Publication date
KR20060105776A (ko)	2006-10-11
EA010424B1 (ru)	2008-08-29
MXPA06006777A (es)	2006-08-23
AU2004303609A1 (en)	2005-07-07
SI1697356T1 (sl)	2008-06-30
NL1027787C2 (nl)	2006-03-09
BRPI0417663A (pt)	2007-04-03
IS8474A (is)	2006-05-18
ZA200604970B (en)	2007-11-28
ECSP066643A (es)	2006-10-25
PE20050681A1 (es)	2005-10-04
PL1697356T3 (pl)	2008-07-31
CN100439366C (zh)	2008-12-03
CL2008001920A1 (es)	2008-10-17
IL175813A0 (en)	2006-10-05
DE602004012154T2 (de)	2009-03-12
AP2006003632A0 (en)	2006-06-30
US20070135457A1 (en)	2007-06-14
EP1697356A1 (en)	2006-09-06
TWI291961B (en)	2008-01-01
HN2004000538A (es)	2008-02-21
TNSN06186A1 (fr)	2007-11-15
CA2549510A1 (en)	2005-07-07
ES2299888T3 (es)	2008-06-01
GT200400268A (es)	2005-09-20
PT1697356E (pt)	2008-05-05
JP2007513996A (ja)	2007-05-31
MA28270A1 (fr)	2006-11-01
UY28671A1 (es)	2005-07-29
EP1697356B1 (en)	2008-02-27
UA83091C2 (en)	2008-06-10
JP4073944B2 (ja)	2008-04-09
DE602004012154D1 (de)	2008-04-10
KR100816179B1 (ko)	2008-03-28
GEP20094720B (en)	2009-06-25
CN1894245A (zh)	2007-01-10
SV2005001979A (es)	2005-12-13
EA200600973A1 (ru)	2006-10-27
ATE387446T1 (de)	2008-03-15
AR046766A1 (es)	2005-12-21
NL1027787A1 (nl)	2005-06-21
WO2005061497A1 (en)	2005-07-07
TW200522952A (en)	2005-07-16
RS50575B (sr)	2010-05-07
HRP20080142T3 (en)	2008-06-30
NO20063231L (no)	2006-07-11

Publication	Publication Date	Title
DK1697356T3 (da)	2009-01-12	Pyrido[2,3-d]pyrimidin-2,4-diaminer som PDE 2-inhibitorer
DK1966202T3 (da)	2012-01-16	Heteroarylsubstituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-d]pyrimidiner som Januskinaseinhibitorer
NO20023828L (no)	2002-09-30	Pyrimidin-4-on derivater som LDL-PLA2 inhibitorer
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